{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T12:20:14Z","timestamp":1783081214181,"version":"3.54.6"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100007819","name":"Shanxi Normal University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007819","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Food and Chemical Toxicology"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.fct.2026.116172","type":"journal-article","created":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T23:33:09Z","timestamp":1779492789000},"page":"116172","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["A combined Ames and in vivo genotoxicity assessment of dimyricetin-yl-diselenide, a structurally defined organoselenium flavonoid"],"prefix":"10.1016","volume":"214","author":[{"given":"Liangliang","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuefang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiahui","family":"Hao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kualian","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lina","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5787-0395","authenticated-orcid":false,"given":"Saisai","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.fct.2026.116172_bib1","doi-asserted-by":"crossref","first-page":"57","DOI":"10.3109\/15563650.2011.641560","article-title":"Case series of selenium toxicity from a nutritional supplement","volume":"50","author":"Aldosary","year":"2012","journal-title":"Clin. Toxicol."},{"issue":"8","key":"10.1016\/j.fct.2026.116172_bib2","doi-asserted-by":"crossref","first-page":"4865","DOI":"10.1007\/s11033-014-3417-x","article-title":"Ebselen, a promising antioxidant drug: mechanisms of action and targets of biological pathways","volume":"41","author":"Azad","year":"2014","journal-title":"Mol. Biol. Rep."},{"key":"10.1016\/j.fct.2026.116172_bib3","doi-asserted-by":"crossref","first-page":"1517S","DOI":"10.1093\/jn\/133.5.1517S","article-title":"Selenoprotein metabolism and function: evidence for more than one function for selenoprotein P","volume":"133","author":"Burk","year":"2003","journal-title":"J. Nutr."},{"key":"10.1016\/j.fct.2026.116172_bib4","doi-asserted-by":"crossref","DOI":"10.3389\/fnut.2021.827759","article-title":"Editorial: selenium, human health and chronic disease","volume":"8","author":"Cardoso","year":"2022","journal-title":"Front. Nutr."},{"key":"10.1016\/j.fct.2026.116172_bib5","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1007\/s00894-025-06291-1","article-title":"A theoretical study on the mechanism and rate constants of luteolin and selenium dioxide","volume":"31","author":"Chen","year":"2025","journal-title":"J. Mol. Model."},{"key":"10.1016\/j.fct.2026.116172_bib6","doi-asserted-by":"crossref","first-page":"1957","DOI":"10.1001\/jama.1996.03540240035027","article-title":"Effects of selenium supplementation for cancer prevention in patients with carcinoma of the skin: a randomized controlled trial","volume":"276","author":"Clark","year":"1996","journal-title":"JAMA"},{"key":"10.1016\/j.fct.2026.116172_bib7","series-title":"ICH Guideline S2 (R1) on Genotoxicity Testing and Data Interpretation for Pharmaceuticals Intended for Human Use","year":"2012"},{"key":"10.1016\/j.fct.2026.116172_bib8","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1080\/10408399709527773","article-title":"Selenium in health and disease: a review","volume":"37","author":"Foster","year":"1997","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"10.1016\/j.fct.2026.116172_bib9","series-title":"National Food Safety Standard \u2014 Mammalian Erythrocyte Micronucleus Test","year":"2014"},{"key":"10.1016\/j.fct.2026.116172_bib10","series-title":"National Food Safety Standard \u2014 Mammalian Bone Marrow Cell Chromosome Aberration Test","year":"2014"},{"key":"10.1016\/j.fct.2026.116172_bib11","series-title":"National Food Safety Standard \u2014 Bacterial Reversion Mutation Test","year":"2014"},{"key":"10.1016\/j.fct.2026.116172_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.jtemb.2019.126435","article-title":"Acute human toxicity and mortality after selenium ingestion: a review","volume":"58","author":"Hadrup","year":"2020","journal-title":"J. Trace Elem. Med. Biol."},{"key":"10.1016\/j.fct.2026.116172_bib13","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1007\/s12011-014-0107-4","article-title":"Effect of supranutritional organic selenium supplementation on postpartum blood micronutrients, antioxidants, metabolites, and inflammation biomarkers in selenium-replete dairy cows","volume":"161","author":"Hall","year":"2014","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.fct.2026.116172_bib14","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1016\/j.jnutbio.2011.06.001","article-title":"Nutritional and supranutritional levels of selenate differentially suppress prostate tumor growth in adult but not young nude mice","volume":"23","author":"Holmstrom","year":"2012","journal-title":"J. Nutr. Biochem."},{"key":"10.1016\/j.fct.2026.116172_bib15","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1007\/s12011-012-9440-7","article-title":"An organoselenium drug with antioxidant activity and free radical scavenging capacity in vitro","volume":"149","author":"Ibrahim","year":"2012","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.fct.2026.116172_bib16","doi-asserted-by":"crossref","DOI":"10.3390\/antiox9010080","article-title":"Selenium anticancer properties and impact on cellular redox status","volume":"9","author":"Kursvietiene","year":"2020","journal-title":"Antioxidants"},{"key":"10.1016\/j.fct.2026.116172_bib17","article-title":"Potential applications and risks of supranutritional selenium supplementation in metabolic dysfunction-associated steatotic liver disease: a critical review","volume":"17","author":"Liu","year":"2025","journal-title":"Nutrients"},{"key":"10.1016\/j.fct.2026.116172_bib18","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1074\/jbc.R800045200","article-title":"Selenoproteins","volume":"284","author":"Lu","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.fct.2026.116172_bib19","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1001\/archinternmed.2009.495","article-title":"Acute selenium toxicity associated with a dietary supplement","volume":"170","author":"MacFarquhar","year":"2010","journal-title":"Arch. Intern. Med."},{"issue":"1","key":"10.1016\/j.fct.2026.116172_bib20","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S0378-4274(03)00090-0","article-title":"Potential renal and hepatic toxicity of diphenyl diselenide, diphenyl ditelluride and ebselen for rats and mice","volume":"143","author":"Meotti","year":"2023","journal-title":"Toxicol. Lett."},{"issue":"4","key":"10.1016\/j.fct.2026.116172_bib21","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.3390\/nu12041049","article-title":"The role of selenium in health and disease: emerging and recurring trends","volume":"12","author":"M\u00e9plan","year":"2020","journal-title":"Nutrients"},{"key":"10.1016\/j.fct.2026.116172_bib22","first-page":"S466","article-title":"Randomized double-blind, placebo-controlled, multicenter phase 2 trial of selenomethionine as a modulator of efficacy and toxicity of chemoradiation in locally-advanced squamous cell carcinoma of the head and neck","volume":"87","author":"Mix","year":"2013","journal-title":"IJROBP"},{"key":"10.1016\/j.fct.2026.116172_bib23","article-title":"Organoselenium compounds as antioxidants","author":"Obieziurska-Fabisiak","year":"2023","journal-title":"ARKIVOC: Online Journal of Organic Chemistry 5, 1-24"},{"key":"10.1016\/j.fct.2026.116172_bib24","series-title":"Test No. 474: Mammalian Erythrocyte Micronucleus Test","year":"2016"},{"key":"10.1016\/j.fct.2026.116172_bib25","series-title":"Test No. 475: Mammalian Bone Marrow Chromosomal Aberration Test","year":"2016"},{"key":"10.1016\/j.fct.2026.116172_bib26","series-title":"Test No. 471: Bacterial Reverse Mutation Test","year":"2020"},{"key":"10.1016\/j.fct.2026.116172_bib27","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1024\/0300-9831\/a000101","article-title":"Young children with excess of weight show an impaired selenium status","volume":"82","author":"Ortega","year":"2012","journal-title":"Int. J. Vitam. Nutr. Res."},{"issue":"9","key":"10.1016\/j.fct.2026.116172_bib28","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1016\/j.bcp.2013.08.028","article-title":"The early research and development of ebselen","volume":"86","author":"Parnham","year":"2013","journal-title":"Biochem. Pharmacol."},{"issue":"5","key":"10.1016\/j.fct.2026.116172_bib29","article-title":"Organoselenium and organotellurium compounds containing chalcogen-oxygen bonds in organic synthesis or related processes","volume":"4","author":"Pop","year":"2019","journal-title":"Phys. Sci. Rev."},{"key":"10.1016\/j.fct.2026.116172_bib30","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1001\/jamaneurol.2018.1669","article-title":"Selenium toxicity associated with reversible leukoencephalopathy and cortical blindness","volume":"75","author":"Rae","year":"2018","journal-title":"JAMA Neurol."},{"issue":"4","key":"10.1016\/j.fct.2026.116172_bib31","doi-asserted-by":"crossref","first-page":"485","DOI":"10.3390\/ph15040485","article-title":"The potential use of ebselen in treatment-resistant depression","volume":"15","author":"Ramli","year":"2022","journal-title":"Pharmaceuticals"},{"key":"10.1016\/j.fct.2026.116172_bib32","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.ejca.2021.07.013","article-title":"Selenium stimulates the antitumour immunity: insights to future research","volume":"155","author":"Razaghi","year":"2021","journal-title":"Eur. J. Cancer"},{"key":"10.1016\/j.fct.2026.116172_bib33","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1017\/S0007114516004633","article-title":"Inadequate dietary intake of minerals: prevalence and association with socio-demographic and lifestyle factors","volume":"117","author":"Sales","year":"2017","journal-title":"Br. J. Nutr."},{"key":"10.1016\/j.fct.2026.116172_bib34","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1093\/jn\/130.7.1653","article-title":"Selenomethionine: a review of its nutritional significance, metabolism and toxicity","volume":"130","author":"Schrauzer","year":"2000","journal-title":"J. Nutr."},{"key":"10.1016\/j.fct.2026.116172_bib35","first-page":"471","article-title":"Observations on effect of sodium selenite in prevention of keshan disease","volume":"92","author":"Sciences","year":"1979","journal-title":"Chin. Med J-Pek."},{"key":"10.1016\/j.fct.2026.116172_bib37","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1146\/annurev.bi.65.070196.000503","article-title":"Selenocysteine","volume":"65","author":"Stadtman","year":"1996","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.fct.2026.116172_bib39","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.foodchem.2013.03.002","article-title":"Speciation of organic and inorganic selenium in selenium-enriched rice by graphite furnace atomic absorption spectrometry after cloud point extraction","volume":"141","author":"Sun","year":"2013","journal-title":"Food Chem."},{"key":"10.1016\/j.fct.2026.116172_bib40","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1080\/10408398.2021.1948818","article-title":"Recent development in Se-enriched yeast, lactic acid bacteria and bifidobacteria","volume":"63","author":"Yang","year":"2023","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"10.1016\/j.fct.2026.116172_bib41","first-page":"3031","article-title":"Effect of organic and inorganic selenium supplementation on growth performance, meat quality and antioxidant property of broilers","volume":"11","author":"Yang","year":"2012","journal-title":"Afr. J. Biotechnol."},{"key":"10.1016\/j.fct.2026.116172_bib42","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2018.01204","article-title":"Recent update on the pharmacological effects and mechanisms of dihydromyricetin","volume":"9","author":"Zhang","year":"2018","journal-title":"Front. Pharmacol."}],"container-title":["Food and Chemical Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278691526002462?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278691526002462?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T11:31:34Z","timestamp":1783078294000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0278691526002462"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":40,"alternative-id":["S0278691526002462"],"URL":"https:\/\/doi.org\/10.1016\/j.fct.2026.116172","relation":{},"ISSN":["0278-6915"],"issn-type":[{"value":"0278-6915","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A combined Ames and in vivo genotoxicity assessment of dimyricetin-yl-diselenide, a structurally defined organoselenium flavonoid","name":"articletitle","label":"Article Title"},{"value":"Food and Chemical Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fct.2026.116172","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"116172"}}