{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T21:27:30Z","timestamp":1786483650445,"version":"build-2736575974"},"reference-count":58,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T00:00:00Z","timestamp":1784332800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100009329","name":"Scientific Research and Technology Development Program of Guangxi","doi-asserted-by":"publisher","award":["No.20241541"],"award-info":[{"award-number":["No.20241541"]}],"id":[{"id":"10.13039\/501100009329","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012434","name":"Middle-aged and Young Teachers' Basic Ability Promotion Project of Guangxi","doi-asserted-by":"publisher","award":["2025KY0568"],"award-info":[{"award-number":["2025KY0568"]}],"id":[{"id":"10.13039\/501100012434","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004607","name":"Guangxi Natural Science Foundation","doi-asserted-by":"publisher","award":["2025GXNSFHA069187"],"award-info":[{"award-number":["2025GXNSFHA069187"]}],"id":[{"id":"10.13039\/501100004607","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Food and Chemical Toxicology"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.fct.2026.116273","type":"journal-article","created":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T23:22:37Z","timestamp":1783725757000},"page":"116273","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Integrated network toxicology, transcriptomics, and metabolomics revealed the potential mechanisms of aluminum-induced testicular injury"],"prefix":"10.1016","volume":"216","author":[{"given":"Siyu","family":"Liao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liqing","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusi","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaofeng","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linjun","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiman","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haimei","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.fct.2026.116273_bib1","first-page":"1","article-title":"Evaluation of certain food additives and contaminants","volume":"995","year":"2016","journal-title":"Eightieth report of the Joint FAO\/WHO Expert Committee on Food Additives. World Health Organ Tech Rep Ser."},{"issue":"48","key":"10.1016\/j.fct.2026.116273_bib3","doi-asserted-by":"crossref","first-page":"72827","DOI":"10.1007\/s11356-022-20735-8","article-title":"Amelioration of aluminum-induced hepatic and nephrotoxicity by Premna odorata extract is mediated by lowering MMP9 and TGF-\u03b2 gene alterations in Wistar rat","volume":"29","author":"Ahmed","year":"2022","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"10.1016\/j.fct.2026.116273_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2021.111594","article-title":"Carvedilol induces the antiapoptotic proteins Nrf(2) and Bcl(2) and inhibits cellular apoptosis in aluminum-induced testicular toxicity in male Wistar rats","volume":"139","author":"Ahmed","year":"2021","journal-title":"Biomed. Pharmacother."},{"issue":"1","key":"10.1016\/j.fct.2026.116273_bib4","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0317939","article-title":"Evaluation of L-carnitine's protective properties against AlCl3-induced brain, liver, and renal toxicity in rats","volume":"20","author":"Alqhtani","year":"2025","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.fct.2026.116273_bib5","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.fertnstert.2021.12.012","article-title":"The sixth edition of the WHO Laboratory Manual for the Examination and processing of human semen: ensuring quality and standardization in basic examination of human ejaculates","volume":"117","author":"Bj\u00f6rndahl","year":"2022","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.fct.2026.116273_bib6","doi-asserted-by":"crossref","DOI":"10.3389\/fnut.2024.1451081","article-title":"Association of phenylalanine and tyrosine metabolism with mortality and response to nutritional support among patients at nutritional risk: a secondary analysis of the randomized clinical trial EFFORT","volume":"11","author":"Buchmueller","year":"2024","journal-title":"Front. Nutr."},{"key":"10.1016\/j.fct.2026.116273_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.canlet.2022.215689","article-title":"Up-regulation of NMRK2 mediated by TFE3 fusions is the key for energy metabolism adaption of Xp11.2 translocation renal cell carcinoma","volume":"538","author":"Chen","year":"2022","journal-title":"Cancer Lett."},{"key":"10.1016\/j.fct.2026.116273_bib8","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1007\/978-3-031-82990-1_19","article-title":"Testis is a sanctuary site for HIV-1","volume":"1469","author":"Chung","year":"2025","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.fct.2026.116273_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2020.111139","article-title":"Preclinical evidences of aluminum-induced neurotoxicity in hippocampus and pre-frontal cortex of rats exposed to low doses","volume":"206","author":"Fernandes","year":"2020","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.fct.2026.116273_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2025.137395","article-title":"Exploring the reproductive exposure risks of phthalates and organophosphates in atmospheric particulate matter based on quantitative structure-activity relationships and network toxicology models","volume":"488","author":"Gao","year":"2025","journal-title":"J. Hazard Mater."},{"issue":"1","key":"10.1016\/j.fct.2026.116273_bib11","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20010031","article-title":"DNA damage and repair in human reproductive cells","volume":"20","author":"Garc\u00eda-Rodr\u00edguez","year":"2018","journal-title":"Int. J. Mol. Sci."},{"issue":"12","key":"10.1016\/j.fct.2026.116273_bib12","doi-asserted-by":"crossref","DOI":"10.1289\/EHP4745","article-title":"New toxicology tools and the emerging paradigm shift in environmental health decision-making","volume":"127","author":"Ginsberg","year":"2019","journal-title":"Environ. Health Perspect."},{"issue":"2\u20133","key":"10.1016\/j.fct.2026.116273_bib13","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1515\/jbcpp-2025-0049","article-title":"The impact of heavy metals exposure on male fertility: a scoping review of human studies","volume":"36","author":"Giulioni","year":"2025","journal-title":"J. Basic Clin. Physiol. Pharmacol."},{"key":"10.1016\/j.fct.2026.116273_bib14","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1016\/j.freeradbiomed.2025.09.043","article-title":"Aluminum exposure induces ferroptosis in spermatogenic cells of mice through iron overload and lipid peroxidation","volume":"241","author":"Guangji","year":"2025","journal-title":"Free Radic. Biol. Med."},{"issue":"1","key":"10.1016\/j.fct.2026.116273_bib15","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1080\/15376516.2020.1828522","article-title":"Chronic exposure to multi-metals on testicular toxicity in rats","volume":"31","author":"Gupta","year":"2021","journal-title":"Toxicol. Mech. Methods"},{"key":"10.1016\/j.fct.2026.116273_bib16","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2025.1573526","article-title":"The impact, mechanisms and prevention strategies of environmental endocrine disruptors on male reproductive health","volume":"16","author":"Han","year":"2025","journal-title":"Front. Endocrinol."},{"issue":"12","key":"10.1016\/j.fct.2026.116273_bib17","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0339558","article-title":"Identification of diagnostic and prognostic biomarkers for tuberculosis based on plasma proteomics","volume":"20","author":"Hu","year":"2025","journal-title":"PLoS One"},{"key":"10.1016\/j.fct.2026.116273_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.tiv.2023.105658","article-title":"Transcriptome-based analysis of the toxic effects of aluminum chloride exposure on spermatocytes","volume":"92","author":"Huixin","year":"2023","journal-title":"Toxicol. Vitro"},{"key":"10.1016\/j.fct.2026.116273_bib19","doi-asserted-by":"crossref","DOI":"10.3389\/fvets.2022.899434","article-title":"The impact of rumen-protected L-Arginine oral supplementation on libido, Semen quality, reproductive organ biometry, and serum biochemical parameters of rams","volume":"9","author":"Hussein","year":"2022","journal-title":"Front. Vet. Sci."},{"key":"10.1016\/j.fct.2026.116273_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.jtemb.2020.126631","article-title":"Bromelain from Ananas comosus stem attenuates oxidative toxicity and testicular dysfunction caused by aluminum in rats","volume":"62","author":"Jebur","year":"2020","journal-title":"J. Trace Elem. Med. Biol."},{"key":"10.1016\/j.fct.2026.116273_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2025.121007","article-title":"Environmental risk factors for all-cause dementia, Alzheimer's disease dementia, vascular dementia, and mild cognitive impairment: an umbrella review and meta-analysis","volume":"270","author":"Jones","year":"2025","journal-title":"Environ. Res."},{"key":"10.1016\/j.fct.2026.116273_bib22","doi-asserted-by":"crossref","DOI":"10.1155\/2024\/3997463","article-title":"Assessment of histopathological alterations and oxidative stress in the liver and kidney of Male rats following exposure to aluminum chloride","volume":"2024","author":"Kadhim","year":"2024","journal-title":"J. Toxicol."},{"issue":"1","key":"10.1016\/j.fct.2026.116273_bib23","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-025-07769-x","article-title":"Thymol alleviates silica dioxide nanoparticle-induced reproductive performance toxicity via antioxidant and anti-inflammatory mechanisms in male rats","volume":"15","author":"Khedr","year":"2025","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.fct.2026.116273_bib24","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.afos.2019.01.001","article-title":"Aluminum toxicity to bone: a multisystem effect?","volume":"5","author":"Klein","year":"2019","journal-title":"Osteoporos Sarcopenia"},{"issue":"39","key":"10.1016\/j.fct.2026.116273_bib25","first-page":"653","article-title":"The health effects of aluminum exposure","volume":"114","author":"Klotz","year":"2017","journal-title":"Dtsch Arztebl Int"},{"issue":"5","key":"10.1016\/j.fct.2026.116273_bib26","doi-asserted-by":"crossref","first-page":"630","DOI":"10.2166\/wh.2025.348","article-title":"Analysis of heavy metal contamination in groundwater and associated probabilistic human health risk assessment using Monte Carlo simulation: a case study in Gaya, Bihar","volume":"23","author":"Kumar","year":"2025","journal-title":"J. Water Health"},{"key":"10.1016\/j.fct.2026.116273_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2025.157055","article-title":"Bupi Yishen formula improves chronic kidney disease by restoring renal energy metabolism and mitochondrial oxidative phosphorylation","volume":"145","author":"Liu","year":"2025","journal-title":"Phytomedicine"},{"issue":"1","key":"10.1016\/j.fct.2026.116273_bib29","doi-asserted-by":"crossref","first-page":"4224","DOI":"10.1038\/s41467-025-59591-8","article-title":"Impaired ketogenesis in leydig cells drives testicular aging","volume":"16","author":"Liu","year":"2025","journal-title":"Nat. Commun."},{"issue":"5","key":"10.1016\/j.fct.2026.116273_bib28","doi-asserted-by":"crossref","DOI":"10.1177\/15579883241286672","article-title":"A study of sperm DNA damage mechanism based on miRNA sequencing","volume":"18","author":"Liu","year":"2024","journal-title":"Am. J. Mens Health"},{"key":"10.1016\/j.fct.2026.116273_bib27","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.ecoenv.2018.10.095","article-title":"Uptake and subcellular distribution of aluminum in a marine diatom","volume":"169","author":"Liu","year":"2019","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.fct.2026.116273_bib31","first-page":"620","volume":"vol. 8","author":"Liu","year":"2025"},{"issue":"9","key":"10.1016\/j.fct.2026.116273_bib32","doi-asserted-by":"crossref","first-page":"4035","DOI":"10.1007\/s12011-021-03010-8","article-title":"Aluminum chloride-induced reproductive toxicity in rats: the protective role of zinc oxide nanoparticles","volume":"200","author":"Lokman","year":"2022","journal-title":"Biol. Trace Elem. Res."},{"issue":"5","key":"10.1016\/j.fct.2026.116273_bib33","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1016\/j.drudis.2016.12.003","article-title":"Targeting amino acid metabolism for cancer therapy","volume":"22","author":"Lukey","year":"2017","journal-title":"Drug Discov. Today"},{"key":"10.1016\/j.fct.2026.116273_bib34","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1007\/978-1-4614-4711-5_17","article-title":"The apical ectoplasmic specialization-blood-testis barrier functional axis is a novel target for male contraception","volume":"763","author":"Mok","year":"2012","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.fct.2026.116273_bib35","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1254586","article-title":"Astrogliosis in multiple sclerosis and neuro-inflammation: what role for the notch pathway?","volume":"14","author":"Mora","year":"2023","journal-title":"Front. Immunol."},{"issue":"2","key":"10.1016\/j.fct.2026.116273_bib36","doi-asserted-by":"crossref","first-page":"27","DOI":"10.4103\/0976-0105.177703","article-title":"A simple practice guide for dose conversion between animals and human","volume":"7","author":"Nair","year":"2016","journal-title":"J. Basic Clin. Pharm."},{"key":"10.1016\/j.fct.2026.116273_bib37","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1007\/978-981-13-1370-7_6","article-title":"Exposure to aluminum in daily life and Alzheimer's Disease","volume":"1091","author":"Nie","year":"2018","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.fct.2026.116273_bib38","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/978-981-13-1370-7_1","article-title":"Overview of the relationship between aluminum exposure and health of human being","volume":"1091","author":"Niu","year":"2018","journal-title":"Adv. Exp. Med. Biol."},{"issue":"7","key":"10.1016\/j.fct.2026.116273_bib39","doi-asserted-by":"crossref","first-page":"3180","DOI":"10.1007\/s12011-023-03904-9","article-title":"Nicotinamide mononucleotide improves spermatogenic disorders in aluminum-exposed rats by modulating the glycolytic pathway","volume":"202","author":"Nong","year":"2024","journal-title":"Biol. Trace Elem. Res."},{"issue":"3","key":"10.1016\/j.fct.2026.116273_bib40","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1007\/s12011-023-03745-6","article-title":"Testicular toxicity in rats exposed to AlCl(3): a proteomics study","volume":"202","author":"Peng","year":"2024","journal-title":"Biol. Trace Elem. Res."},{"issue":"Pt 2","key":"10.1016\/j.fct.2026.116273_bib41","article-title":"Multi-omics approaches for remediation of bisphenol A: toxicity, risk analysis, road blocks and research perspectives","volume":"215","author":"Sharma","year":"2022","journal-title":"Environ. Res."},{"key":"10.1016\/j.fct.2026.116273_bib42","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.semcancer.2019.12.008","article-title":"Natural products targeting the PI3K-Akt-mTOR signaling pathway in cancer: a novel therapeutic strategy","volume":"80","author":"Tewari","year":"2022","journal-title":"Semin. Cancer Biol."},{"issue":"3","key":"10.1016\/j.fct.2026.116273_bib43","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1007\/s10577-014-9406-z","article-title":"Genomic profiling reveals extensive heterogeneity in somatic DNA copy number aberrations of canine hemangiosarcoma","volume":"22","author":"Thomas","year":"2014","journal-title":"Chromosome Res."},{"issue":"1","key":"10.1016\/j.fct.2026.116273_bib44","doi-asserted-by":"crossref","first-page":"1528","DOI":"10.1038\/s41467-020-15271-3","article-title":"Low rates of mutation in clinical grade human pluripotent stem cells under different culture conditions","volume":"11","author":"Thompson","year":"2020","journal-title":"Nat. Commun."},{"issue":"8","key":"10.1016\/j.fct.2026.116273_bib45","doi-asserted-by":"crossref","DOI":"10.3390\/toxins17080390","article-title":"Mechanistic exploration of aristolochic acid I-Induced hepatocellular carcinoma: insights from network toxicology, machine learning, molecular docking, and molecular dynamics simulation","volume":"17","author":"Tu","year":"2025","journal-title":"Toxins"},{"issue":"5","key":"10.1016\/j.fct.2026.116273_bib46","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1038\/s41577-022-00792-3","article-title":"Death by TNF: a road to inflammation","volume":"23","author":"van Loo","year":"2023","journal-title":"Nat. Rev. Immunol."},{"issue":"Suppl. 4","key":"10.1016\/j.fct.2026.116273_bib47","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3109\/10408444.2014.934439","article-title":"Systematic review of potential health risks posed by pharmaceutical, occupational and consumer exposures to metallic and nanoscale aluminum, aluminum oxides, aluminum hydroxide and its soluble salts","volume":"44","author":"Willhite","year":"2014","journal-title":"Crit. Rev. Toxicol."},{"issue":"2","key":"10.1016\/j.fct.2026.116273_bib49","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24021789","article-title":"Neuroprotective effects and metabolomics study of protopanaxatriol (PPT) on cerebral ischemia\/reperfusion injury in vitro and in vivo","volume":"24","author":"Wu","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"2","key":"10.1016\/j.fct.2026.116273_bib48","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.molmed.2019.09.006","article-title":"Crosstalk between sertoli and germ cells in Male fertility","volume":"26","author":"Wu","year":"2020","journal-title":"Trends Mol. Med."},{"issue":"1","key":"10.1016\/j.fct.2026.116273_bib50","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1038\/s41392-025-02253-4","article-title":"Mitochondria in oxidative stress, inflammation and aging: from mechanisms to therapeutic advances","volume":"10","author":"Xu","year":"2025","journal-title":"Signal Transduct. Targeted Ther."},{"issue":"11","key":"10.1016\/j.fct.2026.116273_bib51","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2023.e21000","article-title":"Mechanisms of single herbs and herbal pairs in the treatment of mammary gland hyperplasia: an integrated review","volume":"9","author":"Yang","year":"2023","journal-title":"Heliyon"},{"issue":"4","key":"10.1016\/j.fct.2026.116273_bib52","doi-asserted-by":"crossref","first-page":"1825","DOI":"10.1111\/jcmm.16205","article-title":"The role of androgen and its related signals in PCOS","volume":"25","author":"Ye","year":"2021","journal-title":"J. Cell Mol. Med."},{"key":"10.1016\/j.fct.2026.116273_bib53","doi-asserted-by":"crossref","DOI":"10.1016\/j.tiv.2023.105589","article-title":"High-content analysis of testicular toxicity of BPA and its selected analogs in mouse spermatogonial, sertoli cells, and leydig cells revealed BPAF induced unique multinucleation phenotype associated with the increased DNA synthesis","volume":"89","author":"Yin","year":"2023","journal-title":"Toxicol. Vitro"},{"issue":"6","key":"10.1016\/j.fct.2026.116273_bib54","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1016\/j.fct.2009.02.006","article-title":"Propolis protection from reproductive toxicity caused by aluminium chloride in male rats","volume":"47","author":"Yousef","year":"2009","journal-title":"Food Chem. Toxicol."},{"issue":"10","key":"10.1016\/j.fct.2026.116273_bib55","doi-asserted-by":"crossref","DOI":"10.1111\/cts.70027","article-title":"Is there a possibility that P-glycoprotein reduces reproductive toxicity in males but breast cancer resistance protein does not?","volume":"17","author":"Yu","year":"2024","journal-title":"Clin. Transl. Sci."},{"issue":"1","key":"10.1016\/j.fct.2026.116273_bib56","article-title":"The therapeutic potential of Zuogui Wan in oligoasthenozoospermia: insights from network pharmacology, molecular docking, molecular dynamics simulation, and experimental validation","volume":"15","author":"Zhang","year":"2025","journal-title":"Sci. Rep."},{"issue":"11","key":"10.1016\/j.fct.2026.116273_bib57","doi-asserted-by":"crossref","DOI":"10.3390\/molecules26113345","article-title":"A multi-omics study of human testis and epididymis","volume":"26","author":"Zheng","year":"2021","journal-title":"Molecules"},{"issue":"1","key":"10.1016\/j.fct.2026.116273_bib58","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1007\/s12011-021-02646-w","article-title":"Molecular mechanism of aluminum-induced oxidative damage and apoptosis in rat cardiomyocytes","volume":"200","author":"Zhou","year":"2022","journal-title":"Biol. Trace Elem. Res."}],"container-title":["Food and Chemical Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278691526003479?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278691526003479?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T20:29:24Z","timestamp":1786480164000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0278691526003479"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":58,"alternative-id":["S0278691526003479"],"URL":"https:\/\/doi.org\/10.1016\/j.fct.2026.116273","relation":{},"ISSN":["0278-6915"],"issn-type":[{"value":"0278-6915","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Integrated network toxicology, transcriptomics, and metabolomics revealed the potential mechanisms of aluminum-induced testicular injury","name":"articletitle","label":"Article Title"},{"value":"Food and Chemical Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fct.2026.116273","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"116273"}}