{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T16:03:52Z","timestamp":1791821032659,"version":"4.3.4"},"reference-count":51,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["42277438"],"award-info":[{"award-number":["42277438"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of Hunan Province","doi-asserted-by":"publisher","award":["2020JJ3052"],"award-info":[{"award-number":["2020JJ3052"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Food and Chemical Toxicology"],"published-print":{"date-parts":[[2023,10]]},"DOI":"10.1016\/j.fct.2023.114002","type":"journal-article","created":{"date-parts":[[2023,8,25]],"date-time":"2023-08-25T20:42:27Z","timestamp":1692996147000},"page":"114002","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":36,"special_numbering":"C","title":["The crosstalk between M1 macrophage polarization and energy metabolism disorder contributes to polystyrene nanoplastics-triggered testicular inflammation"],"prefix":"10.1016","volume":"180","author":[{"given":"Siwen","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lemei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Die","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.fct.2023.114002_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2020.114158","article-title":"The emerging risk of exposure to nano(micro)plastics on endocrine disturbance and reproductive toxicity: from a hypothetical scenario to a global public health challenge","volume":"261","author":"Amereh","year":"2020","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.fct.2023.114002_bib2","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1016\/j.cmet.2016.10.008","article-title":"Glutaminolysis and fumarate accumulation integrate immunometabolic and epigenetic programs in trained immunity","volume":"24","author":"Arts","year":"2016","journal-title":"Cell Metabol."},{"key":"10.1016\/j.fct.2023.114002_bib3","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.jri.2016.06.008","article-title":"Macrophages in testis function","volume":"119","author":"Bhushan","year":"2017","journal-title":"J. Reprod. Immunol."},{"key":"10.1016\/j.fct.2023.114002_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2019.113449","article-title":"Microplastic pollution in vegetable farmlands of suburb Wuhan, central China","volume":"257","author":"Chen","year":"2020","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.fct.2023.114002_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2022.102446","article-title":"LDHA-mediated metabolic reprogramming promoted cardiomyocyte proliferation by alleviating ROS and inducing M2 macrophage polarization","volume":"56","author":"Chen","year":"2022","journal-title":"Redox Biol."},{"key":"10.1016\/j.fct.2023.114002_bib7","article-title":"Tissue accumulation of microplastics in mice and biomarker responses suggest widespread health risks of exposure","volume":"7","author":"Deng","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.fct.2023.114002_bib8","doi-asserted-by":"crossref","first-page":"19740","DOI":"10.1074\/jbc.RA118.003935","article-title":"Macrophage migration inhibitory factor regulates mitochondrial dynamics and cell growth of human cancer cell lines through CD74-NF-kappaB signaling","volume":"293","author":"De","year":"2018","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.fct.2023.114002_bib9","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1016\/S0025-326X(02)00220-5","article-title":"The pollution of the marine environment by plastic debris: a review","volume":"44","author":"Derraik","year":"2002","journal-title":"Mar. Pollut. Bull."},{"key":"10.1016\/j.fct.2023.114002_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2021.112790","article-title":"Emodin ameliorates antioxidant capacity and exerts neuroprotective effects via PKM2-mediated Nrf2 transactivation","volume":"160","author":"Ding","year":"2022","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.fct.2023.114002_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.imbio.2023.152357","article-title":"Macrophage migration inhibitory factor contributes to driving phenotypic and functional macrophage activation in response to Toxoplasma gondii infection","volume":"228","author":"Ferreira","year":"2023","journal-title":"Immunobiology"},{"key":"10.1016\/j.fct.2023.114002_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2020.124028","article-title":"Reproductive toxicity of polystyrene microplastics: In vivo experimental study on testicular toxicity in mice","volume":"405","author":"Hou","year":"2021","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.fct.2023.114002_bib13","article-title":"Polystyrene microplastic exposure induces insulin resistance in mice via dysbacteriosis and proinflammation","author":"Huang","year":"2022","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.fct.2023.114002_bib14","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1126\/science.1260352","article-title":"Plastic waste inputs from land into the ocean","volume":"347","author":"Jambeck","year":"2015","journal-title":"Science"},{"key":"10.1016\/j.fct.2023.114002_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2021.118502","article-title":"Microplastics influence physiological processes, growth and reproduction in the Manila clam, Ruditapes philippinarum","volume":"293","author":"Jiang","year":"2022","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.fct.2023.114002_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2020.123430","article-title":"Polystyrene microplastics induced male reproductive toxicity in mice","volume":"401","author":"Jin","year":"2021","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.fct.2023.114002_bib17","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1126\/science.aba5899","article-title":"Seafloor microplastic hotspots controlled by deep-sea circulation","volume":"368","author":"Kane","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.fct.2023.114002_bib18","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.1016\/j.scitotenv.2017.09.005","article-title":"Microplastic and mesoplastic contamination in canned sardines and sprats","volume":"612","author":"Karami","year":"2018","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.fct.2023.114002_bib19","first-page":"607","volume":"vol. 21","author":"Karimi","year":"2018"},{"key":"10.1016\/j.fct.2023.114002_bib20","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.cellsig.2017.03.007","article-title":"Macrophage migration inhibitory factor interacts with thioredoxin-interacting protein and induces NF-kappaB activity","volume":"34","author":"Kim","year":"2017","journal-title":"Cell. Signal."},{"key":"10.1016\/j.fct.2023.114002_bib21","doi-asserted-by":"crossref","first-page":"3691","DOI":"10.1016\/j.molcel.2021.08.018","article-title":"Redox metabolism: ROS as specific molecular regulators of cell signaling and function","volume":"81","author":"Lennicke","year":"2021","journal-title":"Mol. Cell"},{"key":"10.1016\/j.fct.2023.114002_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2022.113071","article-title":"Endogenous hydrogen sulfide counteracts polystyrene nanoplastics-induced mitochondrial apoptosis and excessive autophagy via regulating Nrf2 and PGC-1\u03b1 signaling pathway in mouse spermatocyte-derived GC-2spd(ts) cells","volume":"164","author":"Li","year":"2022","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.fct.2023.114002_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2021.126025","article-title":"Polystyrene microplastics trigger hepatocyte apoptosis and abnormal glycolytic flux via ROS-driven calcium overload","volume":"417","author":"Li","year":"2021","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.fct.2023.114002_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2020.123933","article-title":"Keap1-Nrf2 pathway upregulate via hydrogen sulfide mitigates polystyrene microplastics induced-hepatotoxic effects","volume":"402","author":"Li","year":"2021","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.fct.2023.114002_bib25","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.freeradbiomed.2022.02.005","article-title":"Melatonin alleviates PM2.5-triggered macrophage M1 polarization and atherosclerosis by regulating via regulating NOX2-mediated oxidative stress homeostasis","volume":"181","author":"Liu","year":"2022","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.fct.2023.114002_bib26","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/j.scitotenv.2018.03.051","article-title":"Polystyrene microplastics induce gut microbiota dysbiosis and hepatic lipid metabolism disorder in mice","volume":"631\u2013632","author":"Lu","year":"2018","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.fct.2023.114002_bib27","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.cellimm.2018.03.009","article-title":"Testicular macrophages: guardians of fertility","volume":"330","author":"Mossadegh-Keller","year":"2018","journal-title":"Cell. Immunol."},{"key":"10.1016\/j.fct.2023.114002_bib28","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1038\/nri1057","article-title":"Anatomical basis of tolerance and immunity to intestinal antigens","volume":"3","author":"Mowat","year":"2003","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.fct.2023.114002_bib29","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.cmet.2014.12.005","article-title":"Pyruvate kinase M2 regulates Hif-1alpha activity and IL-1beta induction and is a critical determinant of the warburg effect in LPS-activated macrophages","volume":"21","author":"Palsson-McDermott","year":"2015","journal-title":"Cell Metabol."},{"key":"10.1016\/j.fct.2023.114002_bib30","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1002\/jnr.20180","article-title":"Redox regulation of glial inflammatory response to lipopolysaccharide and interferongamma","volume":"77","author":"Pawate","year":"2004","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.fct.2023.114002_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2021.127093","article-title":"Occurrence of microplastics in commercial marine dried fish in Asian countries","volume":"423","author":"Piyawardhana","year":"2022","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.fct.2023.114002_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2020.123775","article-title":"Oxidative damage and decreased aerobic energy production due to ingestion of polyethylene microplastics by Chironomus riparius (Diptera) larvae","volume":"402","author":"Silva","year":"2021","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.fct.2023.114002_bib34","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.aquatox.2017.06.014","article-title":"Pathway analysis of systemic transcriptome responses to injected polystyrene particles in zebrafish larvae","volume":"190","author":"Veneman","year":"2017","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.fct.2023.114002_bib35","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.chemosphere.2018.11.070","article-title":"Effects of polystyrene microplastics on the composition of the microbiome and metabolism in larval zebrafish","volume":"217","author":"Wan","year":"2019","journal-title":"Chemosphere"},{"key":"10.1016\/j.fct.2023.114002_bib36","doi-asserted-by":"crossref","first-page":"8487","DOI":"10.2147\/IJN.S170723","article-title":"Potential adverse effects of nanoparticles on the reproductive system","volume":"13","author":"Wang","year":"2018","journal-title":"Int. J. Nanomed."},{"key":"10.1016\/j.fct.2023.114002_bib37","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1038\/s41398-020-0731-z","article-title":"Dl-3-n-butylphthalide attenuates mouse behavioral deficits to chronic social defeat stress by regulating energy metabolism via AKT\/CREB signaling pathway","volume":"10","author":"Wang","year":"2020","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.fct.2023.114002_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2023.113642","article-title":"The effect and a mechanistic evaluation of polystyrene nanoplastics on a mouse model of type 2 diabetes","volume":"173","author":"Wang","year":"2023","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.fct.2023.114002_bib39","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1038\/s41467-020-14788-x","article-title":"Pyridoxine induces glutathione synthesis via PKM2-mediated Nrf2 transactivation and confers neuroprotection","volume":"11","author":"Wei","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.fct.2023.114002_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2021.117904","article-title":"Polystyrene microplastics disrupt the blood\u2012testis barrier integrity through ROS-Mediated imbalance of mTORC1 and mTORC2","volume":"289","author":"Wei","year":"2021","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.fct.2023.114002_bib41","article-title":"Comparing the effects of polystyrene microplastics exposure on reproduction and fertility in male and female mice","volume":"465","author":"Wei","year":"2021","journal-title":"Toxicology"},{"key":"10.1016\/j.fct.2023.114002_bib42","doi-asserted-by":"crossref","first-page":"6634","DOI":"10.1021\/acs.est.7b00423","article-title":"Plastic and human health: a micro issue?","volume":"51","author":"Wright","year":"2017","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.fct.2023.114002_bib43","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2023.161962","article-title":"Polystyrene-microplastics and DEHP coexposure induced DNA damage, cell cycle arrest and necroptosis of ovarian granulosa cells in mice by promoting ROS production","volume":"871","author":"Wu","year":"2023","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.fct.2023.114002_bib44","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2023.131971","article-title":"Microplastics perturb nitrogen removal, microbial community and metabolism mechanism in biofilm system","volume":"458","author":"Wu","year":"2023","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.fct.2023.114002_bib45","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2019.110133","article-title":"Exposure to polystyrene microplastics causes reproductive toxicity through oxidative stress and activation of the p38 MAPK signaling pathway","volume":"190","author":"Xie","year":"2020","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.fct.2023.114002_bib46","doi-asserted-by":"crossref","first-page":"13622","DOI":"10.1021\/acs.est.5b03163","article-title":"Microplastic pollution in table salts from China","volume":"49","author":"Yang","year":"2015","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.fct.2023.114002_bib47","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2021.112730","article-title":"Upregulation of autophagy in M2 macrophage by vitamin D alleviates crystalline silica-induced pulmonary inflammatory damage","volume":"225","author":"Yang","year":"2021","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.fct.2023.114002_bib48","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2023.114871","article-title":"Tissue accumulation of polystyrene microplastics causes oxidative stress, hepatopancreatic injury and metabolome alterations in Litopenaeus vannamei","volume":"256","author":"Zeng","year":"2023","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.fct.2023.114002_bib49","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2021.112590","article-title":"NLRP3 inflammasome blocked the glycolytic pathway by targeting to PKLR in arsenic-induced hepatic insulin resistance","volume":"223","author":"Zhang","year":"2021","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.fct.2023.114002_bib50","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2021.112882","article-title":"Prolonged oral ingestion of microplastics induced inflammation in the liver tissues of C57BL\/6J mice through polarization of macrophages and increased infiltration of natural killer cells","volume":"227","author":"Zhao","year":"2021","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.fct.2023.114002_bib51","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2022.161267","article-title":"Energy metabolism response induced by microplastic for marine dinoflagellate Karenia mikimotoi","volume":"866","author":"Zhao","year":"2023","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.fct.2023.114002_bib52","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2019.136279","article-title":"Polystyrene microplastic exposure disturbs hepatic glycolipid metabolism at the physiological, biochemical, and transcriptomic levels in adult zebrafish","volume":"710","author":"Zhao","year":"2020","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.fct.2023.114002_bib53","doi-asserted-by":"crossref","DOI":"10.1016\/j.cyto.2021.155776","article-title":"Inhibition of macrophage migration inhibitory factor alleviates LPS-induced inflammation response of HEI-OC1 cells by suppressing NF-kappaB signaling","volume":"150","author":"Zhu","year":"2022","journal-title":"Cytokine"}],"container-title":["Food and Chemical Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278691523004040?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278691523004040?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T22:22:57Z","timestamp":1759530177000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0278691523004040"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10]]},"references-count":51,"alternative-id":["S0278691523004040"],"URL":"https:\/\/doi.org\/10.1016\/j.fct.2023.114002","relation":{},"ISSN":["0278-6915"],"issn-type":[{"value":"0278-6915","type":"print"}],"subject":[],"published":{"date-parts":[[2023,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The crosstalk between M1 macrophage polarization and energy metabolism disorder contributes to polystyrene nanoplastics-triggered testicular inflammation","name":"articletitle","label":"Article Title"},{"value":"Food and Chemical Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fct.2023.114002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"114002"}}