{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T07:13:38Z","timestamp":1778742818663,"version":"3.51.4"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2020YFA0803900"],"award-info":[{"award-number":["2020YFA0803900"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82030111"],"award-info":[{"award-number":["82030111"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81701463"],"award-info":[{"award-number":["81701463"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Food and Chemical Toxicology"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1016\/j.fct.2025.115598","type":"journal-article","created":{"date-parts":[[2025,6,10]],"date-time":"2025-06-10T02:46:49Z","timestamp":1749523609000},"page":"115598","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Prenatal acetaminophen exposure induces changes of placental morphology and function and its influencing factors"],"prefix":"10.1016","volume":"203","author":[{"given":"Ziyi","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuxi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zheng","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5300-8661","authenticated-orcid":false,"given":"Hui","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.fct.2025.115598_bib1","doi-asserted-by":"crossref","DOI":"10.1093\/eep\/dvz010","article-title":"Acetaminophen use during pregnancy and DNA methylation in the placenta of the extremely low gestational age newborn (ELGAN) cohort","volume":"5","author":"Addo","year":"2019","journal-title":"Environ. Epigenet."},{"key":"10.1016\/j.fct.2025.115598_bib2","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1093\/toxsci\/kfaa160","article-title":"Acetaminophen modulates the expression of steroidogenesis-associated genes and estradiol levels in human placental JEG-3 cells","volume":"179","author":"Addo","year":"2021","journal-title":"Toxicol. Sci. : Off. J. Soc. Toxicol."},{"key":"10.1016\/j.fct.2025.115598_bib3","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/j.siny.2017.07.006","article-title":"Perinatal and neonatal use of paracetamol for pain relief","volume":"22","author":"Allegaert","year":"2017","journal-title":"Semin. Fetal Neonatal Med."},{"key":"10.1016\/j.fct.2025.115598_bib4","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1016\/j.placenta.2013.06.309","article-title":"Placental ABCA1 and ABCG1 expression in gestational disease: Pre-eclampsia affects ABCA1 levels in syncytiotrophoblasts","volume":"34","author":"Baumann","year":"2013","journal-title":"Placenta (Eastbourne)"},{"key":"10.1016\/j.fct.2025.115598_bib5","first-page":"2517","article-title":"Over-the-counter medications in pregnancy","volume":"67","author":"Black","year":"2003","journal-title":"Am. Fam. Physician"},{"key":"10.1016\/j.fct.2025.115598_bib6","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.bbr.2017.01.051","article-title":"Paracetamol - effect of early exposure on neurotransmission, spatial memory and motor performance in rats","volume":"323","author":"Blecharz-Klin","year":"2017","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.fct.2025.115598_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2024.116980","article-title":"The characterization of developmental toxicity in fetal offspring induced by acetaminophen exposure during pregnancy","volume":"283","author":"Chen","year":"2024","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.fct.2025.115598_bib8","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.lfs.2017.10.031","article-title":"ABCA1 affects placental function via trophoblast and macrophage","volume":"191","author":"Chengmao","year":"2017","journal-title":"Life Sci."},{"key":"10.1016\/j.fct.2025.115598_bib9","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1038\/nature00819","article-title":"Placental-specific IGF-II is a major modulator of placental and fetal growth","volume":"417","author":"Constancia","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.fct.2025.115598_bib10","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.ejogrb.2011.10.005","article-title":"Gene expression patterns of insulin-like growth factor 1, 2 (IGF-1, IGF-2) and insulin-like growth factor binding protein 3 (IGFBP-3) in human placenta from preterm deliveries: influence of additional factors","volume":"160","author":"Demendi","year":"2012","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"key":"10.1016\/j.fct.2025.115598_bib11","doi-asserted-by":"crossref","first-page":"7189","DOI":"10.3390\/molecules19067189","article-title":"Effects of the total saponins from Rosa laevigata michx fruit against acetaminophen-induced liver damage in mice via induction of autophagy and suppression of inflammation and apoptosis","volume":"19","author":"Dong","year":"2014","journal-title":"Molecules"},{"key":"10.1016\/j.fct.2025.115598_bib12","doi-asserted-by":"crossref","first-page":"2642","DOI":"10.1093\/humrep\/dew196","article-title":"Prenatal paracetamol exposure is associated with shorter anogenital distance in Male infants","volume":"31","author":"Fisher","year":"2016","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.fct.2025.115598_bib13","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1016\/S0143-4004(03)00080-8","article-title":"The insulin-like growth factors and feto-placental growth","volume":"24","author":"Fowden","year":"2003","journal-title":"Placenta (Eastbourne)"},{"key":"10.1016\/j.fct.2025.115598_bib14","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1002\/bdr2.1696","article-title":"Update on the gestational effects of maternal hyperthermia","volume":"112","author":"Graham","year":"2020","journal-title":"birth defects res"},{"key":"10.1016\/j.fct.2025.115598_bib15","first-page":"215","article-title":"Placental transport of nutrients to the fetus","volume":"42","author":"Hay","year":"1994","journal-title":"Horm. Res."},{"key":"10.1016\/j.fct.2025.115598_bib16","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1530\/REP-17-0165","article-title":"Prenatal exposure to paracetamol\/acetaminophen and precursor aniline impairs masculinisation of Male brain and behaviour","volume":"154","author":"Hay-Schmidt","year":"2017","journal-title":"Reproduction"},{"key":"10.1016\/j.fct.2025.115598_bib18","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1016\/j.placenta.2013.08.010","article-title":"Placental glucose transporter 3 (GLUT3) is up-regulated in human pregnancies complicated by late-onset intrauterine growth restriction","volume":"34","author":"Janzen","year":"2013","journal-title":"Placenta (Eastbourne)"},{"key":"10.1016\/j.fct.2025.115598_bib19","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1016\/j.earlhumdev.2007.07.016","article-title":"Morphological and biological effects of maternal exposure to tobacco smoke on the feto-placental unit","volume":"83","author":"Jauniaux","year":"2007","journal-title":"Early Hum. Dev."},{"key":"10.1016\/j.fct.2025.115598_bib20","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.placenta.2016.12.008","article-title":"Review: sexual dimorphism in the formation, function and adaptation of the placenta","volume":"54","author":"Kalisch-Smith","year":"2017","journal-title":"Placenta (Eastbourne)"},{"key":"10.1016\/j.fct.2025.115598_bib21","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/s13293-017-0138-6","article-title":"Sex differences in rat placental development: from pre-implantation to late gestation","volume":"8","author":"Kalisch-Smith","year":"2017","journal-title":"Biol. Sex Differ."},{"key":"10.1016\/j.fct.2025.115598_bib22","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1080\/15563650903232345","article-title":"The FDA acetaminophen advisory committee meeting - what is the future of acetaminophen in the United States? The perspective of a committee member","volume":"47","author":"Krenzelok","year":"2009","journal-title":"Clin. Toxicol."},{"key":"10.1016\/j.fct.2025.115598_bib23","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/S0303-7207(01)00629-3","article-title":"Enhanced placental GLUT1 and GLUT3 expression in dexamethasone-induced fetal growth retardation","volume":"185","author":"Langdown","year":"2001","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.fct.2025.115598_bib24","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1016\/j.earlhumdev.2006.02.001","article-title":"Expression pattern of fatty acid transport protein-1 (FATP-1), FATP-4 and heart-fatty acid binding protein (H-FABP) genes in human term placenta","volume":"82","author":"Larque","year":"2006","journal-title":"Early Hum. Dev."},{"key":"10.1016\/j.fct.2025.115598_bib25","first-page":"292","article-title":"Placental regulation of fetal nutrient supply","volume":"16","author":"Larque","year":"2013","journal-title":"Curr. Opin. Clin. Nutr. Metab. Care"},{"key":"10.1016\/j.fct.2025.115598_bib26","doi-asserted-by":"crossref","first-page":"7901","DOI":"10.3390\/molecules28237901","article-title":"Natural products for acetaminophen-induced acute liver injury: a review","volume":"28","author":"Li","year":"2023","journal-title":"Molecules"},{"key":"10.1016\/j.fct.2025.115598_bib27","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1001\/jamapediatrics.2013.4914","article-title":"Acetaminophen use during pregnancy, behavioral problems, and hyperkinetic disorders","volume":"168","author":"Liew","year":"2014","journal-title":"JAMA Pediatr."},{"key":"10.1016\/j.fct.2025.115598_bib28","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1016\/j.cmet.2023.06.007","article-title":"Fetal manipulation of maternal metabolism is a critical function of the imprinted Igf2 gene","volume":"35","author":"Lopez-Tello","year":"2023","journal-title":"Cell Metab."},{"key":"10.1016\/j.fct.2025.115598_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.jnutbio.2021.108601","article-title":"Supplementation with high-dose cholecalciferol throughout pregnancy induces fetal growth restriction through inhibiting placental proliferation and trophoblast epithelial-mesenchymal transition","volume":"91","author":"Ma","year":"2021","journal-title":"J. Nutr. Biochem."},{"key":"10.1016\/j.fct.2025.115598_bib30","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1093\/ije\/dyv366","article-title":"Prenatal and infant paracetamol exposure and development of asthma: the Norwegian mother and child cohort study","volume":"45","author":"Magnus","year":"2016","journal-title":"Int. J. Epidemiol."},{"key":"10.1016\/j.fct.2025.115598_bib31","doi-asserted-by":"crossref","first-page":"1817","DOI":"10.1093\/aje\/kwy086","article-title":"Prenatal exposure to acetaminophen and risk for attention deficit hyperactivity disorder and autistic spectrum disorder: a systematic review, meta-analysis, and meta-regression analysis of cohort studies","volume":"187","author":"Masarwa","year":"2018","journal-title":"Am. J. Epidemiol."},{"key":"10.1016\/j.fct.2025.115598_bib32","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.yfrne.2015.09.001","article-title":"The omniscient placenta: metabolic and epigenetic regulation of fetal programming","volume":"39","author":"Nugent","year":"2015","journal-title":"Front. Neuroendocrinol."},{"key":"10.1016\/j.fct.2025.115598_bib33","article-title":"An antioxidant enzyme therapeutic for COVID-19","volume":"32","author":"Qin","year":"2020","journal-title":"Adv. Mater."},{"key":"10.1016\/j.fct.2025.115598_bib34","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1096\/fj.07-9574LSF","article-title":"Dose translation from animal to human studies revisited","volume":"22","author":"Reagan-Shaw","year":"2008","journal-title":"FASEB J."},{"key":"10.1016\/j.fct.2025.115598_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbr.2021.113294","article-title":"Perinatal exposure to paracetamol: dose and sex-dependent effects in behaviour and brain's oxidative stress markers in progeny","volume":"408","author":"Rigobello","year":"2021","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.fct.2025.115598_bib36","first-page":"2192","article-title":"Up-regulation by progesterone of proliferating cell nuclear antigen and epidermal growth factor expression in human uterine leiomyoma","volume":"83","author":"Shimomura","year":"1998","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.fct.2025.115598_bib37","doi-asserted-by":"crossref","first-page":"B14","DOI":"10.1016\/j.ajog.2017.01.021","article-title":"Prenatal acetaminophen use and outcomes in children","volume":"216","year":"2017","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.fct.2025.115598_bib38","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/j.jaci.2014.07.065","article-title":"Prenatal and infant exposure to acetaminophen and ibuprofen and the risk for wheeze and asthma in children","volume":"135","author":"Sordillo","year":"2015","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.fct.2025.115598_bib39","first-page":"650","volume":"32","author":"Stanirowski","year":"2019","journal-title":"Int. Soc. Perinatal Obstet"},{"key":"10.1016\/j.fct.2025.115598_bib40","doi-asserted-by":"crossref","first-page":"4239","DOI":"10.1210\/jc.2019-00335","article-title":"Placental sonic hedgehog pathway regulates fetal growth via the IGF axis in preeclampsia","volume":"104","author":"Takai","year":"2019","journal-title":"J. Clin. Endocrinol. Metabol."},{"key":"10.1016\/j.fct.2025.115598_bib41","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1002\/(SICI)1097-0177(199903)214:3<248::AID-AJA8>3.0.CO;2-N","article-title":"Expression of matrix metalloproteinases during murine chorioallantoic placenta maturation","volume":"214","author":"Teesalu","year":"1999","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.fct.2025.115598_bib42","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.jri.2012.10.014","article-title":"Acetaminophen and pregnancy: Short- and long-term consequences for mother and child","volume":"97","author":"Thiele","year":"2013","journal-title":"J. Reprod. Immunol."},{"key":"10.1016\/j.fct.2025.115598_bib43","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.acthis.2011.02.002","article-title":"Immunolocalization of PCNA, Ki67, p27 and p57 in normal and dexamethasone-induced intrauterine growth restriction placental development in rat","volume":"114","author":"Unek","year":"2012","journal-title":"Acta Histochem."},{"key":"10.1016\/j.fct.2025.115598_bib44","first-page":"5646","article-title":"Impact of perinatal exposure to acetaminophen on hepatocellular metabolic function in offspring","volume":"8","author":"Wu","year":"2016","journal-title":"Am. J. Tourism Res."},{"key":"10.1016\/j.fct.2025.115598_bib45","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1093\/humupd\/dmaa042","article-title":"Over-the-counter analgesics during pregnancy: a comprehensive review of global prevalence and offspring safety","volume":"27","author":"Zafeiri","year":"2021","journal-title":"Hum. Reprod. Update"},{"key":"10.1016\/j.fct.2025.115598_bib46","doi-asserted-by":"crossref","DOI":"10.1016\/j.jnutbio.2021.108760","article-title":"Counter-directed leucine gradient promotes amino acid transfer across the human placenta","volume":"96","author":"Zaugg","year":"2021","journal-title":"J. Nutr. Biochem."}],"container-title":["Food and Chemical Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278691525003667?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278691525003667?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T06:54:43Z","timestamp":1778741683000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0278691525003667"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":45,"alternative-id":["S0278691525003667"],"URL":"https:\/\/doi.org\/10.1016\/j.fct.2025.115598","relation":{},"ISSN":["0278-6915"],"issn-type":[{"value":"0278-6915","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Prenatal acetaminophen exposure induces changes of placental morphology and function and its influencing factors","name":"articletitle","label":"Article Title"},{"value":"Food and Chemical Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fct.2025.115598","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"115598"}}