{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T16:32:23Z","timestamp":1786120343653,"version":"build-2736575974"},"reference-count":60,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82304551"],"award-info":[{"award-number":["82304551"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82273329"],"award-info":[{"award-number":["82273329"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32470989"],"award-info":[{"award-number":["32470989"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["2632025ZD08"],"award-info":[{"award-number":["2632025ZD08"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["2632024TD06"],"award-info":[{"award-number":["2632024TD06"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016692","name":"Key Research and Development Program of Ningxia","doi-asserted-by":"publisher","award":["2022BEG02043"],"award-info":[{"award-number":["2022BEG02043"]}],"id":[{"id":"10.13039\/100016692","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012154","name":"Graduate Research and Innovation Projects of Jiangsu Province","doi-asserted-by":"publisher","award":["KYCX241043"],"award-info":[{"award-number":["KYCX241043"]}],"id":[{"id":"10.13039\/501100012154","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["BK20231023"],"award-info":[{"award-number":["BK20231023"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Food and Chemical Toxicology"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.fct.2026.116244","type":"journal-article","created":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T23:34:46Z","timestamp":1782948886000},"page":"116244","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Alcohol and high-fat diet aggravate colitis-induced liver injury via glucocorticoid\/IL-6-SAA1 axis in mice"],"prefix":"10.1016","volume":"216","author":[{"given":"Mingrui","family":"Zhao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinghua","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huijuan","family":"Da","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-9734-2169","authenticated-orcid":false,"given":"Xun","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongquan","family":"Jing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qixiang","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanling","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenhua","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shentian","family":"Zhuang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiuhua","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.fct.2026.116244_bib1","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0085345","article-title":"Interleukin-6 modulation of intestinal epithelial tight junction permeability is mediated by JNK pathway activation of claudin-2 gene","volume":"9","author":"Al-Sadi","year":"2014","journal-title":"PLoS One"},{"issue":"12","key":"10.1016\/j.fct.2026.116244_bib2","doi-asserted-by":"crossref","first-page":"1781","DOI":"10.1007\/s00134-017-4914-x","article-title":"Critical illness-related corticosteroid insufficiency (CIRCI): a narrative review from a multispecialty task force of the society of critical care medicine (SCCM) and the European Society of Intensive Care Medicine (ESICM)","volume":"43","author":"Annane","year":"2017","journal-title":"Intensive Care Med."},{"issue":"1","key":"10.1016\/j.fct.2026.116244_bib3","doi-asserted-by":"crossref","first-page":"39","DOI":"10.2337\/db08-1079","article-title":"Liver is the site of splanchnic cortisol production in obese nondiabetic humans","volume":"58","author":"Basu","year":"2009","journal-title":"Diabetes"},{"issue":"3","key":"10.1016\/j.fct.2026.116244_bib4","doi-asserted-by":"crossref","first-page":"670","DOI":"10.3350\/cmh.2022.0103","article-title":"Acute-on-chronic liver failure: terminology, mechanisms and management","volume":"29","author":"Br","year":"2023","journal-title":"Clin. Mol. Hepatol."},{"issue":"10","key":"10.1016\/j.fct.2026.116244_bib5","doi-asserted-by":"crossref","DOI":"10.3390\/cells10102759","article-title":"Cellular and molecular mechanisms underlying liver fibrosis regression","volume":"10","author":"Caligiuri","year":"2021","journal-title":"Cells"},{"issue":"25","key":"10.1016\/j.fct.2026.116244_bib6","doi-asserted-by":"crossref","first-page":"7490","DOI":"10.7150\/thno.35015","article-title":"Thymopentin ameliorates dextran sulfate sodium-induced colitis by triggering the production of IL-22 in both innate and adaptive lymphocytes","volume":"9","author":"Cao","year":"2019","journal-title":"Theranostics"},{"issue":"10","key":"10.1016\/j.fct.2026.116244_bib7","doi-asserted-by":"crossref","first-page":"1610","DOI":"10.1038\/s41401-020-00597-x","article-title":"Deletion of TLR4 attenuates lipopolysaccharide-induced acute liver injury by inhibiting inflammation and apoptosis","volume":"42","author":"Chen","year":"2021","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.fct.2026.116244_bib8","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1016\/j.redox.2017.11.002","article-title":"(-)-Epicatechin protects the intestinal barrier from high fat diet-induced permeabilization: implications for steatosis and insulin resistance","volume":"14","author":"Cremonini","year":"2018","journal-title":"Redox Biol."},{"issue":"1","key":"10.1016\/j.fct.2026.116244_bib9","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1002\/hep.24655","article-title":"Glucocorticoids increase interleukin-6-dependent gene induction by interfering with the expression of the suppressor of cytokine signaling 3 feedback inhibitor","volume":"55","author":"Dittrich","year":"2012","journal-title":"Hepatology"},{"issue":"5","key":"10.1016\/j.fct.2026.116244_bib10","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1016\/j.jhep.2022.07.006","article-title":"Combination of G-CSF and a TLR4 inhibitor reduce inflammation and promote regeneration in a mouse model of ACLF","volume":"77","author":"Engelmann","year":"2022","journal-title":"J. Hepatol."},{"key":"10.1016\/j.fct.2026.116244_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhep.2026.01.013","article-title":"Macrophage-derived cathepsin B disrupts intestinal tight junctions through occludin degradation and promotes alcohol-associated liver disease","author":"Fondevila","year":"2026","journal-title":"J. Hepatol."},{"issue":"6","key":"10.1016\/j.fct.2026.116244_bib12","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1177\/1747493018778713","article-title":"Multisociety consensus quality improvement revised consensus statement for endovascular therapy of acute ischemic stroke","volume":"13","author":"From the American Association of Neurological Surgeons","year":"2018","journal-title":"Int. J. Stroke"},{"issue":"13","key":"10.1016\/j.fct.2026.116244_bib13","doi-asserted-by":"crossref","first-page":"E2960","DOI":"10.1073\/pnas.1720696115","article-title":"Chronic stress promotes colitis by disturbing the gut microbiota and triggering immune system response","volume":"115","author":"Gao","year":"2018","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"5","key":"10.1016\/j.fct.2026.116244_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2021.102483","article-title":"SAA1\/TLR2 axis directs chemotactic migration of hepatic stellate cells responding to injury","volume":"24","author":"Getachew","year":"2021","journal-title":"iScience"},{"key":"10.1016\/j.fct.2026.116244_bib15","doi-asserted-by":"crossref","first-page":"e4","DOI":"10.1017\/S1462399411002110","article-title":"Molecular mechanisms underlying chemical liver injury","volume":"14","author":"Gu","year":"2012","journal-title":"Expert Rev. Mol. Med."},{"issue":"19","key":"10.1016\/j.fct.2026.116244_bib16","doi-asserted-by":"crossref","first-page":"11948","DOI":"10.1021\/acs.jafc.4c12425","article-title":"Lactoferrin alleviates LPS-induced oxidative stress and necroptosis in liver by promoting mitophagy","volume":"73","author":"Guan","year":"2025","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.fct.2026.116244_bib17","doi-asserted-by":"crossref","first-page":"2718","DOI":"10.3389\/fimmu.2018.02718","article-title":"Non-redundant functions of IL-6 produced by macrophages and dendritic cells in allergic airway inflammation","volume":"9","author":"Gubernatorova","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.fct.2026.116244_bib18","doi-asserted-by":"crossref","first-page":"28990","DOI":"10.1038\/srep28990","article-title":"High fat diets induce colonic epithelial cell stress and inflammation that is reversed by IL-22","volume":"6","author":"Gulhane","year":"2016","journal-title":"Sci. Rep."},{"issue":"3","key":"10.1016\/j.fct.2026.116244_bib19","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1093\/ecco-jcc\/jjv213","article-title":"The first European evidence-based consensus on extra-intestinal manifestations in inflammatory bowel disease","volume":"10","author":"Harbord","year":"2016","journal-title":"J. Crohns Colitis"},{"key":"10.1016\/j.fct.2026.116244_bib20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/15548627.2026.2678426","article-title":"High-fat diet exacerbates experimental colitis by inhibiting lysosomal function via the STAT3-TFEB axis","author":"He","year":"2026","journal-title":"Autophagy"},{"issue":"2","key":"10.1016\/j.fct.2026.116244_bib21","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1038\/nrgastro.2015.200","article-title":"Immunology in the liver--from homeostasis to disease","volume":"13","author":"Heymann","year":"2016","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"issue":"17","key":"10.1016\/j.fct.2026.116244_bib22","doi-asserted-by":"crossref","DOI":"10.3390\/cells12172129","article-title":"Liver injury and regeneration: current understanding, new approaches, and future perspectives","volume":"12","author":"Hora","year":"2023","journal-title":"Cells"},{"issue":"3","key":"10.1016\/j.fct.2026.116244_bib23","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1038\/s41575-022-00690-y","article-title":"The microbiota and the gut-liver axis in primary sclerosing cholangitis","volume":"20","author":"Hov","year":"2023","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.fct.2026.116244_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.molmet.2022.101462","article-title":"Serum amyloid A1 exacerbates hepatic steatosis via TLR4-mediated NF-kappaB signaling pathway","volume":"59","author":"Jiang","year":"2022","journal-title":"Mol. Metabol."},{"issue":"6775","key":"10.1016\/j.fct.2026.116244_bib25","doi-asserted-by":"crossref","DOI":"10.1126\/science.adz4712","article-title":"An aeromonas variant that produces aerolysin promotes susceptibility to ulcerative colitis","volume":"390","author":"Jiang","year":"2025","journal-title":"Science"},{"issue":"4","key":"10.1016\/j.fct.2026.116244_bib26","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1016\/j.cell.2024.01.001","article-title":"Gut-liver axis calibrates intestinal stem cell fitness","volume":"187","author":"Kim","year":"2024","journal-title":"Cell"},{"key":"10.1016\/j.fct.2026.116244_bib27","article-title":"Microbial metabolism dysfunction induced by transarterial chemoembolization aggravates postprocedural liver injury in HCC","author":"Li","year":"2025","journal-title":"J. Hepatol."},{"issue":"9","key":"10.1016\/j.fct.2026.116244_bib28","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1038\/s41575-023-00775-2","article-title":"Fetal liver development and implications for liver disease pathogenesis","volume":"20","author":"Lotto","year":"2023","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"issue":"1","key":"10.1016\/j.fct.2026.116244_bib29","doi-asserted-by":"crossref","DOI":"10.1136\/egastro-2023-100013","article-title":"Alcohol-associated bowel disease: new insights into pathogenesis","volume":"1","author":"Maccioni","year":"2023","journal-title":"eGastroenterology"},{"issue":"5","key":"10.1016\/j.fct.2026.116244_bib30","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/j.chom.2016.10.016","article-title":"The liver at the nexus of host-microbial interactions","volume":"20","author":"Macpherson","year":"2016","journal-title":"Cell Host Microbe"},{"issue":"6","key":"10.1016\/j.fct.2026.116244_bib31","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/S2468-1253(24)00390-X","article-title":"The intestinal barrier: a pivotal role in health, inflammation, and cancer","volume":"10","author":"Neurath","year":"2025","journal-title":"Lancet Gastroenterol. Hepatol."},{"issue":"2","key":"10.1016\/j.fct.2026.116244_bib32","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1080\/14397595.2018.1515145","article-title":"AA amyloidosis - benefits and prospects of IL-6 inhibitors","volume":"29","author":"Okuda","year":"2019","journal-title":"Mod. Rheumatol."},{"issue":"7","key":"10.1016\/j.fct.2026.116244_bib33","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1038\/s41575-023-00771-6","article-title":"Gut-liver axis: barriers and functional circuits","volume":"20","author":"Pabst","year":"2023","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"issue":"12","key":"10.1016\/j.fct.2026.116244_bib34","doi-asserted-by":"crossref","first-page":"e66","DOI":"10.1038\/emm.2013.97","article-title":"Recognition of lipopolysaccharide pattern by TLR4 complexes","volume":"45","author":"Park","year":"2013","journal-title":"Exp. Mol. Med."},{"issue":"11","key":"10.1016\/j.fct.2026.116244_bib35","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24119671","article-title":"Liver fibrosis resolution: from molecular mechanisms to therapeutic opportunities","volume":"24","author":"Pei","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.fct.2026.116244_bib36","first-page":"137","article-title":"Advances in the research of nanodrug delivery system for targeted treatment of liver fibrosis","author":"Peng","year":"2021","journal-title":"Biomed. Pharmacother."},{"issue":"3","key":"10.1016\/j.fct.2026.116244_bib37","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1053\/j.gastro.2015.11.043","article-title":"Circadian clock control of liver metabolic functions","volume":"150","author":"Reinke","year":"2016","journal-title":"Gastroenterology"},{"issue":"42","key":"10.1016\/j.fct.2026.116244_bib38","doi-asserted-by":"crossref","first-page":"7327","DOI":"10.3748\/wjg.v19.i42.7327","article-title":"Hepatobiliary manifestations in inflammatory bowel disease: the gut, the drugs and the liver","volume":"19","author":"Rojas-Feria","year":"2013","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.fct.2026.116244_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2022.102577","article-title":"ALDH2 deficiency increases susceptibility to binge alcohol-induced gut leakiness, endotoxemia, and acute liver injury in mice through the gut-liver axis","volume":"59","author":"Rungratanawanich","year":"2023","journal-title":"Redox Biol."},{"issue":"1","key":"10.1016\/j.fct.2026.116244_bib40","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1186\/s10020-018-0047-0","article-title":"Serum amyloid A - a review","volume":"24","author":"Sack","year":"2018","journal-title":"Mol Med"},{"issue":"4","key":"10.1016\/j.fct.2026.116244_bib41","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1097\/MPG.0000000000001492","article-title":"Hepatic issues and complications associated with inflammatory bowel disease: a clinical report from the NASPGHAN inflammatory bowel disease and hepatology committees","volume":"64","author":"Saubermann","year":"2017","journal-title":"J. Pediatr. Gastroenterol. Nutr."},{"key":"10.1016\/j.fct.2026.116244_bib42","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhep.2026.04.001","article-title":"Fusobacterium nucleatum alleviates alcohol-associated liver disease through mannose-mediated elevation of Fbp1 and modulation of gut microbiota","author":"Shu","year":"2026","journal-title":"J. Hepatol."},{"issue":"1","key":"10.1016\/j.fct.2026.116244_bib43","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1038\/s41598-020-80637-y","article-title":"Chronic stress and corticosterone exacerbate alcohol-induced tissue injury in the gut-liver-brain axis","volume":"11","author":"Shukla","year":"2021","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.fct.2026.116244_bib44","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.gene.2016.02.044","article-title":"Serum amyloid A1: structure, function and gene polymorphism","volume":"583","author":"Sun","year":"2016","journal-title":"Gene"},{"issue":"6","key":"10.1016\/j.fct.2026.116244_bib45","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1016\/j.jhep.2017.02.026","article-title":"Targeting hepatic macrophages to treat liver diseases","volume":"66","author":"Tacke","year":"2017","journal-title":"J. Hepatol."},{"key":"10.1016\/j.fct.2026.116244_bib46","doi-asserted-by":"crossref","DOI":"10.1038\/s41423-026-01427-6","article-title":"Mapping the holonomic signaling network that drives pathological changes in endotoxic shock","author":"Teng","year":"2026","journal-title":"Cell. Mol. Immunol."},{"issue":"11","key":"10.1016\/j.fct.2026.116244_bib47","doi-asserted-by":"crossref","first-page":"1700","DOI":"10.1016\/j.cmet.2022.09.017","article-title":"Gut-liver axis: pathophysiological concepts and clinical implications","volume":"34","author":"Tilg","year":"2022","journal-title":"Cell Metab."},{"issue":"5","key":"10.1016\/j.fct.2026.116244_bib48","doi-asserted-by":"crossref","DOI":"10.3390\/ijms26052258","article-title":"Functional interactions between recombinant Serum Amyloid A1 (SAA1) and chemokines in Leukocyte recruitment","volume":"26","author":"Van Damme","year":"2025","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.fct.2026.116244_bib49","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.taap.2016.06.031","article-title":"Endogenous glucocorticoids exacerbate cholestasis-associated liver injury and hypercholesterolemia in mice","volume":"306","author":"van der Geest","year":"2016","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"11","key":"10.1016\/j.fct.2026.116244_bib50","first-page":"965","article-title":"Dual-function natural products: Farnesoid X receptor agonist\/inflammation inhibitor for metabolic dysfunction-associated steatotic liver disease therapy","volume":"22","author":"Wang","year":"2024","journal-title":"Chin. J. Nat. Med."},{"key":"10.1016\/j.fct.2026.116244_bib51","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1146\/annurev-pathmechdis-031521-030435","article-title":"Recent advances in understanding of pathogenesis of alcohol-associated liver disease","volume":"18","author":"Wu","year":"2023","journal-title":"Annu. Rev. Pathol."},{"issue":"5","key":"10.1016\/j.fct.2026.116244_bib52","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1016\/j.immuni.2025.03.017","article-title":"Acute exposure to high-fat diet impairs ILC3 functions and gut homeostasis","volume":"58","author":"Xiong","year":"2025","journal-title":"Immunity"},{"issue":"3","key":"10.1016\/j.fct.2026.116244_bib53","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1136\/flgastro-2018-101037","article-title":"Practical clinical approach to the evaluation of hepatobiliary disorders in inflammatory bowel disease","volume":"10","author":"Yaccob","year":"2019","journal-title":"Frontline Gastroenterol."},{"issue":"8","key":"10.1016\/j.fct.2026.116244_bib54","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2024.114636","article-title":"Inherent preference for polyunsaturated fatty acids instigates ferroptosis of Treg cells that aggravates high-fat-diet-related colitis","volume":"43","author":"Yan","year":"2024","journal-title":"Cell Rep."},{"issue":"9","key":"10.1016\/j.fct.2026.116244_bib55","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.1038\/s41591-019-0566-4","article-title":"Stress-glucocorticoid-TSC22D3 axis compromises therapy-induced antitumor immunity","volume":"25","author":"Yang","year":"2019","journal-title":"Nat. Med."},{"issue":"23","key":"10.1016\/j.fct.2026.116244_bib56","doi-asserted-by":"crossref","first-page":"7375","DOI":"10.1158\/1078-0432.CCR-17-1283","article-title":"The immune-microenvironment confers chemoresistance of colorectal cancer through macrophage-derived IL6","volume":"23","author":"Yin","year":"2017","journal-title":"Clin. Cancer Res."},{"issue":"1","key":"10.1016\/j.fct.2026.116244_bib57","doi-asserted-by":"crossref","DOI":"10.1016\/j.yexcr.2021.112856","article-title":"SAA1 is transcriptionally activated by STAT3 and accelerates renal interstitial fibrosis by inducing endoplasmic reticulum stress","volume":"408","author":"Zhang","year":"2021","journal-title":"Exp. Cell Res."},{"issue":"5","key":"10.1016\/j.fct.2026.116244_bib58","doi-asserted-by":"crossref","first-page":"1612","DOI":"10.1002\/hep.32782","article-title":"CD11b + CD43 hi Ly6C lo splenocyte-derived macrophages exacerbate liver fibrosis via spleen-liver axis","volume":"77","author":"Zhang","year":"2023","journal-title":"Hepatology"},{"key":"10.1016\/j.fct.2026.116244_bib59","doi-asserted-by":"crossref","first-page":"6061","DOI":"10.1038\/ncomms7061","article-title":"Chromatin remodelling and autocrine TNFalpha are required for optimal interleukin-6 expression in activated human neutrophils","volume":"6","author":"Zimmermann","year":"2015","journal-title":"Nat. Commun."},{"issue":"3","key":"10.1016\/j.fct.2026.116244_bib60","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1053\/j.gastro.2023.05.039","article-title":"Macrophage-derived cathepsin S remodels the extracellular matrix to promote liver fibrogenesis","volume":"165","author":"Zuo","year":"2023","journal-title":"Gastroenterology"}],"container-title":["Food and Chemical Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278691526003182?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278691526003182?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T22:33:38Z","timestamp":1786055618000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0278691526003182"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":60,"alternative-id":["S0278691526003182"],"URL":"https:\/\/doi.org\/10.1016\/j.fct.2026.116244","relation":{},"ISSN":["0278-6915"],"issn-type":[{"value":"0278-6915","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Alcohol and high-fat diet aggravate colitis-induced liver injury via glucocorticoid\/IL-6-SAA1 axis in mice","name":"articletitle","label":"Article Title"},{"value":"Food and Chemical Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fct.2026.116244","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"116244"}}