{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T18:53:45Z","timestamp":1787424825648,"version":"build-2736575974"},"reference-count":49,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82302903"],"award-info":[{"award-number":["82302903"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82400679"],"award-info":[{"award-number":["82400679"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007101","name":"Liaocheng University","doi-asserted-by":"publisher","award":["31805 2436"],"award-info":[{"award-number":["31805 2436"]}],"id":[{"id":"10.13039\/501100007101","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007101","name":"Liaocheng University","doi-asserted-by":"publisher","award":["2024XT02"],"award-info":[{"award-number":["2024XT02"]}],"id":[{"id":"10.13039\/501100007101","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Shandong Province Natural Science Foundation","doi-asserted-by":"publisher","award":["ZR2023QB257"],"award-info":[{"award-number":["ZR2023QB257"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Shandong Province Natural Science Foundation","doi-asserted-by":"publisher","award":["ZR2024QH006"],"award-info":[{"award-number":["ZR2024QH006"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Food and Chemical Toxicology"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1016\/j.fct.2025.115592","type":"journal-article","created":{"date-parts":[[2025,6,4]],"date-time":"2025-06-04T11:10:55Z","timestamp":1749035455000},"page":"115592","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Mechanisms of aristolochic acid I Hepatotoxicity: Central role of PDK4-Induced mitochondrial dysfunction and hepatic inflammation"],"prefix":"10.1016","volume":"203","author":[{"given":"Zhaobin","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kunyang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqi","family":"Yi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yichen","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pingping","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinghua","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enxiang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.fct.2025.115592_bib1","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1038\/s41584-020-0455-8","article-title":"Cell death in chronic inflammation: breaking the cycle to treat rheumatic disease","volume":"16","author":"Anderton","year":"2020","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.fct.2025.115592_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.hermed.2021.100447","article-title":"Herbal products containing aristolochic acids: a call to revisit the context of safety","volume":"28","author":"Ang","year":"2021","journal-title":"J. Herb. Med."},{"key":"10.1016\/j.fct.2025.115592_bib3","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21031157","article-title":"Aristolochic acid-induced nephrotoxicity: molecular mechanisms and potential protective approaches","volume":"21","author":"Anger","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.fct.2025.115592_bib4","doi-asserted-by":"crossref","first-page":"1882","DOI":"10.4049\/jimmunol.178.3.1882","article-title":"Diverse and potent chemokine production by lung CD11bhigh dendritic cells in homeostasis and in allergic lung inflammation","volume":"178","author":"Beaty","year":"2007","journal-title":"J. Immunol."},{"key":"10.1016\/j.fct.2025.115592_bib5","doi-asserted-by":"crossref","first-page":"5928","DOI":"10.1021\/acs.jafc.6b02203","article-title":"Quantitation of aristolochic acids in corn, wheat grain, and soil samples collected in Serbia: identifying a novel exposure pathway in the etiology of balkan endemic nephropathy","volume":"64","author":"Chan","year":"2016","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.fct.2025.115592_bib6","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.157360","article-title":"Integrated single-cell transcriptomics and proteomics reveal cellular-specific responses and microenvironment remodeling in aristolochic acid nephropathy","volume":"7","author":"Chen","year":"2022","journal-title":"JCI Insight"},{"key":"10.1016\/j.fct.2025.115592_bib7","doi-asserted-by":"crossref","first-page":"4313","DOI":"10.1039\/D3SC04826H","article-title":"STEP: profiling cellular-specific targets and pathways of bioactive small molecules in tissues via integrating single-cell transcriptomics and chemoproteomics","volume":"15","author":"Chen","year":"2024","journal-title":"Chem. Sci."},{"key":"10.1016\/j.fct.2025.115592_bib8","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1038\/s41568-022-00494-x","article-title":"Aristolochic acid-associated cancers: a public health risk in need of global action","volume":"22","author":"Das","year":"2022","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.fct.2025.115592_bib9","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1038\/s41401-023-01052-3","article-title":"Skullcapflavone II, a novel NQO1 inhibitor, alleviates aristolochic acid I-induced liver and kidney injury in mice","volume":"44","author":"Dong","year":"2023","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.fct.2025.115592_bib10","doi-asserted-by":"crossref","first-page":"1887","DOI":"10.1038\/s42255-023-00912-w","article-title":"PDK4-dependent hypercatabolism and lactate production of senescent cells promotes cancer malignancy","volume":"5","author":"Dou","year":"2023","journal-title":"Nat. Metab."},{"key":"10.1016\/j.fct.2025.115592_bib11","doi-asserted-by":"crossref","first-page":"4163","DOI":"10.1007\/s10653-021-00903-4","article-title":"Aristolochic acid I: an investigation into the role of food crops contamination, as a potential natural exposure pathway","volume":"43","author":"Dr\u0103ghia","year":"2021","journal-title":"Environ. Geochem. Health"},{"key":"10.1016\/j.fct.2025.115592_bib12","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1007\/s10653-017-0065-9","article-title":"Balkan endemic nephropathy and aristolochic acid I: an investigation into the role of soil and soil organic matter contamination, as a potential natural exposure pathway","volume":"40","author":"Gruia","year":"2018","journal-title":"Environ. Geochem. Health"},{"key":"10.1016\/j.fct.2025.115592_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.talanta.2022.123261","article-title":"Metabolic study of aristolochic acid I-exposed mice liver by atmospheric pressure matrix-assisted laser desorption\/ionization mass spectrometry imaging and machine learning","volume":"241","author":"Guo","year":"2022","journal-title":"Talanta"},{"key":"10.1016\/j.fct.2025.115592_bib14","doi-asserted-by":"crossref","first-page":"775","DOI":"10.2337\/diabetes.49.5.775","article-title":"Targeted upregulation of pyruvate dehydrogenase kinase (PDK)-4 in slow-twitch skeletal muscle underlies the stable modification of the regulatory characteristics of PDK induced by high-fat feeding","volume":"49","author":"Holness","year":"2000","journal-title":"Diabetes"},{"key":"10.1016\/j.fct.2025.115592_bib15","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1016\/j.tiv.2008.04.002","article-title":"Species-specific toxicity of aristolochic acid (AA) in vitro","volume":"22","author":"Huljic","year":"2008","journal-title":"Toxicol. Vitro"},{"key":"10.1016\/j.fct.2025.115592_bib16","article-title":"p53 activation contributes to patulin-induced nephrotoxicity via modulation of reactive oxygen species generation","volume":"6","author":"Jin","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.fct.2025.115592_bib17","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1038\/s41419-024-06449-4","article-title":"DDRGK1-mediated ER-phagy attenuates acute kidney injury through ER-stress and apoptosis","volume":"15","author":"Jin","year":"2024","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.fct.2025.115592_bib18","article-title":"Anti-cancer natural products and their bioactive compounds inducing ER stress-mediated apoptosis: a review","volume":"10","author":"Kim","year":"2018","journal-title":"Nutrients"},{"key":"10.1016\/j.fct.2025.115592_bib19","doi-asserted-by":"crossref","first-page":"153","DOI":"10.4093\/dmj.2022.0305","article-title":"The link between mitochondrial dysfunction and sarcopenia: an update focusing on the role of pyruvate dehydrogenase kinase 4","volume":"47","author":"Kim","year":"2023","journal-title":"Diabetes Metab. J"},{"key":"10.1016\/j.fct.2025.115592_bib20","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1167\/iovs.65.11.13","article-title":"RNA-seq analysis unraveling novel genes and pathways influencing corneal wound healing","volume":"65","author":"Kumar","year":"2024","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.fct.2025.115592_bib21","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1021\/acs.chemrestox.5b00467","article-title":"Aristolochic acid I causes testis toxicity by inhibiting akt and ERK1\/2 phosphorylation","volume":"29","author":"Kwak","year":"2016","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.fct.2025.115592_bib22","article-title":"Aristolochic acid I exposure decreases oocyte quality","volume":"10","author":"Li","year":"2022","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.fct.2025.115592_bib23","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.toxlet.2020.08.014","article-title":"Aristolochic acid I promotes the invasion and migration of hepatocellular carcinoma cells by activating the C3a\/C3aR complement system","volume":"378","author":"Li","year":"2023","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.fct.2025.115592_bib24","article-title":"Curcumin alleviates aristolochic acid nephropathy based on SIRT1\/Nrf2\/HO-1 signaling pathway","volume":"479","author":"Liu","year":"2022","journal-title":"Toxicology (Amst.)"},{"key":"10.1016\/j.fct.2025.115592_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2022.134111","article-title":"Aristolochic acid I as an emerging biogenic contaminant involved in chronic kidney diseases: a comprehensive review on exposure pathways, environmental health issues and future challenges","volume":"297","author":"Lukinich-Gruia","year":"2022","journal-title":"Chemosphere"},{"key":"10.1016\/j.fct.2025.115592_bib26","doi-asserted-by":"crossref","first-page":"pbac023","DOI":"10.1093\/pcmedi\/pbac023","article-title":"Dissection of cellular and molecular mechanisms of aristolochic acid-induced hepatotoxicity via single-cell transcriptomics","volume":"5","author":"Luo","year":"2022","journal-title":"Precis. Clin. Med."},{"key":"10.1016\/j.fct.2025.115592_bib27","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.mce.2018.08.012","article-title":"Restoring mitochondrial biogenesis with metformin attenuates \u03b2-GP-induced phenotypic transformation of VSMCs into an osteogenic phenotype via inhibition of PDK4\/oxidative stress-mediated apoptosis","volume":"479","author":"Ma","year":"2019","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.fct.2025.115592_bib28","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1016\/j.cell.2012.02.035","article-title":"Mitochondria: in sickness and in health","volume":"148","author":"Nunnari","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.fct.2025.115592_bib29","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1016\/j.kint.2016.10.011","article-title":"Pyruvate dehydrogenase kinase 4 deficiency attenuates cisplatin-induced acute kidney injury","volume":"91","author":"Oh","year":"2017","journal-title":"Kidney Int."},{"key":"10.1016\/j.fct.2025.115592_bib30","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1038\/ncb1087","article-title":"ASC is a bax adaptor and regulates the p53-Bax mitochondrial apoptosis pathway","volume":"6","author":"Ohtsuka","year":"2004","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.fct.2025.115592_bib31","doi-asserted-by":"crossref","DOI":"10.3390\/antiox11071394","article-title":"Macrophage polarization and reprogramming in acute inflammation: a redox perspective","volume":"11","author":"P\u00e9rez","year":"2022","journal-title":"Antioxidants"},{"key":"10.1016\/j.fct.2025.115592_bib32","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.mito.2019.07.009","article-title":"Upregulated PDK4 expression is a sensitive marker of increased fatty acid oxidation","volume":"49","author":"Pettersen","year":"2019","journal-title":"Mitochondrion (Amst.)"},{"key":"10.1016\/j.fct.2025.115592_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2022.113480","article-title":"Fetal exposure of aristolochic acid I undermines ovarian reserve by disturbing primordial folliculogenesis","volume":"236","author":"Qiqi","year":"2022","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.fct.2025.115592_bib34","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1146\/annurev.pathmechdis.3.121806.151456","article-title":"The inflammatory response to cell death","volume":"3","author":"Rock","year":"2008","journal-title":"Annu. Rev. Pathol."},{"key":"10.1016\/j.fct.2025.115592_bib35","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1016\/j.it.2023.10.004","article-title":"Macrophage phenotypes and functions: resolving inflammation and restoring homeostasis","volume":"44","author":"Rodr\u00edguez-Morales","year":"2023","journal-title":"Trends Immunol."},{"key":"10.1016\/j.fct.2025.115592_bib36","doi-asserted-by":"crossref","first-page":"1814","DOI":"10.1093\/carcin\/bgu095","article-title":"Bioactivation of the human carcinogen aristolochic acid","volume":"35","author":"Sidorenko","year":"2014","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.fct.2025.115592_bib37","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.freeradbiomed.2023.05.009","article-title":"Aristolochic acid I exposure triggers ovarian dysfunction by activating NLRP3 inflammasome and affecting mitochondrial homeostasis","volume":"204","author":"Sun","year":"2023","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.fct.2025.115592_bib38","doi-asserted-by":"crossref","first-page":"8298","DOI":"10.7150\/thno.46934","article-title":"ATF6 aggravates acinar cell apoptosis and injury by regulating p53\/AIFM2 transcription in severe acute pancreatitis","volume":"10","author":"Tan","year":"2020","journal-title":"Theranostics"},{"key":"10.1016\/j.fct.2025.115592_bib39","doi-asserted-by":"crossref","first-page":"4277","DOI":"10.1111\/jcmm.17451","article-title":"Aristolochic acid I induces proximal tubule injury through ROS\/HMGB1\/mt DNA mediated activation of TLRs","volume":"26","author":"Upadhyay","year":"2022","journal-title":"J. Cell Mol. Med."},{"key":"10.1016\/j.fct.2025.115592_bib40","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1093\/toxres\/tfac002","article-title":"Exposure to aristolochic acid I is associated with poor prognosis of liver cancer patients","volume":"11","author":"Wang","year":"2022","journal-title":"Toxicol. Res."},{"key":"10.1016\/j.fct.2025.115592_bib41","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2022.102494","article-title":"Lycopene attenuates the inflammation and apoptosis in aristolochic acid nephropathy by targeting the Nrf2 antioxidant system","volume":"57","author":"Wang","year":"2022","journal-title":"Redox Biol."},{"key":"10.1016\/j.fct.2025.115592_bib42","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1293\/tox.2022-0112","article-title":"Macrophage pathology in hepatotoxicity","volume":"36","author":"Yamate","year":"2023","journal-title":"J. Toxicol. Pathol."},{"key":"10.1016\/j.fct.2025.115592_bib43","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1002\/(SICI)1096-9861(19991011)413:1<168::AID-CNE12>3.0.CO;2-Y","article-title":"p53 and bax: putative death factors in taste cell turnover","volume":"413","author":"Zeng","year":"1999","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.fct.2025.115592_bib44","article-title":"Glycycoumarin inhibits hepatocyte lipoapoptosis through activation of autophagy and inhibition of ER stress\/GSK-3-mediated mitochondrial pathway","volume":"6","author":"Zhang","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.fct.2025.115592_bib45","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.fct.2018.11.011","article-title":"The functional role of bax\/bak in palmitate-induced lipoapoptosis","volume":"123","author":"Zhang","year":"2019","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.fct.2025.115592_bib46","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1194\/jlr.RA119000336","article-title":"Hepatic PLIN5 signals via SIRT1 to promote autophagy and prevent inflammation during fasting","volume":"61","author":"Zhang","year":"2020","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.fct.2025.115592_bib47","doi-asserted-by":"crossref","first-page":"2003","DOI":"10.7150\/ijbs.69618","article-title":"Dissection of targeting molecular mechanisms of aristolochic acid-induced nephrotoxicity via a combined deconvolution strategy of chemoproteomics and metabolomics","volume":"18","author":"Zhang","year":"2022","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.fct.2025.115592_bib48","first-page":"349","article-title":"Hepatotoxic effects of aristolochic acid: mechanisms and implications","volume":"3","author":"Zhang","year":"2024","journal-title":"Acta Mater. Medica."},{"key":"10.1016\/j.fct.2025.115592_bib49","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1080\/15376516.2023.2250429","article-title":"Aristolochic acid I aggravates oxidative stress-mediated apoptosis by inhibiting APE1\/Nrf2\/HO-1 signaling","volume":"34","author":"Zhang","year":"2024","journal-title":"Toxicol. Mech. Methods"}],"container-title":["Food and Chemical Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278691525003606?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278691525003606?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T10:47:58Z","timestamp":1777546078000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0278691525003606"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":49,"alternative-id":["S0278691525003606"],"URL":"https:\/\/doi.org\/10.1016\/j.fct.2025.115592","relation":{},"ISSN":["0278-6915"],"issn-type":[{"value":"0278-6915","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mechanisms of aristolochic acid I Hepatotoxicity: Central role of PDK4-Induced mitochondrial dysfunction and hepatic inflammation","name":"articletitle","label":"Article Title"},{"value":"Food and Chemical Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fct.2025.115592","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"115592"}}