{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T23:08:41Z","timestamp":1778540921685,"version":"3.51.4"},"reference-count":48,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of Hunan Province","doi-asserted-by":"publisher","award":["2021JJ30922"],"award-info":[{"award-number":["2021JJ30922"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018925","name":"Health Commission of Henan Province","doi-asserted-by":"publisher","award":["202113010595"],"award-info":[{"award-number":["202113010595"]}],"id":[{"id":"10.13039\/100018925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011790","name":"Xiangya Hospital, Central South University","doi-asserted-by":"publisher","award":["[2021]94"],"award-info":[{"award-number":["[2021]94"]}],"id":[{"id":"10.13039\/501100011790","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016802","name":"Natural Science Foundation of Changzhou Municipality","doi-asserted-by":"publisher","award":["kq2007045"],"award-info":[{"award-number":["kq2007045"]}],"id":[{"id":"10.13039\/100016802","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010083","name":"Hunan Provincial Innovation Foundation for Postgraduate","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010083","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012476","name":"Fundamental Research Funds for Central Universities of the Central South University","doi-asserted-by":"publisher","award":["2023ZZTS0213"],"award-info":[{"award-number":["2023ZZTS0213"]}],"id":[{"id":"10.13039\/501100012476","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012476","name":"Fundamental Research Funds for Central Universities of the Central South University","doi-asserted-by":"publisher","award":["2023ZZTS0883"],"award-info":[{"award-number":["2023ZZTS0883"]}],"id":[{"id":"10.13039\/501100012476","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Food and Chemical Toxicology"],"published-print":{"date-parts":[[2024,3]]},"DOI":"10.1016\/j.fct.2024.114490","type":"journal-article","created":{"date-parts":[[2024,2,5]],"date-time":"2024-02-05T12:29:38Z","timestamp":1707136178000},"page":"114490","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["B-GOS alleviates olanzapine-induced lipid disturbances in mice by enriching Akkermansia and upregulation of PGRMC1-Wnt signaling"],"prefix":"10.1016","volume":"185","author":[{"given":"Cuirong","family":"Zeng","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ting","family":"Cao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liwei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shimeng","family":"Jiao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chenquan","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bikui","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5472-0236","authenticated-orcid":false,"given":"Hualin","family":"Cai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.fct.2024.114490_bib1","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1016\/j.jhep.2019.10.003","article-title":"The gut-liver axis in liver disease: pathophysiological basis for therapy","volume":"72","author":"Albillos","year":"2020","journal-title":"J. Hepatol."},{"key":"10.1016\/j.fct.2024.114490_bib2","doi-asserted-by":"crossref","DOI":"10.1038\/tp.2015.161","article-title":"A potential mechanism underlying atypical antipsychotics-induced lipid disturbances","volume":"5","author":"Cai","year":"2015","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.fct.2024.114490_bib3","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2021.727371","article-title":"Clozapine induced disturbances in hepatic glucose metabolism: the potential role of PGRMC1 signaling","volume":"12","author":"Cao","year":"2021","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.fct.2024.114490_bib4","article-title":"The involvement of PGRMC1 signaling in cognitive impairment induced by long-term clozapine treatment in rats","volume":"1\u201313","author":"Cao","year":"2023","journal-title":"Neuropsychobiology"},{"key":"10.1016\/j.fct.2024.114490_bib5","article-title":"The regulatory effects of second-generation antipsychotics on lipid metabolism: potential mechanisms mediated by the gut microbiota and therapeutic implications","volume":"14","author":"Chen","year":"2023","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.fct.2024.114490_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.psj.2021.101283","article-title":"Lactobacillus casei protects intestinal mucosa from damage in chicks caused by Salmonella pullorum via regulating immunity and the Wnt signaling pathway and maintaining the abundance of gut microbiota","volume":"100","author":"Deng","year":"2021","journal-title":"Poultry Sci."},{"key":"10.1016\/j.fct.2024.114490_bib7","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.jpsychires.2012.10.005","article-title":"The dietary pattern of patients with schizophrenia: a systematic review","volume":"47","author":"Dipasquale","year":"2013","journal-title":"J. Psychiatr. Res."},{"key":"10.1016\/j.fct.2024.114490_bib8","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.1126\/science.1110591","article-title":"Diversity of the human intestinal microbial flora","volume":"308","author":"Eckburg","year":"2005","journal-title":"Science (New York, N.Y.)"},{"key":"10.1016\/j.fct.2024.114490_bib9","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.tins.2013.01.005","article-title":"Gut-brain axis: how the microbiome influences anxiety and depression","volume":"36","author":"Foster","year":"2013","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.fct.2024.114490_bib10","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1176\/appi.ajp.2009.08121873","article-title":"Roles of the Akt\/GSK-3 and Wnt signaling pathways in schizophrenia and antipsychotic drug action","volume":"167","author":"Freyberg","year":"2010","journal-title":"Am. J. Psychiatr."},{"key":"10.1016\/j.fct.2024.114490_bib11","article-title":"Effects of active, inactive, and derivatives of Akkermansia muciniphila on the expression of the endocannabinoid system and PPARs genes","volume":"12","author":"Ghaderi","year":"2022","journal-title":"Sci. Rep."},{"key":"10.1016\/j.fct.2024.114490_bib12","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.cmet.2013.11.023","article-title":"The combined hyperlipidemia caused by impaired Wnt-LRP6 signaling is reversed by Wnt3a rescue","volume":"19","author":"Go","year":"2014","journal-title":"Cell Metabol."},{"key":"10.1016\/j.fct.2024.114490_bib13","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.bbi.2020.09.034","article-title":"Mom's diet matters: maternal prebiotic intake in mice reduces anxiety and alters brain gene expression and the fecal microbiome in offspring","volume":"91","author":"Hebert","year":"2021","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.fct.2024.114490_bib14","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1038\/nature10809","article-title":"Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity","volume":"482","author":"Henao-Mejia","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.fct.2024.114490_bib15","doi-asserted-by":"crossref","first-page":"2543","DOI":"10.1007\/s00213-021-05878-9","article-title":"A potential probiotic bacterium for antipsychotic-induced metabolic syndrome: mechanisms underpinning how Akkermansia muciniphila subtype improves olanzapine-induced glucose homeostasis in mice","volume":"238","author":"Huang","year":"2021","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.fct.2024.114490_bib16","doi-asserted-by":"crossref","DOI":"10.3390\/cells8111460","article-title":"Carbamazepine enhances adipogenesis by inhibiting Wnt\/\u03b2-catenin expression","volume":"8","author":"Im","year":"2019","journal-title":"Cells"},{"key":"10.1016\/j.fct.2024.114490_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.jnutbio.2020.108399","article-title":"Olanzapine-induced liver injury in mice: aggravation by high-fat diet and protection with sulforaphane","volume":"81","author":"Isaacson","year":"2020","journal-title":"J. Nutr. Biochem."},{"key":"10.1016\/j.fct.2024.114490_bib18","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1038\/s41398-018-0116-8","article-title":"Prebiotic attenuation of olanzapine-induced weight gain in rats: analysis of central and peripheral biomarkers and gut microbiota","volume":"8","author":"Kao","year":"2018","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.fct.2024.114490_bib19","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1124\/jpet.102.046987","article-title":"Antipsychotic dosing in preclinical models is often unrepresentative of the clinical condition: a suggested solution based on in vivo occupancy","volume":"305","author":"Kapur","year":"2003","journal-title":"J. Pharmacol. Exp. Therapeut."},{"key":"10.1016\/j.fct.2024.114490_bib20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/19490976.2021.1892441","article-title":"Mucin degrader Akkermansia muciniphila accelerates intestinal stem cell-mediated epithelial development","volume":"13","author":"Kim","year":"2021","journal-title":"Gut Microb."},{"key":"10.1016\/j.fct.2024.114490_bib21","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1152\/physrev.00041.2018","article-title":"Free fatty acid receptors in health and disease","volume":"100","author":"Kimura","year":"2020","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.fct.2024.114490_bib22","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1016\/S0140-6736(13)60733-3","article-title":"Comparative efficacy and tolerability of 15 antipsychotic drugs in schizophrenia: a multiple-treatments meta-analysis","volume":"382","author":"Leucht","year":"2013","journal-title":"Lancet (London, England)"},{"key":"10.1016\/j.fct.2024.114490_bib23","article-title":"JNK downregulation improves olanzapine-induced insulin resistance by suppressing IRS1(Ser307) phosphorylation and reducing inflammation","volume":"142","author":"Li","year":"2021","journal-title":"Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie"},{"key":"10.1016\/j.fct.2024.114490_bib24","doi-asserted-by":"crossref","first-page":"4748","DOI":"10.1038\/s41598-020-61727-3","article-title":"Progesterone receptor membrane component 1 leads to erlotinib resistance, initiating crosstalk of Wnt\/\u03b2-catenin and NF-\u03baB pathways, in lung adenocarcinoma cells","volume":"10","author":"Lin","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.fct.2024.114490_bib25","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.schres.2012.09.019","article-title":"Relationship between metabolic syndrome and cognition in patients with schizophrenia","volume":"142","author":"Lindenmayer","year":"2012","journal-title":"Schizophr. Res."},{"key":"10.1016\/j.fct.2024.114490_bib26","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1093\/schbul\/sbr148","article-title":"Prevalence of metabolic syndrome and metabolic abnormalities in schizophrenia and related disorders--a systematic review and meta-analysis","volume":"39","author":"Mitchell","year":"2013","journal-title":"Schizophr. Bull."},{"key":"10.1016\/j.fct.2024.114490_bib27","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0115225","article-title":"The antipsychotic olanzapine interacts with the gut microbiome to cause weight gain in mouse","volume":"9","author":"Morgan","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.fct.2024.114490_bib28","doi-asserted-by":"crossref","first-page":"27","DOI":"10.4103\/0976-0105.177703","article-title":"A simple practice guide for dose conversion between animals and human","volume":"7","author":"Nair","year":"2016","journal-title":"J. Basic Clin. Pharm."},{"key":"10.1016\/j.fct.2024.114490_bib29","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1016\/j.ajpath.2013.11.029","article-title":"Gut commensal bacteria and regional Wnt gene expression in the proximal versus distal colon","volume":"184","author":"Neumann","year":"2014","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.fct.2024.114490_bib30","doi-asserted-by":"crossref","first-page":"9706","DOI":"10.1096\/fj.201802681RR","article-title":"The PPAR-microbiota-metabolic organ trilogy to fine-tune physiology","volume":"33","author":"Oh","year":"2019","journal-title":"Faseb. J.: official publication of the Federation of American Societies for Experimental Biology"},{"key":"10.1016\/j.fct.2024.114490_bib31","doi-asserted-by":"crossref","first-page":"E624","DOI":"10.1152\/ajpendo.00502.2010","article-title":"Atypical antipsychotic drugs perturb AMPK-dependent regulation of hepatic lipid metabolism","volume":"300","author":"Oh","year":"2011","journal-title":"Am. J. Physiol. Endocrinol. Metabol."},{"key":"10.1016\/j.fct.2024.114490_bib32","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1038\/s41366-020-00712-2","article-title":"Identification of gut microbiota and microbial metabolites regulated by an antimicrobial peptide lipocalin 2 in high fat diet-induced obesity","volume":"45","author":"Qiu","year":"2021","journal-title":"Int. J. Obes."},{"key":"10.1016\/j.fct.2024.114490_bib33","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.phrs.2015.07.022","article-title":"Metabolic syndrome and obesity among users of second generation antipsychotics: a global challenge for modern psychopharmacology","volume":"101","author":"Rojo","year":"2015","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.fct.2024.114490_bib34","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1124\/jpet.113.207621","article-title":"Olanzapine activates hepatic mammalian target of rapamycin: new mechanistic insight into metabolic dysregulation with atypical antipsychotic drugs","volume":"347","author":"Schmidt","year":"2013","journal-title":"J. Pharmacol. Exp. Therapeut."},{"key":"10.1016\/j.fct.2024.114490_bib35","doi-asserted-by":"crossref","DOI":"10.1038\/srep16643","article-title":"Akkermansia muciniphila inversely correlates with the onset of inflammation, altered adipose tissue metabolism and metabolic disorders during obesity in mice","volume":"5","author":"Schneeberger","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.fct.2024.114490_bib36","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1017\/S1461145711001271","article-title":"Olanzapine, but not aripiprazole, weight-independently elevates serum triglycerides and activates lipogenic gene expression in female rats","volume":"15","author":"Skrede","year":"2012","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"10.1016\/j.fct.2024.114490_bib37","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1017\/S1461145713000862","article-title":"Olanzapine depot formulation in rat: a step forward in modelling antipsychotic-induced metabolic adverse effects","volume":"17","author":"Skrede","year":"2014","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"10.1016\/j.fct.2024.114490_bib38","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.neuroscience.2011.09.056","article-title":"The effects of neuropsychiatric drugs on glycogen synthase kinase-3 signaling","volume":"199","author":"Sutton","year":"2011","journal-title":"Neuroscience"},{"key":"10.1016\/j.fct.2024.114490_bib39","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-10734-y","article-title":"Gut microbiota composition is associated with polypharmacy in elderly hospitalized patients","volume":"7","author":"Ticinesi","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.fct.2024.114490_bib40","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1038\/nature05414","article-title":"An obesity-associated gut microbiome with increased capacity for energy harvest","volume":"444","author":"Turnbaugh","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.fct.2024.114490_bib41","doi-asserted-by":"crossref","DOI":"10.1016\/j.tox.2023.153515","article-title":"Insight into mitochondrial dysfunction mediated by clozapine-induced inhibition of PGRMC1 in PC12 cells","volume":"491","author":"Wang","year":"2023","journal-title":"Toxicology"},{"key":"10.1016\/j.fct.2024.114490_bib42","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodres.2021.110360","article-title":"Pu-erh tea ameliorates obesity and modulates gut microbiota in high fat diet fed mice","volume":"144","author":"Ye","year":"2021","journal-title":"Food Res. Int."},{"key":"10.1016\/j.fct.2024.114490_bib43","doi-asserted-by":"crossref","first-page":"2925","DOI":"10.1039\/D0FO03345F","article-title":"Antrodin A from Antrodia camphorata modulates the gut microbiome and liver metabolome in mice exposed to acute alcohol intake","volume":"12","author":"Yi","year":"2021","journal-title":"Food Funct."},{"key":"10.1016\/j.fct.2024.114490_bib44","article-title":"TMEM88 modulates lipid synthesis and metabolism cytokine by regulating Wnt\/\u03b2-catenin signaling pathway in non-alcoholic fatty liver disease","volume":"12","author":"Zhou","year":"2021","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.fct.2024.114490_bib46","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2023.113757","article-title":"Olanzapine-induced nonalcoholic fatty liver disease: the effects of differential food pattern and the involvement of PGRMC1 signaling","volume":"176","author":"Zhu","year":"2023","journal-title":"Food Chem. Toxicol.: an international journal published for the British Industrial Biological Research Association"},{"key":"10.1016\/j.fct.2024.114490_bib47","article-title":"Olanzapine-induced lipid disturbances: a potential mechanism through the gut microbiota-brain axis","volume":"13","author":"Zhu","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.fct.2024.114490_bib48","doi-asserted-by":"crossref","DOI":"10.1002\/mnfr.201800446","article-title":"Sulfated polysaccharide from sea cucumber and its depolymerized derivative prevent obesity in association with modification of gut microbiota in high-fat diet-fed mice","volume":"62","author":"Zhu","year":"2018","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.fct.2024.114490_bib45","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2023.1124607","article-title":"Immune-enhancing activity of polysaccharides and flavonoids derived from Phellinus igniarius YASH1","volume":"14","author":"Zhu","year":"2023","journal-title":"Front. Pharmacol."}],"container-title":["Food and Chemical Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278691524000565?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278691524000565?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T22:08:14Z","timestamp":1778537294000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0278691524000565"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3]]},"references-count":48,"alternative-id":["S0278691524000565"],"URL":"https:\/\/doi.org\/10.1016\/j.fct.2024.114490","relation":{},"ISSN":["0278-6915"],"issn-type":[{"value":"0278-6915","type":"print"}],"subject":[],"published":{"date-parts":[[2024,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"B-GOS alleviates olanzapine-induced lipid disturbances in mice by enriching Akkermansia and upregulation of PGRMC1-Wnt signaling","name":"articletitle","label":"Article Title"},{"value":"Food and Chemical Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fct.2024.114490","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"114490"}}