{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T19:29:14Z","timestamp":1789154954165,"version":"build-2803163510"},"reference-count":32,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Guangdong Provincial Natural Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017607","name":"Shenzhen Basic Research Program","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100017607","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Food and Chemical Toxicology"],"published-print":{"date-parts":[[2024,4]]},"DOI":"10.1016\/j.fct.2024.114519","type":"journal-article","created":{"date-parts":[[2024,2,16]],"date-time":"2024-02-16T21:23:54Z","timestamp":1708118634000},"page":"114519","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Compromised very-low density lipoprotein induced polyunsaturated triglyceride accumulation in N-nitrosodiethylamine-induced hepatic steatosis"],"prefix":"10.1016","volume":"186","author":[{"given":"Xuerao","family":"Lan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiyan","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianjun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guowei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingyang","family":"Zuo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiumei","family":"Xing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohu","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.fct.2024.114519_bib1","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1002\/hep.27016","article-title":"Inflammatory and metabolic biomarkers and risk of liver and biliary tract cancer","volume":"60","author":"Aleksandrova","year":"2014","journal-title":"Hepatology"},{"key":"10.1016\/j.fct.2024.114519_bib2","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1042\/CS20030326","article-title":"Increase in long-chain polyunsaturated fatty acid n - 6\/n - 3 ratio in relation to hepatic steatosis in patients with non-alcoholic fatty liver disease","volume":"106","author":"Araya","year":"2004","journal-title":"Clin. Sci. (Lond.)"},{"key":"10.1016\/j.fct.2024.114519_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2023.164251","article-title":"Occurrence and transport of N-nitrosamines in the urban water systems of the Pearl River Delta, southern China","volume":"890","author":"Chen","year":"2023","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.fct.2024.114519_bib4","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1172\/JCI23621","article-title":"Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease","volume":"115","author":"Donnelly","year":"2005","journal-title":"J. Clin. Invest."},{"issue":"Pt 2","key":"10.1016\/j.fct.2024.114519_bib5","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1042\/bj3200345","article-title":"Mammalian mitochondrial beta-oxidation","volume":"320","author":"Eaton","year":"1996","journal-title":"Biochem. J."},{"key":"10.1016\/j.fct.2024.114519_bib6","doi-asserted-by":"crossref","first-page":"E4571","DOI":"10.1073\/pnas.1507709112","article-title":"Intrinsic mutagenic properties of 5-chlorocytosine: a mechanistic connection between chronic inflammation and cancer","volume":"112","author":"Fedeles","year":"2015","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.fct.2024.114519_bib7","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1007\/BF01689384","article-title":"Volatile nitrosamines in foods and beverages: preliminary survey of the Italian market","volume":"40","author":"Gavinelli","year":"1988","journal-title":"Bull. Environ. Contam. Toxicol."},{"key":"10.1016\/j.fct.2024.114519_bib8","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1186\/s12944-021-01567-w","article-title":"Accumulation of cholesterol, triglycerides and ceramides in hepatocellular carcinomas of diethylnitrosamine injected mice","volume":"20","author":"Haberl","year":"2021","journal-title":"Lipids Health Dis."},{"key":"10.1016\/j.fct.2024.114519_bib9","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1002\/em.22446","article-title":"Permitted daily exposure limits for noteworthy N-nitrosamines","volume":"62","author":"Johnson","year":"2021","journal-title":"Environ. Mol. Mutagen."},{"key":"10.1016\/j.fct.2024.114519_bib10","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1111\/ggi.14561","article-title":"Accumulation of polyunsaturated fatty acid-derived metabolites in the sarcopenic muscle of aging mice","volume":"23","author":"Kadoguchi","year":"2023","journal-title":"Geriatr. Gerontol. Int."},{"key":"10.1016\/j.fct.2024.114519_bib11","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1007\/s00535-013-0758-5","article-title":"Mechanisms of hepatic triglyceride accumulation in non-alcoholic fatty liver disease","volume":"48","author":"Kawano","year":"2013","journal-title":"J. Gastroenterol."},{"issue":"Suppl. 1","key":"10.1016\/j.fct.2024.114519_bib12","first-page":"S7","article-title":"Role of microsomal enzymes in development of alcoholic liver diseases","volume":"22","author":"Konishi","year":"2007","journal-title":"J. Gastroenterol. Hepatol."},{"key":"10.1016\/j.fct.2024.114519_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2020.142121","article-title":"Intake of volatile nitrosamines by Chinese residents in different provinces via food and drinking water","volume":"754","author":"Li","year":"2021","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.fct.2024.114519_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2020.139695","article-title":"Spatial, temporal variability and carcinogenic health risk assessment of nitrosamines in a drinking water system in China","volume":"736","author":"Luo","year":"2020","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.fct.2024.114519_bib15","doi-asserted-by":"crossref","first-page":"1928","DOI":"10.1194\/jlr.M600172-JLR200","article-title":"Colocalization of SCD1 and DGAT2: implying preference for endogenous monounsaturated fatty acids in triglyceride synthesis","volume":"47","author":"Man","year":"2006","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.fct.2024.114519_bib16","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1194\/jlr.D700041-JLR200","article-title":"Lipid extraction by methyl-tert-butyl ether for high-throughput lipidomics","volume":"49","author":"Matyash","year":"2008","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.fct.2024.114519_bib17","doi-asserted-by":"crossref","first-page":"2890","DOI":"10.1021\/acs.jproteome.0c00082","article-title":"Lipidr: a software tool for data mining and analysis of lipidomics datasets","volume":"19","author":"Mohamed","year":"2020","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.fct.2024.114519_bib18","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1172\/JCI32752","article-title":"Inhibition of apolipoprotein B100 secretion by lipid-induced hepatic endoplasmic reticulum stress in rodents","volume":"118","author":"Ota","year":"2008","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.fct.2024.114519_bib19","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1002\/hep.21763","article-title":"A lipidomic analysis of nonalcoholic fatty liver disease","volume":"46","author":"Puri","year":"2007","journal-title":"Hepatology"},{"key":"10.1016\/j.fct.2024.114519_bib20","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/S0022-2275(20)39899-0","article-title":"Unbound free fatty acid levels in human serum","volume":"36","author":"Richieri","year":"1995","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.fct.2024.114519_bib21","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.2174\/1566524013666131111124531","article-title":"Can \u03b3H2AX be used to personalise cancer treatment?","volume":"13","author":"Shah","year":"2013","journal-title":"Curr. Mol. Med."},{"key":"10.1016\/j.fct.2024.114519_bib22","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0069430","article-title":"Association of early age at establishment of chronic hepatitis B infection with persistent viral replication, liver cirrhosis and hepatocellular carcinoma: a systematic review","volume":"8","author":"Shimakawa","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.fct.2024.114519_bib23","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.fct.2018.11.014","article-title":"Neferine suppresses diethylnitrosamine-induced lung carcinogenesis in Wistar rats","volume":"123","author":"Sivalingam","year":"2019","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.fct.2024.114519_bib24","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/S1388-1981(00)00046-9","article-title":"The fatty acid transport function of fatty acid-binding proteins","volume":"1486","author":"Storch","year":"2000","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.fct.2024.114519_bib25","doi-asserted-by":"crossref","first-page":"633","DOI":"10.3892\/br.2014.309","article-title":"Triglyceride is strongly associated with nonalcoholic fatty liver disease among markers of hyperlipidemia and diabetes","volume":"2","author":"Tomizawa","year":"2014","journal-title":"Biomed Rep"},{"key":"10.1016\/j.fct.2024.114519_bib26","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/0163-7258(96)00062-9","article-title":"N-nitrosodiethylamine mechanistic data and risk assessment: bioactivation, DNA-adduct formation, mutagenicity, and tumor initiation","volume":"71","author":"Verna","year":"1996","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.fct.2024.114519_bib27","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.ymgme.2015.06.006","article-title":"Long-term major clinical outcomes in patients with long chain fatty acid oxidation disorders before and after transition to triheptanoin treatment--A retrospective chart review","volume":"116","author":"Vockley","year":"2015","journal-title":"Mol. Genet. Metabol."},{"key":"10.1016\/j.fct.2024.114519_bib28","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/j.scitotenv.2016.01.175","article-title":"Occurrence and profiling of multiple nitrosamines in source water and drinking water of China","volume":"551\u2013552","author":"Wang","year":"2016","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.fct.2024.114519_bib29","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1186\/s12876-021-02039-2","article-title":"Total polyunsaturated fatty acid intake and the risk of non-alcoholic fatty liver disease in Chinese Han adults: a secondary analysis based on a case-control study","volume":"21","author":"Xie","year":"2021","journal-title":"BMC Gastroenterol."},{"key":"10.1016\/j.fct.2024.114519_bib30","doi-asserted-by":"crossref","first-page":"5485","DOI":"10.1007\/s11356-018-4026-3","article-title":"Probabilistic health risk assessment of nitrosamines in drinking water of Shaoxing, Zhejiang, China","volume":"26","author":"Yin","year":"2019","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"10.1016\/j.fct.2024.114519_bib31","first-page":"93","article-title":"Comparative assessment of N-nitrosamines' contamination of baby's canned meat with vegetables and cereals by various methods in Russia and Vietnam","volume":"88","author":"Zaitseva","year":"2019","journal-title":"Vopr. Pitan."},{"key":"10.1016\/j.fct.2024.114519_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2021.145409","article-title":"Determining the leading sources of N-nitrosamines and dissolved organic matter in four reservoirs in Southern China","volume":"771","author":"Zhang","year":"2021","journal-title":"Sci. Total Environ."}],"container-title":["Food and Chemical Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278691524000851?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278691524000851?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T22:27:14Z","timestamp":1759530434000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0278691524000851"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4]]},"references-count":32,"alternative-id":["S0278691524000851"],"URL":"https:\/\/doi.org\/10.1016\/j.fct.2024.114519","relation":{},"ISSN":["0278-6915"],"issn-type":[{"value":"0278-6915","type":"print"}],"subject":[],"published":{"date-parts":[[2024,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Compromised very-low density lipoprotein induced polyunsaturated triglyceride accumulation in N-nitrosodiethylamine-induced hepatic steatosis","name":"articletitle","label":"Article Title"},{"value":"Food and Chemical Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fct.2024.114519","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"114519"}}