{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T15:45:52Z","timestamp":1782488752035,"version":"3.54.5"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100018553","name":"Science and Technology Plan Project of Wenzhou Municipality","doi-asserted-by":"publisher","award":["Y20240140"],"award-info":[{"award-number":["Y20240140"]}],"id":[{"id":"10.13039\/501100018553","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008856","name":"Zhejiang Provincial Health Commission","doi-asserted-by":"publisher","award":["2025KY465"],"award-info":[{"award-number":["2025KY465"]}],"id":[{"id":"10.13039\/501100008856","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007835","name":"Wenzhou Medical University","doi-asserted-by":"publisher","award":["KYYW202205"],"award-info":[{"award-number":["KYYW202205"]}],"id":[{"id":"10.13039\/100007835","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008867","name":"Department of Education of Zhejiang Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008867","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007194","name":"Wenzhou Municipal Science and Technology Bureau","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007194","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017531","name":"Medical and Health Research Project of Zhejiang Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100017531","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Food and Chemical Toxicology"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.fct.2026.116098","type":"journal-article","created":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T15:05:37Z","timestamp":1776351937000},"page":"116098","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Cajaninstilbene acid induced apoptosis and cell cycle arrest in glioblastoma multiforme through mitochondrial ROS\u2013mediated MAPK pathways"],"prefix":"10.1016","volume":"213","author":[{"given":"Yong-Ang","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tian-Zeng","family":"Bian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-Wen","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liu-Tao","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao-Di","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuai","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-Yi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"You-Bing","family":"Mao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Qiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"8","key":"10.1016\/j.fct.2026.116098_bib1","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1038\/s41571-019-0177-5","article-title":"Challenges to curing primary brain tumours","volume":"16","author":"Aldape","year":"2019","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1016\/j.fct.2026.116098_bib2","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.bbcan.2011.10.001","article-title":"New facets of matrix metalloproteinases MMP-2 and MMP-9 as cell surface transducers: outside-in signaling and relationship to tumor progression","volume":"1","author":"Bauvois","year":"2012","journal-title":"Biochim. Biophys. Acta Rev. Canc"},{"issue":"1","key":"10.1016\/j.fct.2026.116098_bib3","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1186\/s13046-020-01621-y","article-title":"Mitochondrial ROS accumulation inhibiting JAK2\/STAT3 pathway is a critical modulator of CYT997-induced autophagy and apoptosis in gastric cancer","volume":"39","author":"Cao","year":"2020","journal-title":"J. Exp. Clin. Cancer Res."},{"issue":"9","key":"10.1016\/j.fct.2026.116098_bib4","doi-asserted-by":"crossref","DOI":"10.1002\/advs.201902971","article-title":"Advances in the knowledge of the molecular biology of glioblastoma and its impact in patient diagnosis, stratification, and treatment","volume":"7","author":"Delgado-Mart\u00edn","year":"2020","journal-title":"Adv. Sci."},{"issue":"4","key":"10.1016\/j.fct.2026.116098_bib5","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1016\/j.phymed.2015.02.005","article-title":"Cell cycle arrest and induction of apoptosis by cajanin stilbene acid from Cajanus cajan in breast cancer cells","volume":"22","author":"Fu","year":"2015","journal-title":"Phytomedicine"},{"issue":"11","key":"10.1016\/j.fct.2026.116098_bib6","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1016\/j.jnutbio.2015.06.004","article-title":"Activity of the antiestrogenic cajanin stilbene acid towards breast cancer","volume":"26","author":"Fu","year":"2015","journal-title":"J. Nutr. Biochem."},{"key":"10.1016\/j.fct.2026.116098_bib7","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.tox.2019.02.010","article-title":"Ginsenoside Rk1 induces cell cycle arrest and apoptosis in MDA-MB-231 triple negative breast cancer cells","volume":"418","author":"Hong","year":"2019","journal-title":"Toxicology"},{"issue":"14","key":"10.1016\/j.fct.2026.116098_bib8","doi-asserted-by":"crossref","first-page":"2893","DOI":"10.1021\/acs.jafc.6b00227","article-title":"Anti-inflammatory effects of cajaninstilbene acid and its derivatives","volume":"64","author":"Huang","year":"2016","journal-title":"J. Agric. Food Chem."},{"issue":"1","key":"10.1016\/j.fct.2026.116098_bib9","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1186\/s12883-021-02461-9","article-title":"Effect of long-term adjuvant temozolomide chemotherapy on primary glioblastoma patient survival","volume":"21","author":"Huang","year":"2021","journal-title":"BMC Neurol."},{"issue":"1","key":"10.1016\/j.fct.2026.116098_bib10","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1186\/1471-2407-11-268","article-title":"Cucurbitacin-I (JSI-124) activates the JNK\/c-Jun signaling pathway independent of apoptosis and cell cycle arrest in B leukemic cells","volume":"11","author":"Ishdorj","year":"2011","journal-title":"BMC Cancer"},{"issue":"4","key":"10.1016\/j.fct.2026.116098_bib11","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1002\/tox.22691","article-title":"Tetrandrine inhibits human brain glioblastoma multiforme GBM 8401 cancer cell migration and invasion in vitro","volume":"34","author":"Jiang","year":"2019","journal-title":"Environ. Toxicol."},{"issue":"24","key":"10.1016\/j.fct.2026.116098_bib12","doi-asserted-by":"crossref","DOI":"10.3390\/ijms222413659","article-title":"Molecular targets of natural compounds with anti-cancer properties","volume":"22","author":"Kubczak","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"3","key":"10.1016\/j.fct.2026.116098_bib13","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1038\/nrm3758","article-title":"Molecular mechanisms of epithelial\u2013mesenchymal transition","volume":"15","author":"Lamouille","year":"2014","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.fct.2026.116098_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2025.114908","article-title":"6-Gingerol overcomes TMZ resistance in GBM by suppressing EMT and cell migration via the PI3K\/Akt\/\u03b2-catenin\/c-Myc pathway","volume":"159","author":"Lee","year":"2025","journal-title":"Int. Immunopharmacol."},{"issue":"4","key":"10.1016\/j.fct.2026.116098_bib15","doi-asserted-by":"crossref","first-page":"418","DOI":"10.7150\/ijbs.23602","article-title":"Glaucocalyxin A induces G2\/M cell cycle arrest and apoptosis through the PI3K\/Akt pathway in human bladder cancer cells","volume":"14","author":"Lin","year":"2018","journal-title":"Int. J. Biol. Sci."},{"issue":"6605","key":"10.1016\/j.fct.2026.116098_bib16","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1126\/science.abn7570","article-title":"Mechanism-based design of agents that selectively target drug-resistant glioma","volume":"377","author":"Lin","year":"2022","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.fct.2026.116098_bib17","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1038\/s41401-020-0404-8","article-title":"Avasimibe exerts anticancer effects on human glioblastoma cells via inducing cell apoptosis and cell cycle arrest","volume":"42","author":"Liu","year":"2021","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.fct.2026.116098_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.tiv.2020.105052","article-title":"Calycosin induces mitochondrial-dependent apoptosis and cell cycle arrest, and inhibits cell migration through a ROS-mediated signaling pathway in HepG2 hepatocellular carcinoma cells","volume":"70","author":"Liu","year":"2021","journal-title":"Toxicol. Vitro"},{"issue":"1","key":"10.1016\/j.fct.2026.116098_bib19","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1111\/jcmm.12937","article-title":"Gartanin induces cell cycle arrest and autophagy and suppresses migration involving PI3K\/Akt\/mTOR and MAPK signalling pathway in human glioma cells","volume":"21","author":"Luo","year":"2017","journal-title":"J. Cell Mol. Med."},{"key":"10.1016\/j.fct.2026.116098_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2021.174069","article-title":"Eriodictyol inhibits glioblastoma migration and invasion by reversing EMT via downregulation of the P38 MAPK\/GSK-3\u03b2\/ZEB1 pathway","volume":"900","author":"Lv","year":"2021","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.fct.2026.116098_bib21","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.freeradbiomed.2020.12.003","article-title":"PKC\u03b4 mediates mitochondrial ROS generation and oxidation of HSP60 to relieve RKIP inhibition on MAPK pathway for HCC progression","volume":"163","author":"Mandal","year":"2021","journal-title":"Free Radic. Biol. Med."},{"issue":"1","key":"10.1016\/j.fct.2026.116098_bib22","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1007\/s00441-015-2197-5","article-title":"Characterization of matrix metalloproteinase-2 and-9, ADAM-10 and N-cadherin expression in human glioblastoma multiforme","volume":"362","author":"Musumeci","year":"2015","journal-title":"Cell Tissue Res."},{"issue":"23","key":"10.1016\/j.fct.2026.116098_bib23","doi-asserted-by":"crossref","first-page":"8367","DOI":"10.3390\/molecules27238367","article-title":"Natural products as anticancer agents: current status and future perspectives","volume":"27","author":"Naeem","year":"2022","journal-title":"Molecules"},{"issue":"3","key":"10.1016\/j.fct.2026.116098_bib24","doi-asserted-by":"crossref","first-page":"2782","DOI":"10.1002\/jcb.27681","article-title":"Extracellular matrix (ECM) stiffness and degradation as cancer drivers","volume":"120","author":"Najafi","year":"2019","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.fct.2026.116098_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2022.175176","article-title":"Echinacoside (ECH) suppresses proliferation, migration, and invasion of human glioblastoma cells by inhibiting Skp2-triggered epithelial-mesenchymal transition (EMT)","volume":"932","author":"Shi","year":"2022","journal-title":"Eur. J. Pharmacol."},{"issue":"1","key":"10.1016\/j.fct.2026.116098_bib26","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1038\/s41392-025-02299-4","article-title":"Glioblastoma at the crossroads: current understanding and future therapeutic horizons","volume":"10","author":"Singh","year":"2025","journal-title":"Signal Transduct. Targeted Ther."},{"issue":"1","key":"10.1016\/j.fct.2026.116098_bib27","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1186\/s12906-024-04605-z","article-title":"Apoptosis induction and inhibition of invasion and migration in gastric cancer cells by Isoorientin studied using network pharmacology","volume":"24","author":"Song","year":"2024","journal-title":"BMC Complement. Med. Ther."},{"issue":"3","key":"10.1016\/j.fct.2026.116098_bib28","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1038\/s41419-021-03535-9","article-title":"Ciclopirox and bortezomib synergistically inhibits glioblastoma multiforme growth via simultaneously enhancing JNK\/p38 MAPK and NF-\u03baB signaling","volume":"12","author":"Su","year":"2021","journal-title":"Cell Death Dis."},{"issue":"7804","key":"10.1016\/j.fct.2026.116098_bib29","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1038\/s41586-020-2209-9","article-title":"Mechanisms and therapeutic implications of hypermutation in gliomas","volume":"580","author":"Touat","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.fct.2026.116098_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.113887","article-title":"Stilbene B10 induces apoptosis and tumor suppression in lymphoid Raji cells by BTK-mediated regulation of the KRAS\/HDAC1\/EP300\/PEBP1 axis","volume":"156","author":"Varier","year":"2022","journal-title":"Biomed. Pharmacother."},{"issue":"16","key":"10.1016\/j.fct.2026.116098_bib31","doi-asserted-by":"crossref","first-page":"2899","DOI":"10.1016\/j.cell.2022.06.054","article-title":"Glioblastoma hijacks neuronal mechanisms for brain invasion","volume":"185","author":"Venkataramani","year":"2022","journal-title":"Cell"},{"key":"10.1016\/j.fct.2026.116098_bib32","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.freeradbiomed.2023.03.021","article-title":"Necroptosis signaling and mitochondrial dysfunction cross-talking facilitate cell death mediated by chelerythrine in glioma","volume":"202","author":"Wang","year":"2023","journal-title":"Free Radic. Biol. Med."},{"issue":"8","key":"10.1016\/j.fct.2026.116098_bib33","doi-asserted-by":"crossref","first-page":"2212","DOI":"10.1021\/acs.jafc.8b07126","article-title":"\" Induction of apoptosis in human glioma cells by fucoxanthin via triggering of ROS-mediated oxidative damage and regulation of MAPKs and PI3K-AKT pathways.\"","volume":"67","author":"Wu","year":"2019","journal-title":"J. Agric. Food Chem."},{"issue":"5","key":"10.1016\/j.fct.2026.116098_bib34","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.21037\/tcr-22-1122","article-title":"Analysis of the key prognostic genes and potential traditional Chinese medicine therapeutic targets in glioblastoma based on bioinformatics and network pharmacology methods","volume":"11","author":"Xia","year":"2022","journal-title":"Transl. Cancer Res."},{"key":"10.1016\/j.fct.2026.116098_bib35","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.jare.2020.07.011","article-title":"Neuroprotective effect of cajaninstilbene acid against cerebral ischemia and reperfusion damages by activating AMPK\/Nrf2 pathway","volume":"34","author":"Xu","year":"2021","journal-title":"J. Adv. Res."},{"key":"10.1016\/j.fct.2026.116098_bib36","article-title":"Network pharmacology and experimental verification reveal the mechanism of safranal against glioblastoma (GBM)","volume":"13","author":"Yang","year":"2023","journal-title":"Front. Oncol."},{"key":"10.1016\/j.fct.2026.116098_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2025.120288","article-title":"Investigation on the antitumor effects of Fisetin extracted from Hedyotis diffuse Willd based on network pharmacology and experimental validation","author":"Yao","year":"2025","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.fct.2026.116098_bib38","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.967141","article-title":"Anticancer effects of OSW-1 on glioma cells via regulation of the PI3K\/AKT signal pathway: a network pharmacology approach and experimental validation in vitro and in vivo","volume":"13","author":"Zhan","year":"2022","journal-title":"Front. Pharmacol."},{"issue":"1","key":"10.1016\/j.fct.2026.116098_bib39","article-title":"Isoliensinine induces apoptosis in triple-negative human breast cancer cells through ROS generation and p38 MAPK\/JNK activation","volume":"5","author":"Zhang","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.fct.2026.116098_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.fitote.2019.104450","article-title":"Antidepressant-like effects of cajaninstilbene acid and its related mechanisms in mice","volume":"141","author":"Zhang","year":"2020","journal-title":"Fitoterapia"},{"key":"10.1016\/j.fct.2026.116098_bib41","article-title":"5-Demethylnobiletin mediates cell cycle arrest and apoptosis via the ERK1\/2\/AKT\/STAT3 signaling pathways in glioblastoma cells","volume":"13","author":"Zhang","year":"2023","journal-title":"Front. Oncol."},{"key":"10.1016\/j.fct.2026.116098_bib42","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2023.116306","article-title":"Network pharmacology, a promising approach to reveal the pharmacology mechanism of Chinese medicine formula","volume":"309","author":"Zhao","year":"2023","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.fct.2026.116098_bib43","article-title":"Self-assembled genistein nanoparticles suppress the epithelial-mesenchymal transition in glioblastoma by targeting MMP9","volume":"31","author":"Zhao","year":"2025","journal-title":"Mater. Today Bio"}],"container-title":["Food and Chemical Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278691526001729?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278691526001729?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T06:56:08Z","timestamp":1778741768000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0278691526001729"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":43,"alternative-id":["S0278691526001729"],"URL":"https:\/\/doi.org\/10.1016\/j.fct.2026.116098","relation":{},"ISSN":["0278-6915"],"issn-type":[{"value":"0278-6915","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cajaninstilbene acid induced apoptosis and cell cycle arrest in glioblastoma multiforme through mitochondrial ROS\u2013mediated MAPK pathways","name":"articletitle","label":"Article Title"},{"value":"Food and Chemical Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fct.2026.116098","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"116098"}}