{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T19:36:32Z","timestamp":1788550592987,"version":"build-2803163510"},"reference-count":63,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100006261","name":"Taif University","doi-asserted-by":"publisher","award":["TU-DSPP-2024-107"],"award-info":[{"award-number":["TU-DSPP-2024-107"]}],"id":[{"id":"10.13039\/501100006261","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Food and Chemical Toxicology"],"published-print":{"date-parts":[[2025,3]]},"DOI":"10.1016\/j.fct.2025.115298","type":"journal-article","created":{"date-parts":[[2025,1,30]],"date-time":"2025-01-30T08:51:04Z","timestamp":1738227064000},"page":"115298","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Nephroprotective potential of robinin to counteract aldicarb induced renal dysfunction via modulating TLR4\/MyD88, HMGB1\/RAGE, NF-\u03baB pathway: A biochemical and pharmacodynamic approach"],"prefix":"10.1016","volume":"197","author":[{"given":"Ning","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6930-5214","authenticated-orcid":false,"given":"Fuad M.","family":"Alzahrani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahmoud","family":"El Safadi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunbal","family":"Attaullah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6688-0106","authenticated-orcid":false,"given":"Khalid J.","family":"Alzahrani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faez Falah","family":"Alshehri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arifa","family":"Mehreen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tawaf Ali","family":"Shah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.fct.2025.115298_bib1","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1007\/s12026-020-09126-8","article-title":"Impact of interleukin IL-6 rs-1474347 and IL-10 rs-1800896 genetic polymorphisms on the susceptibility of HCV-infected Egyptian patients to hepatocellular carcinoma","volume":"68","author":"Abd El-Baky","year":"2020","journal-title":"Immunol. Res."},{"issue":"4","key":"10.1016\/j.fct.2025.115298_bib2","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1007\/s11418-021-01526-w","article-title":"Inhibition of cell-intrinsic NF-\u03baB activity and metastatic abilities of breast cancer by aloe-emodin and emodic-acid isolated from Asphodelus microcarpus","volume":"75","author":"Abdellatef","year":"2021","journal-title":"J. Nat. Med."},{"key":"10.1016\/j.fct.2025.115298_bib3","first-page":"1","article-title":"The cardioprotective effect of robinin ameliorates endoplasmic reticulum stress and apoptosis in H9c2 cells","author":"Abhirami","year":"2024","journal-title":"Cell Biochem. Biophys."},{"issue":"3","key":"10.1016\/j.fct.2025.115298_bib4","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1111\/j.1476-4431.2011.00613.x","article-title":"Acute aldicarb toxicity in dogs: 15 cases (2001\u20132009)","volume":"21","author":"Anastasio","year":"2011","journal-title":"J. Vet. Emerg. Crit. Care"},{"issue":"1","key":"10.1016\/j.fct.2025.115298_bib5","article-title":"Lipid peroxidation: production, metabolism, and signaling mechanisms of malondialdehyde and 4\u2010hydroxy\u20102\u2010nonenal","volume":"2014","author":"Ayala","year":"2014","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.fct.2025.115298_bib6","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1007\/s00705-016-3187-y","article-title":"Implications of oxidative stress on viral pathogenesis","volume":"162","author":"Camini","year":"2017","journal-title":"Arch. Virol."},{"issue":"1\u20133","key":"10.1016\/j.fct.2025.115298_bib7","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.forsciint.2010.04.002","article-title":"Postmortem data related to drug and toxic substance use in the Federal District, Brazil, from 2006 to 2008","volume":"200","author":"Campelo","year":"2010","journal-title":"Forensic Sci. Int."},{"key":"10.1016\/j.fct.2025.115298_bib8","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1016\/S0076-6879(85)13062-4","article-title":"[59] Glutathione reductase","volume":"113","author":"Carlberg","year":"1985","journal-title":"Methods Enzymol."},{"issue":"3","key":"10.1016\/j.fct.2025.115298_bib9","doi-asserted-by":"crossref","first-page":"301","DOI":"10.3350\/kjhep.2010.16.3.301","article-title":"Diagnostic value of cystatin C for predicting acute kidney injury in patients with liver cirrhosis","volume":"16","author":"Chung","year":"2010","journal-title":"Korean J. Hepatol."},{"key":"10.1016\/j.fct.2025.115298_bib10","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.rvsc.2015.08.006","article-title":"Poisoning of cats and dogs by the carbamate pesticides aldicarb and carbofuran","volume":"102","author":"de Siqueira","year":"2015","journal-title":"Res. Vet. Sci."},{"issue":"4","key":"10.1016\/j.fct.2025.115298_bib11","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1007\/s00414-016-1336-1","article-title":"Death by chumbinho: aldicarb intoxication\u2014regarding a corpse in decomposition","volume":"130","author":"Dur\u00e3o","year":"2016","journal-title":"Int. J. Leg. Med."},{"issue":"1","key":"10.1016\/j.fct.2025.115298_bib12","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1021\/acs.chemrestox.8b00179","article-title":"The carbamate aldicarb altered the gut microbiome, metabolome, and lipidome of C57BL\/6J mice","volume":"32","author":"Gao","year":"2018","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.fct.2025.115298_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2022.108711","article-title":"ManNAc protects against podocyte pyroptosis via inhibiting mitochondrial damage and ROS\/NLRP3 signaling pathway in diabetic kidney injury model","volume":"107","author":"Gao","year":"2022","journal-title":"Int. Immunopharm."},{"issue":"50","key":"10.1016\/j.fct.2025.115298_bib14","doi-asserted-by":"crossref","first-page":"51715","DOI":"10.1074\/jbc.R400024200","article-title":"The Nox family of NAD (P) H oxidases: host defense and beyond","volume":"279","author":"Geiszt","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.fct.2025.115298_bib15","doi-asserted-by":"crossref","first-page":"181","DOI":"10.2174\/157436210791112172","article-title":"Oxidative stress-induced caspases are regulated in human myeloid HL-60 cells by calcium signal","volume":"5","author":"Gonzalez","year":"2010","journal-title":"Curr. Signal Transduct. Ther."},{"key":"10.1016\/j.fct.2025.115298_bib16","series-title":"Reproductive and Developmental Toxicology","first-page":"471","article-title":"Organophosphate and carbamate pesticides","author":"Gupta","year":"2011"},{"key":"10.1016\/j.fct.2025.115298_bib17","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.ab.2017.11.013","article-title":"New spectrophotometric assay for assessments of catalase activity in biological samples","volume":"542","author":"Hadwan","year":"2018","journal-title":"Anal. Biochem."},{"issue":"1","key":"10.1016\/j.fct.2025.115298_bib18","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.mrgentox.2007.04.006","article-title":"High-throughput spectrophotometric assay of reactive oxygen species in serum","volume":"631","author":"Hayashi","year":"2007","journal-title":"Mutation research\/genetic toxicology and environmental mutagenesis"},{"issue":"4","key":"10.1016\/j.fct.2025.115298_bib19","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1001\/archinternmed.2008.605","article-title":"Risk factors for end-stage renal disease: 25-year follow-up","volume":"169","author":"Hsu","year":"2009","journal-title":"Arch. Intern. Med."},{"issue":"3","key":"10.1016\/j.fct.2025.115298_bib20","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1159\/000136485","article-title":"Bromobenzene-induced liver necrosis. Protective role of glutathione and evidence for 3, 4-bromobenzene oxide as the hepatotoxic metabolite","volume":"11","author":"Jollow","year":"1974","journal-title":"Pharmacology"},{"issue":"5","key":"10.1016\/j.fct.2025.115298_bib21","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1038\/s41419-020-2536-7","article-title":"The HMGB1-RAGE axis modulates the growth of autophagy-deficient hepatic tumors","volume":"11","author":"Khambu","year":"2020","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.fct.2025.115298_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2022.106507","article-title":"Toll-like receptors and metabolic (dysfunction)-associated fatty liver disease","volume":"185","author":"Khanmohammadi","year":"2022","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.fct.2025.115298_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.jflm.2022.102450","article-title":"Forensic toxicological and analytical aspects of carbamate poisoning\u2013A review","volume":"92","author":"Kumar","year":"2022","journal-title":"Journal of forensic and legal medicine"},{"key":"10.1016\/j.fct.2025.115298_bib24","article-title":"Robinin isolated from solanum asperum exhibits pharmacological actions in the central nervous system of adult zebrafish (Danio rerio)","author":"Lemos","year":"2024","journal-title":"Chem. Biodivers."},{"issue":"3","key":"10.1016\/j.fct.2025.115298_bib25","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1093\/toxres\/tfac031","article-title":"Aldicarb-related suicide attempt cases in North of France (2012\u20132021)","volume":"11","author":"Lenski","year":"2022","journal-title":"Toxicology Research"},{"key":"10.1016\/j.fct.2025.115298_bib26","first-page":"1","article-title":"Robinin protects chondrocytes injury via TLR2\/TLR4\/NF-\u03baB signaling in osteoarthritis","author":"Li","year":"2024","journal-title":"Cell Biochem. Biophys."},{"issue":"20","key":"10.1016\/j.fct.2025.115298_bib64","doi-asserted-by":"crossref","first-page":"7103","DOI":"10.3390\/molecules27207103","article-title":"In silico methods for identification of potential active sites of therapeutic targets","volume":"27","author":"Liao","year":"2022","journal-title":"Molecules"},{"issue":"4","key":"10.1016\/j.fct.2025.115298_bib27","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.7150\/ijbs.80775","article-title":"Mitophagy alleviates cisplatin-induced renal tubular epithelial cell ferroptosis through ROS\/HO-1\/GPX4 axis","volume":"19","author":"Lin","year":"2023","journal-title":"Int. J. Biol. Sci."},{"issue":"4","key":"10.1016\/j.fct.2025.115298_bib28","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1159\/000309421","article-title":"Serum and urinary biomarkers of acute kidney injury","volume":"29","author":"Lisowska-Myjak","year":"2010","journal-title":"Blood Purif."},{"key":"10.1016\/j.fct.2025.115298_bib29","author":"Liu"},{"issue":"4","key":"10.1016\/j.fct.2025.115298_bib30","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2\u2212 \u0394\u0394CT method","volume":"25","author":"Livak","year":"2001","journal-title":"methods"},{"issue":"9","key":"10.1016\/j.fct.2025.115298_bib31","doi-asserted-by":"crossref","first-page":"1997","DOI":"10.1681\/ASN.V1091997","article-title":"In vitro and in vivo immunomodulatory effects of RDP1258, a novel synthetic peptide","volume":"10","author":"Magee","year":"1999","journal-title":"J. Am. Soc. Nephrol."},{"issue":"4","key":"10.1016\/j.fct.2025.115298_bib32","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1002\/hep.29290","article-title":"Plasma cystatin C is a predictor of renal dysfunction, acute\u2010on\u2010chronic liver failure, and mortality in patients with acutely decompensated liver cirrhosis","volume":"66","author":"Markwardt","year":"2017","journal-title":"Hepatology"},{"issue":"1","key":"10.1016\/j.fct.2025.115298_bib33","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/0304-4165(79)90289-7","article-title":"Levels of glutathione, glutathione reductase and glutathione S-transferase activities in rat lung and liver","volume":"582","author":"Moron","year":"1979","journal-title":"Biochimica et biophysica acta (BBA)-general subjects"},{"issue":"16","key":"10.1016\/j.fct.2025.115298_bib34","doi-asserted-by":"crossref","first-page":"2785","DOI":"10.1002\/jcc.21256","article-title":"AutoDock4 and AutoDockTools4: automated docking with selective receptor flexibility","volume":"30","author":"Morris","year":"2009","journal-title":"J. Comput. Chem."},{"key":"10.1016\/j.fct.2025.115298_bib35","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1007\/BF02712155","article-title":"Assay of superoxide dismutase activity in animal tissues","volume":"13","author":"Nandi","year":"1988","journal-title":"J. Biosci."},{"issue":"1","key":"10.1016\/j.fct.2025.115298_bib36","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-020-70253-1","article-title":"Integrated structural and functional analysis of the protective effects of kinetin against oxidative stress in mammalian cellular systems","volume":"10","author":"Naseem","year":"2020","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.fct.2025.115298_bib37","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1038\/ki.1995.40","article-title":"Serum cystatin C measured by automated immunoassay: a more sensitive marker of changes in GFR than serum creatinine","volume":"47","author":"Newman","year":"1995","journal-title":"Kidney Int."},{"issue":"3","key":"10.1016\/j.fct.2025.115298_bib38","doi-asserted-by":"crossref","first-page":"157","DOI":"10.2478\/v10136-009-0035-3","article-title":"Incidental poisoning of animals by carbamates in the Czech Republic","volume":"9","author":"Novotn\u00fd","year":"2011","journal-title":"J. Appl. Biomed."},{"key":"10.1016\/j.fct.2025.115298_bib39","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/bs.acc.2014.11.007","article-title":"Cystatin C: a kidney function biomarker","volume":"68","author":"Onopiuk","year":"2015","journal-title":"Adv. Clin. Chem."},{"issue":"4","key":"10.1016\/j.fct.2025.115298_bib40","doi-asserted-by":"crossref","DOI":"10.1063\/5.0014475","article-title":"Scalable molecular dynamics on CPU and GPU architectures with NAMD","volume":"153","author":"Phillips","year":"2020","journal-title":"J. Chem. Phys."},{"issue":"1","key":"10.1016\/j.fct.2025.115298_bib41","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/0005-2744(78)90005-0","article-title":"Glutathione peroxidase activities from rat liver","volume":"523","author":"Pierce","year":"1978","journal-title":"Biochim. Biophys. Acta Enzymol."},{"issue":"8","key":"10.1016\/j.fct.2025.115298_bib42","doi-asserted-by":"crossref","first-page":"3493","DOI":"10.1590\/S1413-81232011000900017","article-title":"Intoxication due to pesticides in the federal district of Brazil between 2004 and 2007-analysis of notification to the toxicological information and assistance center","volume":"16","author":"Rebelo","year":"2011","journal-title":"Ci\u00eancia Sa\u00fade Coletiva"},{"key":"10.1016\/j.fct.2025.115298_bib43","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1016\/j.scitotenv.2014.10.093","article-title":"Continued implication of the banned pesticides carbofuran and aldicarb in the poisoning of domestic and wild animals of the Canary Islands (Spain)","volume":"505","author":"Ruiz-Su\u00e1rez","year":"2015","journal-title":"Sci. Total Environ."},{"issue":"6","key":"10.1016\/j.fct.2025.115298_bib44","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1016\/j.str.2011.03.019","article-title":"A smoothed backbone-dependent rotamer library for proteins derived from adaptive kernel density estimates and regressions","volume":"19","author":"Shapovalov","year":"2011","journal-title":"Structure"},{"key":"10.1016\/j.fct.2025.115298_bib45","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.redox.2015.01.002","article-title":"Oxidative stress: a concept in redox biology and medicine","volume":"4","author":"Sies","year":"2015","journal-title":"Redox Biol."},{"key":"10.1016\/j.fct.2025.115298_bib46","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1016\/j.aqpro.2015.02.150","article-title":"Contamination of water sources in Mysore city by pesticide residues and plasticizer\u2013A cause of health concern","volume":"4","author":"Somashekar","year":"2015","journal-title":"Aquatic Procedia"},{"issue":"16","key":"10.1016\/j.fct.2025.115298_bib47","doi-asserted-by":"crossref","first-page":"4835","DOI":"10.3390\/molecules26164835","article-title":"Plant-derived pesticides as an alternative to pest management and sustainable agricultural production: prospects, applications and challenges","volume":"26","author":"Souto","year":"2021","journal-title":"Molecules"},{"key":"10.1016\/j.fct.2025.115298_bib48","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.toxlet.2021.09.012","article-title":"A versatile toxicity evaluation of ethyl carbamate (urethane) on zebrafish embryos: morphological, physiological, histopathological, immunohistochemical, transcriptional and behavioral approaches","volume":"353","author":"Sulukan","year":"2021","journal-title":"Toxicol. Lett."},{"issue":"5","key":"10.1016\/j.fct.2025.115298_bib49","doi-asserted-by":"crossref","first-page":"E305","DOI":"10.21037\/jtd.2016.03.62","article-title":"Serum creatinine level, a surrogate of muscle mass, predicts mortality in critically ill patients","volume":"8","author":"Thongprayoon","year":"2016","journal-title":"J. Thorac. Dis."},{"issue":"7","key":"10.1016\/j.fct.2025.115298_bib50","doi-asserted-by":"crossref","first-page":"830","DOI":"10.4236\/health.2015.77098","article-title":"Effect of aldicarb exposure on cellular immunity and antioxidant capacity in kun-ming mice","volume":"7","author":"Tian","year":"2015","journal-title":"Health"},{"issue":"4","key":"10.1016\/j.fct.2025.115298_bib52","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1111\/1541-4337.12204","article-title":"Flavonoids as potent scavengers of hydroxyl radicals","volume":"15","author":"Treml","year":"2016","journal-title":"Compr. Rev. Food Sci. Food Saf."},{"issue":"9","key":"10.1016\/j.fct.2025.115298_bib53","doi-asserted-by":"crossref","first-page":"4642","DOI":"10.3390\/ijms22094642","article-title":"The chemistry of reactive oxygen species (ROS) revisited: outlining their role in biological macromolecules (DNA, lipids and proteins) and induced pathologies","volume":"22","author":"Tsikas Juan","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.fct.2025.115298_bib54","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.ab.2016.10.021","article-title":"Assessment of lipid peroxidation by measuring malondialdehyde (MDA) and relatives in biological samples: analytical and biological challenges","volume":"524","author":"Tsikas","year":"2017","journal-title":"Anal. Biochem."},{"issue":"12","key":"10.1016\/j.fct.2025.115298_bib55","doi-asserted-by":"crossref","first-page":"2806","DOI":"10.1111\/febs.12247","article-title":"Oxidized phosphatidylcholines in membrane\u2010level cellular signaling from biophysics to physiology and molecular pathology","volume":"280","author":"Volinsky","year":"2013","journal-title":"FEBS J."},{"issue":"5","key":"10.1016\/j.fct.2025.115298_bib56","doi-asserted-by":"crossref","first-page":"397","DOI":"10.2174\/187152812803251042","article-title":"Double-stranded RNA induces IL-8 and MCP-1 gene expression via TLR3 in HaCaT-keratinocytes","volume":"11","author":"Voss","year":"2012","journal-title":"Inflamm. Allergy - Drug Targets"},{"issue":"2","key":"10.1016\/j.fct.2025.115298_bib57","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.jmgm.2005.12.005","article-title":"Automatic atom type and bond type perception in molecular mechanical calculations","volume":"25","author":"Wang","year":"2006","journal-title":"J. Mol. Graph. Model."},{"key":"10.1016\/j.fct.2025.115298_bib58","doi-asserted-by":"crossref","first-page":"1650","DOI":"10.1159\/000489241","article-title":"Current mechanistic concepts in ischemia and reperfusion injury","volume":"46","author":"Wu","year":"2018","journal-title":"Cell. Physiol. Biochem."},{"issue":"5","key":"10.1016\/j.fct.2025.115298_bib59","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.3390\/cancers14051255","article-title":"Innate and adaptive immunopathogeneses in viral hepatitis; crucial determinants of hepatocellular carcinoma","volume":"14","author":"Zaki","year":"2022","journal-title":"Cancers"},{"issue":"1","key":"10.1016\/j.fct.2025.115298_bib60","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1080\/0886022X.2018.1544565","article-title":"The anti-inflammatory effects of curcumin on renal ischemia-reperfusion injury in rats","volume":"40","author":"Zhang","year":"2018","journal-title":"Ren. Fail."},{"issue":"4","key":"10.1016\/j.fct.2025.115298_bib61","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1002\/mco2.104","article-title":"NF\u2010\u03baB signaling in inflammation and cancer","volume":"2","author":"Zhang","year":"2021","journal-title":"MedComm"},{"issue":"1","key":"10.1016\/j.fct.2025.115298_bib62","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1186\/s12935-023-03167-3","article-title":"Robinin inhibits pancreatic cancer cell proliferation, EMT and inflammation via regulating TLR2-PI3k-AKT signaling pathway","volume":"23","author":"Zhang","year":"2023","journal-title":"Cancer Cell Int."},{"key":"10.1016\/j.fct.2025.115298_bib63","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2020.118203","article-title":"HMGB1 in kidney diseases","volume":"259","author":"Zhao","year":"2020","journal-title":"Life Sci."}],"container-title":["Food and Chemical Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278691525000651?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278691525000651?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,6,9]],"date-time":"2025-06-09T23:01:50Z","timestamp":1749510110000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0278691525000651"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":63,"alternative-id":["S0278691525000651"],"URL":"https:\/\/doi.org\/10.1016\/j.fct.2025.115298","relation":{},"ISSN":["0278-6915"],"issn-type":[{"value":"0278-6915","type":"print"}],"subject":[],"published":{"date-parts":[[2025,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Nephroprotective potential of robinin to counteract aldicarb induced renal dysfunction via modulating TLR4\/MyD88, HMGB1\/RAGE, NF-\u03baB pathway: A biochemical and pharmacodynamic approach","name":"articletitle","label":"Article Title"},{"value":"Food and Chemical Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fct.2025.115298","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"115298"}}