{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T01:36:49Z","timestamp":1787103409253,"version":"build-2736575974"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004829","name":"Science and Technology Department of Sichuan Province","doi-asserted-by":"publisher","award":["2025ZNSFSC0641"],"award-info":[{"award-number":["2025ZNSFSC0641"]}],"id":[{"id":"10.13039\/501100004829","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004829","name":"Science and Technology Department of Sichuan Province","doi-asserted-by":"publisher","award":["2023YFS0417"],"award-info":[{"award-number":["2023YFS0417"]}],"id":[{"id":"10.13039\/501100004829","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Food and Chemical Toxicology"],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1016\/j.fct.2025.115498","type":"journal-article","created":{"date-parts":[[2025,5,2]],"date-time":"2025-05-02T15:35:46Z","timestamp":1746200146000},"page":"115498","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Prenatal genistein exposure in rats affects pubertal onset and serum reproductive hormone levels in male offsprings via the hypothalamic-pituitary-gonadal axis"],"prefix":"10.1016","volume":"202","author":[{"given":"Jing","family":"Zi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guochen","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifan","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinlong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianqian","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanliu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guo","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9354-862X","authenticated-orcid":false,"given":"Jingyuan","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.fct.2025.115498_bib1","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/S2213-8587(15)00418-0","article-title":"Pubertal development and regulation","volume":"4","author":"Abreu","year":"2016","journal-title":"Lancet Diabetes Endocrinol."},{"issue":"7","key":"10.1016\/j.fct.2025.115498_bib2","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1097\/FBP.0000000000000569","article-title":"Neonatal exposure to genistein affects reproductive physiology and behavior in female and male Long-Evans rats","volume":"31","author":"Ali","year":"2020","journal-title":"Behav. Pharmacol."},{"issue":"8","key":"10.1016\/j.fct.2025.115498_bib3","doi-asserted-by":"crossref","first-page":"1851","DOI":"10.3390\/cells10081851","article-title":"The expanding role of mitochondria, autophagy and lipophagy in steroidogenesis","volume":"10","author":"Bassi","year":"2021","journal-title":"Cells"},{"issue":"4","key":"10.1016\/j.fct.2025.115498_bib4","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1016\/j.jand.2016.10.016","article-title":"Soy isoflavone intake and sleep parameters over 5 years among Chinese adults: longitudinal analysis from the Jiangsu nutrition study","volume":"117","author":"Cao","year":"2017","journal-title":"J. Acad. Nutr. Diet."},{"issue":"12","key":"10.1016\/j.fct.2025.115498_bib5","doi-asserted-by":"crossref","first-page":"2613","DOI":"10.1210\/me.2003-0217","article-title":"An activator protein 1-like motif mediates 17beta-estradiol repression of gonadotropin-releasing hormone receptor promoter via an estrogen receptor alpha-dependent mechanism in ovarian and breast cancer cells","volume":"17","author":"Cheng","year":"2003","journal-title":"Mol. Endocrinol."},{"issue":"2","key":"10.1016\/j.fct.2025.115498_bib6","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/S0890-6238(01)00108-3","article-title":"Placental transfer of the soy isoflavone genistein following dietary and gavage administration to Sprague Dawley rats","volume":"15","author":"Doerge","year":"2001","journal-title":"Reprod. Toxicol."},{"issue":"2","key":"10.1016\/j.fct.2025.115498_bib7","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1080\/03014460.2020.1751286","article-title":"Prenatal anxiety, breastfeeding and child growth and puberty: linking evolutionary models with human cohort studies","volume":"47","author":"English","year":"2020","journal-title":"Ann. Hum. Biol."},{"key":"10.1016\/j.fct.2025.115498_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijheh.2024.114418","article-title":"Association of prenatal exposure to phthalates and synthetic phenols with pubertal development in three European cohorts","volume":"261","author":"Freire","year":"2024","journal-title":"Int. J. Hyg Environ. Health"},{"issue":"2","key":"10.1016\/j.fct.2025.115498_bib9","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1007\/s11934-008-0025-0","article-title":"Associations among hypospadias, cryptorchidism, anogenital distance, and endocrine disruption","volume":"9","author":"Hsieh","year":"2008","journal-title":"Curr. Urol. Rep."},{"issue":"5","key":"10.1016\/j.fct.2025.115498_bib10","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1111\/ppe.12767","article-title":"Breast feeding and timing of puberty in boys and girls: a nationwide cohort study","volume":"35","author":"Hvidt","year":"2021","journal-title":"Paediatr. Perinat. Epidemiol."},{"issue":"7","key":"10.1016\/j.fct.2025.115498_bib11","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1002\/mnfr.200600258","article-title":"Disruption of the developing female reproductive system by phytoestrogens: genistein as an example","volume":"51","author":"Jefferson","year":"2007","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.fct.2025.115498_bib12","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.metabol.2017.11.018","article-title":"The hypothalamus-pituitary-gonad axis: tales of mice and men","volume":"86","author":"Kaprara","year":"2018","journal-title":"Metabolism"},{"issue":"5","key":"10.1016\/j.fct.2025.115498_bib13","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.jnutbio.2011.01.008","article-title":"Circulating isoflavonoid levels in CD-1 mice: effect of oral versus subcutaneous delivery and frequency of administration","volume":"23","author":"Kaludjerovic","year":"2012","journal-title":"J. Nutr. Biochem."},{"issue":"22","key":"10.1016\/j.fct.2025.115498_bib14","doi-asserted-by":"crossref","first-page":"2553","DOI":"10.1161\/CIRCULATIONAHA.106.683755","article-title":"Association of dietary intake of soy, beans, and isoflavones with risk of cerebral and myocardial infarctions in Japanese populations: the Japan Public Health Center-based (JPHC) study cohort I","volume":"116","author":"Kokubo","year":"2007","journal-title":"Circulation"},{"issue":"2","key":"10.1016\/j.fct.2025.115498_bib15","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1095\/biolreprod17.2.298","article-title":"Preputial separation as an external sign of pubertal development in the male rat","volume":"17","author":"Korenbrot","year":"1977","journal-title":"Biol. Reprod."},{"issue":"3","key":"10.1016\/j.fct.2025.115498_bib16","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.reprotox.2010.10.002","article-title":"Neonatal exposure to genistein adversely impacts the ontogeny of hypothalamic kisspeptin signaling pathways and ovarian development in the peripubertal female rat","volume":"31","author":"Losa","year":"2011","journal-title":"Reprod. Toxicol."},{"issue":"2\u20133","key":"10.1016\/j.fct.2025.115498_bib38","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S0300-483X(03)00269-5","article-title":"Impact of dietary exposure to methoxychlor, genistein, or diisononyl phthalate during the perinatal period on the development of the rat endocrine\/reproductive systems in later life","volume":"192","author":"Masutomi","year":"2003","journal-title":"Toxicology"},{"key":"10.1016\/j.fct.2025.115498_bib17","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/B978-1-4557-2758-2.00001-9","article-title":"Neuroendocrinology of reproduction","author":"McCartney","year":"2014","journal-title":"Yen & Jaffe's Reproduct. Endocrinol."},{"issue":"8","key":"10.1016\/j.fct.2025.115498_bib18","first-page":"1032","article-title":"Metabolic syndrome: soybean foods and serum lipids","volume":"96","author":"Merritt","year":"2004","journal-title":"J. Natl. Med. Assoc."},{"key":"10.1016\/j.fct.2025.115498_bib19","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.fct.2016.11.020","article-title":"Altered spermatogenesis, steroidogenesis and suppressed fertility in adult male rats exposed to genistein, a non-steroidal phytoestrogen during embryonic development","volume":"99","author":"Meena","year":"2017","journal-title":"Food Chem. Toxicol."},{"issue":"1","key":"10.1016\/j.fct.2025.115498_bib20","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1007\/s12020-015-0715-6","article-title":"Role of the steroidogenic acute regulatory protein in health and disease","volume":"51","author":"Manna","year":"2016","journal-title":"Endocrine"},{"key":"10.1016\/j.fct.2025.115498_bib21","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/B978-0-08-091906-5.00003-3","article-title":"The hypothalamus and anterior pituitary","author":"Norman","year":"2015","journal-title":"Hormones (Basel)"},{"issue":"2","key":"10.1016\/j.fct.2025.115498_bib22","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1017\/S0029665116000677","article-title":"Endocrine disruption by dietary phyto-oestrogens: impact on dimorphic sexual systems and behaviours","volume":"76","author":"Patisaul","year":"2017","journal-title":"Proc. Nutr. Soc."},{"issue":"3","key":"10.1016\/j.fct.2025.115498_bib23","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1096\/fj.07-9574LSF","article-title":"Dose translation from animal to human studies revisited","volume":"22","author":"Reagan-Shaw","year":"2008","journal-title":"FASEB J."},{"issue":"1","key":"10.1016\/j.fct.2025.115498_bib24","doi-asserted-by":"crossref","DOI":"10.1002\/wrna.1369","article-title":"The organization and regulation of mRNA-protein complexes","volume":"8","author":"Rissland","year":"2017","journal-title":"Wiley Interdiscip. Rev. RNA"},{"issue":"2","key":"10.1016\/j.fct.2025.115498_bib25","doi-asserted-by":"crossref","DOI":"10.1111\/jne.13480","article-title":"The phytoestrogen genistein improves hippocampal neurogenesis and cognitive impairment and decreases neuroinflammation in an animal model of metabolic syndrome","volume":"37","author":"Ronchetti","year":"2025","journal-title":"J. Neuroendocrinol."},{"issue":"6","key":"10.1016\/j.fct.2025.115498_bib26","first-page":"624","article-title":"The laboratory rat: relating its age with human's","volume":"4","author":"Sengupta","year":"2013","journal-title":"Int. J. Prev. Med."},{"key":"10.1016\/j.fct.2025.115498_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.biotechadv.2020.107576","article-title":"Biotransformation of dietary phytoestrogens by gut microbes: a review on bidirectional interaction between phytoestrogen metabolism and gut microbiota","volume":"43","author":"Seyed Hameed","year":"2020","journal-title":"Biotechnol. Adv."},{"issue":"12","key":"10.1016\/j.fct.2025.115498_bib28","doi-asserted-by":"crossref","first-page":"2874","DOI":"10.1271\/bbb.60278","article-title":"Effect of exposure to high isoflavone-containing diets on prenatal and postnatal offspring mice","volume":"70","author":"Takashima-Sasaki","year":"2006","journal-title":"Biosci. Biotechnol. Biochem."},{"issue":"5","key":"10.1016\/j.fct.2025.115498_bib29","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1093\/humupd\/dmac013","article-title":"Prenatal and postnatal exposures to endocrine disrupting chemicals and timing of pubertal onset in girls and boys: a systematic review and meta-analysis","volume":"28","author":"Uldbjerg","year":"2022","journal-title":"Hum. Reprod. Update"},{"issue":"4","key":"10.1016\/j.fct.2025.115498_bib30","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1111\/andr.12840","article-title":"In utero exposure to low doses of genistein and di-(2-ethylhexyl) phthalate (DEHP) alters innate immune cells in neonatal and adult rat testes","volume":"8","author":"Walker","year":"2020","journal-title":"Andrology"},{"issue":"3","key":"10.1016\/j.fct.2025.115498_bib31","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1002\/ptr.5966","article-title":"Comprehensive evaluation of the role of soy and isoflavone supplementation in humans and animals over the past two decades","volume":"32","author":"Xiao","year":"2018","journal-title":"Phytother Res"},{"issue":"24","key":"10.1016\/j.fct.2025.115498_bib32","doi-asserted-by":"crossref","DOI":"10.1002\/mnfr.202200486","article-title":"Impact of physiologically relevant genistein exposure at different time windows on puberty onset and neuroendocrine function in female rats","volume":"66","author":"Xiong","year":"2022","journal-title":"Mol. Nutr. Food Res."},{"issue":"1","key":"10.1016\/j.fct.2025.115498_bib33","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1186\/s12916-022-02320-5","article-title":"Prospective association of dietary soy and fibre intake with puberty timing: a cohort study among Chinese children","volume":"20","author":"Xiong","year":"2022","journal-title":"BMC Med."},{"issue":"1","key":"10.1016\/j.fct.2025.115498_bib34","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1007\/s11154-019-09521-z","article-title":"Endocrine disrupting chemicals: exposure, effects on human health, mechanism of action, models for testing and strategies for prevention","volume":"21","author":"Yilmaz","year":"2020","journal-title":"Rev. Endocr. Metab. Disord."},{"issue":"3","key":"10.1016\/j.fct.2025.115498_bib35","first-page":"1437","article-title":"Genistein attenuates di (2 ethylhexyl) phthalate-induced testicular injuries via activation of Nrf2\/HO 1 following prepubertal exposure","volume":"41","author":"Zhang","year":"2018","journal-title":"Int. J. Mol. Med."},{"issue":"10","key":"10.1016\/j.fct.2025.115498_bib36","first-page":"769","article-title":"Maternal genistein intake can reduce body weight in Male offspring","volume":"28","author":"Zhang","year":"2015","journal-title":"Biomed. Environ. Sci."},{"issue":"1","key":"10.1016\/j.fct.2025.115498_bib37","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1038\/s41467-025-56191-4","article-title":"Cross-trait multivariate GWAS confirms health implications of pubertal timing","volume":"16","author":"Zhou","year":"2025","journal-title":"Nat. Commun."}],"container-title":["Food and Chemical Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278691525002662?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278691525002662?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,6,12]],"date-time":"2025-06-12T20:30:09Z","timestamp":1749760209000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0278691525002662"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":38,"alternative-id":["S0278691525002662"],"URL":"https:\/\/doi.org\/10.1016\/j.fct.2025.115498","relation":{},"ISSN":["0278-6915"],"issn-type":[{"value":"0278-6915","type":"print"}],"subject":[],"published":{"date-parts":[[2025,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Prenatal genistein exposure in rats affects pubertal onset and serum reproductive hormone levels in male offsprings via the hypothalamic-pituitary-gonadal axis","name":"articletitle","label":"Article Title"},{"value":"Food and Chemical Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fct.2025.115498","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"115498"}}