{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T22:56:50Z","timestamp":1787698610556,"version":"build-2784847793"},"reference-count":82,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003009","name":"Science and Technology Development Fund","doi-asserted-by":"publisher","award":["BARG 37106"],"award-info":[{"award-number":["BARG 37106"]}],"id":[{"id":"10.13039\/501100003009","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003009","name":"Science and Technology Development Fund","doi-asserted-by":"publisher","award":["37106"],"award-info":[{"award-number":["37106"]}],"id":[{"id":"10.13039\/501100003009","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Food and Chemical Toxicology"],"published-print":{"date-parts":[[2025,3]]},"DOI":"10.1016\/j.fct.2025.115265","type":"journal-article","created":{"date-parts":[[2025,1,18]],"date-time":"2025-01-18T11:28:14Z","timestamp":1737199694000},"page":"115265","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Ferulic acid protects rat offspring from maternal high-fat, high-fructose diet-induced toxicity and developmental retardation through a direct effect on pancreatic islets"],"prefix":"10.1016","volume":"197","author":[{"given":"Hekmat L.","family":"El-Gammal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatma","family":"Omar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3216-0431","authenticated-orcid":false,"given":"Ayman","family":"Hyder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.fct.2025.115265_bib1","article-title":"The anti-inflammatory effect of ferulic acid is via the modulation of NF\u03baB-TNF-\u03b1-IL-6 and STAT1-PIAS1 signaling pathways in 2-methoxyethanol-induced testicular inflammation in rats","volume":"3","author":"Adeyi","year":"2023","journal-title":"Phytomedicine"},{"issue":"4","key":"10.1016\/j.fct.2025.115265_bib2","doi-asserted-by":"crossref","first-page":"1548","DOI":"10.1096\/fj.15-280800","article-title":"Decreased ovarian reserve, dysregulation of mitochondrial biogenesis, and increased lipid peroxidation in female mouse offspring exposed to an obesogenic maternal diet","volume":"30","author":"Aiken","year":"2016","journal-title":"Faseb. J."},{"issue":"1","key":"10.1016\/j.fct.2025.115265_bib3","doi-asserted-by":"crossref","first-page":"105","DOI":"10.3390\/biom10010105","article-title":"Phytochemicals and gastrointestinal cancer: cellular mechanisms and effects to change cancer progression","volume":"10","author":"Al-Ishaq","year":"2020","journal-title":"Biomolecules"},{"key":"10.1016\/j.fct.2025.115265_bib4","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2021.701767","article-title":"Congenital anomalies programmed by maternal diabetes and obesity on offspring of rats","volume":"12","author":"Araujo-Silva","year":"2021","journal-title":"Front. Physiol."},{"key":"10.1016\/j.fct.2025.115265_bib5","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.jjcc.2020.02.003","article-title":"Developmental origins of health and disease theory in cardiology","volume":"76","author":"Arima","year":"2020","journal-title":"J. Cardiol."},{"key":"10.1016\/j.fct.2025.115265_bib6","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1186\/1758-5996-6-130","article-title":"Metabolic and oxidative stress markers in Wistar rats after 2 months on a high-fat diet","volume":"6","author":"Auberval","year":"2014","journal-title":"Diabetol. Metab. Syndrome"},{"issue":"4","key":"10.1016\/j.fct.2025.115265_bib7","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1002\/ptr.1440","article-title":"Ferulic acid alleviates lipid peroxidation in diabetic rats","volume":"18","author":"Balasubashini","year":"2004","journal-title":"Phytother Res."},{"issue":"2","key":"10.1016\/j.fct.2025.115265_bib8","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1136\/jech.58.2.114","article-title":"Developmental origins of adult health and disease","volume":"58","author":"Barker","year":"2004","journal-title":"J. Epidemiol. Community Health"},{"issue":"2","key":"10.1016\/j.fct.2025.115265_bib9","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1172\/JCI200422422","article-title":"Molecular mediators of hepatic steatosis and liver injury","volume":"114","author":"Browning","year":"2004","journal-title":"J. Clin. Invest."},{"issue":"6","key":"10.1016\/j.fct.2025.115265_bib10","doi-asserted-by":"crossref","first-page":"713","DOI":"10.3390\/nu10060713","article-title":"Ferulic acid supplementation improves lipid profiles, oxidative stress, and inflammatory status in hyperlipidemic subjects: a randomized, double-blind, placebo-controlled clinical trial","volume":"10","author":"Bumrungpert","year":"2018","journal-title":"Nutrients"},{"issue":"6","key":"10.1016\/j.fct.2025.115265_bib11","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.2337\/dc08-2077","article-title":"Fetuses of obese mothers develop insulin resistance in utero","volume":"32","author":"Catalano","year":"2009","journal-title":"Diabetes Care"},{"issue":"1","key":"10.1016\/j.fct.2025.115265_bib12","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1007\/s11011-014-9635-z","article-title":"Antidepressant-like effects of ferulic acid: involvement of serotonergic and norepinergic systems","volume":"30","author":"Chen","year":"2015","journal-title":"Metab. Brain Dis."},{"issue":"6","key":"10.1016\/j.fct.2025.115265_bib13","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1080\/10641963.2018.1516773","article-title":"Ferulic acid ameliorated placental inflammation and apoptosis in rat with preeclampsia","volume":"41","author":"Chen","year":"2019","journal-title":"Clin. Exp. Hypertens."},{"issue":"6","key":"10.1016\/j.fct.2025.115265_bib14","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1016\/j.jare.2017.10.002","article-title":"Increased susceptibility of post-weaning rats on high-fat diet to metabolic syndrome","volume":"8","author":"Cheng","year":"2017","journal-title":"J. Adv. Res."},{"key":"10.1016\/j.fct.2025.115265_bib15","doi-asserted-by":"crossref","first-page":"27","DOI":"10.3389\/fphar.2019.00027","article-title":"Ferulic acid protects hyperglycemia-induced kidney damage by regulating oxidative insult, inflammation and autophagy","volume":"10","author":"Chowdhury","year":"2019","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.fct.2025.115265_bib16","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/7019573","article-title":"Treatment of NASH with antioxidant therapy: beneficial effect of red cabbage on type 2 diabetic rats","volume":"2018","author":"Dal","year":"2018","journal-title":"Oxid. Med. Cell. Longev."},{"issue":"9","key":"10.1016\/j.fct.2025.115265_bib17","doi-asserted-by":"crossref","first-page":"2397","DOI":"10.1111\/cns.14265","article-title":"Ferulic acid as a therapeutic agent in depression: evidence from preclinical studies","volume":"29","author":"Dong","year":"2023","journal-title":"CNS Neurosci. Ther."},{"issue":"11","key":"10.1016\/j.fct.2025.115265_bib18","doi-asserted-by":"crossref","first-page":"1368","DOI":"10.1038\/sj.ijo.0803017","article-title":"Different forms of obesity as a function of diet composition","volume":"29","author":"Dourmashkin","year":"2005","journal-title":"Int. J. Obes."},{"issue":"1","key":"10.1016\/j.fct.2025.115265_bib19","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.repbio.2020.01.004","article-title":"Chitosan coating does not prevent the effect of the transfer of green silver nanoparticles biosynthesized by Streptomyces malachitus into fetuses via the placenta","volume":"20","author":"Elsharawy","year":"2020","journal-title":"Reprod. Biol."},{"key":"10.1016\/j.fct.2025.115265_bib20","doi-asserted-by":"crossref","first-page":"H164","DOI":"10.1152\/ajpheart.01289.2010","article-title":"Effect of age on high-fat diet-induced hypertension","volume":"301","author":"Erdos","year":"2011","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"issue":"1","key":"10.1016\/j.fct.2025.115265_bib21","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/S2213-8587(16)30107-3","article-title":"Influence of maternal obesity on the long-term health of offspring","volume":"5","author":"Godfrey","year":"2017","journal-title":"Lancet Diabetes Endocrinol."},{"issue":"4","key":"10.1016\/j.fct.2025.115265_bib22","doi-asserted-by":"crossref","DOI":"10.1097\/HC9.0000000000000048","article-title":"Overexpression of NgBR inhibits high-fat diet-induced atherosclerosis in ApoE-deficiency mice","volume":"7","author":"Gong","year":"2023","journal-title":"Hepatol Commun"},{"issue":"4","key":"10.1016\/j.fct.2025.115265_bib23","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1152\/physrev.00029.2013","article-title":"Early developmental conditioning of later health and disease: physiology or pathophysiology?","volume":"94","author":"Hanson","year":"2014","journal-title":"Physiol. Rev."},{"issue":"1","key":"10.1016\/j.fct.2025.115265_bib24","doi-asserted-by":"crossref","DOI":"10.1111\/and.12798","article-title":"Ferulic acid prevents lead-induced testicular oxidative stress and suppressed spermatogenesis in rats","volume":"50","author":"Hasanein","year":"2018","journal-title":"Andrologia"},{"issue":"1","key":"10.1016\/j.fct.2025.115265_bib25","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1530\/REP-10-0325","article-title":"Suboptimal maternal nutrition, during early fetal liver development, promotes lipid accumulation in the liver of obese offspring","volume":"141","author":"Hyatt","year":"2011","journal-title":"Reproduction"},{"key":"10.1016\/j.fct.2025.115265_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2023.110368","article-title":"Naturally occurring carboxylic acids from traditional antidiabetic plants as potential pancreatic islet FABP3 inhibitors. A molecular docking-aided study","volume":"372","author":"Hyder","year":"2023","journal-title":"Chem. Biol. Interact."},{"issue":"2","key":"10.1016\/j.fct.2025.115265_bib27","first-page":"578","article-title":"Variable responses of islet cells of different ages and species to hypoxia, Transplant","volume":"30","author":"Hyder","year":"1998","journal-title":"SAVE Proc."},{"issue":"4","key":"10.1016\/j.fct.2025.115265_bib28","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1007\/s592-001-8075-9","article-title":"Effect of extracellular pH on insulin secretion and glucose metabolism in neonatal and adult rat pancreatic islets","volume":"38","author":"Hyder","year":"2001","journal-title":"Acta Diabetol."},{"issue":"3","key":"10.1016\/j.fct.2025.115265_bib29","doi-asserted-by":"crossref","first-page":"174","DOI":"10.4161\/isl.2.3.11454","article-title":"Expression of fatty acid binding proteins 3 and 5 genes in rat pancreatic islets and INS-1E cells. Regulation by fatty acids and glucose","volume":"2","author":"Hyder","year":"2010","journal-title":"Islets"},{"key":"10.1016\/j.fct.2025.115265_bib30","doi-asserted-by":"crossref","DOI":"10.1007\/s00592-024-02325-x","article-title":"Silencing the FABP3 gene in insulin-secreting cells reduces fatty acid uptake and protects against lipotoxicity","author":"Hyder","year":"2024","journal-title":"Acta Diabetol."},{"issue":"6","key":"10.1016\/j.fct.2025.115265_bib31","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1016\/j.ando.2015.10.005","article-title":"Evidence of male hypogonadism at an early age as a familial risk of type 2 diabetes","volume":"76","author":"Janjua","year":"2015","journal-title":"Ann. Endocrinol."},{"issue":"2\u20134","key":"10.1016\/j.fct.2025.115265_bib32","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1515\/JBCPP.1998.9.2-4.325","article-title":"Genetic models for non insulin dependent diabetes mellitus in rodents","volume":"9","author":"Kim","year":"1998","journal-title":"J. Basic Clin. Physiol. Pharmacol."},{"key":"10.1016\/j.fct.2025.115265_bib33","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0085049","article-title":"Effects of a post-weaning cafeteria diet in young rats: metabolic syndrome, reduced activity and low anxiety-like behaviour","volume":"9","author":"Lalanza","year":"2014","journal-title":"PLoS One"},{"issue":"4","key":"10.1016\/j.fct.2025.115265_bib34","doi-asserted-by":"crossref","first-page":"366","DOI":"10.4239\/wjd.v12.i4.366","article-title":"Maternal obesity as a risk factor for developing diabetes in offspring: an epigenetic point of view","volume":"12","author":"Lecoutre","year":"2021","journal-title":"World J. Diabetes"},{"issue":"2","key":"10.1016\/j.fct.2025.115265_bib35","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1007\/s00125-007-0886-7","article-title":"The mechanisms of alloxan- and streptozotocin-induced diabetes","volume":"51","author":"Lenzen","year":"2008","journal-title":"Diabetologia"},{"key":"10.1016\/j.fct.2025.115265_bib36","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.lfs.2019.04.046","article-title":"Multi-system reproductive metabolic disorder: significance for the pathogenesis and therapy of polycystic ovary syndrome (PCOS)","volume":"228","author":"Li","year":"2019","journal-title":"Life Sci."},{"issue":"18","key":"10.1016\/j.fct.2025.115265_bib37","doi-asserted-by":"crossref","first-page":"6010","DOI":"10.3390\/molecules27186010","article-title":"Use of ferulic acid in the management of diabetes mellitus and its complications","volume":"27","author":"Li","year":"2022","journal-title":"Molecules"},{"issue":"3","key":"10.1016\/j.fct.2025.115265_bib38","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1038\/sj.ijo.0801924","article-title":"Early events involved in the development of insulin resistance in Zucker fatty rat","volume":"26","author":"Liu","year":"2002","journal-title":"Int. J. Obes. Relat. Metab. Disord."},{"issue":"12","key":"10.1016\/j.fct.2025.115265_bib39","doi-asserted-by":"crossref","first-page":"2698","DOI":"10.3390\/nu15122698","article-title":"Maternal high-fat diet controls offspring kidney health and disease","volume":"15","author":"Liu","year":"2023","journal-title":"Nutrients"},{"key":"10.1016\/j.fct.2025.115265_bib40","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/s12986-016-0074-1","article-title":"High-fructose and high-fat diet-induced disorders in rats: impact on diabetes risk, hepatic and vascular complications","volume":"13","author":"Lozano","year":"2016","journal-title":"Nutr. Metab."},{"issue":"12","key":"10.1016\/j.fct.2025.115265_bib41","doi-asserted-by":"crossref","first-page":"2530","DOI":"10.3390\/nu14122530","article-title":"Ferulic acid prevents nonalcoholic fatty liver disease by promoting fatty acid oxidation and energy expenditure in C57BL\/6 Mice fed a high-fat diet","volume":"14","author":"Luo","year":"2022","journal-title":"Nutrients"},{"issue":"2","key":"10.1016\/j.fct.2025.115265_bib42","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1017\/S2040174419000503","article-title":"Multigenerational effects of chronic maternal exposure to a high sugar\/fat diet and physical training","volume":"11","author":"Martins Terra","year":"2020","journal-title":"J Dev Orig Health Dis"},{"key":"10.1016\/j.fct.2025.115265_bib43","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1007\/s001250051130","article-title":"Fatty acids, lipotoxicity and insulin secretion","volume":"42","author":"McGarry","year":"1999","journal-title":"Diabetologia"},{"issue":"8","key":"10.1016\/j.fct.2025.115265_bib44","doi-asserted-by":"crossref","first-page":"834","DOI":"10.3390\/cells8080834","article-title":"Mitochondrial involvement in the adaptive response to chronic exposure to environmental pollutants and high-fat feeding in a rat liver and testis","volume":"8","author":"Migliaccio","year":"2019","journal-title":"Cells"},{"issue":"8","key":"10.1016\/j.fct.2025.115265_bib45","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1139\/apnm-2015-0002","article-title":"Ferulic acid exerts its antidiabetic effect by modulating insulin-signalling molecules in the liver of high-fat diet and fructose-induced type-2 diabetic adult male rat","volume":"40","author":"Narasimhan","year":"2015","journal-title":"Appl. Physiol. Nutr. Metabol."},{"issue":"1","key":"10.1016\/j.fct.2025.115265_bib46","doi-asserted-by":"crossref","first-page":"324","DOI":"10.3390\/ijms23010324","article-title":"Lipid-induced adaptations of the pancreatic beta-cell to glucotoxic conditions sustain insulin secretion","volume":"23","author":"Oberhauser","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.fct.2025.115265_bib47","series-title":"Knobil and Neill's Physiology of Reproduction","first-page":"2061","article-title":"Puberty in the rat","author":"Ojeda","year":"2006"},{"issue":"1","key":"10.1016\/j.fct.2025.115265_bib48","doi-asserted-by":"crossref","DOI":"10.1080\/19490976.2022.2152307","article-title":"Prebiotic oligofructose protects against high-fat diet-induced obesity by changing the gut microbiota, intestinal mucus production, glycosylation and secretion","volume":"14","author":"Paone","year":"2022","journal-title":"Gut Microb."},{"key":"10.1016\/j.fct.2025.115265_bib49","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/j.bbadis.2013.07.007","article-title":"Maternal nutrition and risk of obesity in offspring: the Trojan horse of developmental plasticity","volume":"1842","author":"Parlee","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.fct.2025.115265_bib50","doi-asserted-by":"crossref","DOI":"10.1155\/2011\/105076","article-title":"Early-life origins of type 2 diabetes: fetal programming of the beta-cell mass","volume":"2011","author":"Portha","year":"2011","journal-title":"Exp. Diabetes Res."},{"key":"10.1016\/j.fct.2025.115265_bib51","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1016\/j.phymed.2012.12.004","article-title":"Synergistic interaction of ferulic acid with commercial hypoglycemic drugs in streptozotocin induced diabetic rats","volume":"20","author":"Prabhakar","year":"2013","journal-title":"Phytomedicine"},{"key":"10.1016\/j.fct.2025.115265_bib52","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1007\/s12020-012-9868-8","article-title":"Treatment with ferulic acid to rats with streptozotocin-induced diabetes: effects on oxidative stress, pro-inflammatory cytokines, and apoptosis in the pancreatic \u03b2 cell","volume":"44","author":"Roy","year":"2013","journal-title":"Endocrine"},{"issue":"1","key":"10.1016\/j.fct.2025.115265_bib53","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.celrep.2016.05.065","article-title":"Maternal metabolic syndrome programs mitochondrial dysfunction via germline changes across three generations","volume":"16","author":"Saben","year":"2016","journal-title":"Cell Rep."},{"issue":"2","key":"10.1016\/j.fct.2025.115265_bib54","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1111\/fcp.12860","article-title":"Ferulic acid improves glucose homeostasis by modulation of key diabetogenic activities and restoration of pancreatic architecture in diabetic rats","volume":"37","author":"Salau","year":"2023","journal-title":"Fundam. Clin. Pharmacol."},{"issue":"7\u20138","key":"10.1016\/j.fct.2025.115265_bib56","first-page":"3511","article-title":"Oxygen profile of microencapsulated islets: effect of immobilised hemoglobin in the alginate matrix, Transplant","volume":"33","author":"Schrezenmeir","year":"2001","journal-title":"SAVE Proc."},{"key":"10.1016\/j.fct.2025.115265_bib57","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2022.867127","article-title":"Parental high-fat high-sugar diet intake programming inflammatory and oxidative parameters of reproductive health in male offspring","volume":"10","author":"Sertorio","year":"2022","journal-title":"Front. Cell Dev. Biol."},{"issue":"14","key":"10.1016\/j.fct.2025.115265_bib58","doi-asserted-by":"crossref","first-page":"2074","DOI":"10.1080\/10408398.2021.1970509","article-title":"Could parental high-fat intake program the reproductive health of male offspring? A review","volume":"63","author":"Sertorio","year":"2023","journal-title":"Crit. Rev. Food Sci. Nutr."},{"issue":"1","key":"10.1016\/j.fct.2025.115265_bib59","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1038\/s41420-020-00386-9","article-title":"NF-\u03baB activity during pancreas development regulates adult \u03b2-cell mass by modulating neonatal \u03b2-cell proliferation and apoptosis","volume":"7","author":"Sever","year":"2021","journal-title":"Cell Death Dis."},{"issue":"4","key":"10.1016\/j.fct.2025.115265_bib60","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1038\/ijo.2014.190","article-title":"Multigenerational impact of maternal overnutrition\/obesity in the sheep on the neonatal leptin surge in granddaughters","volume":"39","author":"Shasa","year":"2015","journal-title":"Int. J. Obes."},{"key":"10.1016\/j.fct.2025.115265_bib61","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1146\/annurev-cellbio-101512-122405","article-title":"Pancreas organogenesis: from lineage determination to morphogenesis","volume":"29","author":"Shih","year":"2013","journal-title":"Annu. Rev. Cell Dev. Biol."},{"issue":"21","key":"10.1016\/j.fct.2025.115265_bib62","doi-asserted-by":"crossref","first-page":"7653","DOI":"10.3390\/molecules27217653","article-title":"Ferulic acid: a natural phenol that inhibits neoplastic events through modulation of oncogenic signaling","volume":"27","author":"Singh","year":"2022","journal-title":"Molecules"},{"key":"10.1016\/j.fct.2025.115265_bib63","doi-asserted-by":"crossref","first-page":"H7","DOI":"10.1111\/j.1750-3841.2010.01907.x","article-title":"Effect of oryzanol and ferulic acid on the glucose metabolism of mice fed with a high-fat diet","volume":"76","author":"Son","year":"2011","journal-title":"J. Food Sci."},{"issue":"2","key":"10.1016\/j.fct.2025.115265_bib64","doi-asserted-by":"crossref","first-page":"92","DOI":"10.3164\/jcbn.40.92","article-title":"Ferulic acid: therapeutic potential through its antioxidant property","volume":"40","author":"Srinivasan","year":"2007","journal-title":"J. Clin. Biochem. Nutr."},{"key":"10.1016\/j.fct.2025.115265_bib65","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.devcel.2015.01.002","article-title":"Weaning triggers a maturation step of pancreatic \u03b2 cells","volume":"32","author":"Stolovich-Rain","year":"2015","journal-title":"Dev. Cell"},{"issue":"15","key":"10.1016\/j.fct.2025.115265_bib66","doi-asserted-by":"crossref","first-page":"8179","DOI":"10.3390\/ijms23158179","article-title":"Maternal high-fat diet and offspring hypertension","volume":"23","author":"Tain","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"6","key":"10.1016\/j.fct.2025.115265_bib67","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1016\/j.cell.2012.07.029","article-title":"Pancreatic \u03b2 cell dedifferentiation as a mechanism of diabetic \u03b2 cell failure","volume":"150","author":"Talchai","year":"2012","journal-title":"Cell"},{"issue":"6","key":"10.1016\/j.fct.2025.115265_bib68","doi-asserted-by":"crossref","first-page":"H1713","DOI":"10.1152\/ajpheart.00389.2018","article-title":"High-fat diet-induced hypertension is associated with a proinflammatory T cell profile in male and female Dahl salt-sensitive rats","volume":"315","author":"Taylor","year":"2018","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"issue":"4","key":"10.1016\/j.fct.2025.115265_bib69","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1095\/biolreprod.115.135004","article-title":"Maternal high-fat diet-induced loss of fetal oocytes is associated with compromised follicle growth in adult rat offspring","volume":"94","author":"Tsoulis","year":"2016","journal-title":"Biol. Reprod."},{"issue":"11","key":"10.1016\/j.fct.2025.115265_bib70","doi-asserted-by":"crossref","first-page":"1769","DOI":"10.1089\/scd.2009.0351","article-title":"The generation of programmable cells of monocytic origin (PCMOs) involves partial repression of monocyte\/macrophage markers and reactivation of pluripotency genes","volume":"19","author":"Ungefroren","year":"2010","journal-title":"Stem Cell. Dev."},{"key":"10.1016\/j.fct.2025.115265_bib71","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/7132751","article-title":"Peripheral blood monocytes as adult stem cells: molecular characterization and improvements in culture conditions to enhance stem cell features and proliferative potential","author":"Ungefroren","year":"2016","journal-title":"Stem Cell. Int."},{"key":"10.1016\/j.fct.2025.115265_bib72","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2022.909762","article-title":"The impact of maternal high-fat diet on offspring neurodevelopment","volume":"16","author":"Urbonaite","year":"2022","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.fct.2025.115265_bib73","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1038\/s41419-022-05125-9","article-title":"Developmental modeling of hepatogenesis using obese iPSCs-hepatocyte differentiation uncovers pathological features","volume":"13","author":"Varghese","year":"2022","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.fct.2025.115265_bib74","doi-asserted-by":"crossref","first-page":"5997","DOI":"10.1038\/s41598-019-42528-9","article-title":"Early impairments in the retina of rats fed with high fructose\/high fat diet are associated with glucose metabolism deregulation but not dyslipidaemia","volume":"9","author":"Vidal","year":"2019","journal-title":"Sci. Rep."},{"issue":"12","key":"10.1016\/j.fct.2025.115265_bib75","doi-asserted-by":"crossref","first-page":"3811","DOI":"10.3390\/nu12123811","article-title":"Dietary ferulic acid supplementation improves antioxidant capacity and lipid metabolism in weaned piglets","volume":"12","author":"Wang","year":"2020","journal-title":"Nutrients"},{"issue":"19","key":"10.1016\/j.fct.2025.115265_bib76","doi-asserted-by":"crossref","DOI":"10.3390\/ijms241914804","article-title":"Ferulic acid enhances oocyte maturation and the subsequent development of bovine oocytes","volume":"24","author":"Wang","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.fct.2025.115265_bib77","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.mce.2016.07.001","article-title":"Persistent influence of maternal obesity on offspring health: mechanisms from animal models and clinical studies","volume":"435","author":"Wankhade","year":"2016","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.fct.2025.115265_bib78","doi-asserted-by":"crossref","DOI":"10.1016\/j.anireprosci.2023.107294","article-title":"The effect of maternal consumption of high-fat diet on ovarian development in offspring","volume":"255","author":"Wei","year":"2023","journal-title":"Anim. Reprod. Sci."},{"key":"10.1016\/j.fct.2025.115265_bib79","doi-asserted-by":"crossref","first-page":"2519","DOI":"10.2337\/diacare.28.10.2519","article-title":"Decreased \u03b2-cell function in overweight Latino children with impaired fasting glucose","volume":"28","author":"Weigensberg","year":"2005","journal-title":"Diabetes Care"},{"issue":"6","key":"10.1016\/j.fct.2025.115265_bib80","doi-asserted-by":"crossref","first-page":"135","DOI":"10.3892\/etm.2020.9264","article-title":"The effect of maternal high-fat-diet mediated oxidative stress on ovarian function in mice offspring","volume":"20","author":"Yan","year":"2020","journal-title":"Exp. Ther. Med."},{"key":"10.1016\/j.fct.2025.115265_bib81","doi-asserted-by":"crossref","DOI":"10.1016\/j.jcoa.2023.100092","article-title":"The pharmacokinetic study of Saussurea involucrata liquid tonic, a traditional Chinese patent for inflammatory pain, in female rats in breastfeeding period","volume":"4","author":"Yu","year":"2023","journal-title":"Journal of Chromatography Open"},{"issue":"11","key":"10.1016\/j.fct.2025.115265_bib82","doi-asserted-by":"crossref","first-page":"2181","DOI":"10.3390\/nu14112181","article-title":"Long-term high-fat high-fructose diet induces type 2 diabetes in rats through oxidative stress","volume":"14","author":"Zhao","year":"2022","journal-title":"Nutrients"},{"issue":"3","key":"10.1016\/j.fct.2025.115265_bib83","doi-asserted-by":"crossref","first-page":"493","DOI":"10.3390\/ijms20030493","article-title":"Ferulic acid improves depressive-like behavior in prenatally-stressed offspring rats via anti-inflammatory activity and HPA Axis","volume":"20","author":"Zheng","year":"2019","journal-title":"Int. J. Mol. Sci."}],"container-title":["Food and Chemical Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278691525000328?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278691525000328?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T14:25:01Z","timestamp":1778682301000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0278691525000328"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":82,"alternative-id":["S0278691525000328"],"URL":"https:\/\/doi.org\/10.1016\/j.fct.2025.115265","relation":{},"ISSN":["0278-6915"],"issn-type":[{"value":"0278-6915","type":"print"}],"subject":[],"published":{"date-parts":[[2025,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Ferulic acid protects rat offspring from maternal high-fat, high-fructose diet-induced toxicity and developmental retardation through a direct effect on pancreatic islets","name":"articletitle","label":"Article Title"},{"value":"Food and Chemical Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fct.2025.115265","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"115265"}}