{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T16:33:56Z","timestamp":1786120436174,"version":"build-2736575974"},"reference-count":121,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Food and Chemical Toxicology"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.fct.2026.116297","type":"journal-article","created":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T23:36:20Z","timestamp":1784936180000},"page":"116297","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Micro- and nanoplastics disrupt the gut\u2013liver\u2013brain axis: mechanisms of multi-organ toxicity in animal models"],"prefix":"10.1016","volume":"216","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5801-4929","authenticated-orcid":false,"given":"Katarzyna","family":"K\u0119pka-Borkowska","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mateusz","family":"Borkowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Micha\u0142","family":"D\u0105browski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krzysztof","family":"Karpiesiuk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafa\u0142 R.","family":"Starzy\u0144ski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katarzyna","family":"Cha\u0142a\u015bkiewicz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magdalena","family":"Og\u0142uszka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wojciech","family":"Kozera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariusz","family":"Pierzcha\u0142a","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.fct.2026.116297_bib1","series-title":"Probiotics: Advanced Food and Health Applications","first-page":"467","article-title":"Probiotics and the gut-liver axis","author":"Amedei","year":"2022"},{"issue":"15","key":"10.1016\/j.fct.2026.116297_bib2","doi-asserted-by":"crossref","first-page":"7207","DOI":"10.3390\/ijms26157207","article-title":"Nanoplastic disrupts intestinal homeostasis in immature rats by altering the metabolite profile and gene expression","volume":"26","author":"Augustyniak","year":"2025","journal-title":"Int. J. Mol. Sci."},{"issue":"11","key":"10.1016\/j.fct.2026.116297_bib3","doi-asserted-by":"crossref","first-page":"2935","DOI":"10.3390\/nano11112935","article-title":"Uptake and accumulation of nano\/microplastics in plants: a critical review","volume":"11","author":"Azeem","year":"2021","journal-title":"Nanomaterials"},{"key":"10.1016\/j.fct.2026.116297_bib4","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.enceco.2024.07.001","article-title":"The growing threats and mitigation of environmental microplastics","volume":"6","author":"Bamigboye","year":"2024","journal-title":"Environ. Chem. Ecotoxicol."},{"key":"10.1016\/j.fct.2026.116297_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2020.142653","article-title":"Low density microplastics detected in sheep faeces and soil: a case study from intensive vegetable farming in southeast Spain","volume":"755","author":"Beriot","year":"2021","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.fct.2026.116297_bib6","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/j.marpolbul.2018.01.044","article-title":"Occurrence of microplastics in commercial fish from a natural estuarine environment","volume":"128","author":"Bessa","year":"2018","journal-title":"Mar. Pollut. Bull."},{"key":"10.1016\/j.fct.2026.116297_bib7","doi-asserted-by":"crossref","first-page":"394","DOI":"10.3390\/nano15050394","article-title":"Biological effects of micro-\/nano-plastics in macrophages","volume":"15","author":"Bianchi","year":"2025","journal-title":"Nanomaterials"},{"key":"10.1016\/j.fct.2026.116297_bib8","doi-asserted-by":"crossref","DOI":"10.1088\/1361-6528\/ae0c1b","article-title":"Nanoscale plastic pollution: sources, identification and potential mitigation","volume":"36","author":"Boakye","year":"2025","journal-title":"Nanotechnology"},{"issue":"7\u20138","key":"10.1016\/j.fct.2026.116297_bib9","doi-asserted-by":"crossref","first-page":"431","DOI":"10.14314\/polimery.2025.7.1","article-title":"Antioxidants in biodegradable food packaging polymer materials \u2013 a review","volume":"70","author":"Borkowski","year":"2025","journal-title":"Polimery"},{"issue":"15","key":"10.1016\/j.fct.2026.116297_bib10","doi-asserted-by":"crossref","first-page":"8932","DOI":"10.1021\/acs.est.5b01090","article-title":"Potential health impact of environmentally released micro- and nanoplastics in the human food production chain: experiences from nanotoxicology","volume":"49","author":"Bouwmeester","year":"2015","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.fct.2026.116297_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2025.137795","article-title":"Exploring toxicological pathways of microplastics and nanoplastics: insights from animal and cellular models","volume":"490","author":"Bridgeman","year":"2025","journal-title":"J. Hazard. Mater."},{"issue":"7","key":"10.1016\/j.fct.2026.116297_bib13","doi-asserted-by":"crossref","first-page":"2050","DOI":"10.1073\/pnas.0608582104","article-title":"Understanding the nanoparticle-protein corona using methods to quantify exchange rates and affinities of proteins for nanoparticles","volume":"104","author":"Cedervall","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.fct.2026.116297_bib14","article-title":"Effects of polystyrene nanoplastics on oxidative stress, histopathology and intestinal microbiota in largemouth bass (Micropterus salmoides)","volume":"27","author":"Chen","year":"2022","journal-title":"Aquac. Rep."},{"issue":"1","key":"10.1016\/j.fct.2026.116297_bib15","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/s12989-025-00633-w","article-title":"Polystyrene nanoplastics exposure induces cognitive impairment in mice via induction of oxidative stress and ERK\/MAPK-mediated neuronal cuproptosis","volume":"22","author":"Chen","year":"2025","journal-title":"Part. Fibre Toxicol."},{"key":"10.1016\/j.fct.2026.116297_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2025.119440","article-title":"Polystyrene nanoplastics-induced altered glycolipid metabolism in the liver: a comparative study between pregnant and non-pregnant mice","volume":"307","author":"Chen","year":"2025","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.fct.2026.116297_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2022.107128","article-title":"Immunotoxicity responses to polystyrene nanoplastics and their related mechanisms in the liver of zebrafish (Danio rerio) larvae","volume":"161","author":"Cheng","year":"2022","journal-title":"Environ. Int."},{"key":"10.1016\/j.fct.2026.116297_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2024.108949","article-title":"Aged fragmented-polypropylene microplastics induced ageing status-dependent bioenergetic imbalance and reductive stress: in vivo and liver organoids-based in vitro study","volume":"191","author":"Cheng","year":"2024","journal-title":"Environ. Int."},{"key":"10.1016\/j.fct.2026.116297_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2025.119077","article-title":"Environmental plastic pollutants and endocrine-related cancer: an updated view","volume":"304","author":"Cirillo","year":"2025","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"2","key":"10.1016\/j.fct.2026.116297_bib20","doi-asserted-by":"crossref","first-page":"350","DOI":"10.3390\/ani14020350","article-title":"Connecting the dots: livestock animals as missing links in the chain of microplastic contamination and human health","volume":"14","author":"Corte Pause","year":"2024","journal-title":"Animals"},{"key":"10.1016\/j.fct.2026.116297_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2025.125884","article-title":"Rapid egestion of microplastics in juvenile barramundi: no evidence of gut retention or tissue translocation","volume":"370","author":"Dawson","year":"2025","journal-title":"Environ. Pollut."},{"issue":"10","key":"10.1016\/j.fct.2026.116297_bib22","doi-asserted-by":"crossref","first-page":"6044","DOI":"10.1021\/acs.est.9b01339","article-title":"Microplastics can change soil properties and affect plant performance","volume":"53","author":"de Souza Machado","year":"2019","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.fct.2026.116297_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2024.177857","article-title":"Polystyrene microplastic exposure modulates gut microbiota and gut\u2013liver axis in gilthead seabream (Sparus aurata)","volume":"957","author":"Del Piano","year":"2024","journal-title":"Sci. Total Environ."},{"issue":"6","key":"10.1016\/j.fct.2026.116297_bib24","article-title":"Presence of microplastics and nanoplastics in food, with particular focus on seafood","volume":"14","year":"2016","journal-title":"EFSA J."},{"issue":"4","key":"10.1016\/j.fct.2026.116297_bib25","doi-asserted-by":"crossref","first-page":"248","DOI":"10.3390\/toxics13040248","article-title":"Polystyrene microplastics and cadmium drive the gut\u2013liver axis through the TLR4\/MyD88\/NF-\u03baB signaling pathway to cause toxic effects on broilers","volume":"13","author":"Fan","year":"2025","journal-title":"Toxics"},{"issue":"2","key":"10.1016\/j.fct.2026.116297_bib26","doi-asserted-by":"crossref","first-page":"193","DOI":"10.3390\/antiox11020193","article-title":"The pressing issue of micro- and nanoplastic contamination: profiling the reproductive alterations mediated by oxidative stress","volume":"11","author":"Ferrante","year":"2022","journal-title":"Antioxidants"},{"issue":"5","key":"10.1016\/j.fct.2026.116297_bib27","doi-asserted-by":"crossref","first-page":"1687","DOI":"10.1002\/jat.70002","article-title":"Chronic microplastic exposure dose-dependently induces liver failure via oxidative stress, inflammation, and apoptosis in rats","volume":"46","author":"Forutan","year":"2025","journal-title":"J. Appl. Toxicol."},{"key":"10.1016\/j.fct.2026.116297_bib29","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1038\/s41598-024-80337-x","article-title":"Influence of selected dosages of plastic microparticles on the porcine fecal microbiome","volume":"15","author":"Ga\u0142\u0119cka","year":"2025","journal-title":"Sci. Rep."},{"issue":"21","key":"10.1016\/j.fct.2026.116297_bib28","doi-asserted-by":"crossref","DOI":"10.3390\/ijms252111645","article-title":"Microplastic and the enteric nervous system: effect of PET microparticles on selected neurotransmitters and cytokines in the porcine ileum","volume":"25","author":"Ga\u0142\u0119cka","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.fct.2026.116297_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2025.109717","article-title":"Integrative lipidomic and transcriptomic analysis unraveled polystyrene nanoplastics-induced liver injury via oral and inhalation exposure: all roads lead to Rome?","volume":"202","author":"Ge","year":"2025","journal-title":"Environ. Int."},{"key":"10.1016\/j.fct.2026.116297_bib31","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.1700782","article-title":"Production, use, and fate of all plastics ever made","volume":"3","author":"Geyer","year":"2017","journal-title":"Sci. Adv."},{"issue":"5","key":"10.1016\/j.fct.2026.116297_bib32","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1038\/s41565-021-00886-4","article-title":"Nanoplastics are neither microplastics nor engineered nanoparticles","volume":"16","author":"Gigault","year":"2021","journal-title":"Nat. Nanotechnol."},{"issue":"11","key":"10.1016\/j.fct.2026.116297_bib33","doi-asserted-by":"crossref","first-page":"4595","DOI":"10.1007\/s00204-025-04151-8","article-title":"PET microplastics alter the transcriptome profile and oxidative stress markers in the liver of immature piglets: an in vivo study","volume":"99","author":"Golubska","year":"2025","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.fct.2026.116297_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2021.116426","article-title":"Nanoplastics impact on marine biota: a review","volume":"273","author":"Gon\u00e7alves","year":"2021","journal-title":"Environ. Pollut."},{"issue":"1","key":"10.1016\/j.fct.2026.116297_bib35","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/s43591-025-00126-9","article-title":"Size- and polymer-dependent toxicity of amorphous environmentally relevant micro- and nanoplastics in human bronchial epithelial cells","volume":"5","author":"Gosselink","year":"2025","journal-title":"Microplast. Nanoplast."},{"key":"10.1016\/j.fct.2026.116297_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2024.122937","article-title":"The alarming link between environmental microplastics and health hazards with special emphasis on cancer","volume":"355","author":"Goswami","year":"2024","journal-title":"Life Sci."},{"key":"10.1016\/j.fct.2026.116297_bib37","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.bbi.2025.04.002","article-title":"Perinatal exposure to polystyrene nanoplastics alters socioemotional behaviors via the microbiota\u2013gut\u2013brain axis in adult offspring mice","volume":"128","author":"Guo","year":"2025","journal-title":"Brain Behav. Immun."},{"issue":"3","key":"10.1016\/j.fct.2026.116297_bib38","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1021\/acs.est.8b05297","article-title":"Are we speaking the same language? Recommendations for a definition and categorization framework for plastic debris","volume":"53","author":"Hartmann","year":"2019","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.fct.2026.116297_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2023.114906","article-title":"Short-term exposure to polystyrene nanoplastics in mice evokes self-regulation of glycolipid metabolism","volume":"256","author":"He","year":"2023","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"1","key":"10.1016\/j.fct.2026.116297_bib40","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1186\/s12989-020-00387-7","article-title":"Immunotoxicity and intestinal effects of nano- and microplastics: a review of the literature","volume":"17","author":"Hirt","year":"2020","journal-title":"Part. Fibre Toxicol."},{"key":"10.1016\/j.fct.2026.116297_bib42","doi-asserted-by":"crossref","first-page":"5026","DOI":"10.1038\/s41467-025-59884-y","article-title":"Polystyrene nanoplastics disrupt the intestinal microenvironment by altering bacteria\u2013host interactions through extracellular vesicle-delivered microRNAs","volume":"16","author":"Hsu","year":"2025","journal-title":"Nat. Commun."},{"issue":"11","key":"10.1016\/j.fct.2026.116297_bib41","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1038\/s41579-023-00904-3","article-title":"The gut-liver axis and gut microbiota in health and liver disease","volume":"21","author":"Hsu","year":"2023","journal-title":"Nat. Rev. Microbiol."},{"issue":"16","key":"10.1016\/j.fct.2026.116297_bib43","doi-asserted-by":"crossref","first-page":"2781","DOI":"10.3390\/foods14162781","article-title":"Untargeted metabolomics uncovers food safety risks: polystyrene nanoplastics induce metabolic disorders in chicken liver","volume":"14","author":"Hu","year":"2025","journal-title":"Foods"},{"issue":"4","key":"10.1016\/j.fct.2026.116297_bib44","doi-asserted-by":"crossref","first-page":"eadr8243","DOI":"10.1126\/sciadv.adr8243","article-title":"Microplastics in the bloodstream can induce cerebral thrombosis by causing cell obstruction and lead to neurobehavioral abnormalities","volume":"11","author":"Huang","year":"2025","journal-title":"Sci. Adv."},{"key":"10.1016\/j.fct.2026.116297_bib45","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2023.115447","article-title":"Biological interactions of polystyrene nanoplastics: their cytotoxic and immunotoxic effects on the hepatic and enteric systems","volume":"264","author":"Huang","year":"2023","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.fct.2026.116297_bib46","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-14588-2","article-title":"Field evidence for transfer of plastic debris along a terrestrial food chain","volume":"7","author":"Huerta Lwanga","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.fct.2026.116297_bib47","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s00508-024-02375-9","article-title":"Microplastics: omnipresent and an ongoing challenge for medical science","volume":"137","author":"Hutter","year":"2025","journal-title":"Wien. Klin. Wochenschr."},{"issue":"13","key":"10.1016\/j.fct.2026.116297_bib48","doi-asserted-by":"crossref","first-page":"6097","DOI":"10.3390\/ijms26136097","article-title":"Therapeutic benefits of nano-echinacea extract on reproductive injury induced by polystyrene plastic materials in rat model via regulating gut\u2013brain axis","volume":"26","author":"Hwang","year":"2025","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.fct.2026.116297_bib49","doi-asserted-by":"crossref","DOI":"10.1590\/1414-431x2023e13173","article-title":"Didymin protects against polystyrene nanoplastic-induced hepatic damage in male albino rats by modulation of Nrf-2\/Keap-1 pathway","volume":"57","author":"Ijaz","year":"2024","journal-title":"Braz. J. Med. Biol. Res."},{"issue":"9","key":"10.1016\/j.fct.2026.116297_bib50","doi-asserted-by":"crossref","first-page":"1694","DOI":"10.1002\/jat.4797","article-title":"Exposure to polyethylene terephthalate microplastic induces mouse liver fibrosis through oxidative stress and p38 MAPK\/p65 NF-\u03baB signaling pathway","volume":"45","author":"Ji","year":"2025","journal-title":"J. Appl. Toxicol."},{"key":"10.1016\/j.fct.2026.116297_bib51","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2022.107131","article-title":"Polystyrene micro-\/nanoplastics induced hematopoietic damages via the crosstalk of gut microbiota, metabolites, and cytokines","volume":"161","author":"Jing","year":"2022","journal-title":"Environ. Int."},{"issue":"5","key":"10.1016\/j.fct.2026.116297_bib52","doi-asserted-by":"crossref","first-page":"579","DOI":"10.3390\/antiox13050579","article-title":"Microplastics and oxidative stress\u2014current problems and prospects","volume":"13","author":"Kadac-Czapska","year":"2024","journal-title":"Antioxidants"},{"key":"10.1016\/j.fct.2026.116297_bib54","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2023.106061","article-title":"Recent insights into uptake, toxicity, and molecular targets of microplastics and nanoplastics relevant to human health impacts","volume":"26","author":"Khan","year":"2023","journal-title":"iScience"},{"issue":"4","key":"10.1016\/j.fct.2026.116297_bib55","doi-asserted-by":"crossref","first-page":"1748","DOI":"10.1021\/acs.est.8b05512","article-title":"Emergence of nanoplastic in the environment and possible impact on human health","volume":"53","author":"Lehner","year":"2019","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.fct.2026.116297_bib56","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2022.107199","article-title":"Discovery and quantification of plastic particle pollution in human blood","volume":"163","author":"Leslie","year":"2022","journal-title":"Environ. Int."},{"issue":"1","key":"10.1016\/j.fct.2026.116297_bib57","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1093\/toxsci\/kfaf015","article-title":"Evaluation of phenotypic and behavioral toxicity of micro- and nano-plastic polystyrene particles in larval zebrafish (Danio rerio)","volume":"205","author":"Levesque","year":"2025","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.fct.2026.116297_bib58","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbpc.2025.110397","article-title":"Polystyrene microplastics and nanoplastics induce neurotoxicity in zebrafish via oxidative stress and neurotransmitter disruption","volume":"300","author":"Li","year":"2026","journal-title":"Comp. Biochem. Physiol. C Toxicol. Pharmacol."},{"key":"10.1016\/j.fct.2026.116297_bib59","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2024.109026","article-title":"Intergenerational neurotoxicity of polystyrene nanoplastics in offspring mice is mediated by dysfunctional microbe\u2013gut\u2013brain axis","volume":"192","author":"Li","year":"2024","journal-title":"Environ. Int."},{"key":"10.1016\/j.fct.2026.116297_bib60","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2025.109367","article-title":"Polystyrene nanoplastics trigger ferroptosis in Nrf2-deficient gut via ether phospholipid accumulation","volume":"197","author":"Liang","year":"2025","journal-title":"Environ. Int."},{"issue":"1","key":"10.1016\/j.fct.2026.116297_bib61","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1038\/s41531-025-01145-2","article-title":"Dysfunctional digestive tract highlights the metabolic hallmarks of nanoplastic-exacerbated Parkinson's pathology","volume":"11","author":"Liang","year":"2025","journal-title":"npj Parkinson's Dis."},{"issue":"1","key":"10.1016\/j.fct.2026.116297_bib62","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1186\/s12967-025-06634-9","article-title":"Polystyrene nanoplastics trigger pyroptosis in dopaminergic neurons through TSC2\/TFEB-mediated disruption of autophagosome\u2013lysosome fusion in Parkinson's disease","volume":"23","author":"Liang","year":"2025","journal-title":"J. Transl. Med."},{"issue":"11","key":"10.1016\/j.fct.2026.116297_bib63","doi-asserted-by":"crossref","first-page":"977","DOI":"10.3390\/toxics13110977","article-title":"Gut\u2013liver axis mediates the combined hepatointestinal toxicity of triclosan and polystyrene microplastics in mice: implications for human co-exposure risks","volume":"13","author":"Liu","year":"2025","journal-title":"Toxics"},{"issue":"5","key":"10.1016\/j.fct.2026.116297_bib64","doi-asserted-by":"crossref","first-page":"523","DOI":"10.3390\/biology14050523","article-title":"Synergistic toxicity of combined exposure to acrylamide and polystyrene nanoplastics on the gut\u2013liver axis in mice","volume":"14","author":"Liu","year":"2025","journal-title":"Biology"},{"key":"10.1016\/j.fct.2026.116297_bib65","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/j.scitotenv.2018.03.051","article-title":"Polystyrene microplastics induce gut microbiota dysbiosis and hepatic lipid metabolism disorder in mice","volume":"631\u2013632","author":"Lu","year":"2018","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.fct.2026.116297_bib66","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2025.118311","article-title":"Revealing the underlying mechanisms of nanoplastics induces neuroinflammation: from transcriptomic analysis to in vivo and in vitro validation","volume":"298","author":"Lu","year":"2025","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.fct.2026.116297_bib67","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2025.118687","article-title":"Effects of chronic co-exposure polystyrene nanoplastics and cadmium on liver function in Prussian carp (Carassius gibelio)","volume":"302","author":"Luo","year":"2025","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"5","key":"10.1016\/j.fct.2026.116297_bib68","first-page":"348","article-title":"Detection and characterisation of microplastics in animal feed","volume":"13","author":"Maganti","year":"2023","journal-title":"OJAFR"},{"issue":"3","key":"10.1016\/j.fct.2026.116297_bib69","doi-asserted-by":"crossref","first-page":"843","DOI":"10.2478\/aoas-2024-0022","article-title":"Polystyrene nanoplastics disrupt hepatic vitellogenin metabolism and impair the reproduction process in female zebrafish","volume":"24","author":"Mohammadzadeh","year":"2024","journal-title":"Ann. Anim. Sci."},{"issue":"12","key":"10.1016\/j.fct.2026.116297_bib70","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1038\/nnano.2012.207","article-title":"Biomolecular coronas provide the biological identity of nanosized materials","volume":"7","author":"Monopoli","year":"2012","journal-title":"Nat. Nanotechnol."},{"key":"10.1016\/j.fct.2026.116297_bib71","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2025.126966","article-title":"The Trojan horse effect of nanoplastics exacerbates methylmercury-induced neurotoxicity during zebrafish development","volume":"384","author":"Oger","year":"2025","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.fct.2026.116297_bib72","doi-asserted-by":"crossref","first-page":"AN25022","DOI":"10.1071\/AN25022","article-title":"The sources and impact of microplastic intake on livestock and poultry performance and meat products: a review","volume":"65","author":"Olmo","year":"2025","journal-title":"Anim. Prod. Sci."},{"issue":"23","key":"10.1016\/j.fct.2026.116297_bib73","doi-asserted-by":"crossref","DOI":"10.3390\/ijms252312646","article-title":"Effects of polyvinyl chloride (PVC) microplastic particles on gut microbiota composition and health status in rabbit livestock","volume":"25","author":"Papp","year":"2024","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.fct.2026.116297_bib74","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202512030","article-title":"Chronic PET-microplastic exposure: disruption of gut\u2013liver homeostasis and risk of hepatic steatosis","volume":"13","author":"Park","year":"2026","journal-title":"Adv. Sci."},{"key":"10.1016\/j.fct.2026.116297_bib75","article-title":"Exploring the influence of polystyrene nanoplastics on two distinct in vitro systems in farm animals: a pilot study","volume":"976","author":"Pause","year":"2025","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.fct.2026.116297_bib76","series-title":"Plastics\u2014The Fast Facts 2023","year":"2023"},{"key":"10.1016\/j.fct.2026.116297_bib77","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2019.134455","article-title":"Environmental exposure to microplastics: an overview on possible human health effects","volume":"702","author":"Prata","year":"2020","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.fct.2026.116297_bib78","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2020.106274","article-title":"Plasticenta: first evidence of microplastics in human placenta","volume":"146","author":"Ragusa","year":"2021","journal-title":"Environ. Int."},{"key":"10.1016\/j.fct.2026.116297_bib79","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.tifs.2018.12.009","article-title":"Microplastics, a food safety issue?","volume":"84","author":"Rainieri","year":"2019","journal-title":"Trends Food Sci. Technol."},{"key":"10.1016\/j.fct.2026.116297_bib80","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2025.118332","article-title":"Impacts of polystyrene nanoplastics on zebrafish gut microbiota and mechanistic insights","volume":"299","author":"Rehman","year":"2025","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.fct.2026.116297_bib81","author":"Ritchie"},{"issue":"4","key":"10.1016\/j.fct.2026.116297_bib83","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.3390\/ijms21041410","article-title":"Nanoplastics cause neurobehavioral impairments, reproductive and oxidative damages, and biomarker responses in zebrafish","volume":"21","author":"Sarasamma","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.fct.2026.116297_bib84","doi-asserted-by":"crossref","first-page":"3471","DOI":"10.1021\/acs.est.1c06812","article-title":"An outdoor aging study to investigate the release of per- and polyfluoroalkyl substances (PFAS) from functional textiles","volume":"56","author":"Schellenberger","year":"2022","journal-title":"Environ. Sci. Technol."},{"issue":"5","key":"10.1016\/j.fct.2026.116297_bib85","doi-asserted-by":"crossref","first-page":"4186","DOI":"10.3390\/cimb46050256","article-title":"Mind over microplastics: exploring microplastic-induced gut disruption and gut\u2013brain-axis consequences","volume":"46","author":"Sofield","year":"2024","journal-title":"Curr. Issues Mol. Biol."},{"issue":"6","key":"10.1016\/j.fct.2026.116297_bib86","doi-asserted-by":"crossref","first-page":"2595","DOI":"10.1007\/s00204-025-04002-6","article-title":"Exposure to polystyrene nanoplastics causes anxiety and depressive-like behavior and down-regulates EAAT2 expression in mice","volume":"99","author":"Su","year":"2025","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.fct.2026.116297_bib87","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2025.109421","article-title":"Microplastics and nanoplastics co-exposure modulates chromium bioaccumulation and physiological responses in rats","volume":"198","author":"Suljevi\u0107","year":"2025","journal-title":"Environ. Int."},{"key":"10.1016\/j.fct.2026.116297_bib88","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbpc.2023.109699","article-title":"Polystyrene microplastics modulated BDNF expression triggering neurotoxicity via apoptotic pathway in zebrafish embryos","volume":"271","author":"Suman","year":"2023","journal-title":"Comp. Biochem. Physiol. C Toxicol. Pharmacol."},{"key":"10.1016\/j.fct.2026.116297_bib89","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2024.116874","article-title":"Polystyrene nanoplastics induced learning and memory impairments in mice by damaging the glymphatic system","volume":"284","author":"Sun","year":"2024","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"10","key":"10.1016\/j.fct.2026.116297_bib90","doi-asserted-by":"crossref","first-page":"4870","DOI":"10.3390\/ijms26104870","article-title":"Adverse effect of polystyrene nanoplastics in impairing glucose metabolism in liver injury","volume":"26","author":"Susilo","year":"2025","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.fct.2026.116297_bib91","doi-asserted-by":"crossref","DOI":"10.3389\/frwa.2022.925781","article-title":"Early enteric and hepatic responses to ingestion of polystyrene nanospheres from water in C57BL\/6 mice","volume":"4","author":"Szule","year":"2022","journal-title":"Front. Water"},{"key":"10.1016\/j.fct.2026.116297_bib92","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2022.107154","article-title":"Charge-specific adverse effects of polystyrene nanoplastics on zebrafish (Danio rerio) development and behavior","volume":"163","author":"Teng","year":"2022","journal-title":"Environ. Int."},{"issue":"10","key":"10.1016\/j.fct.2026.116297_bib93","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1038\/nnano.2013.181","article-title":"Rapid formation of plasma protein corona critically affects nanoparticle pathophysiology","volume":"8","author":"Tenzer","year":"2013","journal-title":"Nat. Nanotechnol."},{"key":"10.1016\/j.fct.2026.116297_bib94","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2022.107340","article-title":"Experimental evidence that polystyrene nanoplastics cross the intestinal barrier of European seabass","volume":"166","author":"Vagner","year":"2022","journal-title":"Environ. Int."},{"key":"10.1016\/j.fct.2026.116297_bib95","series-title":"Pilot Study on Plastic Particles in Livestock Feed, Milk, Meat and Blood","author":"van der Veen","year":"2022"},{"issue":"1","key":"10.1016\/j.fct.2026.116297_bib96","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1021\/acsestwater.1c00263","article-title":"Effect of the surface hydrophobicity\u2013morphology\u2013functionality of nanoplastics on their homoaggregation in seawater","volume":"2","author":"Veclin","year":"2022","journal-title":"ACS ES&T Water"},{"issue":"3","key":"10.1016\/j.fct.2026.116297_bib97","doi-asserted-by":"crossref","first-page":"241","DOI":"10.3390\/toxics14030241","article-title":"New insights into the relationship between microplastics and diabetes from the perspective of the gut\u2013liver axis and macrophage regulation","volume":"14","author":"Wang","year":"2026","journal-title":"Toxics"},{"key":"10.1016\/j.fct.2026.116297_bib98","doi-asserted-by":"crossref","first-page":"2544","DOI":"10.1016\/j.enceco.2025.07.021","article-title":"Emerging microplastic and nanoplastic threats: decoding winter survival mechanisms in hybrid groupers through hepatic metabolic disruption","volume":"7","author":"Wang","year":"2025","journal-title":"Environ. Chem. Ecotoxicol."},{"key":"10.1016\/j.fct.2026.116297_bib99","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2022.113905","article-title":"Microplastics induce immune suppression via S100A8 downregulation","volume":"242","author":"Wang","year":"2022","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.fct.2026.116297_bib100","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2024.108523","article-title":"Oxidized\/unmodified polyethylene microplastics neurotoxicity in mice: perspective from microbiota\u2013gut\u2013brain axis","volume":"185","author":"Wang","year":"2024","journal-title":"Environ. Int."},{"key":"10.1016\/j.fct.2026.116297_bib101","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2024.170962","article-title":"Microplastic-mediated new mechanism of liver damage: from the perspective of the gut\u2013liver axis","volume":"919","author":"Wang","year":"2024","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.fct.2026.116297_bib103","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2024.116439","article-title":"Exposure to polystyrene nanoplastics induces hepatotoxicity involving NRF2\u2013NLRP3 signaling pathway in mice","volume":"278","author":"Wen","year":"2024","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"4","key":"10.1016\/j.fct.2026.116297_bib104","doi-asserted-by":"crossref","first-page":"119","DOI":"10.12911\/22998993\/183763","article-title":"Comparative study on the microplastics abundance and characteristics in marine protected area in Karimunjawa National Park, Indonesia","volume":"25","author":"Widiaratih","year":"2024","journal-title":"J. Ecol. Eng."},{"issue":"12","key":"10.1016\/j.fct.2026.116297_bib105","doi-asserted-by":"crossref","first-page":"6634","DOI":"10.1021\/acs.est.7b00423","article-title":"Plastic and human health: a micro issue?","volume":"51","author":"Wright","year":"2017","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.fct.2026.116297_bib106","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2021.116790","article-title":"Occurrence of microplastic in livestock and poultry manure in South China","volume":"277","author":"Wu","year":"2021","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.fct.2026.116297_bib107","doi-asserted-by":"crossref","DOI":"10.1016\/j.resconrec.2024.107606","article-title":"Evolving patterns and drivers of waste plastic trade in key global economies","volume":"206","author":"Xu","year":"2024","journal-title":"Resour. Conserv. Recycl."},{"issue":"2","key":"10.1016\/j.fct.2026.116297_bib108","doi-asserted-by":"crossref","DOI":"10.5620\/eaht.2024021","article-title":"Microplastics exposure altered hematological and lipid profiles as well as liver and kidney function parameters in albino rats (Rattus norvegicus)","volume":"39","author":"Yahaya","year":"2024","journal-title":"Environ. Anal. Health Toxicol."},{"key":"10.1016\/j.fct.2026.116297_bib110","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.jare.2022.10.015","article-title":"Dose-effect of polystyrene microplastics on digestive toxicity in chickens (Gallus gallus): Multi-omics reveals critical role of gut\u2013liver axis","volume":"52","author":"Yin","year":"2023","journal-title":"J. Adv. Res."},{"key":"10.1016\/j.fct.2026.116297_bib111","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2021.145758","article-title":"A comparative review of microplastics and nanoplastics: toxicity hazards on digestive, reproductive and nervous system","volume":"774","author":"Yin","year":"2021","journal-title":"Sci. Total Environ."},{"issue":"5","key":"10.1016\/j.fct.2026.116297_bib112","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.3390\/ijerph17051509","article-title":"Toxicity of microplastics and nanoplastics in mammalian systems","volume":"17","author":"Yong","year":"2020","journal-title":"Int. J. Environ. Res. Publ. Health"},{"key":"10.1016\/j.fct.2026.116297_bib113","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2025.118218","article-title":"The impact of polyethylene microplastics exposure on growth performance, reproductive performance, antioxidant capacity, and intestinal microbiota of quails","volume":"296","author":"You","year":"2025","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.fct.2026.116297_bib114","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2025.118379","article-title":"Nanoplastics exposure exacerbates A\u03b2 plaque deposition in Alzheimer's disease mice by inducing microglia pyroptosis","volume":"299","author":"Yu","year":"2025","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.fct.2026.116297_bib115","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2022.153730","article-title":"Human health concerns regarding microplastics in the aquatic environment: from marine to food systems","volume":"823","author":"Yuan","year":"2022","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.fct.2026.116297_bib116","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2024.135900","article-title":"Human exposure to micro\/nano-plastics through vegetables, fruits, and grains: a predictive modelling approach","volume":"480","author":"Yuan","year":"2024","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.fct.2026.116297_bib117","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2025.118529","article-title":"Co-exposure to polystyrene nanoplastics and glyphosate exacerbates NETs-mediated pyroptosis by activating the NLRP3 inflammasome in mouse liver","volume":"302","author":"Zeng","year":"2025","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"6","key":"10.1016\/j.fct.2026.116297_bib118","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1007\/s00128-022-03585-5","article-title":"Toxic effect of combined exposure of microplastics and copper on goldfish (Carassius auratus): insight from oxidative stress, inflammation, apoptosis and autophagy in hepatopancreas and intestine","volume":"109","author":"Zhang","year":"2022","journal-title":"Bull. Environ. Contam. Toxicol."},{"key":"10.1016\/j.fct.2026.116297_bib119","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2024.113154","article-title":"Efficacy of DHA-enriched phosphatidylserine and its underlying mechanism in alleviating polystyrene nanoplastics-induced hepatotoxicity in mice","volume":"142","author":"Zhang","year":"2024","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.fct.2026.116297_bib120","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2023.108353","article-title":"Continuous oral exposure to micro- and nanoplastics induced gut microbiota dysbiosis, intestinal barrier and immune dysfunction in adult mice","volume":"182","author":"Zhang","year":"2023","journal-title":"Environ. Int."},{"issue":"11","key":"10.1016\/j.fct.2026.116297_bib121","doi-asserted-by":"crossref","DOI":"10.1016\/j.psj.2025.105757","article-title":"Gut microbiota dysbiosis exacerbates polystyrene microplastics-induced liver inflammation via activating LPS\/TLR4 signaling pathway in ducks","volume":"104","author":"Zhou","year":"2025","journal-title":"Poult. Sci."},{"issue":"17","key":"10.1016\/j.fct.2026.116297_bib122","doi-asserted-by":"crossref","first-page":"2767","DOI":"10.3390\/w14172767","article-title":"Long-term exposure to polystyrene nanoplastics impairs the liver health of medaka","volume":"14","author":"Zhou","year":"2022","journal-title":"Water"},{"key":"10.1016\/j.fct.2026.116297_bib123","doi-asserted-by":"crossref","DOI":"10.1016\/j.watres.2023.121071","article-title":"Comprehensive assessment of microplastics in Australian biosolids: Abundance, seasonal variation and potential transport to agroecosystems","volume":"250","author":"Ziajahromi","year":"2024","journal-title":"Water Res."},{"issue":"3","key":"10.1016\/j.fct.2026.116297_bib124","doi-asserted-by":"crossref","first-page":"617","DOI":"10.3390\/nu15030617","article-title":"Microplastics: a real global threat for environment and food safety: a state-of-the-art review","volume":"15","author":"Ziani","year":"2023","journal-title":"Nutrients"},{"issue":"30","key":"10.1016\/j.fct.2026.116297_bib125","doi-asserted-by":"crossref","first-page":"16638","DOI":"10.1021\/acs.jafc.4c03238","article-title":"Polystyrene microplastics causes diarrhea and impairs intestinal angiogenesis through the ROS\/METTL3 pathway","volume":"72","author":"Zou","year":"2024","journal-title":"J. Agric. Food Chem."},{"issue":"8","key":"10.1016\/j.fct.2026.116297_bib126","doi-asserted-by":"crossref","first-page":"7382","DOI":"10.3390\/ijms24087382","article-title":"Polystyrene microplastics induce oxidative stress in mouse hepatocytes in relation to their size","volume":"24","author":"Zou","year":"2023","journal-title":"Int. J. Mol. Sci."}],"container-title":["Food and Chemical Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278691526003716?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278691526003716?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T22:32:21Z","timestamp":1786055541000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0278691526003716"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":121,"alternative-id":["S0278691526003716"],"URL":"https:\/\/doi.org\/10.1016\/j.fct.2026.116297","relation":{},"ISSN":["0278-6915"],"issn-type":[{"value":"0278-6915","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Micro- and nanoplastics disrupt the gut\u2013liver\u2013brain axis: mechanisms of multi-organ toxicity in animal models","name":"articletitle","label":"Article Title"},{"value":"Food and Chemical Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fct.2026.116297","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"116297"}}