{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T04:39:39Z","timestamp":1785386379366,"version":"3.55.0"},"reference-count":97,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100006261","name":"Taif University","doi-asserted-by":"publisher","award":["TU-DSPP-2024-243"],"award-info":[{"award-number":["TU-DSPP-2024-243"]}],"id":[{"id":"10.13039\/501100006261","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Food and Chemical Toxicology"],"published-print":{"date-parts":[[2024,11]]},"DOI":"10.1016\/j.fct.2024.115029","type":"journal-article","created":{"date-parts":[[2024,10,2]],"date-time":"2024-10-02T00:03:38Z","timestamp":1727827418000},"page":"115029","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Pumpkin seed oil lessens the colchicine-induced altered sex male hormone balance, testicular oxidative status, sperm abnormalities, and collagen deposition in male rats via Caspase3\/Desmin\/PCNA modulation"],"prefix":"10.1016","volume":"193","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3646-6385","authenticated-orcid":false,"given":"Yasmina M.","family":"Abd-Elhakim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samaa Salah Abd","family":"El-Fatah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amany","family":"Behairy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taghred M.","family":"Saber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nabela I.","family":"El-Sharkawy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gihan G.","family":"Moustafa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fathy Elsayed","family":"Abdelgawad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taisir","family":"Saber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariam M.","family":"Samaha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omnia I.","family":"El Euony","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.fct.2024.115029_bib1","doi-asserted-by":"crossref","first-page":"89954","DOI":"10.1007\/s11356-022-21932-1","article-title":"Curcumin attenuates gentamicin and sodium salicylate ototoxic effects by modulating the nuclear factor-kappaB and apoptotic pathways in rats","volume":"29","author":"Abd-Elhakim","year":"2022","journal-title":"Environ. Sci. Pollut. Control Ser."},{"key":"10.1016\/j.fct.2024.115029_bib2","doi-asserted-by":"crossref","first-page":"826","DOI":"10.3390\/antiox10060826","article-title":"Protective effect of curcumin against sodium salicylate-induced oxidative kidney damage, nuclear factor-kappa dysregulation, and apoptotic consequences in rats","volume":"10","author":"Abd-Elhakim","year":"2021","journal-title":"Antioxidants"},{"key":"10.1016\/j.fct.2024.115029_bib3","doi-asserted-by":"crossref","first-page":"14","DOI":"10.4236\/ijamsc.2016.41002","article-title":"Application of GC\/EIMS in combination with semi-empirical calculations for identification and investigation of some volatile components in basil essential oil","volume":"4","author":"Abd El-Kareem","year":"2016","journal-title":"Int. J. Anal. Mass Spectrom. Chromatogr."},{"key":"10.1016\/j.fct.2024.115029_bib4","first-page":"126","article-title":"Garlic antagonizes skeletal muscle ischemia reperfusion injury through regulating inflammation, apoptosis and desmin expression in adult male rats","volume":"11","author":"Abd El-Mottaleb","year":"2019","journal-title":"International Journal of Physiology, Pathophysiology and Pharmacology"},{"key":"10.1016\/j.fct.2024.115029_bib5","doi-asserted-by":"crossref","first-page":"396","DOI":"10.3390\/antiox9050396","article-title":"Saussurea lappa ethanolic extract attenuates triamcinolone acetonide-induced pulmonary and splenic tissue damage in rats via modulation of oxidative stress, inflammation, and apoptosis","volume":"9","author":"Abd El-Rahman","year":"2020","journal-title":"Antioxidants"},{"key":"10.1016\/j.fct.2024.115029_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2021.111347","article-title":"'Methyl palmitate attenuates adjuvant induced arthritis in rats by decrease of CD68 synovial macrophages","volume":"137","author":"Abdel Jaleel","year":"2021","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.fct.2024.115029_bib7","first-page":"1","article-title":"In vitro and in vivo scolicidal action of pumpkin seed oil alone or combined with nitazoxanide and their alleviative effects on clinicopathological changes in experimentally infected rats with hydatid cyst protoscolices","volume":"19","author":"Abdel Rahman","year":"2023","journal-title":"EVMPSJ"},{"key":"10.1016\/j.fct.2024.115029_bib8","doi-asserted-by":"crossref","first-page":"7321","DOI":"10.1038\/s41598-023-34143-6","article-title":"The potential role of pumpkin seeds oil on methotrexate-induced lung toxicity","volume":"13","author":"Abosrea","year":"2023","journal-title":"Sci. Rep."},{"key":"10.1016\/j.fct.2024.115029_bib9","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1590\/1806-9282.63.02.148","article-title":"Regulation of muscle plasticity and trophism by fatty acids: a short review","volume":"63","author":"Abreu","year":"2017","journal-title":"Rev. Assoc. M\u00e9d. Bras."},{"key":"10.1016\/j.fct.2024.115029_bib10","doi-asserted-by":"crossref","first-page":"53","DOI":"10.21608\/jva.2009.42311","article-title":"Characterizing the gonadosomatic index and its relationship with age in greater cane rat (Thryonomys swinderianus, Temminck)","volume":"2","author":"Adebayo","year":"2009","journal-title":"Journal of veterinary anatomy"},{"key":"10.1016\/j.fct.2024.115029_bib11","first-page":"43","article-title":"Protective effects of oleic acid against palmitic acid-induced apoptosis in pancreatic AR42J cells and its mechanisms","volume":"17","author":"Ahn","year":"2013","journal-title":"kjpp"},{"key":"10.1016\/j.fct.2024.115029_bib12","doi-asserted-by":"crossref","DOI":"10.1111\/and.12636","article-title":"Protective effects of Urtica dioica L. on experimental testicular ischaemia reperfusion injury in rats","volume":"49","author":"Aktas","year":"2017","journal-title":"Andrologia"},{"key":"10.1016\/j.fct.2024.115029_bib13","first-page":"68","article-title":"Colchicine and plaque: a focus on atherosclerosis imaging","volume":"84","author":"Aldana-Bitar","year":"2024","journal-title":"Prog. Cardiovasc. Dis."},{"key":"10.1016\/j.fct.2024.115029_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2019.e02462","article-title":"Comparative study on nutrient contents in the different parts of indigenous and hybrid varieties of pumpkin (Cucurbita maxima Linn.)","volume":"5","author":"Amin","year":"2019","journal-title":"Heliyon"},{"key":"10.1016\/j.fct.2024.115029_bib15","doi-asserted-by":"crossref","first-page":"659","DOI":"10.2174\/1381612824666180123110042","article-title":"Colchicine pharmacokinetics and mechanism of action","volume":"24","author":"Angelidis","year":"2018","journal-title":"Curr. Pharmaceut. Des."},{"key":"10.1016\/j.fct.2024.115029_bib16","doi-asserted-by":"crossref","first-page":"345","DOI":"10.56808\/2985-1130.3036","article-title":"The effects of pumpkin seed oil on carbon tetrachloride induced chronic hepatic damage in rats","volume":"50","author":"Atasever","year":"2020","journal-title":"The Thai Journal of Veterinary Medicine"},{"key":"10.1016\/j.fct.2024.115029_bib17","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/S0027-5107(03)00134-9","article-title":"Linoleic acid and antioxidants protect against DNA damage and apoptosis induced by palmitic acid","volume":"530","author":"Beeharry","year":"2003","journal-title":"Mutat. Res. Fund Mol. Mech. Mutagen"},{"key":"10.1016\/j.fct.2024.115029_bib18","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.3390\/antiox9111053","article-title":"The modulatory role of vitamin C in boldenone undecylenate induced testicular oxidative damage and androgen receptor dysregulation in adult male rats","volume":"9","author":"Behairy","year":"2020","journal-title":"Antioxidants"},{"key":"10.1016\/j.fct.2024.115029_bib19","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.steroids.2011.12.017","article-title":"Saturated fatty acid exposure induces androgen overproduction in bovine adrenal cells","volume":"77","author":"Bellanger","year":"2012","journal-title":"Steroids"},{"key":"10.1016\/j.fct.2024.115029_bib20","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1051\/rnd:2004042","article-title":"Dose-effect of dietary oleic acid: oleic acid is conditionally essential for some organs","volume":"44","author":"Bourre","year":"2004","journal-title":"Reprod. Nutr. Dev."},{"key":"10.1016\/j.fct.2024.115029_bib21","series-title":"British Herbal Compendium. Volume 2: a Handbook of Scientific Information of Widely Used Plant Drugs","author":"Bradley","year":"2006"},{"key":"10.1016\/j.fct.2024.115029_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.mex.2022.101856","article-title":"Whole-slide imaging and a Fiji-based image analysis workflow of immunohistochemistry staining of pancreatic islets","volume":"9","author":"Buckels","year":"2022","journal-title":"MethodsX"},{"key":"10.1016\/j.fct.2024.115029_bib23","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2014.00001","article-title":"Role of estrogen receptors and G protein-coupled estrogen receptor in regulation of hypothalamus\u2013pituitary\u2013testis axis and spermatogenesis","volume":"5","author":"Chimento","year":"2014","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.fct.2024.115029_bib24","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1016\/j.clinthera.2014.07.017","article-title":"Mechanism of action of colchicine in the treatment of gout","volume":"36","author":"Dalbeth","year":"2014","journal-title":"Clin. Therapeut."},{"key":"10.1016\/j.fct.2024.115029_bib25","series-title":"Encyclopedia of Toxicology","first-page":"165","article-title":"Colchicine","author":"Dash","year":"2024"},{"key":"10.1016\/j.fct.2024.115029_bib26","doi-asserted-by":"crossref","first-page":"6725","DOI":"10.3390\/ijms15046725","article-title":"Supercritical carbon dioxide extraction of carotenoids from pumpkin (Cucurbita spp.): a review","volume":"15","author":"Durante","year":"2014","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.fct.2024.115029_bib27","doi-asserted-by":"crossref","first-page":"189","DOI":"10.4103\/2305-0500.268132","article-title":"Male reproductive hormones and semen quality","volume":"8","author":"Dutta","year":"2019","journal-title":"Asian Pacific Journal of Reproduction"},{"key":"10.1016\/j.fct.2024.115029_bib28","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.acthis.2018.10.010","article-title":"The efficacy of chronic zinc oxide nanoparticles using on testicular damage in the streptozotocin-induced diabetic rat model","volume":"121","author":"El-Behery","year":"2019","journal-title":"Acta Histochem."},{"key":"10.1016\/j.fct.2024.115029_bib29","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.taap.2011.04.016","article-title":"Anti-inflammatory and antifibrotic effects of methyl palmitate","volume":"254","author":"El-Demerdash","year":"2011","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.fct.2024.115029_bib30","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.jobaz.2012.10.010","article-title":"Protective effect of pumpkin seed oil against genotoxicity induced by azathioprine","volume":"65","author":"Elfiky","year":"2012","journal-title":"The Journal of Basic & Applied Zoology"},{"key":"10.1016\/j.fct.2024.115029_bib31","doi-asserted-by":"crossref","first-page":"77","DOI":"10.21608\/bvmj.2019.13448.1030","article-title":"Antioxidant and hepatoprotective effect of pumpkin seed oil in CCl4-intoxicated rats","volume":"36","author":"Elmeligy","year":"2019","journal-title":"Benha Veterinary Medical Journal"},{"key":"10.1016\/j.fct.2024.115029_bib32","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1111\/and.12040","article-title":"Saturated, omega\u20106 and omega\u20103 dietary fatty acid effects on the characteristics of fresh, frozen\u2013thawed semen and blood parameters in rams","volume":"46","author":"Esmaeili","year":"2014","journal-title":"Andrologia"},{"key":"10.1016\/j.fct.2024.115029_bib33","doi-asserted-by":"crossref","first-page":"41682","DOI":"10.1007\/s11356-023-25152-z","article-title":"The palliative effect of mulberry leaf and olive leaf ethanolic extracts on hepatic CYP2E1 and caspase-3 immunoexpression and oxidative damage induced by paracetamol in male rats","volume":"30","author":"Fadil","year":"2023","journal-title":"Environ. Sci. Pollut. Control Ser."},{"key":"10.1016\/j.fct.2024.115029_bib34","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1016\/j.toxrep.2018.08.014","article-title":"Improved effect of pumpkin seed oil against the bisphenol-A adverse effects in male mice","volume":"5","author":"Fawzy","year":"2018","journal-title":"Toxicol Rep"},{"key":"10.1016\/j.fct.2024.115029_bib35","first-page":"334","article-title":"Methods for evaluation of rat epididymal sperm morphology","volume":"3","author":"Filler","year":"1993","journal-title":"Methods Toxicol."},{"key":"10.1016\/j.fct.2024.115029_bib36","doi-asserted-by":"crossref","first-page":"407","DOI":"10.3109\/15563650.2010.495348","article-title":"Colchicine poisoning: the dark side of an ancient drug","volume":"48","author":"Finkelstein","year":"2010","journal-title":"Clin. Toxicol."},{"key":"10.1016\/j.fct.2024.115029_bib38","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000016580","article-title":"Clinical outcomes after colchicine overdose: a case report","volume":"98","author":"Fu","year":"2019","journal-title":"Medicine"},{"key":"10.1016\/j.fct.2024.115029_bib39","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1177\/0300985813485099","article-title":"Principles for valid histopathologic scoring in research","volume":"50","author":"Gibson-Corley","year":"2013","journal-title":"Veterinary pathology"},{"key":"10.1016\/j.fct.2024.115029_bib40","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.jcpa.2013.08.001","article-title":"Immunohistochemical expression of markers of immaturity in Sertoli and seminal cells in canine testicular atrophy","volume":"150","author":"Giudice","year":"2014","journal-title":"J. Comp. Pathol."},{"key":"10.1016\/j.fct.2024.115029_bib41","doi-asserted-by":"crossref","first-page":"a022608","DOI":"10.1101\/cshperspect.a022608","article-title":"Microtubules and microtubule-associated proteins","volume":"10","author":"Goodson","year":"2018","journal-title":"Cold Spring Harbor Perspect. Biol."},{"key":"10.1016\/j.fct.2024.115029_bib42","doi-asserted-by":"crossref","DOI":"10.1016\/j.amsu.2022.103593","article-title":"Randomized controlled trial of colchicine add on to the standard therapy in moderate and severe corona virus Disease-19 infection","volume":"77","author":"Gorial","year":"2022","journal-title":"Annals of Medicine and Surgery"},{"key":"10.1016\/j.fct.2024.115029_bib43","first-page":"369","article-title":"Antimicrobial Activity and spectral chemical analysis of methanolic leaves extract of Adiantum Capillus-Veneris using GC-MS and FT-IR spectroscopy","volume":"8","author":"Hadi","year":"2016","journal-title":"Int J Pharmacogn Phytochem Res"},{"key":"10.1016\/j.fct.2024.115029_bib44","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s41936-020-00178-8","article-title":"Testicular dysfunction induced by aluminum oxide nanoparticle administration in albino rats and the possible protective role of the pumpkin seed oil","volume":"81","author":"Hamdi","year":"2020","journal-title":"The Journal of Basic and Applied Zoology"},{"key":"10.1016\/j.fct.2024.115029_bib45","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s41936-020-00178-8","article-title":"Testicular dysfunction induced by aluminum oxide nanoparticle administration in albino rats and the possible protective role of the pumpkin seed oil","volume":"81","author":"Hamdi","year":"2020","journal-title":"The Journal of Basic and Applied Zoology"},{"key":"10.1016\/j.fct.2024.115029_bib46","first-page":"1351","article-title":"Pumpkin seed oil and vitamin E improve reproductive function of male rats inflicted by testicular injury","volume":"23","author":"Hashemi","year":"2013","journal-title":"World Appl. Sci. J."},{"key":"10.1016\/j.fct.2024.115029_bib47","doi-asserted-by":"crossref","first-page":"6865","DOI":"10.1016\/j.arabjc.2020.06.039","article-title":"Extraction methods of fat from food samples and preparation of fatty acid methyl esters for gas chromatography: a review","volume":"13","author":"Hewavitharana","year":"2020","journal-title":"Arab. J. Chem."},{"key":"10.1016\/j.fct.2024.115029_bib48","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2023.110776","article-title":"Metabolomics reveals that sulfotransferase 1 may regulate colchicine-induced liver injury","volume":"386","author":"Huang","year":"2023","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.fct.2024.115029_bib49","doi-asserted-by":"crossref","first-page":"49","DOI":"10.5897\/JPP2015.0368","article-title":"Phytochemical screening of methanolic dried galls extract of Quercus infectoria using gas chromatography-mass spectrometry (GC-MS) and Fourier transform-infrared (FT-IR)","volume":"8","author":"Hussein","year":"2016","journal-title":"J. Pharmacogn. Phytotherapy"},{"key":"10.1016\/j.fct.2024.115029_bib50","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbagen.2023.130488","article-title":"Direct observation of oriented behavior of actin filaments interacting with desmin intermediate filaments","volume":"1867","author":"Ishizaka","year":"2023","journal-title":"Biochim. Biophys. Acta Gen. Subj."},{"key":"10.1016\/j.fct.2024.115029_bib51","first-page":"2","article-title":"Testicular biopsy score count--a method for registration of spermatogenesis in human testes: normal values and results in 335 hypogonadal males","volume":"1","author":"Johnsen","year":"1970","journal-title":"Hormones (Basel)"},{"key":"10.1016\/j.fct.2024.115029_bib52","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1016\/S0028-3908(02)00052-7","article-title":"Cytoskeleton disruption causes apoptotic degeneration of dentate granule cells in hippocampal slice cultures","volume":"42","author":"Kim","year":"2002","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.fct.2024.115029_bib53","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1078\/0940-2993-00349","article-title":"Revised guides for organ sampling and trimming in rats and mice\u2013Part 2: a joint publication of the RITA and NACAD groups","volume":"55","author":"Kittel","year":"2004","journal-title":"Exp. Toxicol. Pathol."},{"key":"10.1016\/j.fct.2024.115029_bib54","series-title":"Proceedings, American Association of Swine Veterinarians 33rd Annual Meeting","first-page":"20","article-title":"Use and accuracy of instruments to estimate sperm concentration: pros, Cons & Economics","author":"Knox","year":"2002"},{"key":"10.1016\/j.fct.2024.115029_bib55","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.121.021198","article-title":"Colchicine in patients with coronary artery disease: a systematic review and meta\u2010analysis of randomized trials","volume":"10","author":"Kofler","year":"2021","journal-title":"J. Am. Heart Assoc."},{"key":"10.1016\/j.fct.2024.115029_bib56","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/S0006-8993(02)04080-5","article-title":"Colchicine induces apoptosis in organotypic hippocampal slice cultures","volume":"964","author":"Kristensen","year":"2003","journal-title":"Brain Res."},{"key":"10.1016\/j.fct.2024.115029_bib57","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.ejphar.2006.08.076","article-title":"Differential effects of cyclooxygenase inhibitors on intracerebroventricular colchicine-induced dysfunction and oxidative stress in rats","volume":"551","author":"Kumar","year":"2006","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.fct.2024.115029_bib58","doi-asserted-by":"crossref","first-page":"702","DOI":"10.2174\/1381612824666180116101823","article-title":"The role of colchicine in pericardial syndromes","volume":"24","author":"Lazaros","year":"2018","journal-title":"Curr. Pharmaceut. Des."},{"key":"10.1016\/j.fct.2024.115029_bib59","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.theriogenology.2022.05.003","article-title":"Linoleic acid reduces apoptosis via NF-\u03baB during the in vitro development of induced parthenogenic porcine embryos","volume":"187","author":"Lee","year":"2022","journal-title":"Theriogenology"},{"key":"10.1016\/j.fct.2024.115029_bib60","doi-asserted-by":"crossref","DOI":"10.1136\/rmdopen-2020-001455","article-title":"Beneficial effects of colchicine for moderate to severe COVID-19: a randomised, double-blinded, placebo-controlled clinical trial","volume":"7","author":"Lopes","year":"2021","journal-title":"RMD Open"},{"key":"10.1016\/j.fct.2024.115029_bib61","doi-asserted-by":"crossref","first-page":"5659","DOI":"10.3390\/ijms23105659","article-title":"Pyridine compounds with antimicrobial and antiviral activities","volume":"23","author":"Marinescu","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.fct.2024.115029_bib62","doi-asserted-by":"crossref","DOI":"10.3390\/antiox9030237","article-title":"Improvement of testicular steroidogenesis using flavonoids and isoflavonoids for prevention of late-onset male hypogonadism","volume":"9","author":"Martin","year":"2020","journal-title":"Antioxidants"},{"key":"10.1016\/j.fct.2024.115029_bib63","first-page":"257","article-title":"The role of hypothalamic-pituitary-gonadal hormones in the normal structure and functioning of the brain","volume":"62","author":"Meethal","year":"2005","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.fct.2024.115029_bib64","doi-asserted-by":"crossref","first-page":"C1609","DOI":"10.1152\/ajpcell.00441.2011","article-title":"Skeletal muscle fibrosis develops in response to desmin deletion","volume":"302","author":"Meyer","year":"2012","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.fct.2024.115029_bib65","doi-asserted-by":"crossref","first-page":"361","DOI":"10.3390\/antiox12020361","article-title":"Green synthesized zinc oxide nanoparticles using moringa olifera ethanolic extract lessens acrylamide-induced testicular damage, apoptosis, and steroidogenesis-related gene dysregulation in adult rats","volume":"12","author":"Mostafa-Hedeab","year":"2023","journal-title":"Antioxidants"},{"key":"10.1016\/j.fct.2024.115029_bib66","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1007\/s11255-021-02877-9","article-title":"Differentiation and proliferation of spermatogonial stem cells using a three-dimensional decellularized testicular scaffold: a new method to study the testicular microenvironment in vitro","volume":"53","author":"Naeemi","year":"2021","journal-title":"Int. Urol. Nephrol."},{"key":"10.1016\/j.fct.2024.115029_bib67","doi-asserted-by":"crossref","first-page":"27","DOI":"10.4103\/0976-0105.177703","article-title":"A simple practice guide for dose conversion between animals and human","volume":"7","author":"Nair","year":"2016","journal-title":"J. Basic Clin. Pharm."},{"key":"10.1016\/j.fct.2024.115029_bib68","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1097\/RD9.0000000000000003","article-title":"Role of fatty acids and calcium in male reproduction","volume":"6","author":"Naz","year":"2022","journal-title":"Reproductive and Developmental Medicine"},{"key":"10.1016\/j.fct.2024.115029_bib69","doi-asserted-by":"crossref","first-page":"687","DOI":"10.5694\/mja14.00846","article-title":"Colchicine\u2014a short history of an ancient drug","volume":"201","author":"Nerlekar","year":"2014","journal-title":"Med. J. Aust."},{"key":"10.1016\/j.fct.2024.115029_bib70","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1016\/j.jbspin.2006.03.006","article-title":"Colchicine today","volume":"73","author":"Niel","year":"2006","journal-title":"Joint Bone Spine"},{"key":"10.1016\/j.fct.2024.115029_bib71","doi-asserted-by":"crossref","first-page":"241","DOI":"10.3390\/antiox13020241","article-title":"Evaluation of antioxidant effects of pumpkin (cucurbita pepo L.) seed extract on aging- and menopause-related diseases using saos-2 cells and ovariectomized rats","volume":"13","author":"Oh","year":"2024","journal-title":"Antioxidants"},{"key":"10.1016\/j.fct.2024.115029_bib72","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1007\/s10495-007-0756-2","article-title":"Mitochondria, oxidative stress and cell death","volume":"12","author":"Ott","year":"2007","journal-title":"Apoptosis"},{"key":"10.1016\/j.fct.2024.115029_bib73","doi-asserted-by":"crossref","first-page":"2811","DOI":"10.1016\/j.fct.2012.05.038","article-title":"Prophylactic effect of \u03b1-linolenic acid and \u03b1-eleostearic acid against MeHg induced oxidative stress, DNA damage and structural changes in RBC membrane","volume":"50","author":"Pal","year":"2012","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.fct.2024.115029_bib74","doi-asserted-by":"crossref","DOI":"10.1095\/biolreprod.116.142802","article-title":"Complete human and rat ex vivo spermatogenesis from fresh or frozen testicular Tissue1","volume":"95","author":"Perrard","year":"2016","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.fct.2024.115029_bib75","doi-asserted-by":"crossref","first-page":"1671","DOI":"10.1590\/0001-3765201720160908","article-title":"Antifungal and antioxidant activity of fatty acid methyl esters from vegetable oils","volume":"89","author":"Pinto","year":"2017","journal-title":"An Acad. Bras Ci\u00eancias"},{"key":"10.1016\/j.fct.2024.115029_bib76","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.ejphar.2013.08.016","article-title":"Lycopene protects against memory impairment and mito-oxidative damage induced by colchicine in rats: an evidence of nitric oxide signaling","volume":"721","author":"Prakash","year":"2013","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.fct.2024.115029_bib77","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1590\/1678-457x.05016","article-title":"Characterization of bioactive compounds, antioxidant activity and minerals in landraces of pumpkin (Cucurbita moschata) cultivated in Southern Brazil","volume":"37","author":"Priori","year":"2016","journal-title":"Food Sci. Technol."},{"key":"10.1016\/j.fct.2024.115029_bib78","doi-asserted-by":"crossref","first-page":"149","DOI":"10.21608\/ejar.2016.151813","article-title":"Effect of diet supplemented with pumpkin (cucurbita moschata) and black seed (nigella ativa) oils on performance of Rabbits: 3-productive and reproductive traits, puberty, sexual activity and semen characteristics of New Zealand white male rabbits","volume":"94","author":"Ragab","year":"2016","journal-title":"Egyptian Journal of Agricultural Research"},{"key":"10.1016\/j.fct.2024.115029_bib79","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0277790","article-title":"Efficacy of colchicine in patients with moderate COVID-19: a double-blinded, randomized, placebo-controlled trial","volume":"17","author":"Rahman","year":"2022","journal-title":"PLoS One"},{"key":"10.1016\/j.fct.2024.115029_bib80","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1080\/87559129.2018.1482496","article-title":"The beneficial effects of pumpkin (Cucurbita pepo L.) seed oil for health condition of men","volume":"35","author":"Ramak","year":"2019","journal-title":"Food Rev. Int."},{"key":"10.1016\/j.fct.2024.115029_bib81","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1530\/jrf.0.0540103","article-title":"Daily sperm production and epididymal sperm reserves of pubertal and adult rats","volume":"54","author":"Robb","year":"1978","journal-title":"J. Reprod. Fertil."},{"key":"10.1016\/j.fct.2024.115029_bib82","doi-asserted-by":"crossref","first-page":"413","DOI":"10.4314\/ahs.v20i1.48","article-title":"Pumpkin seed oil alleviates oxidative stress and liver damage induced by sodium nitrate in adult rats: biochemical and histological approach","volume":"20","author":"Rouag","year":"2020","journal-title":"Afr. Health Sci."},{"key":"10.1016\/j.fct.2024.115029_bib83","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.taap.2012.07.020","article-title":"Anti-inflammatory activity of methyl palmitate and ethyl palmitate in different experimental rat models","volume":"264","author":"Saeed","year":"2012","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.fct.2024.115029_bib84","doi-asserted-by":"crossref","first-page":"3479","DOI":"10.3390\/molecules25153479","article-title":"Chemo-protective potential of cerium oxide nanoparticles against fipronil-induced oxidative stress, apoptosis, inflammation and reproductive dysfunction in male white albino rats","volume":"25","author":"Saleh","year":"2020","journal-title":"Molecules"},{"key":"10.1016\/j.fct.2024.115029_bib85","doi-asserted-by":"crossref","first-page":"152","DOI":"10.5530\/pc.2017.4.22","article-title":"Correlating the anti-aging activity with the bioactive profile of Chlorella emersonii KJ725233; its Toxicological Studies for a Potential use in Cosmeceuticals","volume":"7","author":"Sawant","year":"2017","journal-title":"Pharmacogn. Commun."},{"key":"10.1016\/j.fct.2024.115029_bib86","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/nmeth.2019","article-title":"Fiji: an open-source platform for biological-image analysis","volume":"9","author":"Schindelin","year":"2012","journal-title":"Nat. Methods"},{"key":"10.1016\/j.fct.2024.115029_bib87","doi-asserted-by":"crossref","first-page":"435","DOI":"10.4103\/1008-682X.173932","article-title":"The role of estradiol in male reproductive function","volume":"18","author":"Schulster","year":"2016","journal-title":"Asian J. Androl."},{"key":"10.1016\/j.fct.2024.115029_bib88","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1007\/BF00493008","article-title":"Standardization of the feulgen-schiff technique","volume":"91","author":"Schulte","year":"1989","journal-title":"Histochemistry"},{"key":"10.1016\/j.fct.2024.115029_bib89","doi-asserted-by":"crossref","DOI":"10.1111\/and.13646","article-title":"Environmental contaminants and male infertility: effects and mechanisms","volume":"53","author":"Selvaraju","year":"2021","journal-title":"Andrologia"},{"key":"10.1016\/j.fct.2024.115029_bib90","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1016\/j.jep.2014.02.050","article-title":"Androgenic effect of honeybee drone milk in castrated rats: roles of methyl palmitate and methyl oleate","volume":"153","author":"Seres","year":"2014","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.fct.2024.115029_bib91","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/0890-6238(91)90009-5","article-title":"Rat sperm motility analysis: methodologic considerations","volume":"5","author":"Slott","year":"1991","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.fct.2024.115029_bib92","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1210\/en.2018-00889","article-title":"GnRH\u2014a key regulator of FSH","volume":"160","author":"Stamatiades","year":"2018","journal-title":"Endocrinology"},{"key":"10.1016\/j.fct.2024.115029_bib93","doi-asserted-by":"crossref","first-page":"4005","DOI":"10.1021\/jf0706979","article-title":"Oil and tocopherol content and composition of pumpkin seed oil in 12 cultivars","volume":"55","author":"Stevenson","year":"2007","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.fct.2024.115029_bib94","series-title":"Bancroft's Theory and Practice of Histological Techniques E-Book","author":"Suvarna","year":"2018"},{"key":"10.1016\/j.fct.2024.115029_bib95","doi-asserted-by":"crossref","first-page":"2482","DOI":"10.1210\/jc.2008-2650","article-title":"Low serum testosterone and estradiol predict mortality in elderly men","volume":"94","author":"Tivesten","year":"2009","journal-title":"J. Clin. Endocrinol. Metabol."},{"key":"10.1016\/j.fct.2024.115029_bib96","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1309\/CQWY-E3F6-9KDN-YV36","article-title":"Quantitative analysis of the decay of immunoreactivity in stored prostate needle biopsy sections","volume":"113","author":"Vis","year":"2000","journal-title":"Am. J. Clin. Pathol."},{"key":"10.1016\/j.fct.2024.115029_bib97","doi-asserted-by":"crossref","DOI":"10.1016\/j.steroids.2020.108677","article-title":"Linoleic acid promotes testosterone production by activating Leydig cell GPR120\/ERK pathway and restores BPA-impaired testicular toxicity","volume":"163","author":"Xu","year":"2020","journal-title":"Steroids"},{"key":"10.1016\/j.fct.2024.115029_bib98","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1093\/biolre\/ioy059","article-title":"Leydig cells: formation, function, and regulation","volume":"99","author":"Zirkin","year":"2018","journal-title":"Biol. Reprod."}],"container-title":["Food and Chemical Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278691524005957?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278691524005957?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,11,11]],"date-time":"2024-11-11T07:16:55Z","timestamp":1731309415000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0278691524005957"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11]]},"references-count":97,"alternative-id":["S0278691524005957"],"URL":"https:\/\/doi.org\/10.1016\/j.fct.2024.115029","relation":{},"ISSN":["0278-6915"],"issn-type":[{"value":"0278-6915","type":"print"}],"subject":[],"published":{"date-parts":[[2024,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Pumpkin seed oil lessens the colchicine-induced altered sex male hormone balance, testicular oxidative status, sperm abnormalities, and collagen deposition in male rats via Caspase3\/Desmin\/PCNA modulation","name":"articletitle","label":"Article Title"},{"value":"Food and Chemical Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fct.2024.115029","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"115029"}}