{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T02:45:03Z","timestamp":1792118703391,"version":"4.4.0"},"reference-count":76,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["403729\/2021-1"],"award-info":[{"award-number":["403729\/2021-1"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017595","name":"FEEVALE University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100017595","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Food and Chemical Toxicology"],"published-print":{"date-parts":[[2024,10]]},"DOI":"10.1016\/j.fct.2024.114962","type":"journal-article","created":{"date-parts":[[2024,8,26]],"date-time":"2024-08-26T22:59:05Z","timestamp":1724713145000},"page":"114962","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Diazepam nanocapsules as an alternative for sleep induction: Development study and toxicity assessment"],"prefix":"10.1016","volume":"192","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-3469-5900","authenticated-orcid":false,"given":"Julia Gabriele de Jesus","family":"Ferreira","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria Givankliff","family":"Flores","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4590-3652","authenticated-orcid":false,"given":"Mariana Roza","family":"Marco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-2458-0103","authenticated-orcid":false,"given":"Bianca Bordignon","family":"Fraga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-0260-1253","authenticated-orcid":false,"given":"Roberta Rodrigues","family":"Zorzo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patr\u00edcia da Fonseca","family":"de Morais","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando Dal Pont","family":"Morisso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliane Deise","family":"Fleck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariele Feiffer","family":"Char\u00e3o","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristiane Bastos","family":"de Mattos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7116-5465","authenticated-orcid":false,"given":"Andresa Heemann","family":"Betti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.fct.2024.114962_bib1","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.ajg.2021.06.002","article-title":"Synthesis and characterization of amoxicillin-loaded polymeric nanocapsules as a drug delivery system targeting Helicobacter pylori","volume":"22","author":"Abdelghany","year":"2021","journal-title":"Arab Journal Of Gastroenterology"},{"issue":"18","key":"10.1016\/j.fct.2024.114962_bib2","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.2217\/nnm-2021-0037","article-title":"Recent advances in polymer shell oily-core nanocapsules for drug-delivery applications","volume":"16","author":"Abdelhamid","year":"2021","journal-title":"Nanomedicine"},{"key":"10.1016\/j.fct.2024.114962_bib3","series-title":"Estimativa do consumo e predi\u00e7\u00e3o da concentra\u00e7\u00e3o ambiental de diazepam via epidemiologia do esgoto","author":"Alcantara","year":"2020"},{"key":"10.1016\/j.fct.2024.114962_bib4","article-title":"Sedative and hypnotic activities of the methanolic and aqueous extracts of lavandula officinalisfrom Morocco","volume":"2012","author":"Alnamert","year":"2012","journal-title":"Advances In Pharmacological Sciences"},{"key":"10.1016\/j.fct.2024.114962_bib5","series-title":"Ag\u00eancia Nacional de Vigil\u00e2ncia Sanit\u00e1ria. Resolu\u00e7\u00e3o da diretoria colegiada - RDC n\u00b0 166, de 24 de julho de","year":"2017"},{"issue":"2","key":"10.1016\/j.fct.2024.114962_bib6","first-page":"212","article-title":"Abrindo a caixa de pandora dos nanomedicamentos: h\u00e1 realmente muito mais espa\u00e7o l\u00e1 embaixo","volume":"43","author":"Apolinario","year":"2020","journal-title":"Qu\u00edm. Nova"},{"issue":"2","key":"10.1016\/j.fct.2024.114962_bib7","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1007\/s00128-019-02631-z","article-title":"Development and validation of an analytical method for the detection and quantification of bromazepam, clonazepam and diazepam by UPLC-MS\/MS in surface water","volume":"103","author":"Araujo","year":"2019","journal-title":"Bull. Environ. Contam. Toxicol."},{"issue":"3","key":"10.1016\/j.fct.2024.114962_bib9","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1039\/C6TX00247A","article-title":"DNA damage in the elderly is associated with 5-MTHF levels: a pro-oxidant activity","volume":"6","author":"Baierle","year":"2017","journal-title":"Toxicology Research"},{"issue":"235","key":"10.1016\/j.fct.2024.114962_bib10","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.jconrel.2016.06.017","article-title":"DLS and zeta potential \u2013 what they are and what they are not?","author":"Bhattacharjee","year":"2016","journal-title":"J. Contr. Release"},{"issue":"2","key":"10.1016\/j.fct.2024.114962_bib11","doi-asserted-by":"crossref","first-page":"563","DOI":"10.3390\/molecules28020563","article-title":"Acute toxicity evaluation of phosphatidylcholine nanoliposomes containing nisin in Caenorhabditis elegans","volume":"28","author":"Boelter","year":"2023","journal-title":"Molecules"},{"issue":"1","key":"10.1016\/j.fct.2024.114962_bib12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s40580-016-0061-2","article-title":"Polymeric nanoparticles containing diazepam: preparation, optimization, characterization, in-vitro drug release and release kinetic study","volume":"3","author":"Bohrey","year":"2016","journal-title":"Nano Convergence"},{"key":"10.1016\/j.fct.2024.114962_bib13","series-title":"BRASIL. Lei n\u00b0 11.794, de 8 de outubro de","year":"2008"},{"key":"10.1016\/j.fct.2024.114962_bib14","series-title":"Resolu\u00e7\u00e3o - RE n.\u00b0 01, de 29 de julho de 2005. Autoriza, ad referendum, a publica\u00e7\u00e3o do Guia para Realiza\u00e7\u00e3o de Estudos de Estabilidade","year":"2005"},{"key":"10.1016\/j.fct.2024.114962_bib15","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/j.colsurfa.2017.03.041","article-title":"Lutein-loaded lipid-core nanocapsules: physicochemical characterization and stability evaluation","volume":"522","author":"Brum","year":"2017","journal-title":"Colloids Surf. A Physicochem. Eng. Asp."},{"key":"10.1016\/j.fct.2024.114962_bib16","series-title":"Conselho Federal de Medicina Veterin\u00e1ria. Resolu\u00e7\u00e3o N\u00b0 714, de 20 de junho de","year":"2002"},{"issue":"10","key":"10.1016\/j.fct.2024.114962_bib17","doi-asserted-by":"crossref","first-page":"5093","DOI":"10.2147\/IJN.S84909","article-title":"Caenorhabditis elegans as an alternative in vivo model to determine oral uptake, nanotoxicity, and efficacy of melatonin-loaded lipid-core nanocapsules on paraquat damage","volume":"10","author":"Charao","year":"2015","journal-title":"Int. J. Nanomed."},{"key":"10.1016\/j.fct.2024.114962_bib18","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/5163625","article-title":"A new UPLC-MS\/MS method validated for quantification of jervine in rat plasma and the study of its pharmacokinetics in rats","volume":"2019","author":"Chen","year":"2019","journal-title":"Journal Of Analytical Methods In Chemistry"},{"key":"10.1016\/j.fct.2024.114962_bib19","series-title":"Cristalia Produtos Qu\u00edmicos Farmac\u00eauticos","year":"2021"},{"key":"10.1016\/j.fct.2024.114962_bib20","series-title":"Council for International Organizations of Medical Sciences (CIOMS) Guidelines","year":"2002"},{"issue":"3","key":"10.1016\/j.fct.2024.114962_bib21","doi-asserted-by":"crossref","first-page":"155","DOI":"10.4103\/2230-973X.160853","article-title":"Dual agents loaded polymeric nanoparticle: effect of process variables","volume":"5","author":"Dang","year":"2015","journal-title":"International Journal Of Pharmaceutical Investigation"},{"issue":"2","key":"10.1016\/j.fct.2024.114962_bib22","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1166\/jnn.2010.1847","article-title":"Biodegradable Poly(L-lactic acid)-Lavender Nanocapsules: synthesis, controlled release, and application in remedy of sleep disorder","volume":"10","author":"Daoud","year":"2010","journal-title":"J. Nanosci. Nanotechnol."},{"issue":"6","key":"10.1016\/j.fct.2024.114962_bib23","doi-asserted-by":"crossref","first-page":"1656","DOI":"10.1002\/jbm.a.36040","article-title":"Zein-based composites in biomedical applications","volume":"105","author":"Demir","year":"2019","journal-title":"J. Biomed. Mater. Res., Part A"},{"issue":"12","key":"10.1016\/j.fct.2024.114962_bib24","doi-asserted-by":"crossref","first-page":"8144","DOI":"10.1166\/jnn.2013.7933","article-title":"Characterization of rheology and release profiles of olanzapine-loaded lipid-core nanocapsules in thermosensitive hydrogel","volume":"13","author":"Dimer","year":"2013","journal-title":"J. Nanosci. Nanotechnol."},{"key":"10.1016\/j.fct.2024.114962_bib27","unstructured":"CONCEA 2022. RESOLU\u00c7\u00c3O NORMATIVA CONCEA\/MCTI N\u00b0 55, DE 5 DE OUTUBRO DE 2022. Available at https:\/\/www.in.gov.br\/web\/dou\/-\/resolucao-n-55-de-5-de-outubro-de-2022-434869177."},{"key":"10.1016\/j.fct.2024.114962_bib25","unstructured":"Directive 2010\/63\/EU of the European Parliament and of the Council of 22 September 2010 on the Protection of Animals Used for Scientific Purposes Text with EEA Relevance."},{"issue":"4","key":"10.1016\/j.fct.2024.114962_bib28","doi-asserted-by":"crossref","first-page":"252","DOI":"10.2174\/1872211313666190123153711","article-title":"Nanocapsules for Drug Delivery: an updated review of the last decade","volume":"12","author":"Erdogar","year":"2019","journal-title":"Recent Pat. Drug Deliv. Formulation"},{"key":"10.1016\/j.fct.2024.114962_bib26","unstructured":"CONCEA 2018. RESOLU\u00c7\u00c3O NORMATIVA N\u00b0 37, DE 15 DE FEVEREIRO DE 2018. Available at https:\/\/www.gov.br\/mcti\/pt-br\/composicao\/conselhos\/concea\/arquivos\/arquivo\/legislacao\/anexo-da-resolucao-normativa-no-37-de-15-de-fevereiro-de-2018.pdf."},{"issue":"1","key":"10.1016\/j.fct.2024.114962_bib30","first-page":"86","article-title":"Diazepam loaded solid lipid nanoparticles: in vitro and in vivo evaluations","volume":"12","author":"Faghihi","year":"2020","journal-title":"Adv. Pharmaceut. Bull."},{"key":"10.1016\/j.fct.2024.114962_bib31","series-title":"FDA Guidance for Industry: Dissolution Testing of Immediate Release Solid Oral Dosage Forms","year":"1997"},{"issue":"6","key":"10.1016\/j.fct.2024.114962_bib32","doi-asserted-by":"crossref","first-page":"5223","DOI":"10.1039\/D0FO00473A","article-title":"The influence of oil composition on the transformation, bioaccessibility, and intestinal absorption of curcumin in nanostructured lipid carriers","author":"Feng","year":"2020","journal-title":"Food Funct."},{"issue":"1","key":"10.1016\/j.fct.2024.114962_bib33","doi-asserted-by":"crossref","first-page":"R1","DOI":"10.1016\/0378-5173(89)90281-0","article-title":"Nanocapsule formation by interfacial polymer deposition following solvent displacement","volume":"55","author":"Fessi","year":"1989","journal-title":"Int. J. Pharm."},{"issue":"7","key":"10.1016\/j.fct.2024.114962_bib34","doi-asserted-by":"crossref","first-page":"999","DOI":"10.3390\/brainsci13070999","article-title":"Development and in vivo assessment of 4-Phenyltellanyl-7-chloroquinoline-loaded polymeric nanocapsules in alzheimer's disease models","volume":"13","author":"Funghetto","year":"2023","journal-title":"Brain Sci."},{"issue":"32","key":"10.1016\/j.fct.2024.114962_bib35","doi-asserted-by":"crossref","first-page":"5270","DOI":"10.2174\/0929867329666220329190825","article-title":"The role of alternative toxicological trials in drug discovery Programs.The case of Caenorhabditis elegans and other methods","volume":"29","author":"Goethel","year":"2022","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.fct.2024.114962_bib36","series-title":"Pesquisa em Sa\u00fade e os Direitos dos Animais","author":"Goldim","year":"1997"},{"issue":"3","key":"10.1016\/j.fct.2024.114962_bib37","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1097\/JCP.0000000000001213","article-title":"Diazepam in the Elderly: looking back, ahead, and at the evidence","volume":"40","author":"Greenblatt","year":"2020","journal-title":"J. Clin. Psychopharmacol."},{"key":"10.1016\/j.fct.2024.114962_bib39","series-title":"The Guideline Validation of Analytical Procedures: Text and Methodology","year":"2022"},{"issue":"1","key":"10.1016\/j.fct.2024.114962_bib40","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1166\/jbn.2009.1004","article-title":"Sustained release from lipid-core nanocapsules by varying the core viscosity and the particle surface area","volume":"5","author":"Jager","year":"2009","journal-title":"J. Biomed. Nanotechnol."},{"key":"10.1016\/j.fct.2024.114962_bib41","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.colsurfb.2013.03.027","article-title":"Studies on stabilization mechanism and stealth effect of poloxamer 188 onto PLGA nanoparticles","volume":"109","author":"Jain","year":"2013","journal-title":"Colloids Surf., B"},{"issue":"4","key":"10.1016\/j.fct.2024.114962_bib42","doi-asserted-by":"crossref","first-page":"2602","DOI":"10.1021\/acs.chemrev.5b00346","article-title":"Degradable controlled-release polymers and polymeric nanoparticles: mechanisms of controlling drug release","volume":"116","author":"Kamaly","year":"2016","journal-title":"Chem. Rev."},{"issue":"3","key":"10.1016\/j.fct.2024.114962_bib43","doi-asserted-by":"crossref","first-page":"1844","DOI":"10.3390\/app13031844","article-title":"Non-toxic natural additives to improve the electrical conductivity and viscosity of polycaprolactone for melt electrospinning","volume":"13","author":"Kim","year":"2023","journal-title":"Appl. Sci."},{"issue":"12","key":"10.1016\/j.fct.2024.114962_bib44","doi-asserted-by":"crossref","first-page":"4108","DOI":"10.1111\/1750-3841.15535","article-title":"Development of a nanoparticle delivery system based on zein\/polysaccharide complexes","volume":"85","author":"Li","year":"2020","journal-title":"J. Food Sci."},{"issue":"3","key":"10.1016\/j.fct.2024.114962_bib45","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1016\/j.ijcard.2014.07.284","article-title":"Insomnia and risk of cardiovascular disease: a meta-analysis of cohort studies","volume":"176","author":"Li","year":"2014","journal-title":"Int. J. Cardiol."},{"issue":"125","key":"10.1016\/j.fct.2024.114962_bib46","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.jpba.2016.03.028","article-title":"Microextraction by packed sorbent (MEPS)-UHPLC-UV: a simple and efficient method for the determination of five benzodiazepines in an alcoholic beverage","author":"Magrini","year":"2016","journal-title":"J. Pharmaceut. Biomed. Anal."},{"issue":"10","key":"10.1016\/j.fct.2024.114962_bib47","first-page":"5529","article-title":"Nanoemulsions containing a synthetic chalcone as an alternative for treating cutaneous leshmaniasis: optimization using a full factorial design","author":"Mattos","year":"2015","journal-title":"Int. J. Nanomed."},{"issue":"6","key":"10.1016\/j.fct.2024.114962_bib48","first-page":"6474","article-title":"Mathematical comparison of dissolution profiles","volume":"20","author":"Moore","year":"1996","journal-title":"Pharmaceut. Technol."},{"issue":"2","key":"10.1016\/j.fct.2024.114962_bib49","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1166\/jnn.2016.11668","article-title":"Clozapine-Loaded Polysorbate-Coated Polymeric Nanocapsules: physico-chemical characterization and toxicity evaluation in caenorhabditis elegans model","volume":"16","author":"Moraes","year":"2016","journal-title":"J. Nanosci. Nanotechnol."},{"issue":"1","key":"10.1016\/j.fct.2024.114962_bib50","first-page":"171","article-title":"Prepara\u00e7\u00e3o e caracteriza\u00e7\u00e3o de suspens\u00f5es coloidais nanocarreadores lip\u00eddicos contendo reverastrol destinados \u00e0 administra\u00e7\u00e3o cut\u00e2nea","volume":"36","author":"Nemen","year":"2013","journal-title":"Qu\u00edm. Nova"},{"issue":"36","key":"10.1016\/j.fct.2024.114962_bib51","doi-asserted-by":"crossref","first-page":"9336","DOI":"10.1002\/chem.202100183","article-title":"Formulation of next\u2010generation multicompartment microcapsules by reversible electrostatic attraction","volume":"27","author":"Neumann","year":"2021","journal-title":"Chem. Eur J."},{"key":"10.1016\/j.fct.2024.114962_bib52","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1007\/s43440-022-00412-w","article-title":"Vortioxetine liposomes as a novel alternative to improve drug stability under stress conditions: toxicity studies and evaluation of antidepressant-like effect","volume":"74","author":"Nodari","year":"2022","journal-title":"Pharmacol. Rep."},{"key":"10.1016\/j.fct.2024.114962_bib53","series-title":"Parte 6 \u2013 F\u00e1rmacos Em Neurologia","article-title":"Tratado de farmacologia cl\u00ednica","author":"Nucci","year":"2021"},{"key":"10.1016\/j.fct.2024.114962_bib54","series-title":"The Organization for Economic Co-operation and Development. Acute Oral Toxicity \u2013 Acute Toxic Class Method","year":"2001"},{"key":"10.1016\/j.fct.2024.114962_bib55","first-page":"1","article-title":"Nano based drug delivery systems: recent developments and future prospects","volume":"2018","author":"Patra","year":"2018","journal-title":"J. Nanobiotechnol."},{"issue":"5","key":"10.1016\/j.fct.2024.114962_bib56","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1016\/j.bmcl.2015.01.025","article-title":"Biosynthesis of human diazepam and clonazepam metabolites","volume":"25","author":"Paula","year":"2015","journal-title":"Bioorg. Med. Chem. Lett"},{"issue":"4","key":"10.1016\/j.fct.2024.114962_bib57","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1080\/10837450.2017.1332641","article-title":"Improved photostability and cytotoxic effect of coenzyme Q10 by its association with vitamin E acetate in polymeric nanocapsules","volume":"23","author":"Pegorario","year":"2017","journal-title":"Pharmaceut. Dev. Technol."},{"key":"10.1016\/j.fct.2024.114962_bib58","doi-asserted-by":"crossref","DOI":"10.1016\/j.colsurfb.2020.111555","article-title":"Development of a nanotechnological-based hydrogel containing a novel benzofuroazepine compound in association with vitamin E: an in vitro biological safety and photoprotective hydrogel","volume":"199","author":"Prado","year":"2021","journal-title":"Colloids Surf. B Biointerfaces"},{"issue":"7","key":"10.1016\/j.fct.2024.114962_bib59","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/bmc.5090","article-title":"A UPLC\u2013MS\/MS method for simultaneous determination of nine antiepileptic drugs in human plasma and its application in TDM","volume":"35","author":"Qi","year":"2021","journal-title":"Biomed. Chromatogr."},{"issue":"6","key":"10.1016\/j.fct.2024.114962_bib61","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1111\/jsr.12594","article-title":"European guideline for the diagnosis and treatment of insomnia","volume":"26","author":"Riemann","year":"2017","journal-title":"J. Sleep Res."},{"issue":"7","key":"10.1016\/j.fct.2024.114962_bib62","doi-asserted-by":"crossref","first-page":"789","DOI":"10.3109\/10837450.2013.829097","article-title":"Influence of the type of vegetable oil on the drug release profile from lipid-core nanocapsules and in vivo genotoxicity study","volume":"19","author":"Rigo","year":"2013","journal-title":"Pharmaceut. Dev. Technol."},{"issue":"3\u20134","key":"10.1016\/j.fct.2024.114962_bib63","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1002\/star.201400181","article-title":"Effect of pH and ionic strength on the electrical charge and particle size distribution of starch nanocrystal suspensions","volume":"67","author":"Romdhane","year":"2015","journal-title":"Starch - St\u00e4rke"},{"issue":"12","key":"10.1016\/j.fct.2024.114962_bib64","doi-asserted-by":"crossref","first-page":"671","DOI":"10.3390\/pharmaceutics11120671","article-title":"Poloxamer hydrogels for biomedical applications","volume":"11","author":"Russo","year":"2019","journal-title":"Pharmaceutics"},{"issue":"111","key":"10.1016\/j.fct.2024.114962_bib65","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1016\/j.biopha.2018.12.133","article-title":"Applications of nanotechnology in drug delivery to the central nervous system","author":"Saeedi","year":"2019","journal-title":"Biomed. Pharmacother."},{"issue":"133","key":"10.1016\/j.fct.2024.114962_bib66","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.ejpb.2018.09.023","article-title":"Influence of the surface properties of nanocapsules on their interaction with intestinal barriers","volume":"2018","author":"Santalices","year":"2018","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.fct.2024.114962_bib67","series-title":"Medicamentos na pr\u00e1tica da farm\u00e1cia cl\u00ednica","author":"Santos","year":"2013"},{"issue":"350","key":"10.1016\/j.fct.2024.114962_bib68","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1016\/j.jconrel.2022.08.051","article-title":"Recent advances in drug delivery and targeting to the brain","author":"Sethi","year":"2022","journal-title":"J. Contr. Release"},{"issue":"5","key":"10.1016\/j.fct.2024.114962_bib69","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1208\/s12249-015-0294-0","article-title":"Nose-to-brain delivery of PLGA-diazepam nanoparticles","volume":"16","author":"Sharma","year":"2015","journal-title":"AAPS PharmSciTech"},{"key":"10.1016\/j.fct.2024.114962_bib70","series-title":"Farmacocin\u00e9tica Do Diazepam. [dissertation]","author":"Silva","year":"2013"},{"issue":"1","key":"10.1016\/j.fct.2024.114962_bib71","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1177\/2047487312460020","article-title":"Insomnia and risk of cardiovascular disease: a meta-analysis","volume":"21","author":"Sofi","year":"2012","journal-title":"European Journal of Preventive Cardiology"},{"issue":"12","key":"10.1016\/j.fct.2024.114962_bib72","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1056\/NEJMra1611832","article-title":"Treatment of benzodiazepine dependence","volume":"376","author":"Soyka","year":"2017","journal-title":"N. Engl. J. Med."},{"issue":"1","key":"10.1016\/j.fct.2024.114962_bib73","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1186\/s11671-018-2457-x","article-title":"Dependence of nanoparticle toxicity on their physical and chemical properties","volume":"13","author":"Sukhanova","year":"2018","journal-title":"Nanoscale Res. Lett."},{"issue":"3","key":"10.1016\/j.fct.2024.114962_bib74","doi-asserted-by":"crossref","first-page":"222","DOI":"10.4103\/1735-5362.207203","article-title":"Development of dry powder inhaler containing tadalafil-loaded PLGA nanoparticles","volume":"12","author":"Taymouri","year":"2017","journal-title":"Research In Pharmaceutical Sciences"},{"key":"10.1016\/j.fct.2024.114962_bib75","series-title":"Roche Qu\u00edmicos e Farmac\u00eauticos S.A","year":"2021"},{"issue":"1","key":"10.1016\/j.fct.2024.114962_bib76a","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.colsurfa.2010.12.011","article-title":"Formulation of lipid core nanocapsules","volume":"375","author":"Venturini","year":"2011","journal-title":"Colloids Surfaces a Physicochem. Eng. Asp."},{"issue":"1","key":"10.1016\/j.fct.2024.114962_bib76","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/s12951-020-00747-7","article-title":"Density of surface charge is a more predictive factor of the toxicity of cationic carbon nanoparticles than zeta potential","volume":"19","author":"Weiss","year":"2021","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.fct.2024.114962_bib77","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1016\/j.chemosphere.2019.01.021","article-title":"Caenorhabditis elegans as a complete model organism for biosafety assessments of nanoparticles","volume":"221","author":"Wu","year":"2019","journal-title":"Chemosphere"},{"issue":"9","key":"10.1016\/j.fct.2024.114962_bib78","doi-asserted-by":"crossref","first-page":"4991","DOI":"10.1039\/D0RA10312H","article-title":"Screening of highly effective mixed natural antioxidants to improve the oxidative stability of microalgal DHA-rich oil","volume":"11","author":"Yin","year":"2021","journal-title":"RSC Adv."},{"issue":"23","key":"10.1016\/j.fct.2024.114962_bib79","doi-asserted-by":"crossref","first-page":"3035","DOI":"10.2217\/nnm-2016-0353","article-title":"Do ginger-derived nanoparticles represent an attractive treatment strategy for inflammatory bowel diseases?","volume":"11","author":"Zhang","year":"2016","journal-title":"Nanomedicine"}],"container-title":["Food and Chemical Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278691524005283?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278691524005283?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,9,11]],"date-time":"2024-09-11T05:13:22Z","timestamp":1726031602000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0278691524005283"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10]]},"references-count":76,"alternative-id":["S0278691524005283"],"URL":"https:\/\/doi.org\/10.1016\/j.fct.2024.114962","relation":{},"ISSN":["0278-6915"],"issn-type":[{"value":"0278-6915","type":"print"}],"subject":[],"published":{"date-parts":[[2024,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Diazepam nanocapsules as an alternative for sleep induction: Development study and toxicity assessment","name":"articletitle","label":"Article Title"},{"value":"Food and Chemical Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fct.2024.114962","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"114962"}}