{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T19:06:38Z","timestamp":1793300798483,"version":"4.5.0"},"reference-count":81,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Food and Chemical Toxicology"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1016\/j.fct.2025.115591","type":"journal-article","created":{"date-parts":[[2025,6,4]],"date-time":"2025-06-04T11:10:52Z","timestamp":1749035452000},"page":"115591","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Acetic acid induced-ulcerative colitis is repressed by morin via modulation of CD3\/CD4 mucosal immunity and TLR4\/NF-\u03baB\/ERK1\/2\/IL-6 signalling in rats"],"prefix":"10.1016","volume":"203","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0281-1646","authenticated-orcid":false,"given":"Ghada S.","family":"El-Tanbouly","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5140-1774","authenticated-orcid":false,"given":"Rehab S.","family":"Abdelrahman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.fct.2025.115591_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2020.109276","article-title":"Antiulcerogenic effect of melittin via mitigating TLR4\/TRAF6 mediated NF-\u03baB and p38MAPK pathways in acetic acid-induced ulcerative colitis in mice","volume":"331","author":"Ahmedy","year":"2020","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.fct.2025.115591_bib2","doi-asserted-by":"crossref","first-page":"5633","DOI":"10.3748\/wjg.v19.i34.5633","article-title":"Protective effect of naringenin on acetic acid-induced ulcerative colitis in rats","volume":"19","author":"Al-Rejaie","year":"2013","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.fct.2025.115591_bib3","doi-asserted-by":"crossref","DOI":"10.1007\/s11011-024-01410-y","article-title":"Morin attenuated the global cerebral ischemia via antioxidant, anti-inflammatory, and antiapoptotic mechanisms in rats","author":"Alla","year":"2024","journal-title":"Metab. Brain Dis."},{"key":"10.1016\/j.fct.2025.115591_bib4","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/j.it.2018.04.002","article-title":"The intestinal epithelium: central coordinator of mucosal immunity","volume":"39","author":"Allaire","year":"2018","journal-title":"Trends Immunol."},{"key":"10.1016\/j.fct.2025.115591_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2023.110165","article-title":"Levetiracetam attenuates experimental ulcerative colitis through promoting Nrf2\/HO-1 antioxidant and inhibiting NF-\u03baB, proinflammatory cytokines and iNOS\/NO pathways","volume":"119","author":"Amirshahrokhi","year":"2023","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.fct.2025.115591_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.abb.2020.108552","article-title":"Mechanistic perspective of morin protection against ketoprofen-induced gastric mucosal injury: targeting HMGB1\/RAGE\/NF-\u03baB, DJ-1\/Nrf2\/HO-1 and PI3K\/mTOR pathways","volume":"693","author":"Arab","year":"2020","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.fct.2025.115591_bib7","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1016\/j.toxrep.2022.03.048","article-title":"Aloe vera gel attenuates acetic acid-induced ulcerative colitis in adult male Wistar rats","volume":"9","author":"Babalola","year":"2022","journal-title":"Toxicol. Rep."},{"key":"10.1016\/j.fct.2025.115591_bib8","doi-asserted-by":"crossref","first-page":"6180","DOI":"10.3748\/wjg.v21.i20.6180","article-title":"SGK1 inhibits cellular apoptosis and promotes proliferation via the MEK\/ERK\/p53 pathway in colitis","volume":"21","author":"Bai","year":"2015","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.fct.2025.115591_bib9","first-page":"331","article-title":"Mobilization of CD4+ T lymphocytes in inflamed mucosa reduces pain in colitis mice: toward a vaccinal strategy to alleviate inflammatory visceral pain","volume":"159","author":"Basso","year":"2018","journal-title":"Pain (Amst.)"},{"key":"10.1016\/j.fct.2025.115591_bib10","first-page":"G622","article-title":"Disruption of colonic electrolyte transport in experimental colitis","volume":"268","author":"Bell","year":"1995","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.fct.2025.115591_bib11","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1016\/j.advms.2023.09.010","article-title":"Biological, genetic and epigenetic markers in ulcerative colitis","volume":"68","author":"Caliendo","year":"2023","journal-title":"Adv. Med. Sci."},{"key":"10.1016\/j.fct.2025.115591_bib12","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.crohns.2008.05.004","article-title":"Th17 immune response in IBD: a new pathogenic mechanism","volume":"2","author":"Caprioli","year":"2008","journal-title":"J. Crohns Colitis"},{"key":"10.1016\/j.fct.2025.115591_bib13","first-page":"774","volume":"vol. 23","author":"Caselli","year":"2016"},{"key":"10.1016\/j.fct.2025.115591_bib14","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/9966750","article-title":"Flavonols and flavones as potential anti-Inflammatory, antioxidant, and antibacterial compounds","volume":"2022","author":"Chagas","year":"2022","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.fct.2025.115591_bib15","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1128\/IAI.06101-11","article-title":"Distinct compartmentalization of NF-\u03baB activity in crypt and crypt-denuded lamina propria precedes and accompanies hyperplasia and\/or colitis following bacterial infection","volume":"80","author":"Chandrakesan","year":"2012","journal-title":"Infect. Immun."},{"key":"10.1016\/j.fct.2025.115591_bib16","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1186\/s12943-024-02108-6","article-title":"Discovery of vitexin as a novel VDR agonist that mitigates the transition from chronic intestinal inflammation to colorectal cancer","volume":"23","author":"Chen","year":"2024","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.fct.2025.115591_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2023.110309","article-title":"The coumaric acid and syringic acid ameliorate acetic acid-induced ulcerative colitis in rats via modulator of Nrf2\/HO-1 and pro-inflammatory cytokines","volume":"120","author":"Ekhtiar","year":"2023","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.fct.2025.115591_bib18","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1007\/s10787-022-01016-9","article-title":"The emerging coloprotective effect of sildenafil against ulcerative colitis in rats via exerting counterbalance between NF-\u03baB signaling and Nrf-2\/HO-1 pathway","volume":"30","author":"El-Tanbouly","year":"2022","journal-title":"Inflammopharmacology"},{"key":"10.1016\/j.fct.2025.115591_bib19","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/j.immuni.2005.08.013","article-title":"The role of Erk1 and Erk2 in multiple stages of T cell development","volume":"23","author":"Fischer","year":"2005","journal-title":"Immunity"},{"key":"10.1016\/j.fct.2025.115591_bib20","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1007\/s12026-010-8170-1","article-title":"Signaling through the P38 and ERK pathways: a common link between HIV replication and the immune response","volume":"48","author":"Furler","year":"2010","journal-title":"Immunol. Res."},{"key":"10.1016\/j.fct.2025.115591_bib21","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1038\/nri3707","article-title":"The IL-23\u2013IL-17 immune axis: from mechanisms to therapeutic testing","volume":"14","author":"Gaffen","year":"2014","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.fct.2025.115591_bib22","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/6769789","article-title":"Chlorogenic acid attenuates dextran sodium sulfate\u2010induced ulcerative colitis in mice through MAPK\/ERK\/JNK pathway","volume":"2019","author":"Gao","year":"2019","journal-title":"BioMed Res. Int."},{"key":"10.1016\/j.fct.2025.115591_bib23","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.intimp.2018.02.012","article-title":"Andrographolide derivative CX-10 ameliorates dextran sulphate sodium-induced ulcerative colitis in mice: involvement of NF-\u03baB and MAPK signalling pathways","volume":"57","author":"Gao","year":"2018","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.fct.2025.115591_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2021.111539","article-title":"Morin alleviates hepatic ischemia\/reperfusion-induced mischief: in vivo and in silico contribution of Nrf2, TLR4, and NLRP3","volume":"138","author":"Gendy","year":"2021","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.fct.2025.115591_bib25","doi-asserted-by":"crossref","first-page":"2696","DOI":"10.3390\/ijms24032696","article-title":"CD4 T-cell subsets and the pathophysiology of inflammatory bowel disease","volume":"24","author":"Gomez-Bris","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.fct.2025.115591_bib26","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.phcgj.2013.04.006","article-title":"Morin hydrate: Botanical origin, pharmacological activity and its applications: a mini-review","volume":"5","author":"Gopal","year":"2013","journal-title":"Phcog. J."},{"key":"10.1016\/j.fct.2025.115591_bib27","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.jep.2015.01.039","article-title":"Effect of piperine on inhibition of FFA induced TLR4 mediated inflammation and amelioration of acetic acid induced ulcerative colitis in mice","volume":"164","author":"Gupta","year":"2015","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.fct.2025.115591_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.fbio.2024.104918","article-title":"Fermented licorice extract alleviates ulcerative colitis by inhibiting the TLR4\/NF-\u03baB pathway and rebuilding intestinal microbiota in mice","volume":"61","author":"Hu","year":"2024","journal-title":"Food Biosci."},{"issue":"10","key":"10.1016\/j.fct.2025.115591_bib29","first-page":"9734","article-title":"Citrus limon juice promotes healing of acetic acid-induced ulcerative colitis by enhancing colonic antioxidant defense, immune response, and microbial balance in cadmium exposed Male Wistar rats","volume":"8","author":"Ige","year":"2025","journal-title":"Asian Journal of Research and Reports in Gastroenterology"},{"key":"10.1016\/j.fct.2025.115591_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2022.121187","article-title":"Targeting endoplasmic reticulum stress, Nrf-2\/HO-1, and NF-\u03baB by myristicin and its role in attenuation of ulcerative colitis in rats","volume":"311","author":"Ismail Abo El-Fadl","year":"2022","journal-title":"Life Sci."},{"key":"10.1016\/j.fct.2025.115591_bib31","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/j.intimp.2014.07.020","article-title":"Morin hydrate augments phagocytosis mechanism and inhibits LPS induced autophagic signaling in murine macrophage","volume":"22","author":"Jakhar","year":"2014","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.fct.2025.115591_bib32","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.surg.2010.03.024","article-title":"Lidocaine suppresses mouse Peyer\u2019s Patch T cell functions and induces bacterial translocation","volume":"149","author":"Kawasaki","year":"2011","journal-title":"Surgery"},{"key":"10.1016\/j.fct.2025.115591_bib33","first-page":"12","article-title":"A protective role of nuclear factor-erythroid 2-related factor-2 (Nrf2) in inflammatory disorders","volume":"690","author":"Kim","year":"2010","journal-title":"Mutagenesis"},{"key":"10.1016\/j.fct.2025.115591_bib34","doi-asserted-by":"crossref","first-page":"12099","DOI":"10.1073\/pnas.0705268104","article-title":"IL-6-dependent and -independent pathways in the development of interleukin 17-producing T helper cells","volume":"104","author":"Kimura","year":"2007","journal-title":"PNAS"},{"key":"10.1016\/j.fct.2025.115591_bib35","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/j.immuni.2004.08.018","article-title":"Interleukin-17 family members and inflammation","volume":"21","author":"Kolls","year":"2004","journal-title":"Immunity"},{"key":"10.1016\/j.fct.2025.115591_bib36","doi-asserted-by":"crossref","DOI":"10.3390\/diagnostics10080601","article-title":"Oxidative stress markers in inflammatory bowel diseases: systematic review","volume":"10","author":"Krzystek-Korpacka","year":"2020","journal-title":"Diagnostics"},{"key":"10.1016\/j.fct.2025.115591_bib37","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/162750","article-title":"Chemistry and biological activities of flavonoids: an overview","author":"Kumar","year":"2013","journal-title":"Sci. World J."},{"key":"10.1016\/j.fct.2025.115591_bib38","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1007\/s13205-024-04012-8","article-title":"Morin hydrate ameliorates Di-2-ethylhexyl phthalate (DEHP) induced hepatotoxicity in a mouse model via TNF-\u03b1 and NF-\u03ba\u03b2 signaling","volume":"14","author":"Kumar","year":"2024","journal-title":"3 Biotech"},{"key":"10.1016\/j.fct.2025.115591_bib39","doi-asserted-by":"crossref","first-page":"2209","DOI":"10.1111\/bph.14667","article-title":"Inhibition of phosphodiesterase\u20104 attenuates murine ulcerative colitis through interference with mucosal immunity","volume":"176","author":"Li","year":"2019","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.fct.2025.115591_bib40","doi-asserted-by":"crossref","first-page":"G954","DOI":"10.1152\/ajpgi.00239.2016","article-title":"Somatostatin regulates NHE8 protein expression via the ERK1\/2 MAPK pathway in DSS-induced colitis mice","volume":"311","author":"Li","year":"2016","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.fct.2025.115591_bib41","doi-asserted-by":"crossref","first-page":"1716","DOI":"10.1002\/eji.201242889","article-title":"ERK differentially regulates T h17\u2010and T reg\u2010cell development and contributes to the pathogenesis of colitis","volume":"43","author":"Liu","year":"2013","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.fct.2025.115591_bib42","doi-asserted-by":"crossref","DOI":"10.3390\/ijms17091455","article-title":"Exogenous ghrelin accelerates the healing of acetic acid-induced colitis in rats","volume":"17","author":"Matuszyk","year":"2016","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.fct.2025.115591_bib43","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1007\/s10565-022-09769-3","article-title":"Morin, the PPAR\u03b3 agonist, inhibits Th17 differentiation by limiting fatty acid synthesis in collagen-induced arthritis","volume":"39","author":"Miao","year":"2023","journal-title":"Cell Biol. Toxicol."},{"key":"10.1016\/j.fct.2025.115591_bib44","doi-asserted-by":"crossref","first-page":"1866","DOI":"10.1016\/j.biopha.2018.10.019","article-title":"Crosstalk of toll-like receptors signaling and Nrf2 pathway for regulation of inflammation","volume":"108","author":"Mohan","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.fct.2025.115591_bib45","doi-asserted-by":"crossref","first-page":"3468","DOI":"10.3390\/ijms20143468","article-title":"Interleukin (IL)-22 from IL-20 subfamily of cytokines induces colonic epithelial cell proliferation predominantly through ERK1\/2 pathway","volume":"20","author":"Moniruzzaman","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.fct.2025.115591_bib46","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2024.1390351","article-title":"The emerging role of oxidative stress in inflammatory bowel disease","volume":"15","author":"Muro","year":"2024","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.fct.2025.115591_bib47","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.611256","article-title":"The IL23-IL17 immune axis in the treatment of ulcerative colitis: Successes, defeats, and ongoing challenges","volume":"12","author":"Noviello","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.fct.2025.115591_bib48","doi-asserted-by":"crossref","first-page":"2818","DOI":"10.1096\/fj.09-144295","article-title":"The death effector domain protein PEA-15 negatively regulates T-cell receptor signaling","volume":"24","author":"Pastorino","year":"2010","journal-title":"FASEB J."},{"key":"10.1016\/j.fct.2025.115591_bib49","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1200111","article-title":"The role of Nrf2 in the pathogenesis and treatment of ulcerative colitis","volume":"14","author":"Peng","year":"2023","journal-title":"Front. Immunol."},{"key":"10.1016\/j.fct.2025.115591_bib50","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1038\/s41575-020-0293-9","article-title":"Head-to-head trials in inflammatory bowel disease: past, present and future","volume":"17","author":"Pouillon","year":"2020","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.fct.2025.115591_bib51","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2024.112846","article-title":"Morin alleviates DSS-induced ulcerative colitis in mice via inhibition of inflammation and modulation of intestinal microbiota","volume":"140","author":"Qiu","year":"2024","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.fct.2025.115591_bib52","first-page":"1830","article-title":"Morin exhibits anti-inflammatory effects on IL-1\u03b2-stimulated human osteoarthritis chondrocytes by activating the Nrf2 signaling pathway","volume":"51","author":"Qu","year":"2018","journal-title":"Biochemistry"},{"key":"10.1016\/j.fct.2025.115591_bib53","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2021.111511","article-title":"Morin hydrate: a comprehensive review on novel natural dietary bioactive compound with versatile biological and pharmacological potential","volume":"138","author":"Rajput","year":"2021","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.fct.2025.115591_bib54","doi-asserted-by":"crossref","first-page":"1999","DOI":"10.1007\/s10753-020-01273-2","article-title":"Bupropion ameliorates acetic acid\u2013induced colitis in rat: the involvement of the TLR4\/NF-kB signaling pathway","volume":"43","author":"Rashidian","year":"2020","journal-title":"Inflammation"},{"key":"10.1016\/j.fct.2025.115591_bib55","doi-asserted-by":"crossref","first-page":"1526","DOI":"10.3390\/ijms24021526","article-title":"Pathophysiology of inflammatory bowel disease: Innate immune system","volume":"24","author":"Saez","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.fct.2025.115591_bib56","doi-asserted-by":"crossref","first-page":"1217165","DOI":"10.3389\/fendo.2023.1217165","article-title":"Oxidative stress, hormones, and effects of natural antioxidants on intestinal inflammation in inflammatory bowel disease","volume":"14","author":"Sahoo","year":"2023","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.fct.2025.115591_bib57","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1111\/imm.12672","article-title":"Amelioration of experimental colitis after short-term therapy with glucocorticoid and its relationship to the induction of different regulatory markers","volume":"150","author":"Sales-Campos","year":"2017","journal-title":"Immunology (Oxf.)"},{"key":"10.1016\/j.fct.2025.115591_bib58","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1007\/s00109-013-1003-7","article-title":"ERK controls epithelial cell death receptor signalling and cellular FLICE-like inhibitory protein (c-FLIP) in ulcerative colitis","volume":"91","author":"Seidelin","year":"2013","journal-title":"J. Mol. Med."},{"key":"10.1016\/j.fct.2025.115591_bib60","doi-asserted-by":"crossref","DOI":"10.1007\/s12011-024-04064-0","article-title":"Mitigation of acute hepatotoxicity induced by cadmium through morin: modulation of oxidative and pro-apoptotic endoplasmic reticulum stress and inflammatory responses in rats","author":"Sengul","year":"2024","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.fct.2025.115591_bib61","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1016\/j.biopha.2014.09.006","article-title":"Upregulation of MAPK\/Erk and PI3K\/Akt pathways in ulcerative colitis-associated colon cancer","volume":"68","author":"Setia","year":"2014","journal-title":"Pharmacotherapy"},{"key":"10.1016\/j.fct.2025.115591_bib62","doi-asserted-by":"crossref","first-page":"113","DOI":"10.25122\/jml-2018-0075","article-title":"A review of the diagnosis, prevention, and treatment methods of inflammatory bowel disease","volume":"12","author":"Seyedian","year":"2019","journal-title":"J Med Life"},{"key":"10.1016\/j.fct.2025.115591_bib63","doi-asserted-by":"crossref","first-page":"4139","DOI":"10.3390\/molecules27134139","article-title":"Sinapic acid ameliorates acetic acid-induced ulcerative colitis in rats by suppressing inflammation, oxidative stress, and apoptosis","volume":"27","author":"Shahid","year":"2022","journal-title":"Molecules (Basel)"},{"key":"10.1016\/j.fct.2025.115591_bib64","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1111\/imr.12039","article-title":"CD 4+ T\u2010cell subsets in intestinal inflammation","volume":"252","author":"Shale","year":"2013","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.fct.2025.115591_bib65","doi-asserted-by":"crossref","DOI":"10.1016\/j.etap.2024.104543","article-title":"Morin attenuates sepsis-induced acute kidney injury by regulating inflammatory responses, oxidative stress and tubular regeneration (morin and sepsis-induced acute kidney injury)","volume":"111","author":"Shehata","year":"2024","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"10.1016\/j.fct.2025.115591_bib66","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1097\/MCG.0b013e318151470e","article-title":"Chemical colitis","volume":"42","author":"Sheibani","year":"2008","journal-title":"J. Clin. Gastroenterol."},{"key":"10.1016\/j.fct.2025.115591_bib67","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.intimp.2018.01.031","article-title":"Morin hydrate ameliorates cisplatin-induced ER stress, inflammation and autophagy in HEK-293 cells and mice kidney via PARP-1 regulation","volume":"56","author":"Singh","year":"2018","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.fct.2025.115591_bib68","first-page":"769","article-title":"Morin protects gastric mucosa from nonsteroidal anti-inflammatory drug, indomethacin induced inflammatory damage and apoptosis by modulating NF-\u03baB pathway","volume":"1850","author":"Sinha","year":"2015","journal-title":"BBAG"},{"key":"10.1016\/j.fct.2025.115591_bib69","doi-asserted-by":"crossref","first-page":"1756","DOI":"10.1053\/j.gastro.2011.02.016","article-title":"Proinflammatory cytokines in the pathogenesis of Inflammatory bowel diseases","volume":"140","author":"Strober","year":"2011","journal-title":"Gastroenterology"},{"key":"10.1016\/j.fct.2025.115591_bib70","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.intimp.2017.02.010","article-title":"Protective effects of morin on lipopolysaccharide\/d-galactosamine-induced acute liver injury by inhibiting TLR4\/NF-\u03baB and activating Nrf2\/HO-1 signaling pathways","volume":"45","author":"Tian","year":"2017","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.fct.2025.115591_bib71","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.immuni.2006.01.001","article-title":"TGF\u03b2 in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells","volume":"24","author":"Veldhoen","year":"2006","journal-title":"Immunity"},{"key":"10.1016\/j.fct.2025.115591_bib72","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2020.111680","article-title":"Luteolin ameliorates experimental colitis in mice through ERK-mediated suppression of inflammation, apoptosis and autophagy","volume":"145","author":"Vukeli\u0107","year":"2020","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.fct.2025.115591_bib73","article-title":"Protective effect of methane\u2010rich saline on acetic acid\u2010induced ulcerative colitis via blocking the TLR4\/NF\u2010\u03baB\/MAPK pathway and promoting IL\u201010\/JAK1\/STAT3\u2010Mediated anti\u2010inflammatory response","volume":"2019","author":"Wang","year":"2019","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.fct.2025.115591_bib74","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.molimm.2023.09.002","article-title":"Suppression of mir-150\u20135p attenuates the anti-inflammatory effect of glucocorticoids in mice with ulcerative colitis","volume":"163","author":"Wang","year":"2023","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.fct.2025.115591_bib75","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2024.118733","article-title":"Engeletin attenuates the inflammatory response via inhibiting TLR4-NF\u03baB signaling pathway in Crohn's disease-like colitis","volume":"336","author":"Wei","year":"2025","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.fct.2025.115591_bib76","first-page":"1214","article-title":"The effect of fucoidan on intestinal flora and intestinal barrier function in rats with","volume":"9","author":"Xue","year":"2018","journal-title":"Breast Cancer"},{"key":"10.1016\/j.fct.2025.115591_bib77","doi-asserted-by":"crossref","first-page":"949","DOI":"10.4049\/jimmunol.1201828","article-title":"Paraoxonase-1 suppresses experimental colitis via the inhibition of IFN-\u03b3 production from CD4 T cells","volume":"191","author":"Yamashita","year":"2013","journal-title":"J. Immunol."},{"key":"10.1016\/j.fct.2025.115591_bib78","doi-asserted-by":"crossref","first-page":"2406","DOI":"10.1007\/s10753-022-01701-5","article-title":"Morin inhibits dox-induced vascular inflammation by regulating PTEN\/AKT\/NF-\u03baB pathway","volume":"45","author":"Yu","year":"2022","journal-title":"Inflammation"},{"key":"10.1016\/j.fct.2025.115591_bib79","doi-asserted-by":"crossref","first-page":"2339","DOI":"10.3892\/mmr.2017.6241","article-title":"D-limonene exhibits anti-inflammatory and antioxidant properties in an ulcerative colitis rat model via regulation of iNOS, COX-2. PGE2 and ERK signaling pathways","volume":"15","author":"Yu","year":"2017","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.fct.2025.115591_bib80","first-page":"1012","article-title":"Mechanism of action and therapeutic implications of Nrf2\/HO-1","volume":"13","author":"Yuan","year":"2024","journal-title":"Inflamm. Bowel Dis."},{"key":"10.1016\/j.fct.2025.115591_bib81","first-page":"4054","article-title":"HMGB1-TLR4 signaling participates in renal ischemia reperfusion injury and could be attenuated by dexamethasone-mediated inhibition of the ERK\/NF-\u03baB pathway","volume":"8","author":"Zhang","year":"2016","journal-title":"Am. J. Tourism Res."},{"key":"10.1016\/j.fct.2025.115591_bib82","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1097\/CM9.0000000000001390","article-title":"Potential molecular biomarkers used to predict the response to biological therapies in ulcerative colitis","volume":"134","author":"Zhang","year":"2021","journal-title":"Chin. Med. J."}],"container-title":["Food and Chemical Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S027869152500359X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S027869152500359X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T13:32:09Z","timestamp":1752586329000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S027869152500359X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":81,"alternative-id":["S027869152500359X"],"URL":"https:\/\/doi.org\/10.1016\/j.fct.2025.115591","relation":{},"ISSN":["0278-6915"],"issn-type":[{"value":"0278-6915","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Acetic acid induced-ulcerative colitis is repressed by morin via modulation of CD3\/CD4 mucosal immunity and TLR4\/NF-\u03baB\/ERK1\/2\/IL-6 signalling in rats","name":"articletitle","label":"Article Title"},{"value":"Food and Chemical Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fct.2025.115591","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"115591"}}