{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T22:36:09Z","timestamp":1792794969842,"version":"4.5.0"},"reference-count":68,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100015728","name":"Central University of Kerala","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100015728","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001412","name":"Council of Scientific and Industrial Research, India","doi-asserted-by":"publisher","award":["09\/1108(0030)\/2018-EMR-I"],"award-info":[{"award-number":["09\/1108(0030)\/2018-EMR-I"]}],"id":[{"id":"10.13039\/501100001412","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Food and Chemical Toxicology"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.fct.2026.116266","type":"journal-article","created":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T06:50:44Z","timestamp":1783061444000},"page":"116266","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Redox-dependent cytoprotection by zerumbone via Nrf2\u2013Keap1 mediated restoration of antioxidant and apoptotic balance in Mancozeb-exposed cells"],"prefix":"10.1016","volume":"216","author":[{"given":"Shilpa","family":"T","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aswati","family":"R Nair","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.fct.2026.116266_bib1","first-page":"RA141","article-title":"Pesticides and oxidative stress: a review","volume":"10","author":"Abdollahi","year":"2004","journal-title":"Med. Sci. Monit."},{"issue":"10","key":"10.1016\/j.fct.2026.116266_bib2","first-page":"1593","article-title":"Zerumbone exhibit protective effect against zearalenone induced toxicity via ameliorating inflammation and oxidative stress induced apoptosis","volume":"10","author":"Abuzahra","year":"2021","journal-title":"Antioxidants (Basel, Switzerland)"},{"issue":"3","key":"10.1016\/j.fct.2026.116266_bib3","first-page":"707","article-title":"Evaluation of the genotoxicity of zerumbone in cultured human peripheral blood lymphocytes. Toxicology in Vitro","volume":"24","author":"Al-Zubairi","year":"2010"},{"key":"10.1016\/j.fct.2026.116266_bib4","doi-asserted-by":"crossref","first-page":"489","DOI":"10.2147\/OTT.S140358","article-title":"ROS-dependent Bax\/Bcl2 and caspase 3 pathway-mediated apoptosis induced by zineb in human keratinocyte cells","volume":"11","author":"Ali","year":"2018","journal-title":"OncoTargets Ther."},{"issue":"5","key":"10.1016\/j.fct.2026.116266_bib5","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1093\/toxres\/tfab080","article-title":"Methomyl-induced nephrotoxicity and protective effect of curcumin in male rats","volume":"10","author":"Aslanturk","year":"2021","journal-title":"Toxicol. Res."},{"key":"10.1016\/j.fct.2026.116266_bib6","first-page":"1239","article-title":"Protective effects of silymarin extract on malthion-induced Zebra Cichlid (Cichlasoma Nigrofasciatum) hepatotoxicity. Iran","volume":"9","author":"Banaee","year":"2015","journal-title":"J. Toxicol."},{"key":"10.1016\/j.fct.2026.116266_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2020.128808","article-title":"Assessing the effects of Thiram to oxidative stress responses in a freshwater bioindicator cladoceran (Daphnia magna)","volume":"268","author":"Belaid","year":"2021","journal-title":"Chemosphere"},{"issue":"18","key":"10.1016\/j.fct.2026.116266_bib8","doi-asserted-by":"crossref","first-page":"5613","DOI":"10.1007\/s00253-023-12682-2","article-title":"Zingiber zerumbet (L.) Roscoe ex Sm.: biotechnological advancements and perspectives","volume":"107","author":"Chavan","year":"2023","journal-title":"Appl. Microbiol. Biotechnol."},{"issue":"4","key":"10.1016\/j.fct.2026.116266_bib9","doi-asserted-by":"crossref","first-page":"2241","DOI":"10.1007\/s00210-023-02706-z","article-title":"Protective effect of zerumbone on sepsis-induced acute lung injury through anti-inflammatory and antioxidative activity via NF-\u03baB pathway inhibition and HO-1 activation","volume":"397","author":"Chen","year":"2024","journal-title":"N. Schmied. Arch. Pharmacol."},{"issue":"17","key":"10.1016\/j.fct.2026.116266_bib10","doi-asserted-by":"crossref","DOI":"10.3390\/ijerph191710486","article-title":"Assessment of mancozeb exposure, absorbed dose and oxidative damage in greenhouse farmers","volume":"19","author":"Costa","year":"2022","journal-title":"Intl. J. Environ. Res. Public Health"},{"issue":"11","key":"10.1016\/j.fct.2026.116266_bib11","first-page":"4113","article-title":"Systemic effects of the pesticide mancozeb - a literature review","volume":"25","author":"Dall'agnol","year":"2021","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"issue":"Pt B","key":"10.1016\/j.fct.2026.116266_bib12","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.tifs.2017.02.002","article-title":"KEAP1 and done? Targeting the NRF2 pathway with sulforaphane","volume":"69","author":"Dinkova-Kostova","year":"2017","journal-title":"Trends Food Sci. Technol."},{"issue":"12","key":"10.1016\/j.fct.2026.116266_bib13","article-title":"Peer review of the pesticide risk assessment of the active substance mancozeb","volume":"18","author":"Abdourahime","year":"2020","journal-title":"EFSA J."},{"issue":"11","key":"10.1016\/j.fct.2026.116266_bib14","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.3390\/metabo13111117","article-title":"Curcumin mitigates malathion-induced renal injury: suppression of apoptosis and modulation of NF-\u03ba\u03b2\/TNF-\u03b1 and Nrf2, and HO-1 signaling","volume":"13","author":"Eldesoqui","year":"2023","journal-title":"Metabolites"},{"key":"10.1016\/j.fct.2026.116266_bib15","first-page":"50","article-title":"Commission Implementing Regulation (EU) 2020\/2087 of 14 December 2020 on the non-renewal of approval of the active substance mancozeb, in accordance with Regulation (EC) No 1107\/2009 of the European Parliament and of the Council","volume":"423","year":"2020","journal-title":"Off. J. Eur. Union L"},{"key":"10.1016\/j.fct.2026.116266_bib16","doi-asserted-by":"crossref","first-page":"12","DOI":"10.3390\/bios11010012","article-title":"Advances in the detection of dithiocarbamate fungicides: opportunities for biosensors","volume":"11","author":"Fanjul-Bolado","year":"2021","journal-title":"Biosensors"},{"key":"10.1016\/j.fct.2026.116266_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.110234","article-title":"The therapeutic effect of resveratrol: focusing on the Nrf2 signaling pathway","volume":"127","author":"Farkhondeh","year":"2020","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.fct.2026.116266_bib18","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/S0083-6729(05)72015-X","article-title":"Terpenoids as plant antioxidants","volume":"72","author":"Grassmann","year":"2005","journal-title":"Vitam. Horm."},{"issue":"9","key":"10.1016\/j.fct.2026.116266_bib19","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1094\/PDIS-94-9-1076","article-title":"Mancozeb: past, present, and future","volume":"94","author":"Gullino","year":"2010","journal-title":"Plant Dis."},{"key":"10.1016\/j.fct.2026.116266_bib20","doi-asserted-by":"crossref","first-page":"2927","DOI":"10.1016\/j.scitotenv.2018.10.047","article-title":"Trace elements in soil-vegetables interface: Translocation, bioaccumulation, toxicity and amelioration - A review","volume":"651","author":"Gupta","year":"2019","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.fct.2026.116266_bib21","doi-asserted-by":"crossref","DOI":"10.3389\/fmolb.2024.1470711","article-title":"The ameliorative effect of chrysin on ovarian toxicity caused by methidathion in female rats","volume":"11","author":"Hamed","year":"2024","journal-title":"Front. Mol. Biosci."},{"key":"10.1016\/j.fct.2026.116266_bib22","article-title":"Influence of phytochemical and soil characteristics on composition of culturable endophyte from Zingiber zerumbet (L) Smith rhizome","volume":"26","author":"Harsha","year":"2023","journal-title":"Ecolog. Genet. Genom."},{"issue":"11","key":"10.1016\/j.fct.2026.116266_bib23","first-page":"1961","article-title":"Redox-regulated mechanism may account for zerumbone's ability to suppress cancer-cell proliferation (multiple letters) Carcinogenesis","volume":"23","author":"Hoffman","year":"2002"},{"key":"10.1016\/j.fct.2026.116266_bib24","first-page":"4098674","article-title":"Zerumbone exhibits antiphotoaging and dermatoprotective properties in ultraviolet A-irradiated human skin fibroblast cells via the activation of Nrf2\/ARE defensive pathway","volume":"2019","author":"Hseu","year":"2019","journal-title":"Oxid. Med. Cell. Long."},{"key":"10.1016\/j.fct.2026.116266_bib25","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1007\/s40201-022-00823-0","article-title":"Protective effect of plant compounds in pesticides toxicity","volume":"20","author":"Jab\u0142o\u0144ska\u2013 Trypu\u0107","year":"2022","journal-title":"J. Environ. Health Sci. Eng."},{"issue":"11","key":"10.1016\/j.fct.2026.116266_bib26","doi-asserted-by":"crossref","first-page":"8278","DOI":"10.1007\/s12035-018-0986-z","article-title":"Resveratrol prevents the cellular damages induced by monocrotophos via PI3K signaling pathway in human cord blood mesenchymal stem cells","volume":"55","author":"Jahan","year":"2018","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.fct.2026.116266_bib27","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.neulet.2016.10.050","article-title":"Curcumin attenuates paraquat-induced cell death in human neuroblastoma cells through modulating oxidative stress and autophagy","volume":"636","author":"Jaroonwitchawan","year":"2017","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.fct.2026.116266_bib28","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.arabjc.2013.04.026","article-title":"Dithiocarbamates as hazardous remediation agent: a critical review on progress in environmental chemistry for inorganic species studies of 20th century","volume":"7","author":"Kanchi","year":"2014","journal-title":"Arab. J. Chem."},{"issue":"5","key":"10.1016\/j.fct.2026.116266_bib29","doi-asserted-by":"crossref","first-page":"746","DOI":"10.3390\/antiox10050746","article-title":"Ameliorative effects of the sesquiterpenoid valerenic acid on oxidative stress induced in HepG2 cells after exposure to the fungicide benomyl","volume":"10","author":"Kara","year":"2021","journal-title":"Antioxidants (Basel)"},{"issue":"8","key":"10.1016\/j.fct.2026.116266_bib30","doi-asserted-by":"crossref","first-page":"982","DOI":"10.7150\/ijbs.12096","article-title":"Significance of antioxidant potential of plants and its relevance to therapeutic applications","volume":"11","author":"Kasote","year":"2015","journal-title":"Int. J. Biol. Sci."},{"issue":"1","key":"10.1016\/j.fct.2026.116266_bib31","doi-asserted-by":"crossref","first-page":"39","DOI":"10.2478\/intox-2020-0005","article-title":"Modulatory role of quercetin against chlorpyrifos induced blood toxicity in rats","volume":"13","author":"Kaur","year":"2020","journal-title":"Interdiscip. Toxicol."},{"issue":"2014","key":"10.1016\/j.fct.2026.116266_bib32","doi-asserted-by":"crossref","first-page":"2593","DOI":"10.1007\/s12010-013-0707-z","article-title":"Metabolic profiling of Zingiber zerumbet following Pythium myriotylum infection: investigations on the defensive role of the principal secondary metabolite, Zerumbone","volume":"172","author":"Keerthi","year":"2014","journal-title":"Appl. Biochem. Biotechnol."},{"issue":"5","key":"10.1016\/j.fct.2026.116266_bib33","doi-asserted-by":"crossref","DOI":"10.1002\/jbt.22739","article-title":"Evaluation of the hepatoprotective effects of curcumin and nanocurcumin against paraquat\u2010induced liver injury in rats: modulation of oxidative stress and Nrf2 pathway","volume":"35","author":"Kheiripour","year":"2021","journal-title":"J. Biochem. Mol. Toxicol."},{"key":"10.1016\/j.fct.2026.116266_bib34","article-title":"Detection of total reactive oxygen species in adherent cells by 2',7'-dichlorodihydrofluorescein diacetate staining","volume":"160","author":"Kim","year":"2020","journal-title":"JoVE J."},{"key":"10.1016\/j.fct.2026.116266_bib35","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1186\/s12937-016-0186-5","article-title":"The importance of antioxidants which play the role in cellular response against oxidative\/nitrosative stress: current state","volume":"15","author":"Kurutas","year":"2015","journal-title":"Nutr. J."},{"issue":"1","key":"10.1016\/j.fct.2026.116266_bib36","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1002\/bab.2326","article-title":"Zerumbone-induced reactive oxygen species-mediated oxidative stress re-sensitizes breast cancer cells to paclitaxel","volume":"70","author":"Li","year":"2023","journal-title":"Biotechnol. Appl. Biochem."},{"issue":"3","key":"10.1016\/j.fct.2026.116266_bib37","doi-asserted-by":"crossref","first-page":"2505","DOI":"10.3892\/etm.2017.4795","article-title":"The therapeutic effect of zerumbone on chronic gastritis via antioxidant mechanisms","volume":"14","author":"Li","year":"2017","journal-title":"Exp. Ther. Med."},{"issue":"8","key":"10.1016\/j.fct.2026.116266_bib38","doi-asserted-by":"crossref","first-page":"118","DOI":"10.4103\/0973-7847.70902","article-title":"Free radicals, antioxidants and functional foods: impact on human health","volume":"4","author":"Lobo","year":"2010","journal-title":"Pharmacogn. Rev."},{"issue":"17","key":"10.1016\/j.fct.2026.116266_bib39","doi-asserted-by":"crossref","first-page":"3221","DOI":"10.1007\/s00018-016-2223-0","article-title":"Role of Nrf2\/HO-1 system in development, oxidative stress response and diseases: an evolutionarily conserved mechanism","volume":"73","author":"Loboda","year":"2016","journal-title":"Cell. Mol. Life Sci."},{"issue":"16","key":"10.1016\/j.fct.2026.116266_bib40","doi-asserted-by":"crossref","first-page":"8591","DOI":"10.3390\/ijerph18168591","article-title":"Toxicological comparison of mancozeb and zoxamide fungicides at environmentally relevant concentrations by an in vitro approach","volume":"18","author":"Lori","year":"2021","journal-title":"Intnl. J. Environ. Res. Public Health"},{"issue":"1","key":"10.1016\/j.fct.2026.116266_bib41","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","article-title":"Protein measurement with the Folin phenol reagent","volume":"193","author":"Lowry","year":"1951","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.fct.2026.116266_bib42","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.1039022","article-title":"The protective effect of natural medicines against excessive inflammation and oxidative stress in acute lung injury by regulating the Nrf2 signaling pathway","volume":"13","author":"Luan","year":"2022","journal-title":"Front. Pharmacol."},{"issue":"5","key":"10.1016\/j.fct.2026.116266_bib43","first-page":"7603","article-title":"Zerumbone suppresses the potential of growth and metastasis in hepatoma HepG2 cells via the MAPK signaling pathway","volume":"15","author":"Lv","year":"2018","journal-title":"Oncol. Lett."},{"issue":"5","key":"10.1016\/j.fct.2026.116266_bib44","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1093\/carcin\/23.5.795","article-title":"Zerumbone, a Southeast Asian ginger sesquiterpene, markedly suppresses free radical generation, proinflammatory protein production, and cancer cell proliferation accompanied by apoptosis: the alpha,beta-unsaturated carbonyl group is a prerequisite","volume":"23","author":"Murakami","year":"2002","journal-title":"Carcinogenesis"},{"issue":"22","key":"10.1016\/j.fct.2026.116266_bib45","doi-asserted-by":"crossref","first-page":"1838","DOI":"10.3390\/cells13221838","article-title":"Apoptosis: a comprehensive overview of signaling pathways, morphological changes, and physiological significance and therapeutic implications","volume":"13","author":"Mustafa","year":"2024","journal-title":"Cells"},{"issue":"11","key":"10.1016\/j.fct.2026.116266_bib46","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.3390\/jof9111046","article-title":"Replacing mancozeb with alternative fungicides for the control of late blight in potato","volume":"9","author":"Naim","year":"2023","journal-title":"J Fungi (Basel)"},{"issue":"10","key":"10.1016\/j.fct.2026.116266_bib47","doi-asserted-by":"crossref","first-page":"819","DOI":"10.3390\/toxics13100819","article-title":"Advances in the analytical determination and toxicological assessment of dithiocarbamates and their hydrolysis products in fruits, vegetables, and cereals: methodological evolution, challenges, and future directions","volume":"13","author":"Pacini","year":"2025","journal-title":"Toxics"},{"issue":"4","key":"10.1016\/j.fct.2026.116266_bib48","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1016\/j.fct.2011.01.005","article-title":"Protective effect of gallic acid against lindane induced toxicity in experimental rats","volume":"49","author":"Padma","year":"2011","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.fct.2026.116266_bib49","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.fct.2015.12.029","article-title":"Curcumin attenuates Mancozeb-induced toxicity in rat thymocytes through mitochondrial survival pathway","volume":"88","author":"Pavlovic","year":"2016","journal-title":"Food Chem. Toxicol."},{"issue":"10","key":"10.1016\/j.fct.2026.116266_bib50","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1016\/j.bcp.2012.07.015","article-title":"Key cell signaling pathways modulated by zerumbone: role in the prevention and treatment of cancer","volume":"84","author":"Prasannan","year":"2012","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.fct.2026.116266_bib51","first-page":"3.12.1","article-title":"Alkaline comet assay for assessing DNA damage in individual cells","volume":"65","author":"Pu","year":"2015","journal-title":"Curr. Proto. Toxicol."},{"issue":"6","key":"10.1016\/j.fct.2026.116266_bib52","first-page":"643","article-title":"Mancozeb induced lipid peroxidation and antioxidant system impairment in rat tissues: protective role of vitamin C","volume":"63","author":"Rai","year":"2011","journal-title":"Exp. Toxicol. Pathol."},{"key":"10.1016\/j.fct.2026.116266_bib53","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/1475-2867-7-4","article-title":"Zerumbone induced apoptosis in liver cancer cells via modulation of Bax\/Bcl-2 ratio","volume":"7","author":"Sakinah","year":"2007","journal-title":"Cancer Cell Int."},{"key":"10.1016\/j.fct.2026.116266_bib54","article-title":"Oxidative imbalance induced by dithiocarbamate fungicide, Mancozeb aborts Nrf2 anti-oxidant signaling pathway protection in Vero cell line","volume":"3","author":"Shilpa","year":"2025","journal-title":"Pharmacol. Res. Rep."},{"issue":"1","key":"10.1016\/j.fct.2026.116266_bib55","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1007\/s11101-011-9222-4","article-title":"Biological and chemical properties of Zingiber zerumbet Smith: a review","volume":"11","author":"Singh","year":"2012","journal-title":"Phytochem. Rev."},{"issue":"1\u20132","key":"10.1016\/j.fct.2026.116266_bib56","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S1383-5718(03)00038-X","article-title":"Effect of the dithiocarbamate pesticide zineb and its commercial formulation, the azzurro. V. Abnormalities induced in the spindle apparatus of transformed and non-transformed mammalian cell lines","volume":"536","author":"Soloneski","year":"2003","journal-title":"Mutat. Res."},{"issue":"1\u20132","key":"10.1016\/j.fct.2026.116266_bib57","first-page":"200","article-title":"Phenolics as potential antioxidant therapeutic agents: mechanism and actions","volume":"579","author":"Soobrattee","year":"2005","journal-title":"Mutat. Res."},{"issue":"7","key":"10.1016\/j.fct.2026.116266_bib58","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1016\/j.phymed.2016.03.010","article-title":"Protective effects of lupeol against mancozeb-induced genotoxicity in cultured human lymphocytes","volume":"23","author":"Srivastava","year":"2016","journal-title":"Phytomedicine"},{"issue":"46","key":"10.1016\/j.fct.2026.116266_bib59","doi-asserted-by":"crossref","first-page":"6957","DOI":"10.1038\/sj.onc.1208845","article-title":"Zerumbone abolishes NF-kappaB and IkappaBalpha kinase activation leading to suppression of antiapoptotic and metastatic gene expression, upregulation of apoptosis, and downregulation of invasion","volume":"24","author":"Takada","year":"2005","journal-title":"Oncogene"},{"issue":"9","key":"10.1016\/j.fct.2026.116266_bib60","doi-asserted-by":"crossref","first-page":"228","DOI":"10.4254\/wjh.v3.i9.228","article-title":"Terpenoids as potential chemopreventive and therapeutic agents in liver cancer","volume":"3","author":"Thoppil","year":"2011","journal-title":"World J. Hepatol."},{"key":"10.1016\/j.fct.2026.116266_bib61","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1039\/C8TX00287H","article-title":"Protective effects of resveratrol on biomarkers of oxidative stress, biochemical and histopathological changes induced by sub-chronic oral glyphosate based herbicide in rats","volume":"8","author":"Turkmen","year":"2019","journal-title":"Toxicol. Res."},{"issue":"3","key":"10.1016\/j.fct.2026.116266_bib62","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1093\/toxres\/tfad034","article-title":"The ameliorative effects of quercetin and curcumin against subacute nephrotoxicity of fipronil induced in Wistar rats","volume":"12","author":"Uzunhisarcikli","year":"2023","journal-title":"Toxicol Res (Camb)."},{"key":"10.1016\/j.fct.2026.116266_bib63","unstructured":"Vietnam Ministry of Agriculture and Rural Development. Circular No. 19\/2021\/TT-BNNPTNT. 2021. List of Permissible and Banned Plant Protection Chemicals in Vietnam. Hanoi: Ministry of Agriculture and Rural Development, No. 19\/2021\/TT-BNNPTNT dt 28\/12\/2021."},{"issue":"1","key":"10.1016\/j.fct.2026.116266_bib64","doi-asserted-by":"crossref","first-page":"1","DOI":"10.37934\/araset.27.1.18","article-title":"A comparative study on zerumbone concentration, radical scavenging activity and total phenolic content of Zingiber zerumbet extracted via green and conventional extraction","volume":"27","author":"Wahab","year":"2022","journal-title":"J. Adv. Res. Appl. Sci. Eng. Technol."},{"key":"10.1016\/j.fct.2026.116266_bib65","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.bcp.2017.12.014","article-title":"Zerumbone protects human skin keratinocytes against UVA-irradiated damages through Nrf2 induction","volume":"148","author":"Yang","year":"2018","journal-title":"Biochem. Pharmacol."},{"issue":"4","key":"10.1016\/j.fct.2026.116266_bib66","first-page":"1084","article-title":"Zerumbone enhances TRAIL-induced apoptosis through the induction of death receptors and downregulation of anti-apoptotic proteins","volume":"110","author":"Yodkeeree","year":"2010","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.fct.2026.116266_bib67","article-title":"Ameliorative potential of quercetin and catechin against sodium arsenite and mancozeb-induced oxidative renal damage in Wistar rats","volume":"5","author":"Yousuf","year":"2023","journal-title":"J. Trace Element. Miner."},{"issue":"1","key":"10.1016\/j.fct.2026.116266_bib68","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1186\/s12876-023-02962-6","article-title":"Zerumbone ameliorates the inflammatory response and organ damage in severe acute pancreatitis via the ROS\/NF-\u03baB pathway","volume":"23","author":"Zhang","year":"2023","journal-title":"BMC Gastroenterol."}],"container-title":["Food and Chemical Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278691526003406?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278691526003406?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T22:34:46Z","timestamp":1786055686000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0278691526003406"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":68,"alternative-id":["S0278691526003406"],"URL":"https:\/\/doi.org\/10.1016\/j.fct.2026.116266","relation":{},"ISSN":["0278-6915"],"issn-type":[{"value":"0278-6915","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Redox-dependent cytoprotection by zerumbone via Nrf2\u2013Keap1 mediated restoration of antioxidant and apoptotic balance in Mancozeb-exposed cells","name":"articletitle","label":"Article Title"},{"value":"Food and Chemical Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fct.2026.116266","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"116266"}}