{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T18:19:53Z","timestamp":1778523593960,"version":"3.51.4"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001412","name":"Council of Scientific and Industrial Research, India","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001412","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Food and Chemical Toxicology"],"published-print":{"date-parts":[[2024,7]]},"DOI":"10.1016\/j.fct.2024.114743","type":"journal-article","created":{"date-parts":[[2024,5,17]],"date-time":"2024-05-17T17:51:27Z","timestamp":1715968287000},"page":"114743","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Vallaris solanacea induces mitochondrial mediated apoptosis in HL-60 human promyelocytic leukemia cells"],"prefix":"10.1016","volume":"189","author":[{"given":"Madhunika","family":"Agrawal","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.K.","family":"Saxena","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8127-6380","authenticated-orcid":false,"given":"Satyam Kumar","family":"Agrawal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.fct.2024.114743_bib1","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1080\/01635581.2011.573900","article-title":"Induction of apoptosis in human promyelocytic leukemia HL-60 cells by an extract from Erythrina suberosa stem bark","volume":"63","author":"Agrawal","year":"2011","journal-title":"Nutr. Cancer"},{"key":"10.1016\/j.fct.2024.114743_bib2","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1007\/s11051-017-3972-x","article-title":"Nutraceutical Phycocyanin nanoformulation for efficient drug delivery of paclitaxel in human glioblastoma U87MG cell line","volume":"19","author":"Agrawal","year":"2017","journal-title":"J. Nanoparticle Res."},{"issue":"11\u201312","key":"10.1016\/j.fct.2024.114743_bib3","doi-asserted-by":"crossref","first-page":"2720","DOI":"10.1080\/01635581.2020.1856893","article-title":"Anagallis arvensis induces apoptosis in Hl-60 cells through ROS-mediated mitochondrial pathway","volume":"73","author":"Agrawal","year":"2021","journal-title":"Nutr. Cancer"},{"key":"10.1016\/j.fct.2024.114743_bib4","doi-asserted-by":"crossref","first-page":"477","DOI":"10.3987\/COM-09-S(S)52","article-title":"Glycosides from Vallaris solanacea with TRAIL resistance overcoming activity","volume":"80","author":"Ahmed","year":"2010","journal-title":"Heterocycles"},{"issue":"3S","key":"10.1016\/j.fct.2024.114743_bib5","first-page":"2517","article-title":"Cytotoxic activity of methanolic extract of Nerium oleander naturally grown in Iraq","volume":"10","author":"Ahmed","year":"2023","journal-title":"J Survey Fisheries Sci"},{"issue":"6","key":"10.1016\/j.fct.2024.114743_bib6","doi-asserted-by":"crossref","first-page":"2748","DOI":"10.5958\/0974-360X.2019.00460.8","article-title":"Evaluation of anticancer activity of ethanol extract of Bauhinia tomentosa Linn. on A549, human lung carcinoma cell lines","volume":"12","author":"Balabhaskar","year":"2019","journal-title":"Res. J. Pharm. Technol."},{"key":"10.1016\/j.fct.2024.114743_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2023.161475","article-title":"The HL-60 human promyelocytic cell line constitutes an effective in vitro model for evaluating toxicity, oxidative stress and necrosis\/apoptosis after exposure to black carbon particles and 2.45 GHz radio frequency","volume":"867","author":"Benavides","year":"2023","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.fct.2024.114743_bib8","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1038\/cdd.2016.11","article-title":"Phosphatidylserine is a global immunosuppressive signal in efferocytosis, infectious disease, and cancer","volume":"23","author":"Birge","year":"2016","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.fct.2024.114743_bib9","doi-asserted-by":"crossref","first-page":"925","DOI":"10.3389\/fonc.2019.00925","article-title":"Acridine Orange: a review of novel applications for surgical cancer imaging and therapy","volume":"9","author":"Byvaltsev","year":"2019","journal-title":"Front. Oncol."},{"key":"10.1016\/j.fct.2024.114743_bib10","series-title":"Glossary of Indian Medicinal Plants","author":"Chopra","year":"1956"},{"key":"10.1016\/j.fct.2024.114743_bib11","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1007\/s13596-013-0133-3","article-title":"Preclinical evaluation of Vallaris solanacea (ROTH) Kuntze stem for its antiulcer and antioxidant activity in wistar albino rats","volume":"14","author":"Das","year":"2014","journal-title":"Orient Pharm. Exp. Med."},{"key":"10.1016\/j.fct.2024.114743_bib12","doi-asserted-by":"crossref","DOI":"10.1038\/bcj.2016.50","article-title":"Acute myeloid leukemia: a comprehensive review and 2016 update","volume":"6","author":"De Kouchkovsky","year":"2016","journal-title":"Blood Cancer J."},{"issue":"10","key":"10.1016\/j.fct.2024.114743_bib13","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1002\/ajh.25214","article-title":"Acute myeloid leukemia: 2019 update on risk-stratification and management","volume":"93","author":"Estey","year":"2018","journal-title":"Am. J. Hematol."},{"issue":"6","key":"10.1016\/j.fct.2024.114743_bib14","doi-asserted-by":"crossref","first-page":"944","DOI":"10.3390\/antiox10060944","article-title":"Live Cell Assays for the Assessment of antioxidant activities of plant extracts","volume":"10","author":"Furger","year":"2021","journal-title":"Antioxidants"},{"key":"10.1016\/j.fct.2024.114743_bib15","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/s43094-023-00465-5","article-title":"Anticancer plant-derivatives: deciphering their oncopreventive and therapeutic potential in molecular terms","volume":"9","author":"Gahtori","year":"2023","journal-title":"Futur. J. Pharm. Sci."},{"issue":"11","key":"10.1016\/j.fct.2024.114743_bib16","doi-asserted-by":"crossref","first-page":"3341","DOI":"10.31557\/APJCP.2019.20.11.3341","article-title":"Mdm2-P53 Interaction inhibitor with cisplatin enhances apoptosis in colon and prostate cancer cells in-vitro","volume":"20","author":"Gupta","year":"2019","journal-title":"Asian Pac. J. Cancer Prev. APJCP"},{"issue":"5","key":"10.1016\/j.fct.2024.114743_bib17","doi-asserted-by":"crossref","first-page":"486","DOI":"10.4103\/jispcd.JISPCD_245_19","article-title":"DNA Laddering to evaluate cytogenetic damage in patients with Periodontitis","volume":"9","author":"Harshitha","year":"2019","journal-title":"J. Int. Soc. Prev. Community Dent."},{"issue":"4","key":"10.1016\/j.fct.2024.114743_bib18","first-page":"1624","volume":"2","author":"Hussar","year":"2022","journal-title":"Apoptosis Regulators Bcl-2 and Caspase-3, Encyclopedia"},{"key":"10.1016\/j.fct.2024.114743_bib19","first-page":"935","article-title":"Chemical constituents of Vallaris solanacea O. Ktze","volume":"56","author":"Khosa","year":"1979","journal-title":"J. Indian Chem. Soc."},{"key":"10.1016\/j.fct.2024.114743_bib20","series-title":"Indian Medicinal Plants","author":"Kirtikar","year":"2000"},{"issue":"6","key":"10.1016\/j.fct.2024.114743_bib21","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1007\/BF00227315","article-title":"Isolation and characterization of intergeneric somatic hybrids in the Apocynaceae family","volume":"82","author":"Kostenyuk","year":"1991","journal-title":"Theor. Appl. Genet."},{"key":"10.1016\/j.fct.2024.114743_bib22","doi-asserted-by":"crossref","first-page":"467","DOI":"10.3389\/fcell.2020.00467","article-title":"Mitophagy, mitochondrial Homeostasis, and cell fate","volume":"8","author":"Ma","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.fct.2024.114743_bib23","doi-asserted-by":"crossref","first-page":"493","DOI":"10.3390\/cells13060493","article-title":"Phosphorylations and Acetylations of cytochrome c control mitochondrial Respiration, mitochondrial membrane potential, Energy, ROS, and apoptosis","volume":"13","author":"Morse","year":"2024","journal-title":"Cells"},{"key":"10.1016\/j.fct.2024.114743_bib24","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1038\/s42255-022-00591-z","article-title":"Guidelines for measuring reactive oxygen species and oxidative damage in cells and in vivo","volume":"4","author":"Murphy","year":"2022","journal-title":"Nat. Metab."},{"issue":"1","key":"10.1016\/j.fct.2024.114743_bib25","first-page":"57","article-title":"Systematic review of analytical methods for quantification of natural indole alkaloids from Catharanthus and Rauvolfia species","volume":"10","author":"Murugesan","year":"2023","journal-title":"Res. J. Pharmacogn. (RJP)"},{"issue":"4","key":"10.1016\/j.fct.2024.114743_bib26","doi-asserted-by":"crossref","first-page":"534","DOI":"10.3390\/biom11040534","article-title":"The most competent plant-derived natural products for targeting apoptosis in cancer therapy","volume":"11","author":"Rajabi","year":"2021","journal-title":"Biomolecules"},{"issue":"1","key":"10.1016\/j.fct.2024.114743_bib27","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1186\/s12906-017-1727-y","article-title":"Anticancer potential of Thevetia peruviana fruit methanolic extract","volume":"17","author":"Ramos-Silva","year":"2017","journal-title":"BMC Compl. Alternative Med."},{"issue":"8","key":"10.1016\/j.fct.2024.114743_bib28","doi-asserted-by":"crossref","first-page":"1967","DOI":"10.1093\/emboj\/21.8.1967","article-title":"Caspase-6 gene disruption reveals a requirement for lamin A cleavage in apoptotic chromatin condensation","volume":"21","author":"Ruchaud","year":"2002","journal-title":"EMBO J."},{"issue":"3","key":"10.1016\/j.fct.2024.114743_bib29","doi-asserted-by":"crossref","first-page":"493","DOI":"10.3390\/nano12030493","article-title":"Plumeria alba-mediated green synthesis of silver nanoparticles exhibits antimicrobial effect and anti-oncogenic activity against glioblastoma U118 MG cancer cell line","volume":"12","author":"Rudrappa","year":"2022","journal-title":"Nanomaterials"},{"issue":"3","key":"10.1016\/j.fct.2024.114743_bib30","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1039\/D3CB00090G","article-title":"Cationic dextrin nanoparticles for effective intracellular delivery of cytochrome C in cancer therapy","volume":"25","author":"Sarkar","year":"2023","journal-title":"RSC Chemical Biology"},{"key":"10.1016\/j.fct.2024.114743_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.fitote.2023.105684","article-title":"Hydroalcoholic root extracts of Houttuynia cordata (Thunb.) standardized by UPLC-Q-TOF-MS\/MS promotes apoptosis in human hepatocarcinoma cell HepG2 via GSK-3\u03b2\/\u03b2-catenin\/PDL-1 axis","volume":"171","author":"Sarkar","year":"2023","journal-title":"Fitoterapia"},{"key":"10.1016\/j.fct.2024.114743_bib32","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/j.fct.2009.10.021","article-title":"Cytotoxic and apoptotic activity of essential oil from Ocimum viride towards COLO 205 cells","volume":"48","author":"Sharma","year":"2010","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.fct.2024.114743_bib33","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1186\/s12964-019-0437-0","article-title":"Flipping the dogma \u2013 phosphatidylserine in non-apoptotic cell death","volume":"17","author":"Shlomovitz","year":"2019","journal-title":"Cell Commun. Signal."},{"issue":"21","key":"10.1016\/j.fct.2024.114743_bib34","doi-asserted-by":"crossref","first-page":"5373","DOI":"10.3390\/cancers14215373","article-title":"Luteolin, a potent anticancer compound: from chemistry to cellular interactions and synergetic perspectives","volume":"14","author":"Singh","year":"2022","journal-title":"Cancers"},{"issue":"7","key":"10.1016\/j.fct.2024.114743_bib35","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1007\/s00044-010-9410-6","article-title":"Conventional and microwave-assisted synthesis of imidazole and guanidine derivatives and their biological evaluation","volume":"20","author":"Sondhi","year":"2011","journal-title":"Med. Chem. Res."},{"issue":"8","key":"10.1016\/j.fct.2024.114743_bib36","doi-asserted-by":"crossref","first-page":"2927","DOI":"10.1016\/j.fct.2008.05.036","article-title":"Studies on cytotoxic, hydroxyl radical scavenging and topoisomerase inhibitory activities of extracts of Tabernaemontana divaricata (L.) R.Br. ex Roem. and Schult","volume":"46","author":"Thind","year":"2008","journal-title":"Food Chem. Toxicol."},{"issue":"4","key":"10.1016\/j.fct.2024.114743_bib37","doi-asserted-by":"crossref","first-page":"329","DOI":"10.3109\/01480540903483433","article-title":"Diminution of free radical induced DNA damage by extracts\/fractions from bark of Schleichera oleosa (Lour.) Oken","volume":"33","author":"Thind","year":"2010","journal-title":"Drug Chem. Toxicol."},{"key":"10.1016\/j.fct.2024.114743_bib38","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2021.627837","article-title":"Mitochondrial reactive oxygen species and their contribution in chronic kidney disease progression through oxidative stress","volume":"12","author":"Tirichen","year":"2021","journal-title":"Front. Physiol."},{"issue":"2","key":"10.1016\/j.fct.2024.114743_bib39","first-page":"50","article-title":"Diversity and present status of medicinal plants in and around Srinagar hydroelectric power project in Garhwal Himalaya, India","volume":"2","author":"Tiwari","year":"2010","journal-title":"Needs for Conserv"},{"issue":"6","key":"10.1016\/j.fct.2024.114743_bib40","first-page":"29","article-title":"In vitro antibacterial and antifungal evaluation of Vallaris solanacea (ROTH) Kuntze","volume":"3","author":"Vagdevi","year":"2011","journal-title":"Int. J. Pharm. Res. Develop."},{"issue":"12","key":"10.1016\/j.fct.2024.114743_bib41","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1002\/jps.2600551220","article-title":"Chemistry and pharmacology of a glycoside of Vallaris solanacea","volume":"55","author":"Vohra","year":"1966","journal-title":"J. Pharmaceut. Sci."},{"issue":"10","key":"10.1016\/j.fct.2024.114743_bib42","doi-asserted-by":"crossref","first-page":"1496","DOI":"10.1002\/ptr.4607","article-title":"Bioactive compounds from Carissa spinarum","volume":"26","author":"Wangteeraprasert","year":"2012","journal-title":"Phytother Res."},{"issue":"Suppl. 2","key":"10.1016\/j.fct.2024.114743_bib43","first-page":"S232","article-title":"Antiproliferative activity of Vallaris glabra kuntze (Apocynaceae)","volume":"10","author":"Wong","year":"2014","journal-title":"Phcog. Mag."},{"key":"10.1016\/j.fct.2024.114743_bib44","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1186\/s13046-018-0909-x","article-title":"The role of cellular reactive oxygen species in cancer chemotherapy","volume":"37","author":"Yang","year":"2018","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"10.1016\/j.fct.2024.114743_bib45","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.ab.2017.07.009","article-title":"Mitochondrial membrane potential","volume":"552","author":"Zorova","year":"2018","journal-title":"Anal. Biochem."}],"container-title":["Food and Chemical Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278691524003090?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278691524003090?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,13]],"date-time":"2024-06-13T05:00:42Z","timestamp":1718254842000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0278691524003090"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7]]},"references-count":45,"alternative-id":["S0278691524003090"],"URL":"https:\/\/doi.org\/10.1016\/j.fct.2024.114743","relation":{},"ISSN":["0278-6915"],"issn-type":[{"value":"0278-6915","type":"print"}],"subject":[],"published":{"date-parts":[[2024,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Vallaris solanacea induces mitochondrial mediated apoptosis in HL-60 human promyelocytic leukemia cells","name":"articletitle","label":"Article Title"},{"value":"Food and Chemical Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fct.2024.114743","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"114743"}}