{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T18:27:17Z","timestamp":1747160837878,"version":"3.40.5"},"reference-count":50,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Food and Chemical Toxicology"],"published-print":{"date-parts":[[2024,7]]},"DOI":"10.1016\/j.fct.2024.114647","type":"journal-article","created":{"date-parts":[[2024,4,10]],"date-time":"2024-04-10T15:24:33Z","timestamp":1712762673000},"page":"114647","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"S1","title":["RIFM fragrance ingredient safety assessment, phenethyl salicylate, CAS Registry Number 87-22-9"],"prefix":"10.1016","volume":"189","author":[{"given":"A.M.","family":"Api","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Bartlett","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Belsito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Botelho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Bruze","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Bryant-Freidrich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr.","given":"G.A.","family":"Burton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.A.","family":"Cancellieri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Chon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.L.","family":"Dagli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.","family":"Dekant","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Deodhar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Farrell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.D.","family":"Fryer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Jones","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Joshi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Lapczynski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Lavelle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Moustakas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Muldoon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.M.","family":"Penning","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Ritacco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Sadekar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"Schember","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.W.","family":"Schultz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Siddiqi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.G.","family":"Sipes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7007-0926","authenticated-orcid":false,"given":"G.","family":"Sullivan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Thakkar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Tokura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"104805","key":"10.1016\/j.fct.2024.114647_bib1","article-title":"Updating exposure assessment for skin sensitization quantitative risk assessment for fragrance materials","volume":"118","author":"Api","year":"2020","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"10.1016\/j.fct.2024.114647_bib2","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1016\/j.fct.2014.11.014","article-title":"Criteria for the Research Institute for fragrance materials, Inc. (RIFM) safety evaluation process for fragrance ingredients","volume":"82","author":"Api","year":"2015","journal-title":"Food Chem. Toxicol."},{"volume":"vols. I and II","year":"1969","author":"Arctander","key":"10.1016\/j.fct.2024.114647_bib3"},{"year":"2006","series-title":"Phenethyl Salicylate: Local Lymph Node Assay","author":"Betts","key":"10.1016\/j.fct.2024.114647_bib4"},{"issue":"6","key":"10.1016\/j.fct.2024.114647_bib5","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1016\/j.fct.2009.02.024","article-title":"Exposure based waiving: the application of the toxicological threshold of concern (TTC) to inhalation exposure for aerosol ingredients in consumer products","volume":"47","author":"Carthew","year":"2009","journal-title":"Food Chem. Toxicol."},{"issue":"Suppl. 1","key":"10.1016\/j.fct.2024.114647_bib6","doi-asserted-by":"crossref","first-page":"S4","DOI":"10.1186\/1752-153X-4-S1-S4","article-title":"CAESAR models for developmental toxicity","volume":"4","author":"Cassano","year":"2010","journal-title":"Chem. Cent. J."},{"issue":"3","key":"10.1016\/j.fct.2024.114647_bib7","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1016\/j.yrtph.2015.05.012","article-title":"Novel database for exposure to fragrance ingredients in cosmetics and personal care products","volume":"72","author":"Comiskey","year":"2015","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"10.1016\/j.fct.2024.114647_bib8","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.yrtph.2017.05.017","article-title":"Integrating habits and practices data for soaps, cosmetics and air care products into an existing aggregate exposure model","volume":"88","author":"Comiskey","year":"2017","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"10.1016\/j.fct.2024.114647_bib9","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.tiv.2016.01.007","article-title":"A 3D reconstituted epidermis based model for quantifying chemical sensitization potency: reproducibility and predictivity results from an inter-laboratory study","volume":"32","author":"Cottrez","year":"2016","journal-title":"Toxicol. Vitro"},{"issue":"7","key":"10.1016\/j.fct.2024.114647_bib10","doi-asserted-by":"crossref","first-page":"1709","DOI":"10.1021\/acs.chemrestox.9b00518","article-title":"Clustering a chemical inventory for safety assessment of fragrance ingredients: identifying read-across analogs to address data gaps","volume":"33","author":"Date","year":"2020","journal-title":"Chem. Res. Toxicol."},{"year":"2003","series-title":"Contact sensitisation: Classification according to potency","key":"10.1016\/j.fct.2024.114647_bib14"},{"key":"10.1016\/j.fct.2024.114647_bib15","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.tiv.2016.09.013","article-title":"From genome-wide arrays to tailor-made biomarker readout - progress towards routine analysis of skin sensitizing chemicals with GARD","volume":"37","author":"Forreryd","year":"2016","journal-title":"Toxicol. Vitro"},{"issue":"1","key":"10.1016\/j.fct.2024.114647_bib16","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.jphotobiol.2009.04.005","article-title":"Can light absorption and photostability data be used to assess the photosafety risks in patients for a new drug molecule?","volume":"96","author":"Henry","year":"2009","journal-title":"J. Photochem. Photobiol. B Biol."},{"year":"2019","series-title":"Volume of Use Survey","key":"10.1016\/j.fct.2024.114647_bib17"},{"key":"10.1016\/j.fct.2024.114647_bib18","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.yrtph.2018.10.018","article-title":"Initial hazard assessment of benzyl salicylate: in vitro genotoxicity test and combined repeated-dose and reproductive\/developmental toxicity screening test in rats","volume":"100","author":"Igarashi","year":"2018","journal-title":"Regul. Toxicol. Pharmacol."},{"issue":"Suppl. 2","key":"10.1016\/j.fct.2024.114647_bib19","first-page":"230","article-title":"Closed epicutaneous test","volume":"28","author":"Ishihara","year":"1986","journal-title":"Skin Res."},{"key":"10.1016\/j.fct.2024.114647_bib20","article-title":"The open epicutaneous test (OET), a predictive test procedure in the Guinea pig for estimation of allergenic properties of simple chemical compounds, their mixtures and of finished cosmetic preparations","author":"Klecak","year":"1979","journal-title":"International Federation Societies Cosmetic Chemists"},{"key":"10.1016\/j.fct.2024.114647_bib21","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1159\/000411610","article-title":"The freund's complete adjuvant test and the open epicutaneous test","volume":"14","author":"Klecak","year":"1985","journal-title":"Curr. Probl. Dermatol."},{"key":"10.1016\/j.fct.2024.114647_bib22","first-page":"53","article-title":"Screening of fragrance materials for allergenicity in the Guinea pig. I. Comparison of four testing methods","volume":"28","author":"Klecak","year":"1977","journal-title":"Journal of Society of Cosmetic Chemists of Japan."},{"issue":"12","key":"10.1016\/j.fct.2024.114647_bib23","doi-asserted-by":"crossref","first-page":"2533","DOI":"10.1016\/j.fct.2007.06.021","article-title":"Application of the threshold of toxicological concern (TTC) to the safety evaluation of cosmetic ingredients","volume":"45","author":"Kroes","year":"2007","journal-title":"Food Chem. Toxicol."},{"issue":"1","key":"10.1016\/j.fct.2024.114647_bib24","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.yrtph.2011.09.004","article-title":"Correlation of chemical structure with reproductive and developmental toxicity as it relates to the use of the threshold of toxicological concern","volume":"62","author":"Laufersweiler","year":"2012","journal-title":"Regul. Toxicol. Pharmacol."},{"issue":"5","key":"10.1016\/j.fct.2024.114647_bib26","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1097\/DER.0000000000000684","article-title":"Fragrance skin sensitization evaluation and human testing: 30-year experience","volume":"32","author":"Na","year":"2021","journal-title":"Dermatitis"},{"year":"1973","series-title":"Report on Human Maximization Studies. Report to RIFM. RIFM Report Number 1802","key":"10.1016\/j.fct.2024.114647_bib29"},{"year":"1981","series-title":"Guinea Pig Skin Sensitisation Test with Phenethyl Salicylate","key":"10.1016\/j.fct.2024.114647_bib30"},{"year":"1983","series-title":"Phototoxicity and Photoallergy Tests with Benzyl Salicylate in the guinea Pig Unpublished Report from Rhodia Services - RSP","key":"10.1016\/j.fct.2024.114647_bib31"},{"year":"2000","series-title":"Phenethyl Salicylate: Acute Immobilisation Test to Daphnia Magna","key":"10.1016\/j.fct.2024.114647_bib32"},{"year":"2000","series-title":"Phenethyl Salicylate: Ready Biodegradability Closed Bottle Test. Unpublished Report from Symrise","key":"10.1016\/j.fct.2024.114647_bib33"},{"year":"2001","series-title":"Phenethyl Salicylate: Reverse Mutation Assay (Ames Test) with Salmonella typhimurium","key":"10.1016\/j.fct.2024.114647_bib34"},{"year":"2013","series-title":"Report on the Testing of Phenethyl Salicylate in the BlueScreen HC Assay (-\/+ S9 Metabolic Activation)","key":"10.1016\/j.fct.2024.114647_bib35"},{"year":"2014","series-title":"Phenethyl Salicylate: in Vitro Mammalian Cell Micronucleus Assay in Human Peripheral Blood Lymphocytes (HPBL)","key":"10.1016\/j.fct.2024.114647_bib36"},{"year":"2014","series-title":"Phenethyl Salicylate: Repeated Insult Patch Test (RIPT). RIFM Report Number 68404","key":"10.1016\/j.fct.2024.114647_bib37"},{"year":"2015","series-title":"Phenethyl Salicylate: Neutral Red Uptake Phototoxicity Assay in Balb\/c 3T3 Mouse Fibroblasts","key":"10.1016\/j.fct.2024.114647_bib38"},{"year":"2019","series-title":"Phenethyl Salicylate: Determination of the Dermal Absorption through Human Skin in Vitro","key":"10.1016\/j.fct.2024.114647_bib39"},{"year":"2020","series-title":"Benzyl Salicylate: an Oral (Dietary) Reproductive\/developmental Toxicity Screening Study in Rats","key":"10.1016\/j.fct.2024.114647_bib40"},{"year":"2020","series-title":"Benzyl Salicylate: A 90-Day Oral (Dietary) Toxicity Study in Sprague Dawley Rats","key":"10.1016\/j.fct.2024.114647_bib41"},{"year":"2020","series-title":"Benzyl Salicylate: an Oral (Dietary) Prenatal Developmental Toxicity Study in Sprague Dawley Rats. [Amendment Attached] Unpublished Report from Givaudan. RIFM Report Number 77718","key":"10.1016\/j.fct.2024.114647_bib42"},{"volume":"39","journal-title":"Exposure Survey","year":"2023","key":"10.1016\/j.fct.2024.114647_bib43"},{"issue":"7","key":"10.1016\/j.fct.2024.114647_bib44","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1021\/tx700024w","article-title":"Mechanistic applicability domain classification of a local lymph node assay dataset for skin sensitization","volume":"20","author":"Roberts","year":"2007","journal-title":"Chem. Res. Toxicol."},{"issue":"5","key":"10.1016\/j.fct.2024.114647_bib45","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1021\/ci100050t","article-title":"Extended-connectivity fingerprints","volume":"50","author":"Rogers","year":"2010","journal-title":"J. Chem. Inf. Model."},{"key":"10.1016\/j.fct.2024.114647_bib46","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/j.yrtph.2015.05.017","article-title":"Use of an aggregate exposure model to estimate consumer exposure to fragrance ingredients in personal care and cosmetic products","volume":"72","author":"Safford","year":"2015","journal-title":"Regul. Toxicol. Pharmacol."},{"issue":"3","key":"10.1016\/j.fct.2024.114647_bib47","doi-asserted-by":"crossref","DOI":"10.1016\/j.yrtph.2015.05.017","article-title":"Corrigendum to \"Use of an aggregate exposure model to estimate consumer exposure to fragrance ingredients in personal care and cosmetic products\"","volume":"72","author":"Safford","year":"2024","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"10.1016\/j.fct.2024.114647_bib48","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.yrtph.2017.02.021","article-title":"Application of the expanded Creme RIFM consumer exposure model to fragrance ingredients in cosmetic, personal care and air care products","volume":"86","author":"Safford","year":"2017","journal-title":"Regul. Toxicol. Pharmacol."},{"issue":"6","key":"10.1016\/j.fct.2024.114647_bib49","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1002\/etc.5620210627","article-title":"A Framework for prioritizing fragrance materials for aquatic risk assessment","volume":"21","author":"Salvito","year":"2002","journal-title":"Environ. Toxicol. Chem."},{"issue":"3","key":"10.1016\/j.fct.2024.114647_bib50","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1016\/j.yrtph.2015.05.016","article-title":"A strategy for structuring and reporting a read-across prediction of toxicity","volume":"72","author":"Schultz","year":"2015","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"10.1016\/j.fct.2024.114647_bib51","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.fct.2014.09.015","article-title":"An in silico skin absorption model for fragrance materials","volume":"74","author":"Shen","year":"2014","journal-title":"Food Chem. Toxicol."},{"issue":"9","key":"10.1016\/j.fct.2024.114647_bib52","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1111\/j.2042-7158.1967.tb09600.x","article-title":"The binding of salicylate to plasma proteins in different species","volume":"19","author":"Sturman","year":"1967","journal-title":"[Letter to the Editor] The Journal of Pharmacy and Pharmacology"},{"issue":"1","key":"10.1016\/j.fct.2024.114647_bib53","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1093\/mutage\/geac004","article-title":"The BlueScreen HC assay to predict the genotoxic potential of fragrance materials","volume":"37","author":"Thakkar","year":"2022","journal-title":"Mutagenesis"},{"year":"2012","series-title":"Estimation Programs Interface Suite for Microsoft Windows, v4.0\u2013v4.11","key":"10.1016\/j.fct.2024.114647_bib54"},{"year":"2012","series-title":"The ECOSAR (ECOlogical Structure Activity Relationship) Class Program for Microsoft Windows, v2.0","key":"10.1016\/j.fct.2024.114647_bib55"},{"key":"10.1016\/j.fct.2024.114647_bib56","first-page":"315","article-title":"Experimental production of congenital malformations in rats by salicylate poisoning","volume":"35","author":"Warkany","year":"1959","journal-title":"Am. J. Pathol."}],"container-title":["Food and Chemical Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278691524002138?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278691524002138?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,4,13]],"date-time":"2024-04-13T05:35:37Z","timestamp":1712986537000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0278691524002138"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7]]},"references-count":50,"alternative-id":["S0278691524002138"],"URL":"https:\/\/doi.org\/10.1016\/j.fct.2024.114647","relation":{},"ISSN":["0278-6915"],"issn-type":[{"type":"print","value":"0278-6915"}],"subject":[],"published":{"date-parts":[[2024,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"RIFM fragrance ingredient safety assessment, phenethyl salicylate, CAS Registry Number 87-22-9","name":"articletitle","label":"Article Title"},{"value":"Food and Chemical Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fct.2024.114647","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"114647"}}