{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T23:54:35Z","timestamp":1793922875770,"version":"4.8.0"},"reference-count":159,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Food and Chemical Toxicology"],"published-print":{"date-parts":[[2025,4]]},"DOI":"10.1016\/j.fct.2025.115322","type":"journal-article","created":{"date-parts":[[2025,2,15]],"date-time":"2025-02-15T21:54:52Z","timestamp":1739656492000},"page":"115322","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Acetamiprid-induced pulmonary toxicity via oxidative stress, epithelial-mesenchymal transition, apoptosis, and extracellular matrix accumulation in human lung epithelial cells and fibroblasts: Protective role of heat-killed Lactobacilli"],"prefix":"10.1016","volume":"198","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9863-4495","authenticated-orcid":false,"given":"Samah S.","family":"Arafa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heba A.","family":"Elnoury","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3441-6576","authenticated-orcid":false,"given":"Sahar","family":"Badr El-Din","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5193-7301","authenticated-orcid":false,"given":"Mohamed A.","family":"Sakr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatma Fawzi","family":"Hendawi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rehab Ali Elsayed","family":"Masoud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samia Soliman","family":"Barghash","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doaa Sabry","family":"Elbehairy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayat Abdelaty","family":"Hemeda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Islam Mostafa","family":"Farrag","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4054-2336","authenticated-orcid":false,"given":"Doaa Sayed","family":"Abdelrahman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amira Mohammad","family":"Elsadek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sahar K.","family":"Ghanem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hind S.","family":"AboShabaan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8580-4179","authenticated-orcid":false,"given":"Ahmed M.","family":"Atwa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahmoud","family":"Nour El Din","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdullah F.","family":"Radwan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0781-0121","authenticated-orcid":false,"given":"Majid","family":"Al-Zahrani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmad F.","family":"Alhomodi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-7822-9537","authenticated-orcid":false,"given":"Ahmed M.","family":"Abdulfattah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Afaf","family":"Abdelkader","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.fct.2025.115322_bib1","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1017\/S0954422410000090","article-title":"The probiotic paradox: live and dead cells are biological response modifiers","volume":"23","author":"Adams","year":"2010","journal-title":"Nutr. Res. Rev."},{"key":"10.1016\/j.fct.2025.115322_bib2","series-title":"Methods in Enzymology","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S0076-6879(84)05016-3","article-title":"[13] Catalase in vitro","author":"Aebi","year":"1984"},{"key":"10.1016\/j.fct.2025.115322_bib3","first-page":"1499","article-title":"Acetamipride induced histopathological alteration in lung and liver of male mice alt\u00e9rations histopathologiques Induites","volume":"9","author":"Agrobiologia","year":"2019","journal-title":"Par L \u2019 Ac\u00e9tamipride"},{"key":"10.1016\/j.fct.2025.115322_bib4","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/S0887-2333(02)00133-9","article-title":"Role of reactive oxygen species in organophosphate insecticide phosalone toxicity in erythrocytes in vitro","volume":"17","author":"Altuntas","year":"2003","journal-title":"Toxicol. Vitro"},{"key":"10.1016\/j.fct.2025.115322_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2020.153298","article-title":"Biochanin-A ameliorates pulmonary fibrosis by suppressing the TGF-\u03b2 mediated EMT, myofibroblasts differentiation and collagen deposition in in vitro and in vivo systems","volume":"78","author":"Andugulapati","year":"2020","journal-title":"Phytomedicine"},{"key":"10.1016\/j.fct.2025.115322_bib6","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1080\/15376516.2019.1624907","article-title":"Acetamiprid, a neonicotinoid insecticide, induced cytotoxicity and genotoxicity in PC12 cells","volume":"29","author":"Annabi","year":"2019","journal-title":"Toxicol. Mech. Methods"},{"key":"10.1016\/j.fct.2025.115322_bib7","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24044004","article-title":"Fibrosis: types, effects, markers, mechanisms for disease progression, and its relation with oxidative stress, immunity, and inflammation","volume":"24","author":"Antar","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.fct.2025.115322_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2024.143305","article-title":"Flubendiamide provokes oxidative stress, inflammation, miRNAs alteration, and cell cycle deregulation in human prostate epithelial cells: the attenuation impact of synthesized nano-selenium using Trichodermaaureoviride","volume":"365","author":"Arafa","year":"2024","journal-title":"Chemosphere"},{"key":"10.1016\/j.fct.2025.115322_bib9","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.3390\/biomedicines9101340","article-title":"Biomarkers and utility of the antioxidant potential of probiotic Lactobacilli and Bifidobacteria as representatives of the human gut microbiota","volume":"9","author":"Averina","year":"2021","journal-title":"Biomedicines"},{"key":"10.1016\/j.fct.2025.115322_bib10","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1080\/01480545.2018.1429461","article-title":"Assessment of acetamiprid-induced genotoxic effects in bone marrow cells of Swiss albino male mice","volume":"42","author":"Bagri","year":"2019","journal-title":"Drug Chem. Toxicol."},{"key":"10.1016\/j.fct.2025.115322_bib11","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1111\/j.1600-065X.2012.01095.x","article-title":"Regulation of cell death and autophagy by IKK and NF-\u03baB: critical mechanisms in immune function and cancer","volume":"246","author":"Baldwin","year":"2012","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.fct.2025.115322_bib12","series-title":"Med. Biochem","article-title":"Chapter 37 \"oxygen and life.\"","author":"Baynes","year":"2009"},{"key":"10.1016\/j.fct.2025.115322_bib13","article-title":"Modification of the existing maximum residue levels for acetamiprid in various crops","volume":"19","author":"Bellisai","year":"2021","journal-title":"EFSA J."},{"key":"10.1016\/j.fct.2025.115322_bib14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12866-015-0408-6","article-title":"Lactobacillus paracasei CNCM I-4034 and its culture supernatant modulate Salmonella-induced inflammation in a novel transwell co-culture of human intestinal-like dendritic and Caco-2 cells","volume":"15","author":"Bermudez-Brito","year":"2015","journal-title":"BMC Microbiol."},{"key":"10.1016\/j.fct.2025.115322_bib15","series-title":"Improved Method for Determination of Blood Glutathione","author":"Beutler","year":"1963"},{"key":"10.1016\/j.fct.2025.115322_bib16","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1038\/leu.2011.95","article-title":"The role of Smad signaling in hematopoiesis and translational hematology","volume":"25","author":"Blank","year":"2011","journal-title":"Leukemia"},{"key":"10.1016\/j.fct.2025.115322_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2020.143822","article-title":"Residues of neonicotinoids in soil, water and people's hair: a case study from three agricultural regions of the Philippines","volume":"757","author":"Bonmatin","year":"2021","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.fct.2025.115322_bib18","article-title":"Focussed assessment of certain existing MRLs of concern for acetamiprid and modification of the existing MRLs for table olives, olives for oil production, barley and oats","volume":"16","author":"Brancato","year":"2018","journal-title":"EFSA journal. Eur. Food Saf. Auth."},{"key":"10.1016\/j.fct.2025.115322_bib19","doi-asserted-by":"crossref","first-page":"173","DOI":"10.3389\/fphar.2013.00173","article-title":"The epithelium in idiopathic pulmonary fibrosis: breaking the barrier","volume":"4","author":"Camelo","year":"2014","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.fct.2025.115322_bib20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.pestbp.2014.07.008","article-title":"Effects of fullerenol nanoparticles on acetamiprid induced cytoxicity and genotoxicity in cultured human lung fibroblasts","volume":"114","author":"\u00c7ava\u015f","year":"2014","journal-title":"Pestic. Biochem. Physiol."},{"key":"10.1016\/j.fct.2025.115322_bib21","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.pestbp.2012.08.004","article-title":"In vitro genotoxicity evaluation of acetamiprid in CaCo-2 cells using the micronucleus, comet and \u03b3H2AX foci assays","volume":"104","author":"\u00c7ava\u015f","year":"2012","journal-title":"Pestic. Biochem. Physiol."},{"key":"10.1016\/j.fct.2025.115322_bib22","doi-asserted-by":"crossref","DOI":"10.3390\/cells12060936","article-title":"The role of oxidative stress in vitiligo: an update on its pathogenesis and therapeutic implications","volume":"12","author":"Chang","year":"2023","journal-title":"Cells"},{"key":"10.1016\/j.fct.2025.115322_bib23","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1164\/rccm.200505-717OC","article-title":"Pharmacologic differentiation of inflammation and fibrosis in the rat bleomycin model","volume":"173","author":"Chaudhary","year":"2006","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.fct.2025.115322_bib24","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1038\/s41598-018-19732-0","article-title":"Antioxidative, anti-inflammatory and anti-apoptotic effects of ellagic acid in liver and brain of rats treated by D-galactose","volume":"8","author":"Chen","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.fct.2025.115322_bib25","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.diff.2013.03.003","article-title":"Extracellular matrix proteins regulate epithelial--mesenchymal transition in mammary epithelial cells","volume":"86","author":"Chen","year":"2013","journal-title":"Differentiation"},{"key":"10.1016\/j.fct.2025.115322_bib26","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.fct.2020.111632","article-title":"Assessing the combined toxicity effects of three neonicotinoid pesticide mixtures on human neuroblastoma SK-N-SH and lepidopteran Sf-9 cells","volume":"145","author":"Cheng","year":"2020","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.fct.2025.115322_bib27","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.toxlet.2013.03.009","article-title":"Berberine attenuates bleomycin induced pulmonary toxicity and fibrosis via suppressing NF-\u03baB dependant TGF-\u03b2 activation: a biphasic experimental study","volume":"219","author":"Chitra","year":"2013","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.fct.2025.115322_bib28","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/microorganisms8050709","article-title":"Assessment of the immunomodulatory properties of the probiotic strain Lactobacillus paracasei K5 in vitro and in vivo","volume":"8","author":"Chondrou","year":"2020","journal-title":"Microorganisms"},{"key":"10.1016\/j.fct.2025.115322_bib29","doi-asserted-by":"crossref","DOI":"10.3390\/molecules21111456","article-title":"Heat-killed lactobacillus salivarius and lactobacillus johnsonii reduce liver injury induced by alcohol in vitro and in vivo","volume":"21","author":"Chuang","year":"2016","journal-title":"Molecules"},{"key":"10.1016\/j.fct.2025.115322_bib30","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1681\/ASN.2009010018","article-title":"Advanced glycation end-products induce tubular CTGF via TGF-beta-independent Smad3 signaling","volume":"21","author":"Chung","year":"2010","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.fct.2025.115322_bib31","volume":"vol. 96","author":"Cich\u00f3n","year":"2013"},{"key":"10.1016\/j.fct.2025.115322_bib32","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fmolb.2021.633054","article-title":"GSK-3 Inhibition modulates metalloproteases in a model of lung inflammation and fibrosis","volume":"8","author":"Cinetto","year":"2021","journal-title":"Front. Mol. Biosci."},{"key":"10.1016\/j.fct.2025.115322_bib33","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1111\/j.1574-6968.2008.01206.x","article-title":"Rapid identification of the three major species of dairy obligate heterofermenters Lactobacillus brevis, Lactobacillus fermentum and Lactobacillus parabuchneri by species-specific duplex PCR","volume":"284","author":"Coton","year":"2008","journal-title":"FEMS Microbiol. Lett."},{"key":"10.1016\/j.fct.2025.115322_bib34","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1177\/1753465810379801","article-title":"The pathogenesis of idiopathic pulmonary fibrosis","volume":"4","author":"Coward","year":"2010","journal-title":"Ther. Adv. Respir. Dis."},{"key":"10.1016\/j.fct.2025.115322_bib35","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1177\/2050640617736478","article-title":"Effect of Lactobacillus paracasei CNCM I-1572 on symptoms, gut microbiota, short chain fatty acids, and immune activation in patients with irritable bowel syndrome: a pilot randomized clinical trial","volume":"6","author":"Cremon","year":"2018","journal-title":"United Eur. Gastroenterol. J."},{"key":"10.1016\/j.fct.2025.115322_bib36","first-page":"4285","article-title":"Effect of asiatic acid on epithelial-mesenchymal transition of human alveolar epithelium A549 cells induced by TGF-\u03b21","volume":"17","author":"Cui","year":"2019","journal-title":"Oncol. Lett."},{"key":"10.1016\/j.fct.2025.115322_bib37","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1111\/j.1476-5381.2011.01247.x","article-title":"Novel therapeutic approaches for pulmonary fibrosis","volume":"163","author":"Datta","year":"2011","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.fct.2025.115322_bib38","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1177\/0748233716635003","article-title":"Chlorpyrifos and lambda cyhalothrin-induced oxidative stress in human erythrocytes: in vitro studies","volume":"33","author":"Deeba","year":"2017","journal-title":"Toxicol. Ind. Health"},{"key":"10.1016\/j.fct.2025.115322_bib39","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.pestbp.2010.11.002","article-title":"Subacute chlorpyrifos-induced oxidative stress in rat erythrocytes and the protective effects of catechin and quercetin","volume":"99","author":"Demir","year":"2011","journal-title":"Pestic. Biochem. Physiol."},{"key":"10.1016\/j.fct.2025.115322_bib40","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1038\/nature02006","article-title":"Smad-dependent and Smad-independent pathways in TGF-\u03b2 family signalling","volume":"425","author":"Derynck","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.fct.2025.115322_bib41","doi-asserted-by":"crossref","first-page":"43","DOI":"10.3389\/fmed.2018.00043","article-title":"The role of immune and inflammatory cells in idiopathic pulmonary fibrosis","volume":"5","author":"Desai","year":"2018","journal-title":"Front. Med."},{"key":"10.1016\/j.fct.2025.115322_bib42","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-022-24483-0","article-title":"Modulation of intestinal epithelial cell proliferation and apoptosis by Lactobacillus gasseri SF1183","volume":"12","author":"Di Luccia","year":"2022","journal-title":"Sci. Rep."},{"key":"10.1016\/j.fct.2025.115322_bib43","doi-asserted-by":"crossref","first-page":"4352","DOI":"10.3892\/mmr.2017.6514","article-title":"Regulation of mRNA gene expression of members of the NF-\u03baB transcription factor gene family by angiotensin II and relaxin 2 in normal and cancer prostate cell lines","volume":"15","author":"Dominska","year":"2017","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.fct.2025.115322_bib44","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.pestbp.2009.11.008","article-title":"Acute oxidant and inflammatory effects of imidacloprid on the mammalian central nervous system and liver in rats","volume":"97","author":"Duzguner","year":"2010","journal-title":"Pestic. Biochem. Physiol."},{"key":"10.1016\/j.fct.2025.115322_bib45","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12906-024-04576-1","article-title":"Pasteurized form of a potential probiotic lactobacillus brevis IBRC-M10790 exerts anti-inflammatory effects on inflammatory bowel disease in vitro","volume":"24","author":"Ebrahiminejad","year":"2024","journal-title":"BMC Complement. Med. Ther."},{"key":"10.1016\/j.fct.2025.115322_bib46","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.ygeno.2010.04.005","article-title":"Genomic phenotype of non-cultured pulmonary fibroblasts in idiopathic pulmonary fibrosis","volume":"96","author":"Emblom-Callahan","year":"2010","journal-title":"Genomics"},{"key":"10.1016\/j.fct.2025.115322_bib47","doi-asserted-by":"crossref","first-page":"23","DOI":"10.3906\/biy-1402-62","article-title":"Cytotoxic effects of various lactic acid bacteria on Caco-2 cells","volume":"39","author":"Er","year":"2015","journal-title":"Turkish J. Biol."},{"key":"10.1016\/j.fct.2025.115322_bib48","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fmicb.2019.00782","article-title":"In vitro organic acid production and in vivo food pathogen suppression by probiotic S. thermophilus and L. Bulgaricus","volume":"10","author":"Evivie","year":"2019","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.fct.2025.115322_bib49","doi-asserted-by":"crossref","first-page":"138","DOI":"10.2174\/1389201017666161229153530","article-title":"Probiotic properties of Lactobacillus fermentum Strains isolated from human oral samples and description of their antibacterial activity","volume":"18","author":"Fuochi","year":"2017","journal-title":"Curr. Pharm. Biotechnol."},{"key":"10.1016\/j.fct.2025.115322_bib50","doi-asserted-by":"crossref","first-page":"2368","DOI":"10.1038\/onc.2009.514","article-title":"Extracellular matrix-induced transforming growth factor-beta receptor signaling dynamics","volume":"29","author":"Garamszegi","year":"2010","journal-title":"Oncogene"},{"key":"10.1016\/j.fct.2025.115322_bib51","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1093\/carcin\/20.4.539","article-title":"Colonic epithelial cell activation and the paradoxical effects of butyrate","volume":"20","author":"Gibson","year":"1999","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.fct.2025.115322_bib52","doi-asserted-by":"crossref","DOI":"10.1016\/j.tox.2020.152363","article-title":"Trophoblast toxicity of the neonicotinoid insecticide acetamiprid and an acetamiprid-based formulation","volume":"431","author":"Gomez","year":"2020","journal-title":"Toxicology"},{"key":"10.1016\/j.fct.2025.115322_bib53","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.1007\/s12029-021-00704-z","article-title":"Systematic analysis of cytostatic TGF-beta response in mesenchymal-like hepatocellular carcinoma cell lines","volume":"52","author":"Gungor","year":"2021","journal-title":"J. Gastrointest. Cancer"},{"key":"10.1016\/j.fct.2025.115322_bib54","doi-asserted-by":"crossref","first-page":"7130","DOI":"10.1016\/S0021-9258(19)42083-8","article-title":"Glutathione S-transferases: the first enzymatic step in mercapturic acid formation","volume":"249","author":"Habig","year":"1974","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.fct.2025.115322_bib55","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2024.114571","article-title":"The preventive effect of heat-killed Lactobacillus plantarum on male reproductive toxicity induced by cholestasis in rats","volume":"186","author":"Hajian","year":"2024","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.fct.2025.115322_bib56","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1128\/aem.00608-23","article-title":"Anti-inflammatory effect of Lactiplantibacillus plantarum T1 cell-free supernatants through suppression of oxidative stress and NF-\u03baB- and MAPK-signaling pathways","volume":"89","author":"Hao","year":"2023","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.fct.2025.115322_bib57","doi-asserted-by":"crossref","first-page":"3","DOI":"10.2353\/ajpath.2009.081170","article-title":"Emerging concepts in the pathogenesis of lung fibrosis","volume":"175","author":"Hardie","year":"2009","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.fct.2025.115322_bib58","first-page":"57","article-title":"Alteration of hepatocellular antioxidant gene expression pattern and biomarkers of oxidative damage in diazinon-induced acute toxicity in Wistar rat: a time-course mechanistic study","volume":"17","author":"Hassani","year":"2018","journal-title":"EXCLI J"},{"key":"10.1016\/j.fct.2025.115322_bib59","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.yexcr.2005.03.021","article-title":"Generation of biologically active endostatin fragments from human collagen XVIII by distinct matrix metalloproteases","volume":"307","author":"Heljasvaara","year":"2005","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.fct.2025.115322_bib60","doi-asserted-by":"crossref","first-page":"32458","DOI":"10.1007\/s11356-018-3258-6","article-title":"Influence of sex on biomarkers of oxidative stress in the kidney, lungs, and liver of rabbits after exposure to diazinon","volume":"25","author":"Hern\u00e1ndez-Moreno","year":"2018","journal-title":"Environ. Sci. Pollut. Res."},{"key":"10.1016\/j.fct.2025.115322_bib61","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1080\/08958370801905524","article-title":"Low level of exposure to pesticides leads to lung dysfunction in occupationally exposed subjects","volume":"20","author":"Hern\u00e1ndez","year":"2008","journal-title":"Inhal. Toxicol."},{"key":"10.1016\/j.fct.2025.115322_bib62","doi-asserted-by":"crossref","first-page":"103","DOI":"10.3109\/09687688.2014.894211","article-title":"Evidence of TGF-\u03b21 mediated epithelial-mesenchymal transition in immortalized benign prostatic hyperplasia cells","volume":"31","author":"Hu","year":"2014","journal-title":"Mol. Membr. Biol."},{"key":"10.1016\/j.fct.2025.115322_bib63","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2020.114172","article-title":"TGF-\u03b21-induced miR-424 promotes pulmonary myofibroblast differentiation by targeting Slit2 protein expression","volume":"180","author":"Huang","year":"2020","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.fct.2025.115322_bib64","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1128\/AEM.06983-11","article-title":"Differential targeting of the E-cadherin\/\u03b2-catenin complex by gram-positive probiotic lactobacilli improves epithelial barrier function","volume":"78","author":"Hummel","year":"2012","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.fct.2025.115322_bib65","doi-asserted-by":"crossref","first-page":"851","DOI":"10.3109\/15563650.2010.517207","article-title":"Two cases of acute poisoning with acetamiprid in humans","volume":"48","author":"Imamura","year":"2010","journal-title":"Clin. Toxicol."},{"key":"10.1016\/j.fct.2025.115322_bib66","article-title":"Heat-Killed Latilactobacillus sakei CNSC001WB and Lactobacillus pentosus WB693 have an anti-inflammatory effect on lps-stimulated RAW 264.7 Cells","author":"Jung","year":"2023","journal-title":"Probiotics Antimicrob. Proteins"},{"key":"10.1016\/j.fct.2025.115322_bib67","first-page":"517","article-title":"EMT and interstitial lung disease: a mysterious relationship","volume":"18","author":"Kage","year":"2012","journal-title":"Curr. Opin. Pulm. Med."},{"key":"10.1016\/j.fct.2025.115322_bib68","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s41232-019-0101-5","article-title":"The role of interleukin-1 in general pathology","volume":"39","author":"Kaneko","year":"2019","journal-title":"Inflamm. Regen."},{"key":"10.1016\/j.fct.2025.115322_bib69","first-page":"1530","article-title":"Heat-killed lactic acid bacteria inhibit nitric oxide production via inducible nitric oxide synthase and cyclooxygenase-2 in RAW 264.7 cells. Probiotics Antimicrob","volume":"13","author":"Kang","year":"2021","journal-title":"Proteins"},{"key":"10.1016\/j.fct.2025.115322_bib70","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0262767","article-title":"Probiotics counteract the expression of hepatic profibrotic genes via the attenuation of TGF-\u03b2\/SMAD signaling and autophagy in hepatic stellate cells","volume":"17","author":"Kanmani","year":"2022","journal-title":"PLoS One"},{"key":"10.1016\/j.fct.2025.115322_bib71","doi-asserted-by":"crossref","first-page":"474","DOI":"10.4274\/tjps.galenos.2019.89719","article-title":"Acetamiprid-induced cyto-and genotoxicity in the AR42J pancreatic cell line","volume":"17","author":"Kara","year":"2020","journal-title":"Turkish J. Pharm. Sci."},{"key":"10.1016\/j.fct.2025.115322_bib72","doi-asserted-by":"crossref","first-page":"401","DOI":"10.2217\/fmb-2020-0005","article-title":"The anti-inflammatory, antioxidant and protective effects of a probiotic mixture on organ toxicity in a rat model","volume":"15","author":"Karamese","year":"2020","journal-title":"Future Microbiol."},{"key":"10.1016\/j.fct.2025.115322_bib73","doi-asserted-by":"crossref","DOI":"10.3390\/microorganisms11102466","article-title":"Lactobacillus helveticus isolated from raw milk improves liver function, hepatic steatosis, and lipid metabolism in non-alcoholic fatty liver disease mouse model","volume":"11","author":"Kim","year":"2023","journal-title":"Microorganisms"},{"key":"10.1016\/j.fct.2025.115322_bib74","doi-asserted-by":"crossref","first-page":"680","DOI":"10.22203\/eCM.v041a44","article-title":"Antioxidant effects on hypoxia-induced oxidative stress and apoptosis in rat rotator cuff fibroblasts","volume":"41","author":"Kim","year":"2021","journal-title":"Eur. Cell. Mater."},{"key":"10.1016\/j.fct.2025.115322_bib75","doi-asserted-by":"crossref","first-page":"1949","DOI":"10.1016\/S0140-6736(11)60052-4","article-title":"Idiopathic pulmonary fibrosis","volume":"378","author":"King","year":"2011","journal-title":"Lancet"},{"key":"10.1016\/j.fct.2025.115322_bib76","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1002\/em.20309","article-title":"In Vitro evaluation of the genotoxicity of acetamiprid","volume":"490","author":"Kocaman","year":"2007","journal-title":"Environ. Mol. Mutagen."},{"key":"10.1016\/j.fct.2025.115322_bib77","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1093\/biolre\/iox007","article-title":"Acetamiprid inhibits testosterone synthesis by affecting the mitochondrial function and cytoplasmic adenosine triphosphate production in rat Leydig cells","volume":"96","author":"Kong","year":"2017","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.fct.2025.115322_bib78","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1007\/s10555-021-10013-3","article-title":"The involvement of oncobiosis and bacterial metabolite signaling in metastasis formation in breast cancer","volume":"40","author":"Kov\u00e1cs","year":"2021","journal-title":"Cancer Metastasis Rev."},{"key":"10.1016\/j.fct.2025.115322_bib79","doi-asserted-by":"crossref","first-page":"1666","DOI":"10.1111\/jvim.12432","article-title":"Transforming growth factor beta 1 activation, storage, and signaling pathways in idiopathic pulmonary fibrosis in dogs","volume":"28","author":"Krafft","year":"2014","journal-title":"J. Vet. Intern. Med."},{"key":"10.1016\/j.fct.2025.115322_bib80","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1038\/nrm3758","article-title":"Molecular mechanisms of epithelial--mesenchymal transition","volume":"15","author":"Lamouille","year":"2014","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.fct.2025.115322_bib81","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4161\/19490976.2014.990784","article-title":"Lactobacillus rhamnosus CNCM I-3690 and the commensal bacterium Faecalibacterium prausnitzii A2-165 exhibit similar protective effects to induced barrier hyper-permeability in mice","volume":"6","author":"Laval","year":"2015","journal-title":"Gut Microbes"},{"key":"10.1016\/j.fct.2025.115322_bib82","doi-asserted-by":"crossref","DOI":"10.3390\/microorganisms10112181","article-title":"Different impacts of heat-killed and viable Lactiplantibacillus plantarum TWK10 on exercise performance, fatigue, body composition, and gut microbiota in humans","volume":"10","author":"Lee","year":"2022","journal-title":"Microorganisms"},{"key":"10.1016\/j.fct.2025.115322_bib83","first-page":"1","article-title":"Exopolysaccharide from lactobacillus plantarum hy7714 protects against skin aging through skin\u2013gut axis communication","volume":"26","author":"Lee","year":"2021","journal-title":"Molecules"},{"key":"10.1016\/j.fct.2025.115322_bib84","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.3892\/or.2017.5791","article-title":"Lactobacilli inhibit cervical cancer cell migration in vitro and reduce tumor burden in vivo through upregulation of E-cadherin","volume":"38","author":"Li","year":"2017","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.fct.2025.115322_bib85","doi-asserted-by":"crossref","first-page":"7281","DOI":"10.2147\/JIR.S344564","article-title":"Lactobacillus fermentum ZS09 mediates epithelial\u2013 mesenchymal transition (emt) by regulating the transcriptional activity of the Wnt\/\u03b2-catenin signalling pathway to inhibit colon cancer activity","volume":"14","author":"Liu","year":"2021","journal-title":"J. Inflamm. Res."},{"key":"10.1016\/j.fct.2025.115322_bib86","doi-asserted-by":"crossref","first-page":"2228","DOI":"10.3389\/fimmu.2018.02228","article-title":"Sinomenine inhibits the progression of rheumatoid arthritis by regulating the secretion of inflammatory cytokines and monocyte\/macrophage subsets","volume":"9","author":"Liu","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.fct.2025.115322_bib87","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2-\u0394\u0394CT method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.fct.2025.115322_bib88","first-page":"58","article-title":"Idiopathic pulmonary fibrosis: immunohistochemical analysis provides fresh insights into lung tissue remodelling with implications for novel prognostic markers","volume":"5","author":"Lomas","year":"2012","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"10.1016\/j.fct.2025.115322_bib89","first-page":"42","article-title":"Total antioxidant status--a possible marker of environmental influences on animal organism","volume":"42","author":"Lovasova","year":"2009","journal-title":"Slovak J. Anim. Sci."},{"key":"10.1016\/j.fct.2025.115322_bib90","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.pestbp.2010.07.006","article-title":"Role of oxidative stress in organophosphate insecticide toxicity--Short review","volume":"98","author":"Lukaszewicz-Hussain","year":"2010","journal-title":"Pestic. Biochem. Physiol."},{"key":"10.1016\/j.fct.2025.115322_bib91","doi-asserted-by":"crossref","first-page":"907","DOI":"10.2147\/JIR.S301971","article-title":"Adiponectin, but not tgf-\u03b21, ctgf, il-6 or tnf-\u03b1, may be a potential anti-inflammation and anti-fibrosis factor in keloid","volume":"14","author":"Luo","year":"2021","journal-title":"J. Inflamm. Res."},{"key":"10.1016\/j.fct.2025.115322_bib92","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1471-2180-13-298","article-title":"Differential modulation of innate immunity in vitro by probiotic strains of Lactobacillus gasseri","volume":"13","author":"Luongo","year":"2013","journal-title":"BMC Microbiol."},{"key":"10.1016\/j.fct.2025.115322_bib93","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1080\/01635581.2017.1359317","article-title":"Anti-proliferative effects of Bacillus coagulans unique IS2 in colon cancer cells","volume":"69","author":"Madempudi","year":"2017","journal-title":"Nutr. Cancer"},{"key":"10.1016\/j.fct.2025.115322_bib94","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1007\/s002230010032","article-title":"The first stage of transforming growth factor \u03b21 activation is release of the large latent complex from the extracellular matrix of growth plate chondrocytes by matrix vesicle stromelysin-1 (MMP-3)","volume":"70","author":"Maeda","year":"2002","journal-title":"Calcif. Tissue Int."},{"key":"10.1016\/j.fct.2025.115322_bib95","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1007\/BF00227543","article-title":"Alterations in tissue glutathione antioxidant system in streptozotocin-induced diabetic rats","volume":"162","author":"Mak","year":"1996","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.fct.2025.115322_bib96","doi-asserted-by":"crossref","first-page":"2049","DOI":"10.20546\/ijcmas.2019.801.214","article-title":"\"Postbiotics\" - one step ahead of probiotics","volume":"8","author":"Malashree","year":"2019","journal-title":"Int. J. Curr. Microbiol. Appl. Sci."},{"key":"10.1016\/j.fct.2025.115322_bib97","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.jchromb.2004.01.022","article-title":"Assessment of potential (inhalation and dermal) and actual exposure to acetamiprid by greenhouse applicators using liquid chromatography\u2013tandem mass spectrometry","volume":"804","author":"Mar\u00edn","year":"2004","journal-title":"J. Chromatogr. B"},{"key":"10.1016\/j.fct.2025.115322_bib99","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1183\/09031936.00060708","article-title":"MMP expression and abnormal lung permeability are important determinants of outcome in IPF","volume":"33","author":"McKeown","year":"2008","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.fct.2025.115322_bib100","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1177\/014860719802200114","article-title":"Sodium butyrate inhibits carcinoma development in a 1, 2-dimethylhydrazine-induced rat colon cancer","volume":"22","author":"Medina","year":"1998","journal-title":"J. Parenter. Enteral Nutr."},{"key":"10.1016\/j.fct.2025.115322_bib101","doi-asserted-by":"crossref","first-page":"e6","DOI":"10.1017\/gmb.2022.5","article-title":"Alterations in infant gut microbiome composition and metabolism after exposure to glyphosate and roundup and\/or a spore-based formulation using the SHIME technology","volume":"3","author":"Mesnage","year":"2022","journal-title":"Gut Microbiome"},{"key":"10.1016\/j.fct.2025.115322_bib102","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.14202\/vetworld.2014.1058-1065","article-title":"Toxicopathological changes on Wistar rat after multiple exposures to acetamiprid","volume":"7","author":"Mondal","year":"2014","journal-title":"Vet. World"},{"key":"10.1016\/j.fct.2025.115322_bib103","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1080\/01480545.2017.1337127","article-title":"Protective effect of Nigella sativa oil against acetamiprid induced reproductive toxicity in male rats","volume":"41","author":"Mosbah","year":"2018","journal-title":"Drug Chem. Toxicol."},{"key":"10.1016\/j.fct.2025.115322_bib104","doi-asserted-by":"crossref","first-page":"909","DOI":"10.3727\/096368910X543385","article-title":"Human amnion epithelial cells prevent bleomycin-induced lung injury and preserve lung function","volume":"20","author":"Murphy","year":"2011","journal-title":"Cell Transplant."},{"key":"10.1016\/j.fct.2025.115322_bib105","doi-asserted-by":"crossref","first-page":"4093","DOI":"10.2174\/138161212802430396","article-title":"Cellular players in lung fibrosis","volume":"18","author":"N Lekkerkerker","year":"2012","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.fct.2025.115322_bib106","first-page":"1","article-title":"Effects of astragalus injection on the TGF\u03b2\/Smad pathway in the kidney in type 2 diabetic mice","volume":"14","author":"Nie","year":"2014","journal-title":"BMC Compl. Alternative Med."},{"key":"10.1016\/j.fct.2025.115322_bib107","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.ijfoodmicro.2006.09.010","article-title":"The microbiology of Ghanaian cocoa fermentations analyzed using culture-dependent and culture-independent methods","volume":"114","author":"Nielsen","year":"2007","journal-title":"Int. J. Food Microbiol."},{"key":"10.1016\/j.fct.2025.115322_bib108","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1016\/S0006-291X(72)80218-3","article-title":"The occurrence of superoxide anion in the reaction of reduced phenazine methosulfate and molecular oxygen","volume":"46","author":"Nishikimi","year":"1972","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.fct.2025.115322_bib109","first-page":"127","article-title":"Dual anti-metastatic and anti-proliferative activity assessment of two probiotics on HeLa and HT-29 cell lines","volume":"18","author":"Nouri","year":"2016","journal-title":"Cell J"},{"key":"10.1016\/j.fct.2025.115322_bib110","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/0003-2697(79)90738-3","article-title":"Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction","volume":"95","author":"Ohkawa","year":"1979","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.fct.2025.115322_bib111","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1080\/01635581.2012.717676","article-title":"Anti-proliferative and proapoptotic effects of viable or heat-killed Lactobacillus paracasei IMPC2.1 and Lactobacillus rhamnosus GG in HGC-27 gastric and DLD-1 colon cell lines","volume":"64","author":"Orlando","year":"2012","journal-title":"Nutr. Cancer"},{"key":"10.1016\/j.fct.2025.115322_bib112","doi-asserted-by":"crossref","first-page":"820","DOI":"10.3390\/biology10090820","article-title":"Cellular stress pathways are linked to acetamiprid-induced apoptosis in sh-sy5y neural cells","volume":"10","author":"\u00d6zta\u015f","year":"2021","journal-title":"Biology"},{"key":"10.1016\/j.fct.2025.115322_bib113","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.rvsc.2022.12.014","article-title":"Impact of heat-inactivated Lactobacillus on inflammatory response in endotoxin- and chemotherapeutic-treated porcine enterocytes","volume":"154","author":"Pal\u00f3cz","year":"2023","journal-title":"Res. Vet. Sci."},{"key":"10.1016\/j.fct.2025.115322_bib114","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1136\/bjo.2007.130542","article-title":"The change of oxidative stress products in diabetes mellitus and diabetic retinopathy","volume":"92","author":"Pan","year":"2008","journal-title":"Br. J. Ophthalmol."},{"key":"10.1016\/j.fct.2025.115322_bib115","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0112300","article-title":"TGF-\u03b21\/Smad signaling pathway regulates epithelial-to-mesenchymal transition in esophageal squamous cell carcinoma: in vitro and clinical analyses of cell lines and nomadic Kazakh patients from northwest Xinjiang, China","volume":"9","author":"Pang","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.fct.2025.115322_bib116","doi-asserted-by":"crossref","DOI":"10.3390\/molecules25173895","article-title":"Anti-cancer effects of Lactobacillus plantarum L-14 cell-free extract on human malignant melanoma A375 Cells","volume":"25","author":"Park","year":"2020","journal-title":"Molecules"},{"key":"10.1016\/j.fct.2025.115322_bib117","first-page":"1","article-title":"Insulin resistance mediates high-fat diet-induced pulmonary fibrosis and airway hyperresponsiveness through the TGF-\u03b21 pathway","volume":"51","author":"Park","year":"2019","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.fct.2025.115322_bib118","doi-asserted-by":"crossref","DOI":"10.1016\/j.crtox.2022.100088","article-title":"Lactobacilli metabolites restore E-cadherin and suppress MMP9 in cervical cancer cells","volume":"3","author":"Pawar","year":"2022","journal-title":"Curr. Res. Toxicol."},{"key":"10.1016\/j.fct.2025.115322_bib119","doi-asserted-by":"crossref","first-page":"8","DOI":"10.3390\/ijms20102534","article-title":"Health benefits of heat-killed (Tyndallized) probiotics: an overview","volume":"20","author":"Piqu\u00e9","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.fct.2025.115322_bib120","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1017\/S0007114518003410","article-title":"Synbiotic combination of prebiotic grape pomace extract and probiotic Lactobacillus sp. reduced important intestinal inflammatory markers and in-depth signalling mediators in lipopolysaccharide-treated Caco-2 cells","volume":"121","author":"Pistol","year":"2019","journal-title":"Br. J. Nutr."},{"key":"10.1016\/j.fct.2025.115322_bib121","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1378\/chest.127.1.266","article-title":"Expression of apoptotic and anti-apoptotic markers in epithelial cells in idiopathic pulmonary fibrosis","volume":"127","author":"Plataki","year":"2005","journal-title":"Chest"},{"key":"10.1016\/j.fct.2025.115322_bib122","article-title":"Are heat-killed probiotics more effective than live ones on colon length shortness, disease activity index, and the histological score of an inflammatory bowel disease-induced murine model? A meta-analysis","volume":"134","author":"Poaty Ditengou","year":"2023","journal-title":"J. Appl. Microbiol."},{"key":"10.1016\/j.fct.2025.115322_bib123","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.pestbp.2018.04.001","article-title":"The insecticides chlorpyrifos and acetamiprid induce redox imbalance in umbilical cord blood erythrocytes in vitro","volume":"148","author":"Quintana","year":"2018","journal-title":"Pestic. Biochem. Physiol."},{"key":"10.1016\/j.fct.2025.115322_bib124","doi-asserted-by":"crossref","first-page":"99","DOI":"10.2174\/1573401311309020004","article-title":"Protection and restitution of gut barrier by probiotics: nutritional and clinical implications","volume":"9","author":"Rao","year":"2013","journal-title":"Curr. Nutr. Food Sci."},{"key":"10.1016\/j.fct.2025.115322_bib126","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1136\/thx.2008.102814","article-title":"Soluble endostatin is a novel inhibitor of epithelial repair in idiopathic pulmonary fibrosis","volume":"64","author":"Richter","year":"2009","journal-title":"Thorax"},{"key":"10.1016\/j.fct.2025.115322_bib127","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.bbamcr.2009.09.015","article-title":"Matrix metalloproteinases: what do they not do? New substrates and biological roles identified by murine models and proteomics","volume":"1803","author":"Rodr\u00edguez","year":"2010","journal-title":"Biochim. Biophys. Acta, Mol. Cell Res."},{"key":"10.1016\/j.fct.2025.115322_bib128","doi-asserted-by":"crossref","first-page":"3691","DOI":"10.1007\/s00253-013-5484-7","article-title":"Riboflavin-overproducing strains of Lactobacillus fermentum for riboflavin-enriched bread","volume":"98","author":"Russo","year":"2014","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"10.1016\/j.fct.2025.115322_bib129","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/femspd\/ftaa044","article-title":"Interaction between Lactobacillus reuteri and periodontopathogenic bacteria using in vitro and in vivo (G. mellonella) approaches","volume":"78","author":"Santos","year":"2020","journal-title":"Pathog. Dis."},{"key":"10.1016\/j.fct.2025.115322_bib130","doi-asserted-by":"crossref","DOI":"10.1016\/j.xcrp.2021.100446","article-title":"A critical review of palladium organometallic anticancer agents","volume":"2","author":"Scattolin","year":"2021","journal-title":"Cell Reports Phys. Sci."},{"key":"10.1016\/j.fct.2025.115322_bib131","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1016\/j.jcf.2019.04.011","article-title":"Oxidative stress and abnormal bioactive lipids in early cystic fibrosis lung disease","volume":"18","author":"Scholte","year":"2019","journal-title":"J. Cyst. Fibros."},{"key":"10.1016\/j.fct.2025.115322_bib132","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1513\/pats.200601-003TK","article-title":"Role of epithelial cells in idiopathic pulmonary fibrosis: from innocent targets to serial killers","volume":"3","author":"Selman","year":"2006","journal-title":"Proc. Am. Thorac. Soc."},{"key":"10.1016\/j.fct.2025.115322_bib133","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/ijms241311010","article-title":"Combined inhibition of the TGF-\u03b21\/Smad pathway by Prevotella copri and Lactobacillus murinus to reduce inflammation and fibrosis in primary sclerosing cholangitis","volume":"24","author":"Shen","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.fct.2025.115322_bib134","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.pestbp.2014.11.014","article-title":"IRAC: mode of action classification and insecticide resistance management","volume":"121","author":"Sparks","year":"2015","journal-title":"Pestic. Biochem. Physiol."},{"key":"10.1016\/j.fct.2025.115322_bib135","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.tiv.2019.05.022","article-title":"Inflammatory and tumorigenic effects of environmental pollutants found in particulate matter on lung epithelial cells","volume":"59","author":"Ta\u015f","year":"2019","journal-title":"Toxicol. Vitro"},{"key":"10.1016\/j.fct.2025.115322_bib136","doi-asserted-by":"crossref","first-page":"3481","DOI":"10.1007\/s11033-022-07185-8","article-title":"Inhibition of nuclear factor \u03baB in the lungs protect bleomycin-induced lung fibrosis in mice","volume":"49","author":"Thakur","year":"2022","journal-title":"Mol. Biol. Rep."},{"key":"10.1016\/j.fct.2025.115322_bib137","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1146\/annurev.med.55.091902.103810","article-title":"Mechanisms of pulmonary fibrosis","volume":"55","author":"Thannickal","year":"2004","journal-title":"Annu. Rev. Med."},{"key":"10.1016\/j.fct.2025.115322_bib138","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1016\/j.jaci.2019.05.002","article-title":"Butyrate ameliorates allergic airway inflammation by limiting eosinophil trafficking and survival","volume":"144","author":"Theiler","year":"2019","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.fct.2025.115322_bib139","first-page":"387","article-title":"Acute poisoning with neonicotinoid insecticide acetamiprid. Chudoku kenkyu Chudoku Kenkyukai jun kikanshi = Japanese","volume":"21","author":"Todani","year":"2008","journal-title":"J. Toxicol."},{"key":"10.1016\/j.fct.2025.115322_bib140","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1146\/annurev.pharmtox.45.120403.095930","article-title":"Neonicotinoid insecticide toxicology: mechanisms of selective action","volume":"45","author":"Tomizawa","year":"2005","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1016\/j.fct.2025.115322_bib141","author":"Trinder"},{"key":"10.1016\/j.fct.2025.115322_bib142","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.tiv.2018.05.004","article-title":"Variation in doses and duration of particulate matter exposure in bronchial epithelial cells results in upregulation of different genes associated with airway disorders","volume":"51","author":"Tripathi","year":"2018","journal-title":"Toxicol. Vitro"},{"key":"10.1016\/j.fct.2025.115322_bib143","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/cells10113264","article-title":"Heat-killed lactobacilli preparations promote healing in the experimental cutaneous wounds","volume":"10","author":"Tsai","year":"2021","journal-title":"Cells"},{"key":"10.1016\/j.fct.2025.115322_bib144","first-page":"1","article-title":"Bifidobacterium lactis combined with Lactobacillus plantarum inhibit glioma growth in mice through modulating PI3K\/AKT pathway and gut microbiota","volume":"13","author":"Wang","year":"2022","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.fct.2025.115322_bib145","doi-asserted-by":"crossref","DOI":"10.3390\/nu9050521","article-title":"Antioxidant properties of probiotic bacteria","volume":"9","author":"Wang","year":"2017","journal-title":"Nutrients"},{"key":"10.1016\/j.fct.2025.115322_bib146","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1183\/09031936.00073012","article-title":"The pathogenesis of pulmonary fibrosis: a moving target","volume":"41","author":"Wuyts","year":"2013","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.fct.2025.115322_bib147","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1084\/jem.20110551","article-title":"Integrating mechanisms of pulmonary fibrosis","volume":"208","author":"Wynn","year":"2011","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.fct.2025.115322_bib148","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/j.immuni.2016.02.015","article-title":"Macrophages in tissue repair, regeneration, and fibrosis","volume":"44","author":"Wynn","year":"2016","journal-title":"Immunity"},{"key":"10.1016\/j.fct.2025.115322_bib149","article-title":"MAP3K19 promotes the progression of tuberculosis-induced pulmonary fibrosis through activation of the TGF-\u03b2\/Smad2 Signaling Pathway","author":"Xia","year":"2023","journal-title":"Mol. Biotechnol."},{"key":"10.1016\/j.fct.2025.115322_bib150","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2022.1083432","article-title":"The role of short-chain fatty acids in inflammatory skin diseases","volume":"13","author":"Xiao","year":"2023","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.fct.2025.115322_bib151","doi-asserted-by":"crossref","DOI":"10.3390\/nu15071758","article-title":"Heat-Killed Lacticaseibacillus paracasei repairs lipopolysaccharide-induced intestinal epithelial barrier damage via MLCK\/MLC pathway activation","volume":"15","author":"Xie","year":"2023","journal-title":"Nutrients"},{"key":"10.1016\/j.fct.2025.115322_bib152","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1369\/0022155415627681","article-title":"TGF-\u03b2\/SMAD pathway and its regulation in hepatic fibrosis","volume":"64","author":"Xu","year":"2016","journal-title":"J. Histochem. Cytochem."},{"key":"10.1016\/j.fct.2025.115322_bib153","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.1016\/j.ajpath.2011.06.041","article-title":"Matrix metalloproteinase 3 is a mediator of pulmonary fibrosis","volume":"179","author":"Yamashita","year":"2011","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.fct.2025.115322_bib154","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1183\/09031936.00095609","article-title":"Platelet-activating factor reduces endothelial nitric oxide production: role of acid sphingomyelinase","volume":"36","author":"Yang","year":"2010","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.fct.2025.115322_bib155","first-page":"309","article-title":"Response of superoxide dismutase, catalase, and ATPase activity in bacteria exposed to acetamiprid","volume":"19","author":"Yao","year":"2006","journal-title":"Biomed. Environ. Sci."},{"key":"10.1016\/j.fct.2025.115322_bib156","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1111\/1556-4029.12368","article-title":"Determination of acetamiprid and IM-1-2 in post mortem human blood, liver, stomach contents by HPLC-DAD","volume":"59","author":"Yeter","year":"2014","journal-title":"J. Forensic Sci."},{"key":"10.1016\/j.fct.2025.115322_bib157","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12934-020-01466-2","article-title":"Metabolite secretions of Lactobacillus plantarum YYC-3 may inhibit colon cancer cell metastasis by suppressing the VEGF-MMP2\/9 signaling pathway","volume":"19","author":"Yue","year":"2020","journal-title":"Microb. Cell Fact."},{"key":"10.1016\/j.fct.2025.115322_bib158","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1039\/D2FO02189G","article-title":"Evaluation of the potential anti-soybean allergic activity of different forms of Lactobacillus delbrueckii subsp. bulgaricus based on cell model in vitro","volume":"14","author":"Zhang","year":"2022","journal-title":"Food Funct."},{"key":"10.1016\/j.fct.2025.115322_bib159","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1152\/ajplung.00221.2003","article-title":"DEP-induced fra-1 expression correlates with a distinct activation of AP-1-dependent gene transcription in the lung","volume":"286","author":"Zhang","year":"2004","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"10.1016\/j.fct.2025.115322_bib160","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1002\/jcb.27128","article-title":"Sirtuin 6 inhibits myofibroblast differentiation via inactivating transforming growth factor-\u03b21\/Smad2 and nuclear factor-\u03baB signaling pathways in human fetal lung fibroblasts","volume":"120","author":"Zhang","year":"2019","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.fct.2025.115322_bib161","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1007\/s00128-018-2476-4","article-title":"Occurrence of acetamiprid residues in water reservoirs in the cotton basin of Northern Benin","volume":"102","author":"Zoumenou","year":"2019","journal-title":"Bull. Environ. Contam. Toxicol."}],"container-title":["Food and Chemical Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278691525000894?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278691525000894?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,2,27]],"date-time":"2025-02-27T03:39:51Z","timestamp":1740627591000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0278691525000894"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4]]},"references-count":159,"alternative-id":["S0278691525000894"],"URL":"https:\/\/doi.org\/10.1016\/j.fct.2025.115322","relation":{},"ISSN":["0278-6915"],"issn-type":[{"value":"0278-6915","type":"print"}],"subject":[],"published":{"date-parts":[[2025,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Acetamiprid-induced pulmonary toxicity via oxidative stress, epithelial-mesenchymal transition, apoptosis, and extracellular matrix accumulation in human lung epithelial cells and fibroblasts: Protective role of heat-killed Lactobacilli","name":"articletitle","label":"Article Title"},{"value":"Food and Chemical Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fct.2025.115322","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"115322"}}