{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T14:59:30Z","timestamp":1787237970952,"version":"build-2736575974"},"reference-count":51,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100015399","name":"Guangdong Administration for Market Regulation","doi-asserted-by":"publisher","award":["2023CS02"],"award-info":[{"award-number":["2023CS02"]}],"id":[{"id":"10.13039\/501100015399","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020084","name":"Guangzhou Municipal Science and Technology Bureau","doi-asserted-by":"publisher","award":["202206010095"],"award-info":[{"award-number":["202206010095"]}],"id":[{"id":"10.13039\/501100020084","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Food and Chemical Toxicology"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.fct.2026.116092","type":"journal-article","created":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T15:13:06Z","timestamp":1775315586000},"page":"116092","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Physiologically based toxicokinetic-toxicodynamic (PBTK-TD) modeling of oral exposure to bongkrekic acid in rats"],"prefix":"10.1016","volume":"213","author":[{"given":"Xiafei","family":"Cao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9420-6197","authenticated-orcid":false,"given":"Jian","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Lei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxin","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xusheng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meidan","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weibin","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.fct.2026.116092_bib1","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1007\/s13181-016-0577-1","article-title":"Bongkrekic Acid\u2014A review of a lesser-known mitochondrial toxin","volume":"13","author":"Anwar","year":"2017","journal-title":"J. Med. Toxicol."},{"issue":"1","key":"10.1016\/j.fct.2026.116092_bib2","doi-asserted-by":"crossref","first-page":"33","DOI":"10.2174\/138920007779315053","article-title":"Scaling factors for the extrapolation of in vivo metabolic drug clearance from in vitro data: reaching a consensus on values of human microsomal protein and hepatocellularity per gram of liver","volume":"8","author":"Barter","year":"2007","journal-title":"Curr. Drug Metabol."},{"issue":"3","key":"10.1016\/j.fct.2026.116092_bib3","doi-asserted-by":"crossref","first-page":"3075","DOI":"10.1021\/acsnano.9b08142","article-title":"Meta-analysis of nanoparticle delivery to tumors using a physiologically based pharmacokinetic modeling and simulation approach","volume":"14","author":"Cheng","year":"2020","journal-title":"ACS Nano"},{"issue":"4","key":"10.1016\/j.fct.2026.116092_bib4","doi-asserted-by":"crossref","first-page":"168","DOI":"10.3390\/pharmaceutics11040168","article-title":"Interpretation of non-clinical data for prediction of human pharmacokinetic parameters: in Vitro-In vivo extrapolation and allometric scaling","volume":"11","author":"Choi","year":"2019","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.fct.2026.116092_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.tiv.2025.106111","article-title":"Beyond traditional toxicology: the transformative power of PBTK modeling","volume":"109","author":"Damre","year":"2025","journal-title":"Toxicol. Vitro"},{"issue":"Pt 3","key":"10.1016\/j.fct.2026.116092_bib6","article-title":"Physiologically based toxicokinetic and toxicodynamic (PBTK-TD) modelling of cis-bifenthrin in Carassius auratus and Xenopus laevis accounting for reproductive toxicity","volume":"263","author":"Du","year":"2024","journal-title":"Environ. Res."},{"key":"10.1016\/j.fct.2026.116092_bib7","doi-asserted-by":"crossref","first-page":"e5","DOI":"10.1016\/j.forsciint.2016.10.015","article-title":"Identification of the potent toxin bongkrekic acid in a traditional African beverage linked to a fatal outbreak","volume":"270","author":"Falconer","year":"2017","journal-title":"Forensic Sci. Int."},{"issue":"1","key":"10.1016\/j.fct.2026.116092_bib8","doi-asserted-by":"crossref","first-page":"22","DOI":"10.5599\/admet.628","article-title":"A physiologically-based pharmacokinetic model of oseltamivir phosphate and its carboxylate metabolite for rats and humans","volume":"7","author":"Gao","year":"2019","journal-title":"ADMET DMPK."},{"issue":"22","key":"10.1016\/j.fct.2026.116092_bib9","doi-asserted-by":"crossref","DOI":"10.3390\/ijms242216224","volume":"24","author":"Gaohua","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"13","key":"10.1016\/j.fct.2026.116092_bib10","doi-asserted-by":"crossref","DOI":"10.1002\/mnfr.202000063","article-title":"Predicting the acute liver toxicity of aflatoxin B1 in rats and humans by an in Vitro\u2013In silico testing strategy","volume":"64","author":"Gilbert-Sandoval","year":"2020","journal-title":"Mol. Nutr. Food Res."},{"issue":"5","key":"10.1016\/j.fct.2026.116092_bib11","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1159\/000525049","article-title":"Methods for assessment of the glomerular filtration rate in laboratory animals","volume":"8","author":"Gu","year":"2022","journal-title":"Kidney Dis."},{"key":"10.1016\/j.fct.2026.116092_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.comtox.2023.100278","article-title":"Physiologically-based toxicokinetic model of botulinum neurotoxin biodistribution in mice and rats","volume":"27","author":"Gutting","year":"2023","journal-title":"Comput. Toxicol."},{"issue":"21","key":"10.1016\/j.fct.2026.116092_bib13","doi-asserted-by":"crossref","first-page":"3926","DOI":"10.3390\/foods12213926","article-title":"Bongkrekic acid and Burkholderia gladioli pathovar cocovenenans: formidable foe and ascending threat to food safety","volume":"12","author":"Han","year":"2023","journal-title":"Foods"},{"issue":"1","key":"10.1016\/j.fct.2026.116092_bib14","first-page":"130","article-title":"PBPK modeling: what is the role of CYP3A4 expression in the gastrointestinal tract to accurately predict first\u2010pass metabolism? CPT pharmacometrics syst","volume":"14","author":"Henriot","year":"2025","journal-title":"Pharmacol."},{"key":"10.1016\/j.fct.2026.116092_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.meegid.2025.105760","article-title":"A highly virulent BA-producing Burkholderia gladioli strain linked to a fatal foodborne outbreak in China, 2020","volume":"131","author":"Hu","year":"2025","journal-title":"Infect. Genet. Evol."},{"issue":"10","key":"10.1016\/j.fct.2026.116092_bib16","article-title":"Unexplained rhabdomyolysis and hepatic renal dysfunction: a case of bongkrekic acid poisoning","volume":"16","author":"Hu","year":"2024","journal-title":"Cureus"},{"issue":"10","key":"10.1016\/j.fct.2026.116092_bib17","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1002\/psp4.12553","article-title":"Novel mechanistic PBPK model to predict renal clearance in varying stages of CKD by incorporating tubular adaptation and dynamic passive reabsorption","volume":"9","author":"Huang","year":"2020","journal-title":"CPT Pharmacometrics Syst. Pharmacol."},{"key":"10.1016\/j.fct.2026.116092_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.fm.2025.104811","article-title":"Novel application of L-type phenyllactate in the \u201cthree birds one stone\u201d control of Burkholderia gladioli growth and bongkrekic acid production in Auricularia auricula","volume":"131","author":"Jiao","year":"2025","journal-title":"Food Microbiol."},{"key":"10.1016\/j.fct.2026.116092_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.lwt.2025.118336","article-title":"Modified dSPE combined with ultra-high-performance liquid chromatography tandem mass spectrometry to determine bongkrekic acid, iso-bongkrekic acid, and toxoflavin in wet rice noodles","volume":"231","author":"Lai","year":"2025","journal-title":"LWT--Food Sci. Technol."},{"issue":"3","key":"10.1016\/j.fct.2026.116092_bib20","doi-asserted-by":"crossref","DOI":"10.1002\/prp2.305","article-title":"Physiologically based pharmacokinetic modeling of tea catechin mixture in rats and humans","volume":"5","author":"Law","year":"2017","journal-title":"Pharmacol. Res. Perspect."},{"issue":"1","key":"10.1016\/j.fct.2026.116092_bib21","doi-asserted-by":"crossref","first-page":"F27","DOI":"10.1152\/ajprenal.00224.2004","article-title":"Cd2+ -induced cytochrome c release in apoptotic proximal tubule cells: role of mitochondrial permeability transition pore and Ca2+ uniporter","volume":"288","author":"Lee","year":"2005","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"10.1016\/j.fct.2026.116092_bib22","doi-asserted-by":"crossref","first-page":"1757","DOI":"10.1007\/s00204-024-03698-2","article-title":"PBTK model-based analysis of CYP3A4 induction and the toxicokinetics of the pyrrolizidine alkaloid retrorsine in man","volume":"98","author":"Lehmann","year":"2024","journal-title":"Arch. Toxicol."},{"issue":"10","key":"10.1016\/j.fct.2026.116092_bib23","doi-asserted-by":"crossref","first-page":"1650","DOI":"10.4315\/0362-028X.JFP-19-121","article-title":"An investigation of bongkrekic acid poisoning caused by consumption of a nonfermented rice noodle product without noticeable signs of spoilage","volume":"82","author":"Li","year":"2019","journal-title":"J. Food Protect."},{"issue":"2","key":"10.1016\/j.fct.2026.116092_bib24","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/j.etap.2014.01.005","article-title":"A physiologically based toxicokinetic and toxicodynamic model links the tissue distribution of benzo[a]pyrene and toxic effects in the scallop Chlamys farreri","volume":"37","author":"Liu","year":"2014","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"10.1016\/j.fct.2026.116092_bib25","article-title":"Analyzing the metabolic fate of oral administration drugs: a review and state-of-the-art roadmap","volume":"13","author":"Liu","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.fct.2026.116092_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.toxicon.2023.107275","article-title":"The toxicokinetic and extracorporeal removal of bongkrekic acid during blood purification therapies: a case report","volume":"233","author":"Lv","year":"2023","journal-title":"Toxicon"},{"issue":"8","key":"10.1016\/j.fct.2026.116092_bib28","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1080\/19420862.2018.1506648","article-title":"A minimal physiologically based pharmacokinetic model to investigate FcRn-mediated monoclonal antibody salvage: effects of Kon, Koff, endosome trafficking, and animal species","volume":"10","author":"Maas","year":"2018","journal-title":"mAbs"},{"issue":"24","key":"10.1016\/j.fct.2026.116092_bib29","doi-asserted-by":"crossref","first-page":"9125","DOI":"10.1021\/acs.jcim.4c00961","article-title":"MCNN_MC: computational prediction of mitochondrial carriers and investigation of bongkrekic acid toxicity using protein language models and convolutional neural networks","volume":"64","author":"Malik","year":"2024","journal-title":"J. Chem. Inf. Model."},{"issue":"2","key":"10.1016\/j.fct.2026.116092_bib30","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.taap.2009.12.033","article-title":"Physiologically based pharmacokinetic modeling of dibromoacetic acid in F344 rats","volume":"244","author":"Matthews","year":"2010","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"9","key":"10.1016\/j.fct.2026.116092_bib31","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1016\/j.chembiol.2012.07.022","article-title":"Biosynthesis of the respiratory toxin bongkrekic acid in the pathogenic bacterium Burkholderia gladioli","volume":"19","author":"Moebius","year":"2012","journal-title":"Chem. Bio."},{"issue":"3","key":"10.1016\/j.fct.2026.116092_bib32","doi-asserted-by":"crossref","first-page":"G424","DOI":"10.1152\/ajpgi.00048.2024","article-title":"Assessing the degree of hepatic ischemia-reperfusion injury using physiologically based pharmacokinetic modeling of sodium fluorescein disposition in ex vivo machine-perfused livers","volume":"327","author":"Monti","year":"2024","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"issue":"4","key":"10.1016\/j.fct.2026.116092_bib33","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1080\/15563650.2025.2459763","article-title":"Loperamide-induced severe cardiotoxicity: a toxicokinetic and toxicodynamic analysis derived from a case series and the published literature","volume":"63","author":"Nic Ionmhain","year":"2025","journal-title":"Clin. Toxicol."},{"issue":"7","key":"10.1016\/j.fct.2026.116092_bib34","article-title":"Use of physiologically-based pharmacokinetic modeling to simulate the profiles of 3-Hydroxybenzo(a)pyrene in workers exposed to polycyclic aromatic hydrocarbons","volume":"9","author":"Ortiz","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.fct.2026.116092_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2025.125969","article-title":"Exposure risk assessment through toxicodynamics assessment of 4-tert-octylphenol and estimation of new reference values based on human tissue toxicity","volume":"372","author":"Park","year":"2025","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.fct.2026.116092_bib36","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2021.628538","article-title":"Comparative genomic analysis of the foodborne pathogen Burkholderia gladioli pv. cocovenenans harboring a bongkrekic acid biosynthesis gene cluster","volume":"12","author":"Peng","year":"2021","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.fct.2026.116092_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2020.111130","article-title":"A method to assess lifetime dietary risk: example of cadmium exposure","volume":"137","author":"Pruvost-Couvreur","year":"2020","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.fct.2026.116092_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.compbiomed.2025.109922","article-title":"Evaluating cardiac function in ex vivo heart perfusion using lumped parameter models","volume":"189","author":"Roig","year":"2025","journal-title":"Comput. Biol. Med."},{"key":"10.1016\/j.fct.2026.116092_bib39","series-title":"Clinical Pharmacokinetics and Pharmacodynamics: Concepts and Applications","author":"Roland","year":"2010"},{"issue":"3","key":"10.1016\/j.fct.2026.116092_bib40","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.cell.2018.11.025","article-title":"The molecular mechanism of transport by the mitochondrial ADP\/ATP carrier","volume":"176","author":"Ruprecht","year":"2019","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.fct.2026.116092_bib41","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1186\/s12906-024-04726-5","article-title":"Severe bongkrekic acid poisoning caused by eating spoiled auricularia auricula: a case report","volume":"24","author":"Shi","year":"2024","journal-title":"BMC Complement. Med. Ther."},{"issue":"7","key":"10.1016\/j.fct.2026.116092_bib42","doi-asserted-by":"crossref","first-page":"3546","DOI":"10.1021\/acs.jmedchem.0c01930","article-title":"Successful and unsuccessful prediction of human hepatic clearance for lead optimization","volume":"64","author":"Sodhi","year":"2021","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.fct.2026.116092_bib43","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2024.116277","article-title":"Development and application of the physiologically-based toxicokinetic (PBTK) model for ochratoxin A (OTA) in rats and humans","volume":"276","author":"Su","year":"2024","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"7","key":"10.1016\/j.fct.2026.116092_bib44","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1002\/psp4.13154","article-title":"Elucidating nonlinear pharmacokinetics of telmisartan: integration of target\u2010mediated drug disposition and OATP1B3\u2010mediated hepatic uptake in a physiologically based model","volume":"13","author":"Tsuchitani","year":"2024","journal-title":"CPT Pharmacometrics Syst. Pharmacol."},{"issue":"3","key":"10.1016\/j.fct.2026.116092_bib45","doi-asserted-by":"crossref","DOI":"10.1128\/aac.01518-24","article-title":"Prediction of higher ceftazidime\u2013avibactam concentrations in the human renal interstitium compared with unbound plasma using a minimal physiologically based pharmacokinetic model developed in rats and pigs through microdialysis","volume":"69","author":"Vall\u00e9e","year":"2025","journal-title":"Antimicrob. Agents Chemother."},{"issue":"5","key":"10.1016\/j.fct.2026.116092_bib46","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1002\/jcph.1365","article-title":"Physiologically based modeling approach to predict dopamine D2 receptor occupancy of antipsychotics in brain: translation from rat to human","volume":"59","author":"Wong","year":"2019","journal-title":"J. Clin. Pharmacol."},{"issue":"Pt 2","key":"10.1016\/j.fct.2026.116092_bib48","article-title":"Bioinspired Core-shell nanospheres integrated in multi-signal immunochromatographic sensor for high throughput sensitive detection of bongkrekic acid in food","volume":"460","author":"Xuan","year":"2024","journal-title":"Food Chem."},{"key":"10.1016\/j.fct.2026.116092_bib49","doi-asserted-by":"crossref","DOI":"10.1016\/j.fm.2023.104449","article-title":"Exploring the characteristics of Burkholderia gladioli pathovar cocovenenans: growth, bongkrekic acid production, and potential risks of food contamination in wet rice noodles and vermicelli","volume":"120","author":"Yao","year":"2024","journal-title":"Food Microbiol."},{"issue":"2","key":"10.1016\/j.fct.2026.116092_bib50","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.stemcr.2020.12.017","article-title":"Generation of human-induced pluripotent stem cell-derived functional enterocyte-like cells for pharmacokinetic studies","volume":"16","author":"Yoshida","year":"2021","journal-title":"Stem Cell Rep."},{"issue":"1","key":"10.1016\/j.fct.2026.116092_bib51","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.tjog.2024.10.003","article-title":"Unexpectedly life-threatening meal: contamination by bongkrekic acid in Taiwan","volume":"64","author":"Yu","year":"2025","journal-title":"Taiwan. J. Obstet. Gynecol."},{"issue":"1","key":"10.1016\/j.fct.2026.116092_bib52","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0279957","article-title":"Epidemiology of foodborne bongkrekic acid poisoning outbreaks in China, 2010 to 2020","volume":"18","author":"Zhang","year":"2023","journal-title":"PLoS One"},{"key":"10.1016\/j.fct.2026.116092_bib53","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1016\/j.envpol.2019.03.115","article-title":"Physiologically based toxicokinetic and toxicodynamic (PBTK-TD) modelling of Cd and Pb exposure in adult zebrafish danio rerio: accumulation and toxicity","volume":"249","author":"Zhang","year":"2019","journal-title":"Environ. Pollut."}],"container-title":["Food and Chemical Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278691526001663?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278691526001663?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T14:30:20Z","timestamp":1777991420000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0278691526001663"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":51,"alternative-id":["S0278691526001663"],"URL":"https:\/\/doi.org\/10.1016\/j.fct.2026.116092","relation":{},"ISSN":["0278-6915"],"issn-type":[{"value":"0278-6915","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Physiologically based toxicokinetic-toxicodynamic (PBTK-TD) modeling of oral exposure to bongkrekic acid in rats","name":"articletitle","label":"Article Title"},{"value":"Food and Chemical Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fct.2026.116092","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"116092"}}