{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T14:46:38Z","timestamp":1785941198026,"version":"3.56.0"},"reference-count":61,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,8,18]],"date-time":"2025-08-18T00:00:00Z","timestamp":1755475200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100014440","name":"Spain Ministry of Science Innovation and Universities","doi-asserted-by":"publisher","award":["PID2020-115348RB-I00"],"award-info":[{"award-number":["PID2020-115348RB-I00"]}],"id":[{"id":"10.13039\/100014440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004895","name":"European Social Fund Plus","doi-asserted-by":"publisher","award":["PRE2021 -096942"],"award-info":[{"award-number":["PRE2021 -096942"]}],"id":[{"id":"10.13039\/501100004895","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004895","name":"European Social Fund Plus","doi-asserted-by":"publisher","award":["MCIN\/AEI\/10.13039\/501100011033"],"award-info":[{"award-number":["MCIN\/AEI\/10.13039\/501100011033"]}],"id":[{"id":"10.13039\/501100004895","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004837","name":"Ministerio de Ciencia e Innovaci\u00f3n","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011033","name":"Agencia Estatal de Investigaci\u00f3n","doi-asserted-by":"publisher","award":["MCIN \/ AEI \/10.13039\/501100011033"],"award-info":[{"award-number":["MCIN \/ AEI \/10.13039\/501100011033"]}],"id":[{"id":"10.13039\/501100011033","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011033","name":"Agencia Estatal de Investigaci\u00f3n","doi-asserted-by":"publisher","award":["FPU21\/03187"],"award-info":[{"award-number":["FPU21\/03187"]}],"id":[{"id":"10.13039\/501100011033","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Food and Chemical Toxicology"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.fct.2025.115663","type":"journal-article","created":{"date-parts":[[2025,7,22]],"date-time":"2025-07-22T23:04:16Z","timestamp":1753225456000},"page":"115663","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Evaluation of potassium bromate as a positive control in the in vivo Fpg-modified comet assay for the detection of oxidised bases"],"prefix":"10.1016","volume":"205","author":[{"given":"E.","family":"Saenz-Martinez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-6198-6958","authenticated-orcid":false,"given":"M.","family":"Collia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7693-0560","authenticated-orcid":false,"given":"A.","family":"Rodriguez-Garraus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.G.","family":"Gil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Lopez de Cerain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4857-9931","authenticated-orcid":false,"given":"A.","family":"Azqueta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.fct.2025.115663_bib1","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1016\/j.chemosphere.2011.12.073","article-title":"Oral administration of potassium bromate, a major water disinfection by-product, induces oxidative stress and impairs the antioxidant power of rat blood","volume":"87","author":"Ahmad","year":"2012","journal-title":"Chemosphere"},{"key":"10.1016\/j.fct.2025.115663_bib2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12993-016-0098-8","article-title":"Oral administration of potassium bromate induces neurobehavioral changes, alters cerebral neurotransmitters level and impairs brain tissue of Swiss mice","volume":"12","author":"Ajarem","year":"2016","journal-title":"Behav. Brain Funct."},{"key":"10.1016\/j.fct.2025.115663_bib3","article-title":"The protective effect of arbutin against potassium bromate-induced oxidative damage in the rat brain","volume":"37","author":"Akkoyun","year":"2022","journal-title":"J. Biochem. Mol. Toxicol."},{"key":"10.1016\/j.fct.2025.115663_bib4","doi-asserted-by":"crossref","first-page":"2355","DOI":"10.1007\/s00210-020-01938-7","article-title":"Chemopreventive effect of riboflavin on the potassium bromate \u2013 induced renal toxicity in vivo","volume":"393","author":"Alhazza","year":"2020","journal-title":"Naunyn-Schmiedebergs Arch Pharmacol"},{"key":"10.1016\/j.fct.2025.115663_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.mrgentox.2022.503481","article-title":"Potassium bromate-induced oxidative stress, genotoxicity and cytotoxicity in the blood and liver cells of mice","volume":"878","author":"Al-Mareed","year":"2022","journal-title":"Mutat. Res., Genet. Toxicol. Environ. Mutagen."},{"key":"10.1016\/j.fct.2025.115663_bib7","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1007\/s00204-013-1070-0","article-title":"The essential comet assay: a comprehensive guide to measuring DNA damage and repair","volume":"87","author":"Azqueta","year":"2013","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.fct.2025.115663_bib8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fgene.2014.00288","article-title":"Comet assay to measure DNA repair: approach and applications","volume":"5","author":"Azqueta","year":"2014","journal-title":"Front. Genet."},{"key":"10.1016\/j.fct.2025.115663_bib9","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.mrgentox.2019.04.007","article-title":"Technical recommendations to perform the alkaline standard and enzyme-modified comet assay in human biomonitoring studies","volume":"843","author":"Azqueta","year":"2019","journal-title":"Mutat. Res., Genet. Toxicol. Environ. Mutagen."},{"key":"10.1016\/j.fct.2025.115663_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.mrrev.2019.108288","article-title":"Application of the comet assay in human biomonitoring: an hCOMET perspective","volume":"783","author":"Azqueta","year":"2020","journal-title":"Mutat. Res., Rev. Mutat. Res."},{"key":"10.1016\/j.fct.2025.115663_bib11","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1093\/carcin\/16.2.335","article-title":"Oxidative DNA damage induced by potassium bromate under cell-free conditions and in mammalian cells","volume":"16","author":"Ballmaier","year":"1995","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.fct.2025.115663_bib12","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.tox.2006.01.009","article-title":"DNA damage by bromate : mechanism and consequences","volume":"221","author":"Ballmaier","year":"2006","journal-title":"Toxicology"},{"key":"10.1016\/j.fct.2025.115663_bib13","doi-asserted-by":"crossref","first-page":"611","DOI":"10.18388\/abp.2001_3895","article-title":"Detection of alkylation damage in human lymphocyte DNA with the comet assay","volume":"48","author":"Collins","year":"2001","journal-title":"Acta Biochim. Pol."},{"key":"10.1016\/j.fct.2025.115663_bib14","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1016\/j.bbagen.2013.04.022","article-title":"Measuring oxidative damage to DNA and its repair with the comet assay","volume":"1840","author":"Collins","year":"2014","journal-title":"Biochim. Biophys. Acta Gen. Subj."},{"key":"10.1016\/j.fct.2025.115663_bib15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fgene.2014.00359","article-title":"Controlling variation in the comet assay","volume":"5","author":"Collins","year":"2014","journal-title":"Front. Genet."},{"key":"10.1016\/j.fct.2025.115663_bib16","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.toxlet.2020.03.016","article-title":"The role of the enzyme-modified comet assay in in vivo studies","volume":"1","author":"Collins","year":"2020","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.fct.2025.115663_bib17","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1038\/s41596-022-00754-y","article-title":"Measuring DNA modifications with the comet assay: a compendium of protocols","volume":"18","author":"Collins","year":"2023","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.fct.2025.115663_bib18","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1093\/toxres\/tfaa093","article-title":"Comet assay: a versatile but complex tool in genotoxicity testing","volume":"10","author":"Cordelli","year":"2021","journal-title":"Toxicol. Res."},{"key":"10.1016\/j.fct.2025.115663_bib19","doi-asserted-by":"crossref","DOI":"10.3389\/fgene.2015.00180","article-title":"The comet assay and its applications in the field of ecotoxicology: a mature tool that continues to expand its perspectives","volume":"6","author":"de Lapuente","year":"2015","journal-title":"Front. Genet."},{"key":"10.1016\/j.fct.2025.115663_bib20","article-title":"The ARRIVE guidelines 2.0: updated guidelines for reporting animal research","volume":"18","author":"du Sert","year":"2020","journal-title":"PLoS Biol."},{"key":"10.1016\/j.fct.2025.115663_bib21","first-page":"2379","article-title":"Scientific opinion on genotoxicity testing strategies applicable to food and feed safety assessment","volume":"9","year":"2011","journal-title":"EFSA J."},{"key":"10.1016\/j.fct.2025.115663_bib23","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1093\/mutage\/get001","article-title":"An ECVAG inter-laboratory validation study of the comet assay: inter-laboratory and intra-laboratory variations of DNA strand breaks and FPG-sensitive sites in human mononuclear cells","volume":"28","author":"Ersson","year":"2013","journal-title":"Mutagenesis"},{"key":"10.1016\/j.fct.2025.115663_bib24","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1093\/mutage\/gep048","article-title":"Variation in the measurement of DNA damage by comet assay measured by the ECVAG\u2020 inter-laboratory validation trial","volume":"25","author":"Forchhammer","year":"2009","journal-title":"Mutagenesis"},{"key":"10.1016\/j.fct.2025.115663_bib25","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1093\/mutage\/ges032","article-title":"Inter-laboratory variation in DNA damage using a standard comet assay protocol","volume":"27","author":"Forchhammer","year":"2012","journal-title":"Mutagenesis"},{"key":"10.1016\/j.fct.2025.115663_bib26","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1016\/0045-6535(84)90120-6","article-title":"Metabolism of potassium bromate in rats I. In vivo studies","volume":"13","author":"Fujii","year":"1984","journal-title":"Chemosphere"},{"key":"10.1016\/j.fct.2025.115663_bib27","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1093\/mutage\/geu012","article-title":"Variation of DNA damage levels in peripheral blood mononuclear cells isolated in different laboratories","volume":"29","author":"Godshalk","year":"2014","journal-title":"Mutagenesis"},{"key":"10.1016\/j.fct.2025.115663_bib28","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1093\/mutage\/gex036","article-title":"Using the comet assay and lysis conditions to characterize DNA lesions from the acrylamide metabolite glycidamide","volume":"33","author":"Hansen","year":"2018","journal-title":"Mutagenesis"},{"key":"10.1016\/j.fct.2025.115663_bib29","doi-asserted-by":"crossref","first-page":"9966","DOI":"10.1007\/s11356-019-04443-4","article-title":"Ameliorative effect of zinc oxide nanoparticles against potassium bromate-mediated toxicity in Swiss albino rats","volume":"26","author":"Hassan","year":"2019","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"10.1016\/j.fct.2025.115663_bib30","article-title":"The alleviative effect of vitamin B 2 on potassium bromate-induced hepatotoxicity in Male rats","volume":"30","author":"Hassan","year":"2020","journal-title":"BioMed Res. Int."},{"key":"10.1016\/j.fct.2025.115663_bib31","first-page":"481","article-title":"Some chemicals that cause tumours of the kidney or urinary bladder in rodents and some other substances potassium bromate","year":"1999","journal-title":"IARC (Int. Agency Res. Cancer) Monogr. Eval. Carcinog. Risks Hum."},{"key":"10.1016\/j.fct.2025.115663_bib32","doi-asserted-by":"crossref","first-page":"1959","DOI":"10.1093\/carcin\/8.12.1959","article-title":"Oral administration of the renal carcinogen, potassium bromate, specifically produces 8-hydroxydeoxyguanosine in rat target organ DNA","volume":"8","author":"Kasai","year":"1987","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.fct.2025.115663_bib33","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.tox.2006.01.002","article-title":"Mechanism of DNA damage induced by bromate differs from general types of oxidative stress","volume":"221","author":"Kawanishi","year":"2006","journal-title":"Toxicology"},{"key":"10.1016\/j.fct.2025.115663_bib34","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1186\/1472-6882-12-204","article-title":"Protective effects of rutin against potassium bromate induced nephrotoxicity in rats","volume":"12","author":"Khan","year":"2012","journal-title":"BMC Compl. Alternative Med."},{"key":"10.1016\/j.fct.2025.115663_bib35","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/s10565-007-9043-9","article-title":"Comet assay measurements: a perspective","volume":"25","author":"Kumaravel","year":"2009","journal-title":"Cell Biol. Toxicol."},{"key":"10.1016\/j.fct.2025.115663_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.mrgentox.2024.503729","article-title":"Possible contribution of 8-hydroxydeoxyguanosine to gene mutations in the kidney DNA of gpt delta rats following potassium bromate treatment","volume":"894","author":"Kuroda","year":"2024","journal-title":"Mutat. Res., Genet. Toxicol. Environ. Mutagen."},{"key":"10.1016\/j.fct.2025.115663_bib37","first-page":"309","article-title":"Toxicity and carcinogenicity of potassium bromate - a new renal carcinogen","volume":"87","author":"Kurokawa","year":"1990","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.fct.2025.115663_bib38","doi-asserted-by":"crossref","DOI":"10.1186\/s12989-017-0189-1","article-title":"Biological effects of carbon black nanoparticles are changed by surface coating with polycyclic aromatic hydrocarbons","volume":"14","author":"Lindner","year":"2017","journal-title":"Part. Fibre Toxicol."},{"key":"10.1016\/j.fct.2025.115663_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.mrrev.2021.108371","article-title":"The hCOMET project: international database comparison of results with the comet assay in human biomonitoring. Baseline frequency of DNA damage and effect of main confounders","volume":"787","author":"Mili\u0107","year":"2021","journal-title":"Mutat. Res. Rev. Mutat. Res."},{"key":"10.1016\/j.fct.2025.115663_bib40","doi-asserted-by":"crossref","first-page":"1811","DOI":"10.1016\/0006-2952(93)90587-M","article-title":"Roles for oxidative stress and poly(ADP-ribosyl)ation in the killing of cultured hepatocytes by methyl methanesulfonate","volume":"46","author":"Mizumoto","year":"1993","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.fct.2025.115663_bib41","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/mutage\/gex046","article-title":"The comet assay: ready for 30 more years","volume":"33","author":"M\u00f8ller","year":"2018","journal-title":"Mutagenesis"},{"key":"10.1016\/j.fct.2025.115663_bib42","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1093\/mutage\/gex015","article-title":"Searching for assay controls for the Fpg- and hOGG1-modified comet assay","volume":"33","author":"M\u00f8ller","year":"2018","journal-title":"Mutagenesis"},{"key":"10.1016\/j.fct.2025.115663_bib43","doi-asserted-by":"crossref","first-page":"3817","DOI":"10.1038\/s41596-020-0398-1","article-title":"Minimum information for reporting on the comet assay (MIRCA): recommendations for describing comet assay procedures and results","volume":"15","author":"M\u00f8ller","year":"2020","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.fct.2025.115663_bib44","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1093\/mutage\/geaa011","article-title":"Potassium bromate as positive assay control for the Fpg-modified comet assay","volume":"35","author":"M\u00f8ller","year":"2020","journal-title":"Mutagenesis"},{"key":"10.1016\/j.fct.2025.115663_bib45","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1093\/mutage\/gead020","article-title":"Long-term cryopreservation of potassium bromate positive assay controls for measurement of oxidatively damaged DNA by the Fpg-modified comet assay : results from the hCOMET ring trial","volume":"38","author":"M\u00f8ller","year":"2023","journal-title":"Mutagenesis"},{"key":"10.1016\/j.fct.2025.115663_bib46","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1021\/tx000209q","article-title":"Requirement of glutathione and cysteine in guanine-specific oxidation of DNA by carcinogenic potassium bromate","volume":"14","author":"Murata","year":"2001","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.fct.2025.115663_bib47","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.toxlet.2020.04.021","article-title":"Novel approach for the detection of alkylated bases using the enzyme-modified comet assay","volume":"330","author":"Muruzabal","year":"2020","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.fct.2025.115663_bib48","doi-asserted-by":"crossref","first-page":"2825","DOI":"10.1007\/s00204-021-03102-3","article-title":"Validation of the in vitro comet assay for DNA cross-links and altered bases detection","volume":"95","author":"Muruzabal","year":"2021","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.fct.2025.115663_bib49","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2020.111865","article-title":"The enzyme-modified comet assay: past, present and future","volume":"147","author":"Muruzabal","year":"2021","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.fct.2025.115663_bib50","doi-asserted-by":"crossref","first-page":"e13","DOI":"10.1093\/nar\/gkz1077","article-title":"Sensitive comet chip assay for screening potentially carcinogenic DNA adducts by trapping DNA repair intermediates","volume":"48","author":"Ngo","year":"2021","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.fct.2025.115663_bib51","series-title":"OECD Guidelines for the Testing of Chemicals. Section 4","article-title":"Test no. 489: in vivo mammalian alkaline comet assay","year":"2016"},{"key":"10.1016\/j.fct.2025.115663_bib52","first-page":"1","article-title":"Comparative study between effects of ginkgo biloba extract and extract loaded on gold nanoparticles on hepatotoxicity induced by potassium bromate","volume":"30","author":"Osman","year":"2023","journal-title":"Environ. Sci. Pollut. Control Ser."},{"key":"10.1016\/j.fct.2025.115663_bib53","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/0006-291X(84)90411-X","article-title":"Microelectrophoretic study of radiation-induced DNA damages in individual mammalian cells","volume":"123","author":"Ostling","year":"1984","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.fct.2025.115663_bib54","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1093\/mutage\/15.4.311","article-title":"The role of glutathione in DNA damage by potassium bromate in vitro","volume":"15","author":"Parsons","year":"2000","journal-title":"Mutagenesis"},{"key":"10.1016\/j.fct.2025.115663_bib55","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1093\/mutage\/gew064","article-title":"Weak silica nanomaterial-induced genotoxicity can be explained by indirect DNA damage as shown by the OGG1-modified comet assay and genomic analysis","volume":"32","author":"Pfuhler","year":"2017","journal-title":"Mutagenesis"},{"key":"10.1016\/j.fct.2025.115663_bib56","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/0014-4827(88)90265-0","article-title":"A simple technique for quantitation of low levels of DNA damage in individual cells","volume":"175","author":"Singh","year":"1988","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.fct.2025.115663_bib57","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1093\/mutage\/gel019","article-title":"hOGG1 recognizes oxidative damage using the comet assay with greater specificity than FPG or ENDOIII","volume":"21","author":"Smith","year":"2006","journal-title":"Mutagenesis"},{"key":"10.1016\/j.fct.2025.115663_bib58","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.toxlet.2003.09.010","article-title":"Sensitivity of the FPG protein towards alkylation damage in the comet assay","volume":"146","author":"Speit","year":"2004","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.fct.2025.115663_bib59","first-page":"1","article-title":"Toxicological properties of potassium bromate","volume":"1","author":"Starek","year":"2016","journal-title":"Journal of Pharmacological Reports"},{"key":"10.1016\/j.fct.2025.115663_bib60","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1293\/tox.2018-0024","article-title":"Mechanisms of oxidative stress-induced in vivo mutagenicity by potassium bromate and nitrofurantoin","volume":"31","author":"Tsuchiya","year":"2018","journal-title":"J. Toxicol. Pathol."},{"key":"10.1016\/j.fct.2025.115663_bib61","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1093\/carcin\/16.3.593","article-title":"A possible role for oxidative stress in potassium bromate (KBRO3) carcinogenesis","volume":"16","author":"Umemura","year":"1995","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.fct.2025.115663_bib62","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1111\/j.1349-7006.2004.tb03221.x","article-title":"Dose-related changes of oxidative stress and cell proliferation in kidneys of male and female F344 rats exposed to potassium bromate","volume":"95","author":"Umemura","year":"2004","journal-title":"Cancer Sci."},{"key":"10.1016\/j.fct.2025.115663_bib64","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.mrrev.2008.11.001","article-title":"Environmental and occupational biomonitoring using the comet assay","volume":"681","author":"Valverde","year":"2009","journal-title":"Mutat. Res."}],"container-title":["Food and Chemical Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278691525004314?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278691525004314?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T17:34:41Z","timestamp":1772818481000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0278691525004314"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":61,"alternative-id":["S0278691525004314"],"URL":"https:\/\/doi.org\/10.1016\/j.fct.2025.115663","relation":{},"ISSN":["0278-6915"],"issn-type":[{"value":"0278-6915","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Evaluation of potassium bromate as a positive control in the in vivo Fpg-modified comet assay for the detection of oxidised bases","name":"articletitle","label":"Article Title"},{"value":"Food and Chemical Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fct.2025.115663","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"115663"}}