{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T06:50:40Z","timestamp":1785912640455,"version":"3.56.0"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Food and Chemical Toxicology"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.fct.2026.116236","type":"journal-article","created":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T06:48:56Z","timestamp":1782283736000},"page":"116236","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["CXCL8 is associated with aflatoxin B1\u2013triggered injury and caspase-3 activation in porcine kidney epithelial PK15\u202fcells: integrated transcriptomics and CRISPR\/Cas9 knockout"],"prefix":"10.1016","volume":"215","author":[{"given":"Jianlin","family":"Yuan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhan","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinfeng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xizhu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiping","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinfeng","family":"Hang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heng","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Senyan","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiping","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi-Gui","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaobo","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng","family":"Yi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"San-Jie","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3184-2932","authenticated-orcid":false,"given":"Qin","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.fct.2026.116236_bib1","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-025-05296-3","article-title":"Pan-cancer Exome-wide analysis of germline mutational patterns and pathways","volume":"15","author":"Alnaqbi","year":"2025","journal-title":"Sci. Rep."},{"issue":"4","key":"10.1016\/j.fct.2026.116236_bib2","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/j.bbrc.2011.07.127","article-title":"CXCL8 protects human neurons from amyloid-\u03b2-induced neurotoxicity: relevance to Alzheimer's disease","volume":"412","author":"Ashutosh","year":"2011","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.fct.2026.116236_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2021.112438","article-title":"Bacillus amyloliquefaciens B10 inhibits aflatoxin B1-induced cecal inflammation in mice by regulating their intestinal flora","volume":"156","author":"Chen","year":"2021","journal-title":"Food Chem. Toxicol."},{"issue":"1","key":"10.1016\/j.fct.2026.116236_bib4","doi-asserted-by":"crossref","first-page":"8010","DOI":"10.1038\/s41598-019-44515-6","article-title":"An unusually high production of hepatic aflatoxin B(1)-dihydrodiol, the possible explanation for the high susceptibility of ducks to aflatoxin B(1)","volume":"9","author":"Diaz","year":"2019","journal-title":"Sci. Rep."},{"issue":"3","key":"10.1016\/j.fct.2026.116236_bib5","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1080\/03601234.2018.1536578","article-title":"Cytotoxicity of gamma irradiated aflatoxin B(1) and ochratoxin A","volume":"54","author":"Domijan","year":"2019","journal-title":"J. Environ. Sci. Health B"},{"issue":"2","key":"10.1016\/j.fct.2026.116236_bib6","doi-asserted-by":"crossref","DOI":"10.3390\/toxins14020083","article-title":"Tissular genomic responses to oral FB1 exposure in pigs","volume":"14","author":"Dopavogui","year":"2022","journal-title":"Toxins"},{"issue":"7","key":"10.1016\/j.fct.2026.116236_bib7","doi-asserted-by":"crossref","DOI":"10.3390\/ijerph14070719","article-title":"Health risks associated with exposure to filamentous fungi","volume":"14","author":"Egbuta","year":"2017","journal-title":"Int. J. Environ. Res. Publ. Health"},{"issue":"6","key":"10.1016\/j.fct.2026.116236_bib8","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1080\/15376516.2023.2195488","article-title":"Fermented whey modulated AFB1 and OTA-induced hepatotoxicity and nephrotoxicity in vivo. A relative and absolute quantification about sex differences","volume":"33","author":"Frangiamone","year":"2023","journal-title":"Toxicol. Mech. Methods"},{"key":"10.1016\/j.fct.2026.116236_bib9","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.fct.2017.11.021","article-title":"Modified mycotoxins: an updated review on their formation, detection, occurrence, and toxic effects","volume":"111","author":"Freire","year":"2018","journal-title":"Food Chem. Toxicol."},{"issue":"3","key":"10.1016\/j.fct.2026.116236_bib10","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0119808","article-title":"Selenium alleviates porcine nephrotoxicity of ochratoxin A by improving selenoenzyme expression in vitro","volume":"10","author":"Gan","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.fct.2026.116236_bib11","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1016\/j.chemosphere.2017.05.030","article-title":"Ochratoxin A induces nephrotoxicity and immunotoxicity through different MAPK signaling pathways in PK15 cells and porcine primary splenocytes","volume":"182","author":"Gan","year":"2017","journal-title":"Chemosphere"},{"issue":"12","key":"10.1016\/j.fct.2026.116236_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.psj.2021.101513","article-title":"Morin alleviates aflatoxin B1-induced liver and kidney injury by inhibiting heterophil extracellular traps release, oxidative stress and inflammatory responses in chicks","volume":"100","author":"Gao","year":"2021","journal-title":"Poult. Sci."},{"issue":"Pt 2","key":"10.1016\/j.fct.2026.116236_bib13","article-title":"Aflatoxin B(1) promotes autophagy associated with oxidative stress-related PI3K\/AKT\/mTOR signaling pathway in mice testis","volume":"255","author":"Huang","year":"2019","journal-title":"Environ. Pollut."},{"issue":"7\u20138","key":"10.1016\/j.fct.2026.116236_bib14","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1016\/j.etp.2013.05.007","article-title":"In vitro investigation of individual and combined cytotoxic effects of aflatoxin B1 and other selected mycotoxins on the cell line porcine kidney 15","volume":"65","author":"Lei","year":"2013","journal-title":"Exp. Toxicol. Pathol."},{"key":"10.1016\/j.fct.2026.116236_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbrc.2024.150394","article-title":"Chromatin accessibility and transcriptional landscape in PK-15 cells during early exposure to aflatoxin B(1)","volume":"731","author":"Li","year":"2024","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.fct.2026.116236_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2022.110240","article-title":"Low doses of fumonisin B1 exacerbate ochratoxin A-induced renal injury in mice and the protective roles of heat shock protein 70","volume":"369","author":"Li","year":"2023","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.fct.2026.116236_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2025.108962","article-title":"Oxidative stress and antioxidant therapeutic mechanisms","volume":"278","author":"Liu","year":"2026","journal-title":"Pharmacol. Ther."},{"issue":"5","key":"10.1016\/j.fct.2026.116236_bib18","doi-asserted-by":"crossref","DOI":"10.3390\/toxins12050290","article-title":"AFB1 induced transcriptional regulation related to apoptosis and lipid metabolism in liver of chicken","volume":"12","author":"Liu","year":"2020","journal-title":"Toxins"},{"key":"10.1016\/j.fct.2026.116236_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2023.115742","article-title":"SeMet alleviates AFB(1)-induced oxidative stress and apoptosis in rabbit kidney by regulating Nrf2\/\/Keap1\/NQO1 and PI3K\/AKT signaling pathways","volume":"269","author":"Liu","year":"2024","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.fct.2026.116236_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2025.148130","article-title":"RIPK4-P53 interaction drives aflatoxin B1-induced renal mitochondrial apoptosis via Ser15 phosphorylation: a CRISPR-Cas9 mechanistic study","author":"Ma","year":"2025","journal-title":"Int. J. Biol. Macromol."},{"issue":"3","key":"10.1016\/j.fct.2026.116236_bib21","doi-asserted-by":"crossref","DOI":"10.3390\/foods11030354","article-title":"Curcumin-based photosensitization, a green treatment in inactivating Aspergillus flavus spores in peanuts","volume":"11","author":"Mukubesa","year":"2022","journal-title":"Foods"},{"issue":"1","key":"10.1016\/j.fct.2026.116236_bib22","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1007\/BF00636179","article-title":"Binding of aflatoxin B1, G1 and M to plasma albumin","volume":"79","author":"Nassar","year":"1982","journal-title":"Mycopathologia"},{"issue":"1","key":"10.1016\/j.fct.2026.116236_bib23","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1007\/s12550-016-0265-7","article-title":"Mycotoxins as human carcinogens-the IARC monographs classification","volume":"33","author":"Ostry","year":"2017","journal-title":"Mycotoxin Res."},{"issue":"8","key":"10.1016\/j.fct.2026.116236_bib24","doi-asserted-by":"crossref","DOI":"10.1111\/jfbc.13316","article-title":"Gallic acid protects against aflatoxin B(1) -induced oxidative and inflammatory stress damage in rats kidneys and liver","volume":"44","author":"Owumi","year":"2020","journal-title":"J. Food Biochem."},{"issue":"2","key":"10.1016\/j.fct.2026.116236_bib26","doi-asserted-by":"crossref","DOI":"10.3390\/toxins13020148","article-title":"The effectiveness of dietary byproduct antioxidants on induced CYP genes expression and histological alteration in piglets liver and kidney fed with aflatoxin B1 and ochratoxin A","volume":"13","author":"Popescu","year":"2021","journal-title":"Toxins"},{"issue":"12","key":"10.1016\/j.fct.2026.116236_bib27","doi-asserted-by":"crossref","DOI":"10.3390\/toxins14120853","article-title":"Aflatoxins in feed: types, metabolism, health consequences in swine and mitigation strategies","volume":"14","author":"Popescu","year":"2022","journal-title":"Toxins"},{"issue":"11","key":"10.1016\/j.fct.2026.116236_bib25","doi-asserted-by":"crossref","DOI":"10.3390\/toxins9110339","article-title":"Investigation of non-covalent interactions of aflatoxins (B1, B2, G1, G2, and M1) with serum albumin","volume":"9","author":"Po\u00f3r","year":"2017","journal-title":"Toxins"},{"key":"10.1016\/j.fct.2026.116236_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.dci.2024.105261","article-title":"First report of a chemokine from camelids: dromedary CXCL8 is induced by poxvirus and heavy metal toxicity","volume":"161","author":"Premraj","year":"2024","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.fct.2026.116236_bib29","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.cancergen.2025.09.002","article-title":"Exploring replication stress and cellular senescence as key targets in novel cancer therapies","volume":"298\u2013299","author":"Ray","year":"2025","journal-title":"Cancer Genet."},{"issue":"1","key":"10.1016\/j.fct.2026.116236_bib30","doi-asserted-by":"crossref","DOI":"10.3390\/toxins11010055","article-title":"Differential transcriptome responses to aflatoxin B1 in the cecal tonsil of susceptible and resistant turkeys","volume":"11","author":"Reed","year":"2019","journal-title":"Toxins"},{"key":"10.1016\/j.fct.2026.116236_bib31","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.toxicon.2014.08.006","article-title":"Differential activation of MAPKs by individual and combined ochratoxin A and citrinin treatments in porcine kidney PK15 cells","volume":"90","author":"Rumora","year":"2014","journal-title":"Toxicon"},{"key":"10.1016\/j.fct.2026.116236_bib32","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.fct.2018.11.047","article-title":"Aflatoxin B1: a review on metabolism, toxicity, occurrence in food, occupational exposure, and detoxification methods","volume":"124","author":"Rushing","year":"2019","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.fct.2026.116236_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2020.110899","article-title":"Diet containing grape seed meal by-product counteracts AFB1 toxicity in liver of pig after weaning","volume":"203","author":"Taranu","year":"2020","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.fct.2026.116236_bib35","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.cancergen.2025.08.010","article-title":"Comprehensive analysis of oncogenic determinants across tumor types via multi-omics integration","volume":"298\u2013299","author":"Ubaid","year":"2025","journal-title":"Cancer Genet."},{"key":"10.1016\/j.fct.2026.116236_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.toxicon.2025.108262","article-title":"The impact of aflatoxin B1 on animal health: metabolic processes, detection methods, and preventive measures","volume":"255","author":"Wang","year":"2025","journal-title":"Toxicon"},{"key":"10.1016\/j.fct.2026.116236_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2022.109884","article-title":"PINK1\/Parkin-mediated mitophagy is activated to protect against AFB(1)-induced kidney damage in mice","volume":"358","author":"Wang","year":"2022","journal-title":"Chem. Biol. Interact."},{"issue":"1 Pt A","key":"10.1016\/j.fct.2026.116236_bib38","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.tiv.2014.10.006","article-title":"Mechanism of cisplatin proximal tubule toxicity revealed by integrating transcriptomics, proteomics, metabolomics and biokinetics","volume":"30","author":"Wilmes","year":"2015","journal-title":"Toxicol. Vitro"},{"issue":"8","key":"10.1016\/j.fct.2026.116236_bib39","doi-asserted-by":"crossref","DOI":"10.3390\/toxins15080503","article-title":"Deciphering the hazardous effects of AFB1 and T-2 toxins: unveiling toxicity and oxidative stress mechanisms in PK15 cells and mouse kidneys","volume":"15","author":"Xiao","year":"2023","journal-title":"Toxins"},{"key":"10.1016\/j.fct.2026.116236_bib40","article-title":"Signaling pathways and targeted therapy for rosacea","volume":"15","author":"Yang","year":"2024","journal-title":"Front. Immunol."},{"issue":"7","key":"10.1016\/j.fct.2026.116236_bib41","doi-asserted-by":"crossref","first-page":"2121","DOI":"10.1007\/s11427-024-2866-1","article-title":"CRISPR screening identifies protein methylation and ubiquitination modifications that modulate aflatoxin B(1) cytotoxicity","volume":"68","author":"Yang","year":"2025","journal-title":"Sci. China Life Sci."},{"issue":"10","key":"10.1016\/j.fct.2026.116236_bib42","doi-asserted-by":"crossref","DOI":"10.3390\/ijms25105330","article-title":"CXCL8 knockout: a key to resisting Pasteurella multocida toxin-induced cytotoxicity","volume":"25","author":"Yuan","year":"2024","journal-title":"Int. J. Mol. Sci."},{"issue":"9","key":"10.1016\/j.fct.2026.116236_bib43","doi-asserted-by":"crossref","DOI":"10.3390\/ijms27093928","article-title":"CRISPR\/Cas9-Mediated knockout of CGNL1 confers resistance to aflatoxin B1 in porcine intestinal epithelial cells via suppressing ROS generation","volume":"27","author":"Yuan","year":"2026","journal-title":"Int. J. Mol. Sci."},{"issue":"4","key":"10.1016\/j.fct.2026.116236_bib44","doi-asserted-by":"crossref","DOI":"10.3390\/toxins14040276","article-title":"Aflatoxin M(1) in raw milk, pasteurized milk and cottage cheese collected along value chain actors from three regions of Ethiopia","volume":"14","author":"Zebib","year":"2022","journal-title":"Toxins"},{"issue":"9","key":"10.1016\/j.fct.2026.116236_bib45","doi-asserted-by":"crossref","DOI":"10.3390\/antiox11091787","article-title":"Genome-scale CRISPR knockout screening identifies BACH1 as a key regulator of aflatoxin B(1)-Induced oxidative damage","volume":"11","author":"Zhang","year":"2022","journal-title":"Antioxidants"},{"issue":"6","key":"10.1016\/j.fct.2026.116236_bib46","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23063280","article-title":"A comparative transcriptomic analysis reveals that HSP90AB1 is involved in the immune and inflammatory responses to porcine deltacoronavirus infection","volume":"23","author":"Zhao","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.fct.2026.116236_bib47","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2021.112286","article-title":"Bacillus amyloliquefaciens B10 can alleviate aflatoxin B1-induced kidney oxidative stress and apoptosis in mice","volume":"218","author":"Zhao","year":"2021","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"1","key":"10.1016\/j.fct.2026.116236_bib48","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1186\/s12943-025-02449-w","article-title":"BRD9-p53-E2F1 circuit orchestrates cell growth and DNA damage repair in gastric cancer","volume":"24","author":"Zhou","year":"2025","journal-title":"Mol. Cancer"}],"container-title":["Food and Chemical Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278691526003108?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278691526003108?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T06:21:01Z","timestamp":1785910861000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0278691526003108"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":47,"alternative-id":["S0278691526003108"],"URL":"https:\/\/doi.org\/10.1016\/j.fct.2026.116236","relation":{},"ISSN":["0278-6915"],"issn-type":[{"value":"0278-6915","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"CXCL8 is associated with aflatoxin B1\u2013triggered injury and caspase-3 activation in porcine kidney epithelial PK15\u202fcells: integrated transcriptomics and CRISPR\/Cas9 knockout","name":"articletitle","label":"Article Title"},{"value":"Food and Chemical Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fct.2026.116236","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"116236"}}