{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T23:42:35Z","timestamp":1792453355966,"version":"4.5.0"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Food and Chemical Toxicology"],"published-print":{"date-parts":[[2023,11]]},"DOI":"10.1016\/j.fct.2023.114104","type":"journal-article","created":{"date-parts":[[2023,10,15]],"date-time":"2023-10-15T09:57:43Z","timestamp":1697363863000},"page":"114104","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":26,"special_numbering":"C","title":["Co-exposure to polystyrene microplastics and microcystin-LR aggravated male reproductive toxicity in mice"],"prefix":"10.1016","volume":"181","author":[{"given":"Hongru","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haibo","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yabing","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongmei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaodong","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.fct.2023.114104_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2021.126124","article-title":"Presence of airborne microplastics in human lung tissue","volume":"416","author":"Amato-Lourenco","year":"2021","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.fct.2023.114104_bib2","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1016\/j.toxicon.2009.07.006","article-title":"Recreational exposure to microcystins during algal blooms in two California lakes","volume":"55","author":"Backer","year":"2010","journal-title":"Toxicon"},{"key":"10.1016\/j.fct.2023.114104_bib3","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.jhazmat.2015.08.041","article-title":"A review of reproductive toxicity of microcystins","volume":"301","author":"Chen","year":"2016","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.fct.2023.114104_bib4","volume":"vol. 764","author":"Chen","year":"2021"},{"key":"10.1016\/j.fct.2023.114104_bib5","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1016\/j.envpol.2017.07.081","article-title":"Microcystin-leucine arginine exhibits immunomodulatory roles in testicular cells resulting in orchitis","volume":"229","author":"Chen","year":"2017","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.fct.2023.114104_bib6","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/j.reprotox.2011.02.006","article-title":"Decline of sperm quality and testicular function in male mice during chronic low-dose exposure to microcystin-LR","volume":"31","author":"Chen","year":"2011","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.fct.2023.114104_bib7","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1016\/j.envpol.2017.07.081","article-title":"Microcystin-leucine arginine exhibits immunomodulatory roles in testicular cells resulting in orchitis","volume":"229","author":"Chen","year":"2017","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.fct.2023.114104_bib8","doi-asserted-by":"crossref","first-page":"7068","DOI":"10.1021\/acs.est.9b01517","article-title":"Human consumption of microplastics","volume":"53","author":"Cox","year":"2019","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.fct.2023.114104_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2020.105916","article-title":"Microplastics release phthalate esters and cause aggravated adverse effects in the mouse gut","volume":"143","author":"Deng","year":"2020","journal-title":"Environ. Int."},{"key":"10.1016\/j.fct.2023.114104_bib10","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1016\/j.scitotenv.2018.06.123","article-title":"Microcystin-LR reduces the synthesis of gonadotropin-releasing hormone by activating multiple signaling pathways resulting in decrease of testosterone in mice","volume":"643","author":"Ding","year":"2018","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.fct.2023.114104_bib11","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.chemosphere.2015.04.012","article-title":"Fluoride exposure changed the structure and the expressions of reproductive related genes in the hypothalamus-pituitary-testicular axis of male mice","volume":"135","author":"Han","year":"2015","journal-title":"Chemosphere"},{"key":"10.1016\/j.fct.2023.114104_bib12","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1111\/andr.12703","article-title":"Essential roles of interstitial cells in testicular development and function","volume":"8","author":"Heinrich","year":"2020","journal-title":"Andrology"},{"key":"10.1016\/j.fct.2023.114104_bib13","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1038\/s41586-019-1648-7","article-title":"Widespread global increase in intense lake phytoplankton blooms since the 1980s","volume":"574","author":"Ho","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.fct.2023.114104_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2020.140349","article-title":"Microplastic pollution in a rapidly changing world: implications for remote and vulnerable marine ecosystems","volume":"738","author":"Horton","year":"2020","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.fct.2023.114104_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2020.123430","article-title":"Polystyrene microplastics induced male reproductive toxicity in mice","volume":"401","author":"Jin","year":"2021","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.fct.2023.114104_bib16","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/s12989-022-00453-2","article-title":"Chronic exposure to polystyrene microplastics induced male reproductive toxicity and decreased testosterone levels via the LH-mediated LHR\/cAMP\/PKA\/StAR pathway","volume":"19","author":"Jin","year":"2022","journal-title":"Part. Fibre Toxicol."},{"key":"10.1016\/j.fct.2023.114104_bib17","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.anireprosci.2007.11.029","article-title":"Role of Sertoli cell number and function on regulation of spermatogenesis","volume":"105","author":"Johnson","year":"2008","journal-title":"Anim. Reprod. Sci."},{"key":"10.1016\/j.fct.2023.114104_bib18","article-title":"Effects of microplastics in freshwater fishes health and the implications for human health","volume":"84","author":"Khan","year":"2023","journal-title":"Braz. J. Biol."},{"key":"10.1016\/j.fct.2023.114104_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2022.107199","article-title":"Discovery and quantification of plastic particle pollution in human blood","volume":"163","author":"Leslie","year":"2022","journal-title":"Environ. Int."},{"key":"10.1016\/j.fct.2023.114104_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2023.162664","article-title":"Polystyrene microplastics enhance the microcystin-LR-induced gonadal damage and reproductive endocrine disruption in zebrafish","volume":"876","author":"Lin","year":"2023","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.fct.2023.114104_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2021.151749","article-title":"The presence of polystyrene nanoplastics enhances the MCLR uptake in zebrafish leading to the exacerbation of oxidative liver damage","volume":"818","author":"Ling","year":"2022","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.fct.2023.114104_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2022.113454","article-title":"Long-term exposure to low concentrations of MC-LR induces blood-testis barrier damage through the RhoA\/ROCK pathway","volume":"236","author":"Liu","year":"2022","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.fct.2023.114104_bib23","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.fct.2023.114104_bib24","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1126\/science.aad8828","article-title":"RETRACTED: environmentally relevant concentrations of microplastic particles influence larval fish ecology","volume":"352","author":"Lonnstedt","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.fct.2023.114104_bib25","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1016\/j.cell.2016.11.016","article-title":"Zika virus causes testis damage and leads to male infertility in mice","volume":"167","author":"Ma","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.fct.2023.114104_bib26","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.semcdb.2016.04.009","article-title":"Spermatogenesis in humans and its affecting factors","volume":"59","author":"Neto","year":"2016","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.fct.2023.114104_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2023.164292","article-title":"Microplastics in Australian indoor air: abundance, characteristics, and implications for human exposure","volume":"889","author":"Perera","year":"2023","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.fct.2023.114104_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.marpolbul.2020.111948","article-title":"Meso- and microplastics monitoring in harbour environments: a case study for the Port of Durban, South Africa","volume":"163","author":"Preston-Whyte","year":"2021","journal-title":"Mar. Pollut. Bull."},{"key":"10.1016\/j.fct.2023.114104_bib29","doi-asserted-by":"crossref","DOI":"10.3390\/polym15112425","article-title":"Insights into anthropogenic micro- and nanoplastic accumulation in drinking water sources and their potential effects on human health","volume":"15","author":"Rapa","year":"2023","journal-title":"Polymers (Basel)"},{"key":"10.1016\/j.fct.2023.114104_bib30","doi-asserted-by":"crossref","DOI":"10.1007\/s11356-023-27914-1","article-title":"Health risk assessment of lake water contaminated with microcystins for fruit crop irrigation and farm animal drinking","author":"Redouane","year":"2023","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"10.1016\/j.fct.2023.114104_bib31","doi-asserted-by":"crossref","first-page":"453","DOI":"10.7326\/M19-0618","article-title":"Detection of various microplastics in human stool: a prospective case series","volume":"171","author":"Schwabl","year":"2019","journal-title":"Ann. Intern. Med."},{"key":"10.1016\/j.fct.2023.114104_bib32","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.marpolbul.2016.05.077","article-title":"Microplastic contamination in the San Francisco Bay, California, USA","volume":"109","author":"Sutton","year":"2016","journal-title":"Mar. Pollut. Bull."},{"key":"10.1016\/j.fct.2023.114104_bib33","doi-asserted-by":"crossref","DOI":"10.1155\/2010\/684504","article-title":"Endocrine disruptors and Leydig cell function","author":"Svechnikov","year":"2010","journal-title":"J. Biomed. Biotechnol."},{"key":"10.1016\/j.fct.2023.114104_bib34","doi-asserted-by":"crossref","first-page":"2198","DOI":"10.3390\/toxins7062198","article-title":"Cyanobacteria and cyanotoxins occurrence and removal from five high-risk conventional treatment drinking water plants","volume":"7","author":"Szlag","year":"2015","journal-title":"Toxins"},{"key":"10.1016\/j.fct.2023.114104_bib35","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1126\/science.1094559","article-title":"Lost at sea: where is all the plastic?","volume":"304","author":"Thompson","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.fct.2023.114104_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2021.112919","article-title":"The activated ATM\/p53 pathway promotes autophagy in response to oxidative stress-mediated DNA damage induced by Microcystin-LR in male germ cells","volume":"227","author":"Tian","year":"2021","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.fct.2023.114104_bib37","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.steroids.2015.08.001","article-title":"Molecular regulation of steroidogenesis in endocrine Leydig cells","volume":"103","author":"Tremblay","year":"2015","journal-title":"Steroids"},{"key":"10.1016\/j.fct.2023.114104_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2023.121146","article-title":"Microcystin bound on microplastics in eutrophic waters: a potential threat to zooplankton revealed by adsorption-desorption processes","volume":"321","author":"Wan","year":"2023","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.fct.2023.114104_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2023.121960","article-title":"Combined effects of microplastics and cadmium on the soil-plant system: phytotoxicity, Cd accumulation and microbial activity","volume":"333","author":"Wang","year":"2023","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.fct.2023.114104_bib40","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.1007\/s10646-013-1141-2","article-title":"Distribution of microcystin-LR to testis of male Sprague-Dawley rats","volume":"22","author":"Wang","year":"2013","journal-title":"Ecotoxicology"},{"key":"10.1016\/j.fct.2023.114104_bib41","doi-asserted-by":"crossref","first-page":"1795","DOI":"10.1100\/tsw.2010.172","article-title":"Factors affecting temporal and spatial variations of microcystins in Gonghu Bay of Lake Taihu, with potential risk of microcystin contamination to human health","volume":"10","author":"Wang","year":"2010","journal-title":"Sci. World J."},{"key":"10.1016\/j.fct.2023.114104_bib42","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.toxicon.2016.10.011","article-title":"Microcystin-LR causes sexual hormone disturbance in male rat by targeting gonadotropin-releasing hormone neurons","volume":"123","author":"Wang","year":"2016","journal-title":"Toxicon"},{"key":"10.1016\/j.fct.2023.114104_bib43","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1016\/j.scitotenv.2018.09.049","article-title":"Adsorption mechanisms of five bisphenol analogues on PVC microplastics","volume":"650","author":"Wu","year":"2019","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.fct.2023.114104_bib44","doi-asserted-by":"crossref","DOI":"10.1289\/EHP9736","article-title":"Association between semen microcystin levels and reproductive quality: a cross-sectional study in Jiangsu and Anhui Provinces, China","volume":"129","author":"Xu","year":"2021","journal-title":"Environ. Health Perspect."}],"container-title":["Food and Chemical Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278691523005069?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278691523005069?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,8]],"date-time":"2025-01-08T09:13:35Z","timestamp":1736327615000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0278691523005069"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11]]},"references-count":44,"alternative-id":["S0278691523005069"],"URL":"https:\/\/doi.org\/10.1016\/j.fct.2023.114104","relation":{},"ISSN":["0278-6915"],"issn-type":[{"value":"0278-6915","type":"print"}],"subject":[],"published":{"date-parts":[[2023,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Co-exposure to polystyrene microplastics and microcystin-LR aggravated male reproductive toxicity in mice","name":"articletitle","label":"Article Title"},{"value":"Food and Chemical Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fct.2023.114104","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"114104"}}