{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T17:52:14Z","timestamp":1786989134518,"version":"build-2736575974"},"reference-count":94,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Food and Chemical Toxicology"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.fct.2025.115744","type":"journal-article","created":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T21:56:09Z","timestamp":1758578169000},"page":"115744","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["New microplate disc volatilization assay for in vitro evaluation of toxicity and antimicrobial activity of volatiles in vapour phase"],"prefix":"10.1016","volume":"206","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4629-2032","authenticated-orcid":false,"given":"Marketa","family":"Houdkova","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucie","family":"Vistejnova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6028-8841","authenticated-orcid":false,"given":"Julien","family":"Antih","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4263-658X","authenticated-orcid":false,"given":"Aishwarya","family":"Chaure","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iveta","family":"Paurova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mukund Lal","family":"Naik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pavel","family":"Novy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pavel","family":"Klein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manas Kanti","family":"Deb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ladislav","family":"Kokoska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.fct.2025.115744_bib1","series-title":"Identification of Essential Oil Components by Gas Chromatography\/mass Spectrometry","author":"Adams","year":"2007"},{"issue":"4","key":"10.1016\/j.fct.2025.115744_bib2","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1002\/ptr.1309","article-title":"Pharmacological and toxicological properties of Nigella sativa","volume":"17","author":"Ali","year":"2003","journal-title":"Phytother. Res."},{"issue":"6","key":"10.1016\/j.fct.2025.115744_bib3","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1111\/lam.12804","article-title":"A vapour phase assay for evaluating the antimicrobial activities of essential oils against bovine respiratory bacterial pathogens","volume":"65","author":"Amat","year":"2017","journal-title":"Lett. Appl. Microbiol."},{"issue":"2","key":"10.1016\/j.fct.2025.115744_bib4","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1016\/j.tiv.2012.11.017","article-title":"Toxicological analysis of limonene reaction products using an in vitro exposure system","volume":"27","author":"Anderson","year":"2013","journal-title":"Toxicol. In Vitro"},{"issue":"21","key":"10.1016\/j.fct.2025.115744_bib5","doi-asserted-by":"crossref","first-page":"6553","DOI":"10.3390\/molecules26216553","article-title":"Antibacterial activity of Thymus vulgaris L. essential oil vapours and their GC\/MS analysis using solid-phase microextraction and syringe headspace sampling techniques","volume":"26","author":"Antih","year":"2021","journal-title":"Molecules"},{"issue":"1","key":"10.1016\/j.fct.2025.115744_bib6","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/0027-5107(94)90307-7","article-title":"Improved method for mutagenicity testing of gaseous compounds by using a gas sampling bag","volume":"307","author":"Araki","year":"1994","journal-title":"Mutat. Res."},{"issue":"2\u20133","key":"10.1016\/j.fct.2025.115744_bib7","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.etp.2008.01.015","article-title":"An efficient approach to study the toxicological effects of complex mixtures","volume":"60","author":"Aufderheide","year":"2008","journal-title":"Exp. Toxicol. Pathol."},{"issue":"1","key":"10.1016\/j.fct.2025.115744_bib8","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1039\/B509812B","article-title":"A novel in vitro exposure technique for toxicity testing of selected volatile organic compounds","volume":"8","author":"Bakand","year":"2006","journal-title":"J. Environ. Monit."},{"issue":"2","key":"10.1016\/j.fct.2025.115744_bib9","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1016\/j.fct.2007.09.106","article-title":"Biological effects of essential oils \u2013 a review","volume":"46","author":"Bakkali","year":"2008","journal-title":"Food Chem. Toxicol."},{"issue":"4","key":"10.1016\/j.fct.2025.115744_bib10","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1080\/10412905.2020.1746698","article-title":"The progress of essential oils as potential therapeutic agents: a review","volume":"32","author":"Baptista-Silva","year":"2020","journal-title":"J. Essent. Oil Res."},{"issue":"4","key":"10.1016\/j.fct.2025.115744_bib11","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1002\/(SICI)1099-1026(1998070)13:4<235::AID-FFJ733>3.0.CO;2-T","article-title":"Antimicrobial and antioxidant properties of some commercial essential oils","volume":"13","author":"Baratta","year":"1998","journal-title":"Flavour Fragr. J."},{"issue":"3","key":"10.1016\/j.fct.2025.115744_bib12","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1002\/ijc.2910150309","article-title":"Human, rat and mouse liver-mediated mutagenicity of vinyl-chloride in s-typhimurium strains","volume":"15","author":"Bartsch","year":"1975","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.fct.2025.115744_bib13","article-title":"Optimizing the cell culture microenvironment","volume":"vol. 1940","author":"Bertoncello","year":"2019"},{"issue":"1","key":"10.1016\/j.fct.2025.115744_bib14","first-page":"89","article-title":"In vitro models of inhalation toxicity and disease","volume":"37","author":"BeruBe","year":"2009","journal-title":"Altern. Lab. Anim."},{"key":"10.1016\/j.fct.2025.115744_bib15","article-title":"Investigation on antioxidant, antimicrobial, anti-inflammatory, and neuropsychiatry potential of phyto-mediated ZnONPs using Colebrookea oppositifolia","volume":"97","author":"Bhardwaj","year":"2024","journal-title":"J. Drug Deliv. Technol."},{"issue":"4","key":"10.1016\/j.fct.2025.115744_bib16","doi-asserted-by":"crossref","DOI":"10.1002\/cbdv.201800661","article-title":"Antimicrobial and cytotoxic activities of Lepidium latifolium L. hydrodistillate, extract and its major sulfur volatile allyl isothiocyanate","volume":"16","author":"Blazevic","year":"2019","journal-title":"Chem. Biodivers."},{"key":"10.1016\/j.fct.2025.115744_bib17","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.956541","article-title":"Essential oils as multicomponent mixtures and their potential for human health and well-being","volume":"13","author":"Bunse","year":"2022","journal-title":"Front. Pharmacol."},{"issue":"8","key":"10.1016\/j.fct.2025.115744_bib18","article-title":"Alternative to FBS in animal cell culture - an overview and future perspective","volume":"7","author":"Chelladurai","year":"2021","journal-title":"Heliyon"},{"issue":"2","key":"10.1016\/j.fct.2025.115744_bib19","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1002\/(SICI)1097-4636(199802)39:2<286::AID-JBM16>3.0.CO;2-B","article-title":"False positive results in cytotoxicity testing due to unexpectedly volatile compounds","volume":"39","author":"Ciapetti","year":"1998","journal-title":"J. Biomed. Mater. Res."},{"key":"10.1016\/j.fct.2025.115744_bib20","unstructured":"Clinical and Laboratory Standards Institute (CLSI, 2012) Performance standards for antimicrobial disk susceptibility tests, eleventh ed.; Approved Standard Document M02-A11. CLSI, Wayne pp. 32."},{"key":"10.1016\/j.fct.2025.115744_bib21","unstructured":"Clinical and Laboratory Standards Institute (CLSI, 2015) Performance Standards for Antimicrobial Susceptibility Testing, 25th Informational Supplement M100-S25. CLSI, Wayne, pp 158\u2013163."},{"issue":"3","key":"10.1016\/j.fct.2025.115744_bib22","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.jep.2006.04.003","article-title":"Anti-infective potential of natural products: how to develop a stronger in vitro 'proof-of-concept'","volume":"106","author":"Cos","year":"2006","journal-title":"J. Ethnopharmacol."},{"issue":"5","key":"10.1016\/j.fct.2025.115744_bib23","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1002\/bit.22335","article-title":"Rapid depletion of dissolved oxygen in 96-well microtiter plate Staphylococcus epidermidis biofilm assays promotes biofilm development and is influenced by inoculum cell concentration","volume":"103","author":"Cotter","year":"2009","journal-title":"Biotechnol. Bioeng."},{"issue":"3","key":"10.1016\/j.fct.2025.115744_bib24","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1080\/105172399242654","article-title":"Novel in vitro method for rapid screening of volatile compounds using primary or immortalized rat hepatocytes","volume":"9","author":"DelRaso","year":"1999","journal-title":"Toxicol. Methods"},{"key":"10.1016\/j.fct.2025.115744_bib25","unstructured":"European Directorate for the Quality of Medicines and Healthcare (EDQM, 2014) Essential oils in herbal drugs (Monograph 2. 8.12.), In European Pharmacopoeia, eighth ed. Strasbourg, pp 273\u2013274."},{"issue":"8","key":"10.1016\/j.fct.2025.115744_bib26","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1016\/j.burns.2004.06.006","article-title":"The effect of essential oils on methicillin-resistant Staphylococcus aureus using a dressing model","volume":"30","author":"Edwards-Jones","year":"2004","journal-title":"Burns"},{"key":"10.1016\/j.fct.2025.115744_bib28","unstructured":"Food and Drug Administration (FDA, 2009). Guidance for industry and FDA. Class II special controls guidance document: antimicrobial susceptibility test (AST) systems. Center for Devices and Radiological Health, FDA, Rockville."},{"issue":"2","key":"10.1016\/j.fct.2025.115744_bib29","doi-asserted-by":"crossref","first-page":"63","DOI":"10.4103\/jpbs.jpbs_364_22","article-title":"Black seeds (Nigella sativa) medical application and pharmaceutical perspectives","volume":"15","author":"Ferizi","year":"2023","journal-title":"J. Pharm. BioAllied Sci."},{"key":"10.1016\/j.fct.2025.115744_bib30","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1002\/ffj.1875","article-title":"Factors affecting secondary metabolite production in plants: volatile components and essential oils","volume":"23","author":"Figueiredo","year":"2008","journal-title":"Flavour Fragr. J."},{"issue":"3","key":"10.1016\/j.fct.2025.115744_bib31","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.tifs.2007.11.006","article-title":"Potential antimicrobial uses of essential oils in food: is citrus the answer?","volume":"19","author":"Fisher","year":"2008","journal-title":"Trends Food Sci. Technol."},{"key":"10.1016\/j.fct.2025.115744_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2020.113220","article-title":"In vitro antibacterial activity of extracts from Samoan medicinal plants and their effect on proliferation and migration of human fibroblasts","volume":"264","author":"Frankova","year":"2021","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.fct.2025.115744_bib33","doi-asserted-by":"crossref","DOI":"10.3389\/fmats.2020.582030","article-title":"Advances in microtechnology for improved cytotoxicity assessment","volume":"7","author":"Garcia-Hernando","year":"2020","journal-title":"Front. Mater."},{"issue":"2","key":"10.1016\/j.fct.2025.115744_bib34","doi-asserted-by":"crossref","DOI":"10.1002\/cbdv.202201098","article-title":"Cytotoxic activity of herbal medicines as assessed in vitro: a review","volume":"20","author":"Gavanji","year":"2023","journal-title":"Chem. Biodivers."},{"issue":"3","key":"10.1016\/j.fct.2025.115744_bib35","first-page":"101","article-title":"Antimicrobial activity of topical formulation containing Eugenia caryophyllata L. (Krunfud) and Myritus communis L. (Ades) essential oils on selected skin disease causing microorganisms","volume":"18","author":"Gemeda","year":"2008","journal-title":"Ethiop. J. Health Sci."},{"issue":"1","key":"10.1016\/j.fct.2025.115744_bib36","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.toxlet.2010.03.015","article-title":"Cytotoxicity and genotoxicity in human lung epithelial A549 cells caused by airborne volatile organic compounds emitted from pine wood and oriented strand boards","volume":"196","author":"Gminski","year":"2010","journal-title":"Toxicol. Lett."},{"issue":"1","key":"10.1016\/j.fct.2025.115744_bib38","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1089\/jam.2006.19.47","article-title":"Systemic delivery of drugs to humans via inhalation","volume":"19","author":"Gonda","year":"2006","journal-title":"J. Aerosol Med."},{"issue":"3","key":"10.1016\/j.fct.2025.115744_bib39","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1166\/jbmb.2023.2276","article-title":"Chemical composition and biological properties of essential oils of Zingiber officinale, Citrus sinensis, Cinnamomum camphora, and Cinnamomum cassia","volume":"17","author":"Hamdi","year":"2023","journal-title":"J. Biobased Mater. Bioenergy"},{"issue":"3","key":"10.1016\/j.fct.2025.115744_bib40","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/0027-5107(74)90175-4","article-title":"Optimal conditions for mutagenesis by ozone in Escherichia-coli-K12","volume":"24","author":"Hamelin","year":"1974","journal-title":"Mutat. Res."},{"key":"10.1016\/j.fct.2025.115744_bib41","series-title":"Molecular, Clinical and Environmental Toxicology. Volume 2: Clinical Toxicology","first-page":"461","article-title":"Inhalation toxicology","author":"Hayes","year":"2010"},{"issue":"7","key":"10.1016\/j.fct.2025.115744_bib42","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1517\/17425255.2014.916276","article-title":"Toxicological perspectives and nanoparticles","volume":"10","author":"Hayes","year":"2014","journal-title":"Expert Opin. Drug Metab. Toxicol."},{"issue":"5","key":"10.1016\/j.fct.2025.115744_bib43","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1080\/14786411003792165","article-title":"Variation in the composition of the essential oils, phenolic compounds and mineral elements of Hypericum perforatum L. growing in Estonia","volume":"25","author":"Helmja","year":"2011","journal-title":"Nat. Prod. Res."},{"key":"10.1016\/j.fct.2025.115744_bib44","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1002\/ffj.3252","article-title":"Essential oils in the treatment of respiratory tract diseases highlighting their role in bacterial infections and their anti-inflammatory action: a review","volume":"30","author":"Horvath","year":"2015","journal-title":"Flavour Fragr. J."},{"issue":"12","key":"10.1016\/j.fct.2025.115744_bib45","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1055\/a-1158-4529","article-title":"Volatile Antimicrobial agents and in vitro methods for evaluating their activity in the vapour phase: a review","volume":"86","author":"Houdkova","year":"2020","journal-title":"Planta Med."},{"key":"10.1016\/j.fct.2025.115744_bib46","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.fitote.2017.02.008","article-title":"Evaluation of antibacterial potential and toxicity of plant volatile compounds using new broth microdilution volatilization method and modified MTT assay","volume":"118","author":"Houdkova","year":"2017","journal-title":"Fitoterapia"},{"issue":"64","key":"10.1016\/j.fct.2025.115744_bib47","doi-asserted-by":"crossref","first-page":"6004","DOI":"10.3390\/molecules25246004","article-title":"Vapors of volatile plant-derived products significantly affect the results of antimicrobial, antioxidative and cytotoxicity microplate-based assays","volume":"25","author":"Houdkova","year":"2020","journal-title":"Molecules"},{"issue":"14","key":"10.1016\/j.fct.2025.115744_bib48","doi-asserted-by":"crossref","first-page":"4179","DOI":"10.3390\/molecules26144179","article-title":"New broth macrodilution volatilization method for antibacterial susceptibility testing of volatile agents and evaluation of their toxicity using modified MTT assay in vitro","volume":"26","author":"Houdkova","year":"2021","journal-title":"Molecules"},{"issue":"4","key":"10.1016\/j.fct.2025.115744_bib49","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1134\/S0026261714040067","article-title":"Chemical constituents, antibacterial activity and mechanism of action of the essential oil from Cinnamomum cassia bark against four food-related bacteria","volume":"83","author":"Huang","year":"2014","journal-title":"Microbiol."},{"issue":"1","key":"10.1016\/j.fct.2025.115744_bib50","first-page":"1","article-title":"Comparison between human scent compounds collected on cotton and cotton blend materials for SPME-GC\/MS analysis","volume":"1","author":"Hudson-Holness","year":"2010","journal-title":"J. Forensics Res."},{"issue":"4","key":"10.1016\/j.fct.2025.115744_bib51","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1002\/em.2860090408","article-title":"Vaporization technique to measure mutagenic activity of volatile organic-chemicals in the Ames Salmonella assay","volume":"9","author":"Hughes","year":"1987","journal-title":"Environ. Mutagen."},{"key":"10.1016\/j.fct.2025.115744_bib52","first-page":"131","article-title":"Inhalation drug delivery devices: technology update","volume":"8","author":"Ibrahim","year":"2015","journal-title":"Med. Devices"},{"issue":"5","key":"10.1016\/j.fct.2025.115744_bib53","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1093\/jac\/47.5.565","article-title":"Antibacterial activity of essential oils and their major constituents against respiratory tract pathogens by gaseous contact","volume":"47","author":"Inouye","year":"2001","journal-title":"J. Antimicrob. Chemother."},{"issue":"2","key":"10.1016\/j.fct.2025.115744_bib54","doi-asserted-by":"crossref","DOI":"10.1590\/0001-3765202020190387","article-title":"Antioxidant potential and chemical characterization of bioactive compounds from a medicinal plant Colebrokea oppositifolia Sm","volume":"92","author":"Ishtiaq","year":"2020","journal-title":"An. Acad. Bras. Cienc."},{"key":"10.1016\/j.fct.2025.115744_bib55","unstructured":"International Organization for Standardization (ISO, 2019). Susceptibility testing of infectious agents and evaluation of performance of antimicrobial susceptibility devices, Part 1. Broth Micro-dilution Reference Method for Testing the in Vitro Activity of Antimicrobial Agents against Rapidly Growing Aerobic Bacteria Involved in Infectious Diseases, second ed. ISO, Geneva."},{"issue":"2","key":"10.1016\/j.fct.2025.115744_bib37","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1080\/10412905.1992.9698038","article-title":"Essential oils of Cinnamomum species from peninsular Malaysia","volume":"4","author":"Jantan","year":"1992","journal-title":"J. Essent. Oil Res."},{"issue":"1","key":"10.1016\/j.fct.2025.115744_bib56","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1515\/chem-2021-0191","article-title":"Antimicrobial and antioxidant activities of Cinnamomum cassia essential oil and its application in food preservation","volume":"19","author":"Kacaniova","year":"2021","journal-title":"Open Chem."},{"issue":"1","key":"10.1016\/j.fct.2025.115744_bib57","first-page":"1","article-title":"Application of electronic nose systems for assessing quality of medicinal and aromatic plant products: a review","volume":"3","author":"Kiani","year":"2016","journal-title":"J. Appl. Res. Med. Aromat. Plants"},{"issue":"5","key":"10.1016\/j.fct.2025.115744_bib58","first-page":"817","article-title":"Antimicrobial effects of 8-quinolinol","volume":"15","author":"Kim","year":"2006","journal-title":"Food Sci. Biotechnol."},{"issue":"4","key":"10.1016\/j.fct.2025.115744_bib59","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1603\/EC12049","article-title":"Fumigant toxicity of plant essential oils against Camptomyia corticalis (Diptera: cecidomyiidae)","volume":"105","author":"Kim","year":"2012","journal-title":"J. Econ. Entomol."},{"issue":"13","key":"10.1016\/j.fct.2025.115744_bib60","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1080\/14656566.2017.1363179","article-title":"New treatment options for lower respiratory tract infections","volume":"18","author":"Kocsis","year":"2017","journal-title":"Expert Opin. Pharmacother."},{"key":"10.1016\/j.fct.2025.115744_bib61","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1046\/j.1365-4362.42.s1.4.x","article-title":"Evaluation of in vitro activity of ciclopirox olamine, butenafine HCl and econazole nitrate against dermatophytes, yeasts and bacteria","volume":"42","author":"Kokjohn","year":"2003","journal-title":"Int. J. Dermatol."},{"issue":"6","key":"10.1016\/j.fct.2025.115744_bib62","article-title":"Odoriferous therapy: a review identifying essential oils against pathogens of the respiratory tract","volume":"17","author":"Leigh-de Rapper","year":"2020","journal-title":"Chem. Biodivers."},{"key":"10.1016\/j.fct.2025.115744_bib63","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.indcrop.2012.04.056","article-title":"Analysis and evaluation of essential oil components of cinnamon barks using GC-MS and FTIR spectroscopy","volume":"41","author":"Li","year":"2013","journal-title":"Ind. Crops Prod."},{"key":"10.1016\/j.fct.2025.115744_bib64","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2022.115962","article-title":"Pharmacologic effects approach of essential oils and their components on respiratory diseases","volume":"304","author":"Li","year":"2023","journal-title":"J. Ethnopharmacol."},{"issue":"17","key":"10.1016\/j.fct.2025.115744_bib65","doi-asserted-by":"crossref","first-page":"6939","DOI":"10.1021\/jf050709v","article-title":"Solid- and vapour-phase antimicrobial activities of six essential oils: susceptibility of selected foodborne bacterial and fungal strains","volume":"53","author":"Lopez","year":"2005","journal-title":"J. Agric. Food Chem."},{"issue":"1\u20132","key":"10.1016\/j.fct.2025.115744_bib66","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0021-9673(01)01314-0","article-title":"Gas chromatographic technologies for the analysis of essential oils","volume":"936","author":"Marriott","year":"2001","journal-title":"J. Chromatogr. A"},{"issue":"5","key":"10.1016\/j.fct.2025.115744_bib67","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.3390\/ijms18051062","article-title":"Inhaled antibiotic therapy in chronic respiratory diseases","volume":"18","author":"Maselli","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.fct.2025.115744_bib68","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.tiv.2006.08.002","article-title":"Validation of a method for acute and subchronic exposure of cells in vitro to volatile organic solvents","volume":"21","author":"McDermott","year":"2007","journal-title":"Toxicol. In Vitro"},{"key":"10.1016\/j.fct.2025.115744_bib69","article-title":"Development of an in vitro approach to point-of-contact inhalation toxicity testing of volatile compounds, using organotypic culture and air-liquid interface exposure","volume":"69","author":"Mistri","year":"2020","journal-title":"Toxicol. In Vitro"},{"issue":"1\u20132","key":"10.1016\/j.fct.2025.115744_bib70","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S0027-5107(00)00064-6","article-title":"The Ames Salmonella\/microsome mutagenicity assay","volume":"455","author":"Mortelmans","year":"2000","journal-title":"Mutat. Res."},{"key":"10.1016\/j.fct.2025.115744_bib71","series-title":"Methods for Dilution Antimicrobial Susceptibility Tests for Bacteria that Growth Aerobically; Approved Standard","year":"2003"},{"key":"10.1016\/j.fct.2025.115744_bib72","series-title":"Cinnamaldehyde","year":"2024"},{"key":"10.1016\/j.fct.2025.115744_bib73","series-title":"o-Cymene","year":"2024"},{"issue":"4","key":"10.1016\/j.fct.2025.115744_bib74","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1111\/jam.14683","article-title":"In vitro antimicrobial combinatory effect of Cinnamomum cassia essential oil with 8-hydroxyquinoline against Staphylococcus aureus in liquid and vapour phase","volume":"129","author":"Netopilova","year":"2020","journal-title":"J. Appl. Microbiol."},{"issue":"6","key":"10.1016\/j.fct.2025.115744_bib75","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1517\/17460441.3.6.655","article-title":"Update on in vitro cytotoxicity assays for drug development","volume":"3","author":"Niles","year":"2008","journal-title":"Expert Opin. Drug Discov."},{"key":"10.1016\/j.fct.2025.115744_bib76","series-title":"OECD Guidelines for the Testing of Chemicals, Section 4","article-title":"Test No. 471: bacterial reverse mutation test","year":"2020"},{"issue":"1","key":"10.1016\/j.fct.2025.115744_bib77","doi-asserted-by":"crossref","first-page":"109","DOI":"10.3109\/01480545.2011.648327","article-title":"Regulatory toxicology considerations for the development of inhaled pharmaceuticals","volume":"36","author":"Owen","year":"2012","journal-title":"Drug Chem. Toxicol."},{"key":"10.1016\/j.fct.2025.115744_bib78","doi-asserted-by":"crossref","first-page":"5421","DOI":"10.1046\/j.1432-1327.2000.01606.x","article-title":"Investigation of the Alamar Blue (resazurin) fluorescent dye for the assessment of mammalian cell cytotoxicity","volume":"267","author":"O'Brien","year":"2000","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.fct.2025.115744_bib79","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.ijfoodmicro.2010.04.001","article-title":"Use of natural antimicrobials to increase antibiotic susceptibility of drug resistant bacteria","volume":"140","author":"Palaniappan","year":"2010","journal-title":"Int. J. Food Microbiol."},{"key":"10.1016\/j.fct.2025.115744_bib80","doi-asserted-by":"crossref","first-page":"658","DOI":"10.3389\/fphar.2017.00658","article-title":"Antimicrobial, anthelmintic, and antiviral activity of plants traditionally used for treating infectious disease in the Similipal Biosphere Reserve, Odisha, India","volume":"8","author":"Panda","year":"2017","journal-title":"Front. Pharmacol."},{"issue":"10","key":"10.1016\/j.fct.2025.115744_bib81","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1177\/24725552211039754","article-title":"Treating cells as reagents to design reproducible assays","volume":"26","author":"Riss","year":"2021","journal-title":"SLAS Discov."},{"issue":"3","key":"10.1016\/j.fct.2025.115744_bib82","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1093\/ecam\/nen036","article-title":"Therapeutic potential of plants as anti-microbials for drug discovery","volume":"7","author":"Samy","year":"2010","journal-title":"Evid. Based Complementary Altern. Med."},{"key":"10.1016\/j.fct.2025.115744_bib83","first-page":"171","article-title":"Effect of mustard extract vapour on fungi and spore-forming bacteria","volume":"24","author":"Sekiyama","year":"1996","journal-title":"J. Antibact. Antifung. Agens"},{"key":"10.1016\/j.fct.2025.115744_bib84","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.ijfoodmicro.2015.08.021","article-title":"Development of an experimental apparatus and protocol for determining antimicrobial activities of gaseous plant essential oils","volume":"215","author":"Seo","year":"2015","journal-title":"Int. J. Food Microbiol."},{"issue":"10","key":"10.1016\/j.fct.2025.115744_bib85","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1097\/FPC.0b013e328307bddf","article-title":"Genomic biomarkers of pulmonary exposure to tobacco smoke components","volume":"18","author":"Sexton","year":"2008","journal-title":"Pharmacogenet. Genom."},{"key":"10.1016\/j.fct.2025.115744_bib86","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.trac.2015.04.015","article-title":"Volatile sampling by headspace techniques","volume":"71","author":"Soria","year":"2015","journal-title":"Trends Anal. Chem."},{"issue":"1","key":"10.1016\/j.fct.2025.115744_bib87","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1093\/toxsci\/kfac040","article-title":"Benchmark dose modeling approaches for volatile organic chemicals using a novel air-liquid interface in vitro exposure system","volume":"188","author":"Speen","year":"2022","journal-title":"Toxicol. Sci."},{"issue":"2","key":"10.1016\/j.fct.2025.115744_bib88","doi-asserted-by":"crossref","first-page":"170","DOI":"10.3923\/ijp.2013.170.175","article-title":"Antimicrobial activity of 8-hydroxyquinoline and transition metal complexes","volume":"9","author":"Srisung","year":"2013","journal-title":"Int. J. Pharmacol."},{"key":"10.1016\/j.fct.2025.115744_bib89","series-title":"Katzung and Trevor's Pharmacology Examination and Board Review","first-page":"20","author":"Trevor","year":"2015"},{"key":"10.1016\/j.fct.2025.115744_bib90","series-title":"Globally Harmonized System of Classification and Labelling of Chemicals (GHS)","first-page":"279","year":"2011"},{"issue":"4","key":"10.1016\/j.fct.2025.115744_bib91","doi-asserted-by":"crossref","DOI":"10.1111\/jfs.12900","article-title":"In vitro growth-inhibitory effect of essential oils and supercritical carbon dioxide extracts from Cinnamomum spp. barks and fruits against food bacterial pathogens in liquid and vapor phase","volume":"41","author":"Vihanova","year":"2021","journal-title":"J. Food Saf."},{"issue":"2","key":"10.1016\/j.fct.2025.115744_bib92","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1007\/s13596-020-00513-y","article-title":"Traditional uses, phytochemistry, and ethnopharmacology of Colebrookea oppositifolia Smith: a mini-review","volume":"21","author":"Viswanatha","year":"2021","journal-title":"Adv. Tradit. Med."},{"issue":"1","key":"10.1016\/j.fct.2025.115744_bib93","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1111\/j.1745-4530.2008.00347.x","article-title":"Comparison of volatile compound composition of cinnamon (Cinnamomum cassia Presl) bark prepared by hydrodistillation and headspace solid phase microextraction","volume":"34","author":"Wang","year":"2011","journal-title":"J. Food Process. Eng."},{"issue":"4","key":"10.1016\/j.fct.2025.115744_bib94","doi-asserted-by":"crossref","first-page":"343","DOI":"10.3109\/10408449309104076","article-title":"Toxicologic testing of inhaled pharmaceutical aerosols","volume":"23","author":"Wolff","year":"1993","journal-title":"Crit. Rev. Toxicol."},{"issue":"19","key":"10.1016\/j.fct.2025.115744_bib96","doi-asserted-by":"crossref","first-page":"3473","DOI":"10.3390\/molecules24193473","article-title":"Cinnamomum cassia Presl: a review of its traditional uses, phytochemistry, pharmacology and toxicology","volume":"24","author":"Zhang","year":"2019","journal-title":"Molecules"}],"container-title":["Food and Chemical Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278691525005125?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278691525005125?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T21:59:15Z","timestamp":1760738355000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0278691525005125"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":94,"alternative-id":["S0278691525005125"],"URL":"https:\/\/doi.org\/10.1016\/j.fct.2025.115744","relation":{},"ISSN":["0278-6915"],"issn-type":[{"value":"0278-6915","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"New microplate disc volatilization assay for in vitro evaluation of toxicity and antimicrobial activity of volatiles in vapour phase","name":"articletitle","label":"Article Title"},{"value":"Food and Chemical Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fct.2025.115744","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"115744"}}