{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T03:15:33Z","timestamp":1783394133247,"version":"3.54.6"},"reference-count":81,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T00:00:00Z","timestamp":1782086400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100019899","name":"National Alliance for Life and Health Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100019899","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Food and Chemical Toxicology"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.fct.2026.116228","type":"journal-article","created":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T06:12:43Z","timestamp":1781935963000},"page":"116228","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Characterization of human isogenic epithelial cell lines as a relevant tool to study colon carcinogenesis and interactions between genes and environment"],"prefix":"10.1016","volume":"215","author":[{"given":"Arnaud","family":"T\u00eate","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1097-3944","authenticated-orcid":false,"given":"Liana","family":"Arnaud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e9l\u00e8ne","family":"Le Mentec","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Poupin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5302-8029","authenticated-orcid":false,"given":"Isabelle","family":"Gallais","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"No\u00e9mie","family":"Tournadre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina","family":"Duarte-Hospital","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4717-078X","authenticated-orcid":false,"given":"Yannick","family":"Lippi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fanny","family":"Mathevet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ga\u00eblle","family":"Lefort","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4800-1320","authenticated-orcid":false,"given":"Catherine","family":"Lavau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agn\u00e8s","family":"Burel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8165-2072","authenticated-orcid":false,"given":"Reggie","family":"Surya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerry W","family":"Shay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camilla","family":"Pilati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"Coumoul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurence","family":"Huc","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Vialaneix","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1008-1241","authenticated-orcid":false,"given":"Sylvie","family":"Bortoli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4888-236X","authenticated-orcid":false,"given":"Dominique","family":"Lagadic-Gossmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.fct.2026.116228_bib1","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0228551","article-title":"Differences in cancer survival by area-level socio-economic disadvantage: a population-based study using cancer registry data","volume":"15","author":"Afshar","year":"2020","journal-title":"PLoS One"},{"key":"10.1016\/j.fct.2026.116228_bib2","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0082487","article-title":"Expression profile of CYP1A1 and CYP1B1 enzymes in colon and bladder tumors","volume":"8","author":"Androutsopoulos","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.fct.2026.116228_bib3","doi-asserted-by":"crossref","first-page":"4337","DOI":"10.3390\/cancers13174337","article-title":"Short-term and long-term carcinogenic effects of food contaminants (4-Hydroxynonenal and pesticides) on colorectal human cells: involvement of genotoxic and non-genomic mechanisms","volume":"13","author":"Arnaud","year":"2021","journal-title":"Cancers"},{"key":"10.1016\/j.fct.2026.116228_bib4","doi-asserted-by":"crossref","DOI":"10.1136\/bmj.d6617","article-title":"Dietary fibre, whole grains, and risk of colorectal cancer: systematic review and dose-response meta-analysis of prospective studies","volume":"343","author":"Aune","year":"2011","journal-title":"BMJ"},{"key":"10.1016\/j.fct.2026.116228_bib5","doi-asserted-by":"crossref","first-page":"1984","DOI":"10.1021\/tx2003036","article-title":"4-Hydroxy-2(E)-nonenal metabolism differs in Apc(+\/+) cells and in Apc(Min\/+) cells: it may explain colon cancer promotion by heme iron","volume":"24","author":"Baradat","year":"2011","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.fct.2026.116228_bib6","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1186\/1471-2105-15-293","article-title":"Jvenn: an interactive Venn diagram viewer","volume":"15","author":"Bardou","year":"2014","journal-title":"BMC Bioinf."},{"key":"10.1016\/j.fct.2026.116228_bib7","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1158\/0008-5472.CAN-14-2554","article-title":"A central role for heme iron in colon carcinogenesis associated with red meat intake","volume":"75","author":"Bastide","year":"2015","journal-title":"Cancer Res."},{"key":"10.1016\/j.fct.2026.116228_bib8","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1158\/1940-6207.CAPR-10-0113","article-title":"Heme iron from meat and risk of colorectal cancer: a meta-analysis and a review of the mechanisms involved","volume":"4","author":"Bastide","year":"2011","journal-title":"Cancer Prev. Res. Phila. Pa"},{"key":"10.1016\/j.fct.2026.116228_bib9","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1016\/j.steroids.2010.04.003","article-title":"Metabolic bioactivation of oestradiol-17beta (E2beta) in mouse colon epithelial cells bearing ApcMin mutation","volume":"75","author":"Bellocq","year":"2010","journal-title":"Steroids"},{"key":"10.1016\/j.fct.2026.116228_bib10","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1158\/2159-8290.CD-22-1038","article-title":"Early-Onset cancer in the gastrointestinal tract is on the rise-evidence and implications","volume":"13","author":"Ben-Aharon","year":"2023","journal-title":"Cancer Discov."},{"key":"10.1016\/j.fct.2026.116228_bib11","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1186\/s12943-017-0691-y","article-title":"Multi-omics of 34 colorectal cancer cell lines - a resource for biomedical studies","volume":"16","author":"Berg","year":"2017","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.fct.2026.116228_bib12","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1038\/s41568-020-00320-2","article-title":"The metabolism of cancer cells during metastasis","volume":"21","author":"Bergers","year":"2021","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.fct.2026.116228_bib13","doi-asserted-by":"crossref","first-page":"2591","DOI":"10.1002\/ijc.25599","article-title":"Butyrate elicits a metabolic switch in human colon cancer cells by targeting the pyruvate dehydrogenase complex","volume":"128","author":"Blouin","year":"2011","journal-title":"Int. J. Cancer"},{"issue":"2","key":"10.1016\/j.fct.2026.116228_bib14","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1093\/bioinformatics\/19.2.185","article-title":"A comparison of normalization methods for high density oligonucleotide array data based on variance and bias","volume":"19","author":"Bolstad","year":"2003","journal-title":"Bioinformatics"},{"key":"10.1016\/j.fct.2026.116228_bib15","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.cotox.2017.12.001","article-title":"Nrf2 and AhR in metabolic reprogramming after contaminant exposure","volume":"8","author":"Bortoli","year":"2018","journal-title":"Curr. Opin. Toxicol., Mechanistic Toxicology: Metabolic Disruption in Environmental Diseases"},{"key":"10.1016\/j.fct.2026.116228_bib16","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.cotox.2017.12.002","article-title":"DNA damage response upon environmental contaminants: an exhausting work for genomic integrity","volume":"8","author":"Boutet-Robinet","year":"2018","journal-title":"Curr. Opin. Toxicol., Mechanistic Toxicology: Metabolic Disruption in Environmental Diseases"},{"key":"10.1016\/j.fct.2026.116228_bib17","first-page":"229","article-title":"Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"74","author":"Bray","year":"2024","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.fct.2026.116228_bib18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/10520295.2018.1493220","article-title":"Expression of CYP and GST in human normal and colon tumor tissues","volume":"94","author":"Bulus","year":"2019","journal-title":"Biotech. Histochem."},{"key":"10.1016\/j.fct.2026.116228_bib19","first-page":"1","article-title":"Expression of CYP and GST in human normal and colon tumor tissues","volume":"94","author":"Bulus","year":"2019","journal-title":"Biotech. Histochem. Off. Publ. Biol. Stain Comm."},{"key":"10.1016\/j.fct.2026.116228_bib20","doi-asserted-by":"crossref","first-page":"3694","DOI":"10.3390\/ijms20153694","article-title":"The role of sodium hydrogen exchanger 1 in dysregulation of proton dynamics and reprogramming of cancer metabolism as a sequela","volume":"20","author":"Cardone","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.fct.2026.116228_bib21","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.gie.2017.04.005","article-title":"Public health impact of colonoscopy use on colorectal cancer mortality in Germany and the United States","volume":"87","author":"Chen","year":"2018","journal-title":"Gastrointest. Endosc."},{"key":"10.1016\/j.fct.2026.116228_bib22","article-title":"Tumour recurrence, gastrointestinal symptoms and inflammation associated with microplastic-positive intestinal tumours","volume":"1\u201311","author":"Chen","year":"2026","journal-title":"Nat. Health"},{"key":"10.1016\/j.fct.2026.116228_bib23","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1124\/dmd.32.8.840","article-title":"Metabolism of retinoids and arachidonic acid by human and mouse cytochrome P450 1B1","volume":"32","author":"Choudhary","year":"2004","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.fct.2026.116228_bib24","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pcbi.1011381","article-title":"Genome scale metabolic network modelling for metabolic profile predictions","volume":"20","author":"Cooke","year":"2024","journal-title":"PLoS Comput. Biol."},{"key":"10.1016\/j.fct.2026.116228_bib25","doi-asserted-by":"crossref","first-page":"W495","DOI":"10.1093\/nar\/gky301","article-title":"MetExplore: collaborative edition and exploration of metabolic networks","volume":"46","author":"Cottret","year":"2018","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.fct.2026.116228_bib26","first-page":"324","article-title":"Polycyclic aromatic hydrocarbons and digestive tract cancers - a perspective","volume":"29","author":"Diggs","year":"2011","journal-title":"J. Environ. Sci. Health Part C Environ. Carcinog. Ecotoxicol. Rev."},{"key":"10.1016\/j.fct.2026.116228_bib27","first-page":"527","article-title":"Cytochrome P450 1B1 (CYP1B1) is overexpressed in human colon adenocarcinomas relative to normal colon: implications for drug development","volume":"2","author":"Gibson","year":"2003","journal-title":"Mol. Cancer Therapeut."},{"key":"10.1016\/j.fct.2026.116228_bib28","doi-asserted-by":"crossref","first-page":"34","DOI":"10.3389\/fcimb.2016.00034","article-title":"Genotoxicity of cytolethal distending toxin (CDT) on isogenic human colorectal cell lines: potential promoting effects for colorectal carcinogenesis","volume":"6","author":"Graillot","year":"2016","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.fct.2026.116228_bib29","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1021\/acs.chemrestox.1c00364","article-title":"Alternaria alternata mycotoxins activate the aryl hydrocarbon receptor and Nrf2-ARE pathway to alter the structure and immune response of Colon epithelial cells","volume":"35","author":"Groestlinger","year":"2022","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.fct.2026.116228_bib30","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.1038\/nprot.2016.085","article-title":"A real-time fluorometric method for the simultaneous detection of cell death type and rate","volume":"11","author":"Grootjans","year":"2016","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.fct.2026.116228_bib31","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1158\/2159-8290.CD-21-1059","article-title":"Hallmarks of cancer: new dimensions","volume":"12","author":"Hanahan","year":"2022","journal-title":"Cancer Discov."},{"key":"10.1016\/j.fct.2026.116228_bib32","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.semcancer.2017.01.001","article-title":"Environmental carcinogenesis and pH homeostasis: not only a matter of dysregulated metabolism","volume":"43","author":"Hardonni\u00e8re","year":"2017","journal-title":"Semin. Cancer Biol."},{"key":"10.1016\/j.fct.2026.116228_bib33","doi-asserted-by":"crossref","DOI":"10.1038\/srep30776","article-title":"The environmental carcinogen benzo[a]pyrene induces a Warburg-like metabolic reprogramming dependent on NHE1 and associated with cell survival","volume":"6","author":"Hardonni\u00e8re","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.fct.2026.116228_bib34","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1007\/s00384-019-03344-9","article-title":"G12V and G12C mutations in the gene KRAS are associated with a poorer prognosis in primary colorectal cancer","volume":"34","author":"Hayama","year":"2019","journal-title":"Int. J. Colorectal Dis."},{"key":"10.1016\/j.fct.2026.116228_bib35","doi-asserted-by":"crossref","first-page":"850","DOI":"10.2174\/138920021610151210164501","article-title":"Role of metabolic enzymes P450 (CYP) on activating procarcinogen and their polymorphisms on the risk of cancers","volume":"16","author":"He","year":"2015","journal-title":"Curr. Drug Metabol."},{"key":"10.1016\/j.fct.2026.116228_bib36","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1038\/s41586-022-05311-x","article-title":"Phenotypic plasticity and genetic control in colorectal cancer evolution","volume":"611","author":"Househam","year":"2022","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.fct.2026.116228_bib37","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1038\/nmeth.3252","article-title":"Orchestrating high-throughput genomic analysis with Bioconductor","volume":"12","author":"Huber","year":"2015","journal-title":"Nat. Methods"},{"key":"10.1016\/j.fct.2026.116228_bib38","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0076446","article-title":"Beyond cell death - antiapoptotic Bcl-2 proteins regulate migration and invasion of colorectal cancer cells in vitro","volume":"8","author":"Koehler","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.fct.2026.116228_bib39","doi-asserted-by":"crossref","first-page":"1","DOI":"10.18637\/jss.v025.i01","article-title":"FactoMineR: an R package for multivariate analysis","volume":"25","author":"L\u00ea","year":"2008","journal-title":"J. Stat. Software"},{"key":"10.1016\/j.fct.2026.116228_bib40","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.biochi.2019.06.013","article-title":"Disturbances in H+ dynamics during environmental carcinogenesis","volume":"163","author":"Lagadic-Gossmann","year":"2019","journal-title":"Biochimie"},{"key":"10.1016\/j.fct.2026.116228_bib41","doi-asserted-by":"crossref","first-page":"2657","DOI":"10.1002\/ijc.22170","article-title":"Meat consumption and risk of colorectal cancer: a meta-analysis of prospective studies","volume":"119","author":"Larsson","year":"2006","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.fct.2026.116228_bib42","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0208546","article-title":"Association of colorectal polyps and cancer with low-dose persistent organic pollutants: a case-control study","volume":"13","author":"Lee","year":"2018","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.fct.2026.116228_bib43","article-title":"Unhealthy lifestyle factors and the risk of colorectal cancer: a Mendelian randomization study","volume":"14","author":"Li","year":"2024","journal-title":"Sci. Rep."},{"key":"10.1016\/j.fct.2026.116228_bib44","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2025.118072","article-title":"Environmental pollutants and rectal cancer: the impact of water contamination","volume":"294","author":"Li","year":"2025","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.fct.2026.116228_bib45","doi-asserted-by":"crossref","first-page":"6740","DOI":"10.1038\/s41598-019-43231-5","article-title":"miR-150-5p represses TP53 tumor suppressor gene to promote proliferation of Colon adenocarcinoma","volume":"9","author":"Liu","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.fct.2026.116228_bib46","first-page":"5275","article-title":"Mechanisms of resistance to etoposide and teniposide in acquired resistant human colon and lung carcinoma cell lines","volume":"51","author":"Long","year":"1991","journal-title":"Cancer Res."},{"key":"10.1016\/j.fct.2026.116228_bib47","doi-asserted-by":"crossref","first-page":"1827","DOI":"10.1038\/s41591-026-04342-5","article-title":"Epigenetic fingerprints link early-onset colon and rectal cancer to pesticide exposure","volume":"32","author":"Maas","year":"2026","journal-title":"Nat. Med."},{"key":"10.1016\/j.fct.2026.116228_bib48","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1186\/1476-4598-10-118","article-title":"BRAF and RAS oncogenes regulate Rho GTPase pathways to mediate migration and invasion properties in human colon cancer cells: a comparative study","volume":"10","author":"Makrodouli","year":"2011","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.fct.2026.116228_bib49","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/s40001-019-0365-x","article-title":"Staurosporine induces apoptosis in pancreatic carcinoma cells PaTu 8988t and Panc-1 via the intrinsic signaling pathway","volume":"24","author":"Malsy","year":"2019","journal-title":"Eur. J. Med. Res."},{"key":"10.1016\/j.fct.2026.116228_bib50","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1186\/s40168-019-0685-7","article-title":"Haem iron reshapes colonic luminal environment: impact on mucosal homeostasis and microbiome through aldehyde formation","volume":"7","author":"Martin","year":"2019","journal-title":"Microbiome"},{"key":"10.1016\/j.fct.2026.116228_bib51","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.mam.2019.06.005","article-title":"Lifestyle and dietary environmental factors in colorectal cancer susceptibility","volume":"69","author":"Murphy","year":"2019","journal-title":"Mol. Aspect. Med."},{"key":"10.1016\/j.fct.2026.116228_bib52","doi-asserted-by":"crossref","first-page":"6262","DOI":"10.3390\/ijms22126262","article-title":"Metabolic reprogramming of colorectal cancer cells and the microenvironment: implication for therapy","volume":"22","author":"Nenkov","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.fct.2026.116228_bib53","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1053\/j.gastro.2019.08.059","article-title":"Pathways of colorectal carcinogenesis","volume":"158","author":"Nguyen","year":"2020","journal-title":"Gastroenterology"},{"key":"10.1016\/j.fct.2026.116228_bib54","doi-asserted-by":"crossref","first-page":"12431","DOI":"10.3748\/wjg.v20.i35.12431","article-title":"Occupational exposures and colorectal cancers: a quantitative overview of epidemiological evidence","volume":"20","author":"Oddone","year":"2014","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.fct.2026.116228_bib55","first-page":"5747","article-title":"Changes in subcellular distribution of topoisomerase IIalpha correlate with etoposide resistance in multicell spheroids and xenograft tumors","volume":"60","author":"Oloumi","year":"2000","journal-title":"Cancer Res."},{"key":"10.1016\/j.fct.2026.116228_bib56","doi-asserted-by":"crossref","DOI":"10.1016\/j.critrevonc.2023.104018","article-title":"The prognostic role of p53 mutations in metastatic colorectal cancer: a systematic review and meta-analysis","volume":"186","author":"Ottaiano","year":"2023","journal-title":"Crit. Rev. Oncol. Hematol."},{"key":"10.1016\/j.fct.2026.116228_bib57","doi-asserted-by":"crossref","DOI":"10.1155\/2012\/509348","article-title":"Genetic and epigenetic events generate multiple pathways in colorectal cancer progression","volume":"2012","author":"Pancione","year":"2012","journal-title":"Pathol. Res. Int."},{"key":"10.1016\/j.fct.2026.116228_bib58","doi-asserted-by":"crossref","first-page":"2709","DOI":"10.1002\/ijc.31655","article-title":"Rotating night shift work and colorectal cancer risk in the nurses' health studies","volume":"143","author":"Papantoniou","year":"2018","journal-title":"Int. J. Cancer"},{"issue":"Suppl. 2","key":"10.1016\/j.fct.2026.116228_bib59","doi-asserted-by":"crossref","first-page":"S24","DOI":"10.1038\/bjc.2011.478","article-title":"5. Cancers attributable to dietary factors in the UK in 2010. II. Meat consumption","volume":"105","author":"Parkin","year":"2011","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.fct.2026.116228_bib60","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1093\/carcin\/bgl127","article-title":"Apc mutation induces resistance of colonic cells to lipoperoxide-triggered apoptosis induced by faecal water from haem-fed rats","volume":"28","author":"Pierre","year":"2007","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.fct.2026.116228_bib61","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1038\/nrc3106","article-title":"RAS oncogenes: weaving a tumorigenic web","volume":"11","author":"Pylayeva-Gupta","year":"2011","journal-title":"Nat. Rev. Cancer"},{"issue":"7","key":"10.1016\/j.fct.2026.116228_bib62","doi-asserted-by":"crossref","first-page":"e47","DOI":"10.1093\/nar\/gkv007","article-title":"limma powers differential expression analyses for RNA-sequencing and microarray studies","volume":"43","author":"Ritchie","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.fct.2026.116228_bib63","doi-asserted-by":"crossref","DOI":"10.1126\/scisignal.aaz1482","article-title":"An atlas of human metabolism","volume":"13","author":"Robinson","year":"2020","journal-title":"Sci. Signal."},{"key":"10.1016\/j.fct.2026.116228_bib64","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1053\/j.gastro.2009.11.052","article-title":"Immortalized epithelial cells derived from human colon biopsies express stem cell markers and differentiate in vitro","volume":"138","author":"Roig","year":"2010","journal-title":"Gastroenterology"},{"key":"10.1016\/j.fct.2026.116228_bib65","doi-asserted-by":"crossref","first-page":"6945","DOI":"10.1038\/s41598-017-07006-0","article-title":"Resveratrol reverses the Warburg effect by targeting the pyruvate dehydrogenase complex in colon cancer cells","volume":"7","author":"Saunier","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.fct.2026.116228_bib66","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1038\/s41419-020-03092-7","article-title":"Identification of BCL-XL as highly active survival factor and promising therapeutic target in colorectal cancer","volume":"11","author":"Scherr","year":"2020","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.fct.2026.116228_bib67","first-page":"17","article-title":"Cancer statistics, 2023","volume":"73","author":"Siegel","year":"2023","journal-title":"CA Cancer J. Clin."},{"issue":"14","key":"10.1016\/j.fct.2026.116228_bib68","doi-asserted-by":"crossref","first-page":"9433","DOI":"10.1073\/pnas.122612899","article-title":"Mutations in APC, Kirsten-ras, and p53\u2014alternative genetic pathways to colorectal cancer","volume":"99","author":"Smith","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.fct.2026.116228_bib69","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1093\/carcin\/bgw035","article-title":"Red meat and colorectal cancer: Nrf2-dependent antioxidant response contributes to the resistance of preneoplastic colon cells to fecal water of hemoglobin- and beef-fed rats","volume":"37","author":"Surya","year":"2016","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.fct.2026.116228_bib70","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1038\/s41568-023-00628-9","article-title":"How protons pave the way to aggressive cancers","volume":"23","author":"Swietach","year":"2023","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.fct.2026.116228_bib71","article-title":"Costs of molecular adaptation to the chemical exposome: a focus on xenobiotic metabolism pathways","volume":"379","author":"Tomkiewicz","year":"2023","journal-title":"Philos. Trans. R. Soc. B Biol. Sci."},{"key":"10.1016\/j.fct.2026.116228_bib72","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.freeradbiomed.2018.09.042","article-title":"Mechanisms involved in the death of steatotic WIF-B9 hepatocytes co-exposed to benzo[a]pyrene and ethanol: a possible key role for xenobiotic metabolism and nitric oxide","volume":"129","author":"T\u00eate","year":"2018","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.fct.2026.116228_bib73","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2020.111798","article-title":"MEHP\/ethanol co-exposure favors the death of steatotic hepatocytes, possibly through CYP4A and ADH involvement","volume":"146","author":"T\u00eate","year":"2020","journal-title":"Food Chem. Toxicol. Int. J. Publ. Br. Ind. Biol. Res. Assoc."},{"key":"10.1016\/j.fct.2026.116228_bib74","doi-asserted-by":"crossref","first-page":"11748","DOI":"10.3748\/wjg.v21.i41.11748","article-title":"Eicosanoid pathway in colorectal cancer: recent updates","volume":"21","author":"Tuncer","year":"2015","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.fct.2026.116228_bib75","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1126\/science.1160809","article-title":"Understanding the Warburg effect: the metabolic requirements of cell proliferation","volume":"324","author":"Vander Heiden","year":"2009","journal-title":"Science"},{"key":"10.1016\/j.fct.2026.116228_bib76","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1002\/ijc.10146","article-title":"Resistance of colon cancer cells to long-term 5-fluorouracil exposure is correlated to the relative level of Bcl-2 and Bcl-X(L) in addition to Bax and p53 status","volume":"98","author":"Violette","year":"2002","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.fct.2026.116228_bib77","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1158\/1541-7786.MCR-18-1195","article-title":"TP53 mutation by CRISPR System enhances the malignant potential of Colon cancer","volume":"17","author":"Watanabe","year":"2019","journal-title":"Mol. Cancer Res. MCR"},{"key":"10.1016\/j.fct.2026.116228_bib78","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1186\/s13099-025-00784-3","article-title":"Gut microbiota and intestinal polyps: a systematic review and meta-analysis based on 16S rRNA gene sequencing","volume":"17","author":"Wu","year":"2025","journal-title":"Gut Pathog."},{"key":"10.1016\/j.fct.2026.116228_bib79","doi-asserted-by":"crossref","first-page":"1436","DOI":"10.3390\/cancers7030847","article-title":"Role of the Aryl hydrocarbon receptor in Colon neoplasia","volume":"7","author":"Xie","year":"2015","journal-title":"Cancers"},{"key":"10.1016\/j.fct.2026.116228_bib80","doi-asserted-by":"crossref","first-page":"17751","DOI":"10.1074\/jbc.M600831200","article-title":"Adenomatous polyposis coli (APC) differentially regulates beta-catenin phosphorylation and ubiquitination in colon cancer cells","volume":"281","author":"Yang","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.fct.2026.116228_bib81","doi-asserted-by":"crossref","first-page":"djw332","DOI":"10.1093\/jnci\/djw332","article-title":"Multiple roles of APC and its therapeutic implications in colorectal cancer","volume":"109","author":"Zhang","year":"2017","journal-title":"J. Natl. Cancer Inst."}],"container-title":["Food and Chemical Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278691526003029?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278691526003029?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T02:47:25Z","timestamp":1783392445000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0278691526003029"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":81,"alternative-id":["S0278691526003029"],"URL":"https:\/\/doi.org\/10.1016\/j.fct.2026.116228","relation":{},"ISSN":["0278-6915"],"issn-type":[{"value":"0278-6915","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Characterization of human isogenic epithelial cell lines as a relevant tool to study colon carcinogenesis and interactions between genes and environment","name":"articletitle","label":"Article Title"},{"value":"Food and Chemical Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fct.2026.116228","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"116228"}}