{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T05:35:08Z","timestamp":1792128908232,"version":"4.4.0"},"reference-count":62,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004748","name":"Mashhad University of Medical Sciences","doi-asserted-by":"publisher","award":["970859"],"award-info":[{"award-number":["970859"]}],"id":[{"id":"10.13039\/501100004748","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Food and Chemical Toxicology"],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1016\/j.fct.2025.115495","type":"journal-article","created":{"date-parts":[[2025,4,29]],"date-time":"2025-04-29T15:18:09Z","timestamp":1745939889000},"page":"115495","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Evaluation of the effects of Mangiferin on human lymphocytes of healthy individuals and the balance of Th1 and Th2"],"prefix":"10.1016","volume":"202","author":[{"given":"Vahid Reza","family":"Askari","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saeideh","family":"Saadat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vafa","family":"Baradaran Rahimi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elahe","family":"Kamelnia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5736-9755","authenticated-orcid":false,"given":"Mohammad Hossein","family":"Boskabady","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6603","key":"10.1016\/j.fct.2025.115495_bib1","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1038\/383787a0","article-title":"Functional diversity of helper T lymphocytes","volume":"383","author":"Abbas","year":"1996","journal-title":"Nature"},{"issue":"3","key":"10.1016\/j.fct.2025.115495_bib2","doi-asserted-by":"crossref","first-page":"1864","DOI":"10.3390\/ijerph19031864","article-title":"Renoprotective effects of mangiferin: pharmacological advances and future perspectives","volume":"19","author":"Akter","year":"2022","journal-title":"Int. J. Environ. Res. Publ. Health"},{"issue":"2","key":"10.1016\/j.fct.2025.115495_bib3","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1097\/COH.0b013e32833647c2","article-title":"Human and murine Th17","volume":"5","author":"Annunziato","year":"2010","journal-title":"Curr. Opin. HIV AIDS"},{"issue":"4","key":"10.1016\/j.fct.2025.115495_bib4","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.aller.2015.10.002","article-title":"The impact of \u201cRamadan fasting period\u201d on total and differential white blood cells, haematological indices, inflammatory biomarker, respiratory symptoms and pulmonary function tests of healthy and asthmatic patients","volume":"44","author":"Askari","year":"2016","journal-title":"Allergol. Immunopathol."},{"key":"10.1016\/j.fct.2025.115495_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.cyto.2020.155387","article-title":"Immuno-modulatory effects of methanolic extract of Ferula szowitsiana on isolated human Th1\/Th2\/Treg cytokines levels, and their genes expression and nitric oxide production","volume":"138","author":"Askari","year":"2021","journal-title":"Cytokine"},{"issue":"4","key":"10.1016\/j.fct.2025.115495_bib7","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1080\/01480545.2019.1572182","article-title":"Evaluation of the anti-oxidant and anti-inflammatory effects of the methanolic extract of Ferula szowitsiana root on PHA-Induced inflammation in human lymphocytes","volume":"43","author":"Askari","year":"2020","journal-title":"Drug Chem. Toxicol."},{"key":"10.1016\/j.fct.2025.115495_bib8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.phymed.2018.03.049","article-title":"Auraptene regulates Th1\/Th2\/TReg balances, NF-\u03baB nuclear localization and nitric oxide production in normal and Th2 provoked situations in human isolated lymphocytes","volume":"43","author":"Askari","year":"2018","journal-title":"Phytomedicine"},{"issue":"1","key":"10.1016\/j.fct.2025.115495_bib9","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1007\/s43440-020-00083-5","article-title":"Anti-oxidant and anti-inflammatory effects of auraptene on phytohemagglutinin (PHA)-Induced inflammation in human lymphocytes","volume":"73","author":"Askari","year":"2021","journal-title":"Pharmacol. Rep."},{"key":"10.1016\/j.fct.2025.115495_bib10","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1016\/j.jep.2016.10.082","article-title":"The influence of hydro-ethanolic extract of Portulaca oleracea L. on Th1\/Th2 balance in isolated human lymphocytes","volume":"194","author":"Askari","year":"2016","journal-title":"J. Ethnopharmacol."},{"issue":"2","key":"10.1016\/j.fct.2025.115495_bib11","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.ijom.2011.12.011","article-title":"Comparative study of the effect of dexamethasone injection and consumption in lower third molar surgery","volume":"41","author":"Boonsiriseth","year":"2012","journal-title":"Int. J. Oral Maxillofac. Surg."},{"issue":"3","key":"10.1016\/j.fct.2025.115495_bib12","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1016\/j.jep.2013.10.003","article-title":"The impact of Zataria multiflora boiss extract on in vitro and in vivo Th1\/Th2 cytokine (IFN-\u03b3\/IL4) balance","volume":"150","author":"Boskabady","year":"2013","journal-title":"J. Ethnopharmacol."},{"issue":"12","key":"10.1016\/j.fct.2025.115495_bib13","doi-asserted-by":"crossref","first-page":"1538","DOI":"10.1089\/jmf.2011.1697","article-title":"The effect of crocus sativus extract on human lymphocytes' cytokines and T helper 2\/T helper 1 balance","volume":"14","author":"Boskabady","year":"2011","journal-title":"J. Med. Food"},{"issue":"3","key":"10.1016\/j.fct.2025.115495_bib14","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/S0091-6749(97)70255-0","article-title":"Corticosteroid modulation of human, antigen-specific Th1 and Th2 responses","volume":"100","author":"Braun","year":"1997","journal-title":"J. Allergy Clin. Immunol."},{"issue":"1","key":"10.1016\/j.fct.2025.115495_bib15","doi-asserted-by":"crossref","DOI":"10.1038\/srep42683","article-title":"Mangiferin from Pueraria tuberosa reduces inflammation via inactivation of NLRP3 inflammasome","volume":"7","author":"Bulugonda","year":"2017","journal-title":"Sci. Rep."},{"issue":"4","key":"10.1016\/j.fct.2025.115495_bib16","doi-asserted-by":"crossref","first-page":"301","DOI":"10.3109\/08916939409009532","article-title":"Review human Th1 and Th2 cells: functional properties, regulation of development and role in autoimmunity","volume":"18","author":"Carli","year":"1994","journal-title":"Autoimmunity"},{"issue":"8","key":"10.1016\/j.fct.2025.115495_bib17","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1111\/j.1398-9995.2011.02576.x","article-title":"Th17 cells: new players in asthma pathogenesis","volume":"66","author":"Cosmi","year":"2011","journal-title":"Allergy"},{"issue":"1","key":"10.1016\/j.fct.2025.115495_bib18","doi-asserted-by":"crossref","first-page":"164","DOI":"10.4049\/jimmunol.0801998","article-title":"The effects of cytokines on suppression of lymphocyte proliferation by dexamethasone","volume":"183","author":"Creed","year":"2009","journal-title":"J. Immunol."},{"key":"10.1016\/j.fct.2025.115495_bib19","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1146\/annurev-immunol-061020-053702","article-title":"Cytokine regulation and function in T cells","volume":"39","author":"Dong","year":"2021","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.fct.2025.115495_bib20","doi-asserted-by":"crossref","first-page":"987","DOI":"10.3389\/fbioe.2020.00987","article-title":"An inflamed human alveolar model for testing the efficiency of anti-inflammatory drugs in vitro","volume":"8","author":"Drasler","year":"2020","journal-title":"Front. Bioeng. Biotechnol."},{"issue":"6","key":"10.1016\/j.fct.2025.115495_bib21","first-page":"4775","article-title":"Mangiferin: an effective therapeutic agent against several disorders","volume":"18","author":"Du","year":"2018","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.fct.2025.115495_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.jff.2023.105637","article-title":"Promising influences of caffeic acid and caffeic acid phenethyl ester against natural and chemical toxins: a comprehensive and mechanistic review","volume":"107","author":"Ehtiati","year":"2023","journal-title":"J. Funct.Foods"},{"key":"10.1016\/j.fct.2025.115495_bib23","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.amsu.2020.11.027","article-title":"Comparison of efficacy of dexamethasone and methylprednisolone in moderate to severe covid 19 disease","volume":"60","author":"Fatima","year":"2020","journal-title":"Ann. Med. Surg."},{"issue":"4","key":"10.1016\/j.fct.2025.115495_bib24","first-page":"263","article-title":"The effect of safranal on Th1\/Th2 cytokine balance","volume":"13","author":"Feyzi","year":"2016","journal-title":"Iran. J. Immunol."},{"issue":"3","key":"10.1016\/j.fct.2025.115495_bib25","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1007\/s10787-021-00819-6","article-title":"Standardised pomegranate peel extract lavage prevents postoperative peritoneal adhesion by regulating TGF-\u03b2 and VEGF levels","volume":"29","author":"Ghadiri","year":"2021","journal-title":"Inflammopharmacology"},{"key":"10.1016\/j.fct.2025.115495_bib26","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1007\/s00262-006-0225-8","article-title":"Metronomic cyclophosphamide regimen selectively depletes CD4+ CD25+ regulatory T cells and restores T and NK effector functions in end stage cancer patients","volume":"56","author":"Ghiringhelli","year":"2007","journal-title":"Cancer Immunol. Immunother."},{"key":"10.1016\/j.fct.2025.115495_bib27","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.fct.2015.08.028","article-title":"Immunomodulatory and cytotoxic effects of Nigella sativa and thymoquinone on rat splenocytes","volume":"86","author":"Gholamnezhad","year":"2015","journal-title":"Food Chem. Toxicol."},{"issue":"5","key":"10.1016\/j.fct.2025.115495_bib28","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1007\/s10787-021-00865-0","article-title":"Colchicine effectively attenuates inflammatory biomarker high-sensitivity C-reactive protein (hs-CRP) in patients with non-ST-segment elevation myocardial infarction: a randomised, double-blind, placebo-controlled clinical trial","volume":"29","author":"Gholoobi","year":"2021","journal-title":"Inflammopharmacology"},{"key":"10.1016\/j.fct.2025.115495_bib29","series-title":"Immune Function in Sport and Exercise","author":"Gleeson","year":"2006"},{"issue":"2","key":"10.1016\/j.fct.2025.115495_bib30","doi-asserted-by":"crossref","first-page":"7039","DOI":"10.4238\/2015.June.26.13","article-title":"Immunomodulatory effect of bone marrow mesenchymal stem cells on T lymphocytes in patients with decompensated liver cirrhosis","volume":"14","author":"Guo","year":"2015","journal-title":"Genet. Mol. Res."},{"issue":"6","key":"10.1016\/j.fct.2025.115495_bib31","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0100394","article-title":"Mangiferin attenuates TH1\/TH2 cytokine imbalance in an ovalbumin-induced asthmatic mouse model","volume":"9","author":"Guo","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.fct.2025.115495_bib32","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.1028932","article-title":"Mangiferin promotes osteogenic differentiation and alleviates osteoporosis in the ovariectomized mouse via the AXL\/ERK5 pathway","volume":"13","author":"He","year":"2022","journal-title":"Front. Pharmacol."},{"issue":"2","key":"10.1016\/j.fct.2025.115495_bib33","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.phrs.2006.11.004","article-title":"Protective effect of Mangifera indica L. polyphenols on human T lymphocytes against activation-induced cell death","volume":"55","author":"Hernandez","year":"2007","journal-title":"Pharmacol. Res."},{"issue":"1","key":"10.1016\/j.fct.2025.115495_bib34","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12944-017-0449-y","article-title":"Mangiferin: a natural miracle bioactive compound against lifestyle related disorders","volume":"16","author":"Imran","year":"2017","journal-title":"Lipids Health Dis."},{"key":"10.1016\/j.fct.2025.115495_bib35","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/327470","article-title":"T helper lymphocyte subsets and plasticity in autoimmunity and cancer: an overview","volume":"2015","author":"Ivanova","year":"2015","journal-title":"BioMed Res. Int."},{"key":"10.1016\/j.fct.2025.115495_bib36","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1007\/s13596-020-00471-5","article-title":"The multifaceted role of mangiferin in health and diseases: a review","volume":"21","author":"Jangra","year":"2021","journal-title":"Advances in Traditional Medicine"},{"key":"10.1016\/j.fct.2025.115495_bib37","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.fct.2016.11.019","article-title":"Immunomodulatory effect of characterized extract of Zataria multiflora on Th1, Th2 and Th17 in normal and Th2 polarization state","volume":"99","author":"Kianmehr","year":"2017","journal-title":"Food Chem. Toxicol."},{"issue":"3","key":"10.1016\/j.fct.2025.115495_bib38","first-page":"223","article-title":"Th1\/Th2 balance: the hypothesis, its limitations, and implications for health and disease","volume":"8","author":"Kidd","year":"2003","journal-title":"Alternative Med. Rev."},{"issue":"8","key":"10.1016\/j.fct.2025.115495_bib39","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1016\/S0006-2952(03)00041-8","article-title":"In vitro effects of mangiferin on superoxide concentrations and expression of the inducible nitric oxide synthase, tumour necrosis factor-\u03b1 and transforming growth factor-\u03b2 genes","volume":"65","author":"Leiro","year":"2003","journal-title":"Biochem. Pharmacol."},{"issue":"13","key":"10.1016\/j.fct.2025.115495_bib40","doi-asserted-by":"crossref","first-page":"2469","DOI":"10.3390\/foods12132469","article-title":"Mangiferin for the management of liver diseases: a review","volume":"12","author":"Li","year":"2023","journal-title":"Foods"},{"key":"10.1016\/j.fct.2025.115495_bib41","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2023.1189957","article-title":"Neuroprotective potency of mangiferin against 3-nitropropionic acid induced Huntington's disease-like symptoms in rats: possible antioxidant and anti-inflammatory mechanisms","volume":"14","author":"Lum","year":"2023","journal-title":"Front. Pharmacol."},{"issue":"9","key":"10.1016\/j.fct.2025.115495_bib42","doi-asserted-by":"crossref","first-page":"11260","DOI":"10.3390\/ijms130911260","article-title":"Quantification and purification of mangiferin from Chinese mango (Mangifera indica L.) cultivars and its protective effect on human umbilical vein endothelial cells under H2O2-induced stress","volume":"13","author":"Luo","year":"2012","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.fct.2025.115495_bib43","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/5171525","article-title":"Anti-inflammatory activity of ferula assafoetida oleo-gum-resin (asafoetida) against TNF-\u03b1-stimulated human umbilical vein endothelial cells (HUVECs)","volume":"2022","author":"Mobasheri","year":"2022","journal-title":"Mediat. Inflamm."},{"issue":"2","key":"10.1016\/j.fct.2025.115495_bib44","doi-asserted-by":"crossref","DOI":"10.14814\/phy2.15584","article-title":"HPLC\/MS characterization of Syzygium aromaticum L. and evaluation of its effects on peritoneal adhesion: investigating the role of inflammatory cytokines, oxidative factors, and fibrosis and angiogenesis biomarkers","volume":"11","author":"Moradi","year":"2023","journal-title":"Physiological Reports"},{"issue":"1","key":"10.1016\/j.fct.2025.115495_bib45","doi-asserted-by":"crossref","first-page":"79","DOI":"10.3390\/biom11010079","article-title":"Mangiferin as new potential anti-cancer agent and mangiferin-integrated polymer systems\u2014A novel research direction","volume":"11","author":"Morozkina","year":"2021","journal-title":"Biomolecules"},{"issue":"4","key":"10.1016\/j.fct.2025.115495_bib46","first-page":"895","article-title":"The significance application of Indigenous phytohemagglutinin (PHA) mitogen on metaphase and cell culture procedure","volume":"10","author":"Movafagh","year":"2011","journal-title":"Iran. J. Pharm. Res. (IJPR): Int. J. Psychol. Res."},{"issue":"2","key":"10.1016\/j.fct.2025.115495_bib47","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.coi.2011.12.004","article-title":"Transcriptional mechanisms that regulate T helper 1 cell differentiation","volume":"24","author":"Oestreich","year":"2012","journal-title":"Curr. Opin. Immunol."},{"key":"10.1016\/j.fct.2025.115495_bib48","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/5945101","article-title":"Intraperitoneal lavage with crocus sativus prevents postoperative-induced peritoneal adhesion in a rat model: evidence from animal and cellular studies","volume":"2021","author":"Rahmanian-Devin","year":"2021","journal-title":"Oxid. Med. Cell. Longev."},{"issue":"18","key":"10.1016\/j.fct.2025.115495_bib49","doi-asserted-by":"crossref","first-page":"6075","DOI":"10.3390\/molecules27186075","article-title":"Protective effect of Portulaca oleracea on streptozotocin-induced type I diabetes-associated reproductive system dysfunction and inflammation","volume":"27","author":"Rakhshandeh","year":"2022","journal-title":"Molecules"},{"issue":"6","key":"10.1016\/j.fct.2025.115495_bib50","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1055\/a-1118-3918","article-title":"Evaluation of the effects of peritoneal lavage with rosmarinus officinalis extract against the prevention of postsurgical-induced peritoneal adhesion","volume":"86","author":"Roohbakhsh","year":"2020","journal-title":"Planta Med."},{"issue":"16","key":"10.1016\/j.fct.2025.115495_bib51","doi-asserted-by":"crossref","first-page":"4194","DOI":"10.3390\/cancers15164194","article-title":"Nanotechnology-based drug delivery approaches of mangiferin: promises, reality and challenges in cancer chemotherapy","volume":"15","author":"Sarfraz","year":"2023","journal-title":"Cancers"},{"issue":"2","key":"10.1016\/j.fct.2025.115495_bib52","doi-asserted-by":"crossref","first-page":"1328","DOI":"10.3892\/mmr.2017.6752","article-title":"Mangiferin positively regulates osteoblast differentiation and suppresses osteoclast differentiation","volume":"16","author":"Sekiguchi","year":"2017","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.fct.2025.115495_bib53","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1007\/s10787-007-0013-x","article-title":"Role of nitric oxide in inflammatory diseases","volume":"15","author":"Sharma","year":"2007","journal-title":"Inflammopharmacology"},{"key":"10.1016\/j.fct.2025.115495_bib54","doi-asserted-by":"crossref","first-page":"7081","DOI":"10.2147\/JIR.S476288","article-title":"Mangiferin ameliorates CCl4-Triggered acute liver injury by inhibiting inflammatory response and oxidative stress: involving the Nrf2-ARE pathway","author":"Shi","year":"2024","journal-title":"J. Inflamm. Res."},{"issue":"Suppl. l_1","key":"10.1016\/j.fct.2025.115495_bib55","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1269\/jrr.33.SUPPLEMENT_222","article-title":"Combined use of several mitogens for mitotic stimulation to human lymphocytes","volume":"33","author":"Sofuni","year":"1992","journal-title":"J. Radiat. Res."},{"issue":"2","key":"10.1016\/j.fct.2025.115495_bib56","first-page":"149","article-title":"Health benefits of mango (Mangifera indica L.) and mangiferin","volume":"1","author":"Swaroop","year":"2018","journal-title":"Jpn. J. Med."},{"key":"10.1016\/j.fct.2025.115495_bib57","article-title":"Evaluation of protective effects of non-selective cannabinoid receptor agonist WIN 55,212-2 against the nitroglycerine-induced acute and chronic animal models of migraine: a mechanistic study","volume":"232","author":"Vosough","year":"2019","journal-title":"Life Sci."},{"issue":"6","key":"10.1016\/j.fct.2025.115495_bib58","doi-asserted-by":"crossref","first-page":"783","DOI":"10.3390\/ph16060783","article-title":"NF-\u03baB in cell deaths, therapeutic resistance and nanotherapy of tumors: recent advances","volume":"16","author":"Wu","year":"2023","journal-title":"Pharmaceuticals"},{"issue":"9","key":"10.1016\/j.fct.2025.115495_bib59","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1038\/aps.2014.65","article-title":"Timosaponin A3 induces hepatotoxicity in rats through inducing oxidative stress and down-regulating bile acid transporters","volume":"35","author":"Wu","year":"2014","journal-title":"Acta Pharmacol. Sin."},{"issue":"2","key":"10.1016\/j.fct.2025.115495_bib60","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.jphs.2018.05.008","article-title":"Mangiferin alleviates hypertension induced by hyperuricemia via increasing nitric oxide releases","volume":"137","author":"Yang","year":"2018","journal-title":"J. Pharmacol. Sci."},{"key":"10.1016\/j.fct.2025.115495_bib61","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.molimm.2019.07.025","article-title":"Mangiferin suppresses allergic asthma symptoms by decreased Th9 and Th17 responses and increased treg response","volume":"114","author":"Yun","year":"2019","journal-title":"Mol. Immunol."},{"issue":"2","key":"10.1016\/j.fct.2025.115495_bib62","doi-asserted-by":"crossref","first-page":"209","DOI":"10.3109\/1547691X.2015.1043606","article-title":"In vitro anti-inflammatory and immunomodulatory properties of umbelliprenin and methyl galbanate","volume":"13","author":"Zamani Taghizadeh Rabe","year":"2016","journal-title":"J. Immunot."},{"key":"10.1016\/j.fct.2025.115495_bib63","doi-asserted-by":"crossref","first-page":"45","DOI":"10.2174\/9781681081595116020004","article-title":"Allergic asthma pathogenesis and antioxidant therapy","volume":"2","author":"Zuo","year":"2016","journal-title":"Frontiers in Clinical Drug Research\u2013Anti Allergy Agents"}],"container-title":["Food and Chemical Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278691525002637?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278691525002637?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,6,12]],"date-time":"2025-06-12T20:30:08Z","timestamp":1749760208000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0278691525002637"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":62,"alternative-id":["S0278691525002637"],"URL":"https:\/\/doi.org\/10.1016\/j.fct.2025.115495","relation":{},"ISSN":["0278-6915"],"issn-type":[{"value":"0278-6915","type":"print"}],"subject":[],"published":{"date-parts":[[2025,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Evaluation of the effects of Mangiferin on human lymphocytes of healthy individuals and the balance of Th1 and Th2","name":"articletitle","label":"Article Title"},{"value":"Food and Chemical Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fct.2025.115495","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"115495"}}