{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T18:18:44Z","timestamp":1783189124917,"version":"3.54.6"},"reference-count":66,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T00:00:00Z","timestamp":1777420800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100016928","name":"Instituto Nacional de Pediatria","doi-asserted-by":"publisher","award":["INP-2024\/033"],"award-info":[{"award-number":["INP-2024\/033"]}],"id":[{"id":"10.13039\/100016928","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016928","name":"Instituto Nacional de Pediatria","doi-asserted-by":"publisher","award":["INP-035\/2018"],"award-info":[{"award-number":["INP-035\/2018"]}],"id":[{"id":"10.13039\/100016928","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003141","name":"Secretar\u00eda de Ciencia, Humanidades, Tecnolog\u00eda e Innovaci\u00f3n","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020704","name":"Instituto de Investigaciones Biom\u00e9dicas, Universidad Nacional Aut\u00f3noma de M\u00e9xico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100020704","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005739","name":"Universidad Nacional Aut\u00f3noma de M\u00e9xico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005739","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Food and Chemical Toxicology"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.fct.2026.116109","type":"journal-article","created":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T03:02:05Z","timestamp":1777518125000},"page":"116109","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Physicochemical, structural, and immunological characterization of recombinant Mal d 1.02 allergen in Mexican pediatric patients. A valuable tool for diagnosing"],"prefix":"10.1016","volume":"214","author":[{"given":"Ang\u00e9lica","family":"Torres-Arroyo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A.","family":"Mendoza-Hern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1112-0708","authenticated-orcid":false,"given":"Ram\u00f3n","family":"L\u00f3pez-Salgueiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-5419-3018","authenticated-orcid":false,"given":"Enrique","family":"L\u00f3pez-Hern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abril M.","family":"Amaro-Leal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8619-1220","authenticated-orcid":false,"given":"Sara T.","family":"M\u00e9ndez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aramiz","family":"L\u00f3pez-Dur\u00e1n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulises","family":"Carrasco-Navarro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4676-1828","authenticated-orcid":false,"given":"Francisco J.","family":"Fern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3604-9629","authenticated-orcid":false,"given":"Horacio","family":"Reyes-Vivas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.fct.2026.116109_bib1","doi-asserted-by":"crossref","first-page":"1606","DOI":"10.1021\/acs.jafc.6b05752","article-title":"Structure of the major apple allergen Mal d 1","volume":"65","author":"Ahammer","year":"2017","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.fct.2026.116109_bib2","doi-asserted-by":"crossref","first-page":"5227","DOI":"10.1021\/jf053137n","article-title":"Isolation of high-quality RNA from apple (Malus domestica) fruit","volume":"54","author":"Asif","year":"2006","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.fct.2026.116109_bib3","doi-asserted-by":"crossref","first-page":"142","DOI":"10.29262\/ram.v64i2.235","article-title":"Clinical-epidemiological profile of oral allergy syndrome in the population aged 6 to 18 years","volume":"64","author":"Azamar-J\u00e1come","year":"2017","journal-title":"Rev. Alerg. M\u00e9x."},{"key":"10.1016\/j.fct.2026.116109_bib4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2012\/646901","article-title":"Reflux revisited: advancing the role of pepsin","author":"Bardhan","year":"2012","journal-title":"Int. J. Otolaryngol."},{"key":"10.1016\/j.fct.2026.116109_bib5","doi-asserted-by":"crossref","first-page":"511","DOI":"10.4168\/aair.2014.6.6.511","article-title":"Food hypersensitivity in Mexican adults at 18 to 50 years of age: a questionnaire survey","volume":"6","author":"Bedolla-Barajas","year":"2014","journal-title":"Allergy Asthma Immunol. Res."},{"key":"10.1016\/j.fct.2026.116109_bib6","first-page":"1","article-title":"Prevalence of food-hypersensitivity and food-dependent anaphylaxis in colombian schoolchildren by parent-report","volume":"57","author":"Beltr\u00e1n-C\u00e1rdenas","year":"2021","journal-title":"Medicina (Lithuania)"},{"key":"10.1016\/j.fct.2026.116109_bib7","doi-asserted-by":"crossref","first-page":"3303","DOI":"10.1002\/eji.200324321","article-title":"Bet v 1, the major birch pollen allergen, initiates sensitization to Api g 1, the major allergen in celery: evidence at the T cell level","volume":"33","author":"Bohle","year":"2003","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.fct.2026.116109_bib8","doi-asserted-by":"crossref","DOI":"10.3390\/ijerph15112446","article-title":"Food allergy prevalence in salvadoran schoolchildren estimated by parent-report","volume":"15","author":"Cabrera-Ch\u00e1vez","year":"2018","journal-title":"Int. J. Environ. Res. Publ. Health"},{"key":"10.1016\/j.fct.2026.116109_bib9","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.atmosenv.2018.05.006","article-title":"Pollen in the atmosphere of Mexico City and its impact on the health of the pediatric population","volume":"186","author":"Calderon-Ezquerro","year":"2018","journal-title":"Atmos. Environ."},{"key":"10.1016\/j.fct.2026.116109_bib10","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1002\/elps.200305844","article-title":"Blue silver: a very sensitive colloidal commassie G-250 staining for proteome analisys","volume":"25","author":"Candiano","year":"2004","journal-title":"Electrophoresis"},{"key":"10.1016\/j.fct.2026.116109_bib11","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1111\/all.14300","article-title":"Past, present, and future of allergen immunotherapy vaccines","volume":"76","author":"Dorofeeva","year":"2021","journal-title":"Allergy: European Journal of Allergy and Clinical Immunology"},{"key":"10.1016\/j.fct.2026.116109_bib12","doi-asserted-by":"crossref","DOI":"10.1111\/pai.12066","article-title":"Testing children for allergies: why, how, who and when: an updated statement of the European Academy of Allergy and Clinical Immunology (EAACI) Section on Pediatrics and the EAACI-Clemens von Pirquet Foundation","author":"Eigenmann","year":"2013","journal-title":"Pediatr. Allergy Immunol."},{"key":"10.1016\/j.fct.2026.116109_bib13","series-title":"WAO 2019 Food Allergy Information Sheet. WAO 1\u20138","author":"Ei-Ghoneimy","year":"2019"},{"key":"10.1016\/j.fct.2026.116109_bib14","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.molbiopara.2007.10.013","article-title":"Species-specific inhibition of Giardia lamblia triosephosphate isomerase by localized perturbation of the homodimer","volume":"157","author":"Enriquez-Flores","year":"2008","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/j.fct.2026.116109_bib15","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.jaip.2020.09.037","article-title":"Improving diagnostic accuracy in food allergy","volume":"9","author":"Foong","year":"2021","journal-title":"J. Allergy Clin. Immunol. Pract."},{"key":"10.1016\/j.fct.2026.116109_bib16","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/S0091-6749(98)70287-8","article-title":"Bet v 1, the major birch pollen allergen, and Mal d 1, the major apple allergen, cross-react at the level of allergen-specific T helper cells","volume":"102","author":"Fritsch","year":"1998","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.fct.2026.116109_bib17","article-title":"Purification and structural stability of the peach allergens Pru p 1 and Pru p 3","volume":"52","author":"Gaier","year":"2008","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.fct.2026.116109_bib18","series-title":"The Proteomics Protocols Handbook","first-page":"571","article-title":"Protein identification and analysis tools on the ExPASy server","author":"Gasteiger","year":"2005"},{"key":"10.1016\/j.fct.2026.116109_bib19","first-page":"210","article-title":"Food allergy in Argentinian schoolchildren: a survey-based cross-sectional study Alergia alimentaria en escolares argentinos: Un estudio transversal basado en encuestas","volume":"10","author":"Gilberto Ar\u00e1mburo-G\u00e1lvez","year":"2020","journal-title":"Revista M\u00e9dica de la UAS"},{"key":"10.1016\/j.fct.2026.116109_bib20","first-page":"405","article-title":"Amplification of cDNA generated by reverse transcription of mRNA: two-step reverse transcription-polymerase chain reaction (RT-PCR)","author":"Green","year":"2019","journal-title":"Cold Spring Harb. Protoc."},{"key":"10.1016\/j.fct.2026.116109_bib21","doi-asserted-by":"crossref","DOI":"10.1021\/jf035458+","article-title":"Maillard reaction and enzymatic browning affect the allergenicity of pru av 1, the major allergen from cherry (Prunus avium)","author":"Gruber","year":"2004","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.fct.2026.116109_bib22","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1542\/peds.2018-1235","article-title":"The public health impact of parent-reported childhood food allergies in the United States","volume":"142","author":"Gupta","year":"2018","journal-title":"Pediatrics"},{"key":"10.1016\/j.fct.2026.116109_bib23","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1080\/003655299750025994","article-title":"Effect of 7-day therapy with different doses of the proton pump inhibitor lansoprazole on the intragastric pH in healthy human subjects","volume":"34","author":"Harder","year":"1999","journal-title":"Scand. J. Gastroenterol."},{"key":"10.1016\/j.fct.2026.116109_bib24","doi-asserted-by":"crossref","first-page":"4230","DOI":"10.1021\/bi011950f","article-title":"Catalysis and stability of triosephosphate isomerase from Trypanosoma brucei with different residues at position 14 of the dimer interface. Characterization of a catalytically competent monomeric enzyme","volume":"41","author":"Hern\u00e1ndez-Alc\u00e1ntara","year":"2002","journal-title":"Biochemistry"},{"key":"10.1016\/j.fct.2026.116109_bib25","doi-asserted-by":"crossref","DOI":"10.1111\/j.1398-9995.2005.00809.x","article-title":"The SAFE project: \u201cplant food allergies: field to table strategies for reducing their incidence in Europe\u201d an EC-funded study","author":"Hoffmann-Sommergruber","year":"2005","journal-title":"Allergy: European Journal of Allergy and Clinical Immunology"},{"key":"10.1016\/j.fct.2026.116109_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/S0378-1119(97)00246-1","article-title":"Genomic characterization of members of the Bet v 1 family: genes coding for allergens and pathogenesis-related proteins share intron positions","author":"Hoffmann-Sommergruber","year":"1997","journal-title":"Gene"},{"key":"10.1016\/j.fct.2026.116109_bib27","first-page":"1","article-title":"Purification and characterization of recombinant expressed apple allergen mal d 1","volume":"4","author":"Kaeswurm","year":"2021","journal-title":"Methods Protoc."},{"key":"10.1016\/j.fct.2026.116109_bib28","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.alit.2024.08.007","article-title":"Comprehensive review of pollen-food allergy syndrome: pathogenesis, epidemiology, and treatment approaches","volume":"74","author":"Kato","year":"2025","journal-title":"Allergol. Int."},{"key":"10.1016\/j.fct.2026.116109_bib29","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1038\/227680a0","article-title":"Cleavage of structural proeins during the assembly of the head of Bacteriophage T4","volume":"227","author":"Laemmli","year":"1970","journal-title":"Nature"},{"key":"10.1016\/j.fct.2026.116109_bib30","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1111\/pai.13435","article-title":"Emergence of pollen food allergy syndrome in asthmatic children in Paris","volume":"32","author":"Loraud","year":"2021","journal-title":"Pediatr. Allergy Immunol."},{"key":"10.1016\/j.fct.2026.116109_bib31","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1159\/000089756","article-title":"Mutational analysis of amino acid positions crucial for IgE-binding epitopes of the major apple (Malus domestica) allergen, Mal d 1","volume":"139","author":"Ma","year":"2005","journal-title":"Int. Arch. Allergy Immunol."},{"key":"10.1016\/j.fct.2026.116109_bib32","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1111\/pai.13490","article-title":"Time trends of childhood food allergy in China: three cross-sectional surveys in 1999, 2009, and 2019","volume":"32","author":"Ma","year":"2021","journal-title":"Pediatr. Allergy Immunol."},{"key":"10.1016\/j.fct.2026.116109_bib33","article-title":"Pollen-food allergy syndrome: a not so rare disease in childhood","volume":"55","author":"Mastrorilli","year":"2019","journal-title":"Medicina (Lithuania)"},{"key":"10.1016\/j.fct.2026.116109_bib34","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1016\/j.jaci.2018.12.1021","article-title":"Molecular diagnosis for allergen immunotherapy","volume":"143","author":"Matricardi","year":"2019","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.fct.2026.116109_bib35","doi-asserted-by":"crossref","first-page":"10548","DOI":"10.1021\/jf901938q","article-title":"Apple (Malus domestica L. Borkh.) allergen Mal d 1: effect of cultivar, cultivation system, and storage conditions","volume":"57","author":"Matthes","year":"2009","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.fct.2026.116109_bib36","doi-asserted-by":"crossref","DOI":"10.1002\/mnfr.201700278","article-title":"Current (Food) allergenic risk assessment: is it fit for novel foods? Status quo and identification of gaps","volume":"62","author":"Mazzucchelli","year":"2018","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.fct.2026.116109_bib37","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1038\/s41592-022-01488-1","article-title":"ColabFold: making protein folding accessible to all","volume":"19","author":"Mirdita","year":"2022","journal-title":"Nat. Methods"},{"key":"10.1016\/j.fct.2026.116109_bib38","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1111\/all.12423","article-title":"Prevalence of common food allergies in Europe: a systematic review and meta-analysis","volume":"69","author":"Nwaru","year":"2014","journal-title":"Allergy"},{"key":"10.1016\/j.fct.2026.116109_bib39","article-title":"Purification and characterisation of relevant natural and recombinant apple allergens","volume":"52","author":"Oberhuber","year":"2008","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.fct.2026.116109_bib40","doi-asserted-by":"crossref","DOI":"10.1111\/all.15089","article-title":"Advances and highlights in biomarkers of allergic diseases","author":"Ogulur","year":"2021","journal-title":"Allergy: European Journal of Allergy and Clinical Immunology"},{"key":"10.1016\/j.fct.2026.116109_bib41","doi-asserted-by":"crossref","first-page":"2411","DOI":"10.1002\/pro.5560041120","article-title":"How to measure and predict the molar absorption coefficient of a protein","volume":"4","author":"Pace","year":"1995","journal-title":"Protein Sci."},{"key":"10.1016\/j.fct.2026.116109_bib42","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1080\/14620316.2009.11512617","article-title":"Cloning and expression of the major allergen genes in apple fruit","volume":"84","author":"Pagliarani","year":"2009","journal-title":"J. Hortic. Sci. Biotechnol."},{"key":"10.1016\/j.fct.2026.116109_bib43","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1111\/j.1365-2222.2010.03468.x","article-title":"Antacids and dietary supplements with an influence on the gastric pH increase the risk for food sensitization","volume":"40","author":"Pali-Sch\u00f6ll","year":"2010","journal-title":"Clin. Exp. Allergy"},{"key":"10.1016\/j.fct.2026.116109_bib44","doi-asserted-by":"crossref","DOI":"10.3390\/nu10091129","article-title":"The effect of digestion and digestibility on allergenicity of food","volume":"10","author":"Pali-Sch\u00f6ll","year":"2018","journal-title":"Nutrients"},{"key":"10.1016\/j.fct.2026.116109_bib45","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1056\/NEJM197708182970701","article-title":"Healing of dodenal ulcer with an antacid regimen","volume":"297","author":"Peterson","year":"1977","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.fct.2026.116109_bib46","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/j.anai.2016.03.010","article-title":"Self-reported prevalence and risk factors associated with food hypersensitivity in Mexican young adults","volume":"116","author":"Puente-Fern\u00e1ndez","year":"2016","journal-title":"Ann. Allergy Asthma Immunol."},{"key":"10.1016\/j.fct.2026.116109_bib47","doi-asserted-by":"crossref","DOI":"10.1186\/1471-2148-8-286","article-title":"The Bet v 1 fold: an ancient, versatile scaffold for binding of large, hydrophobic ligands","volume":"8","author":"Radauer","year":"2008","journal-title":"BMC Evol. Biol."},{"key":"10.1016\/j.fct.2026.116109_bib48","doi-asserted-by":"crossref","first-page":"34","DOI":"10.29262\/ram.v67i1.731","article-title":"Fisiopatolog\u00eda de la alergia alimentaria","volume":"67","author":"Reyes-Pav\u00f3n","year":"2020","journal-title":"Rev. Alerg. M\u00e9x."},{"key":"10.1016\/j.fct.2026.116109_bib49","series-title":"Alergia alimentaria: de la teor\u00eda a la pr\u00e1ctica","author":"Rivero Yeverino","year":"2023"},{"key":"10.1016\/j.fct.2026.116109_bib50","doi-asserted-by":"crossref","first-page":"65","DOI":"10.29262\/ram.v61i2.28","article-title":"S\u00edndrome de alergia oral en adultos de un hospital de tercer nivel","volume":"61","author":"Rodr\u00edguez-Mireles","year":"2014","journal-title":"Rev. Alerg. M\u00e9x."},{"key":"10.1016\/j.fct.2026.116109_bib51","doi-asserted-by":"crossref","DOI":"10.1016\/j.aller.2013.07.001","article-title":"Epidemiology of food allergy in Latin America","author":"S\u00e1nchez","year":"2015","journal-title":"Allergol. Immunopathol."},{"key":"10.1016\/j.fct.2026.116109_bib52","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/nmeth.2089","article-title":"NIH image to ImageJ: 25 years of image analysis HHS public access","volume":"9","author":"Schneider","year":"2012","journal-title":"Nat. Methods"},{"key":"10.1016\/j.fct.2026.116109_bib53","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.jaci.2017.11.003","article-title":"Food allergy: a review and update on epidemiology, pathogenesis, diagnosis, prevention, and management","volume":"141","author":"Sicherer","year":"2018","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.fct.2026.116109_bib54","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1002\/pro.3290","article-title":"Clustal omega for making accurate alignments of many protein sequences","volume":"27","author":"Sievers","year":"2018","journal-title":"Protein Sci."},{"key":"10.1016\/j.fct.2026.116109_bib55","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1007\/s003940050063","article-title":"Pollen-related food allergy: cloning and immunological analysis of isoforms and mutants of Mal d 1, the major apple allergen, and Bet v1, the major birch pollen allergen","volume":"38","author":"Son","year":"1999","journal-title":"Eur. J. Nutr."},{"key":"10.1016\/j.fct.2026.116109_bib56","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1016\/j.jmii.2023.04.008","article-title":"Rising prevalence of food allergies in Taiwan: an epidemiological study","volume":"56","author":"Su","year":"2023","journal-title":"J. Microbiol. Immunol. Infect."},{"key":"10.1016\/j.fct.2026.116109_bib57","article-title":"Immunoproteomics of cow's milk allergy in Mexican pediatric patients","volume":"273","author":"Torres-Arroyo","year":"2023","journal-title":"J. Proteonomics"},{"key":"10.1016\/j.fct.2026.116109_bib58","doi-asserted-by":"crossref","first-page":"284","DOI":"10.3390\/diseases13090284","article-title":"Immunoblotting analysis of fruit proteins in Mexican pediatric patients suggests the existence of new allergens","volume":"13","author":"Torres-Arroyo","year":"2025","journal-title":"Diseases"},{"key":"10.1016\/j.fct.2026.116109_bib59","doi-asserted-by":"crossref","first-page":"8904","DOI":"10.1039\/D4FO00064A","article-title":"Immunoproteomic profile of Malus domestica in Mexican pediatric patients. Evidence of new allergen prospects","volume":"15","author":"Torres-Arroyo","year":"2024","journal-title":"Food Funct."},{"key":"10.1016\/j.fct.2026.116109_bib60","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1016\/j.jaci.2008.04.025","article-title":"The role of protein digestibility and antacids on food allergy outcomes","volume":"121","author":"Untersmayr","year":"2008","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.fct.2026.116109_bib61","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1006\/bbrc.1995.2320","article-title":"Cloning and sequencing of Mal d 1, the major allergen from apple (Malus domestica), and its immunological relationship to Bet v 1, the major birch pollen allergen","author":"Vanek-Krebitz","year":"1995","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.fct.2026.116109_bib62","doi-asserted-by":"crossref","first-page":"D368","DOI":"10.1093\/nar\/gkad1011","article-title":"AlphaFold protein structure database in 2024: providing structure coverage for over 214 million protein sequences","volume":"52","author":"Varadi","year":"2024","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.fct.2026.116109_bib63","doi-asserted-by":"crossref","first-page":"91","DOI":"10.35366\/108840","article-title":"Cap\u00edtulo 4. Alergia alimentaria","volume":"31","author":"Vega-D\u00edaz","year":"2022","journal-title":"Alerg. Asma Inmunol. Pedi\u00e1tricas"},{"key":"10.1016\/j.fct.2026.116109_bib64","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1111\/j.1749-6632.2002.tb04132.x","article-title":"Current understanding of cross-reactivity of food allergens and pollen","volume":"964","author":"Vieths","year":"2002","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.fct.2026.116109_bib65","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1093\/bioinformatics\/btq066","article-title":"How significant is a protein structure similarity with TM-score = 0.5?","volume":"26","author":"Xu","year":"2010","journal-title":"Bioinformatics"},{"key":"10.1016\/j.fct.2026.116109_bib66","first-page":"702","article-title":"Scoring function for automated assessment of protein structure template quality. Proteins: structure","volume":"57","author":"Zhang","year":"2004","journal-title":"Function and Genetics"}],"container-title":["Food and Chemical Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278691526001833?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278691526001833?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T17:50:26Z","timestamp":1783187426000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0278691526001833"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":66,"alternative-id":["S0278691526001833"],"URL":"https:\/\/doi.org\/10.1016\/j.fct.2026.116109","relation":{},"ISSN":["0278-6915"],"issn-type":[{"value":"0278-6915","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Physicochemical, structural, and immunological characterization of recombinant Mal d 1.02 allergen in Mexican pediatric patients. A valuable tool for diagnosing","name":"articletitle","label":"Article Title"},{"value":"Food and Chemical Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fct.2026.116109","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"116109"}}