{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T06:46:11Z","timestamp":1792565171875,"version":"4.5.0"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31860252"],"award-info":[{"award-number":["31860252"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Food and Chemical Toxicology"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.fct.2026.116353","type":"journal-article","created":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T15:30:22Z","timestamp":1788190222000},"page":"116353","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Di(2-ethylhexyl) phthalate and mono(2-ethylhexyl) phthalate upregulate PPARG and induce metabolic reprogramming in hepatocellular carcinoma cells: a pan-cancer and metabolomics study"],"prefix":"10.1016","volume":"218","author":[{"given":"Yuxing","family":"Liao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiqing","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongmei","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjie","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuangyan","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cuixiang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxi","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaqi","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qirong","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guihua","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guiyuan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueying","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.fct.2026.116353_bib1","doi-asserted-by":"crossref","first-page":"3888","DOI":"10.1182\/blood-2004-12-4709","article-title":"PPAR-gamma agonists inhibit toll-like receptor-mediated activation of dendritic cells via the MAP kinase and NF-kappaB pathways","volume":"106","author":"Appel","year":"2005","journal-title":"Blood"},{"key":"10.1016\/j.fct.2026.116353_bib2","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1016\/j.celrep.2018.10.035","article-title":"PPAR\u03b3\u03945, a naturally occurring dominant-negative splice isoform, impairs PPAR\u03b3 function and adipocyte differentiation","volume":"25","author":"Aprile","year":"2018","journal-title":"Cell Rep."},{"key":"10.1016\/j.fct.2026.116353_bib3","doi-asserted-by":"crossref","first-page":"2167","DOI":"10.3390\/ijms20092167","article-title":"Membrane lipid composition: effect on membrane and Organelle structure, function and compartmentalization and therapeutic avenues","volume":"20","author":"Casares","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.fct.2026.116353_bib4","doi-asserted-by":"crossref","first-page":"13167","DOI":"10.18632\/oncotarget.23481","article-title":"Phthalate exposure promotes chemotherapeutic drug resistance in colon cancer cells","volume":"9","author":"Chen","year":"2018","journal-title":"Oncotarget"},{"key":"10.1016\/j.fct.2026.116353_bib5","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2021.737776","article-title":"PPAR-\u03b3 modulators as current and potential cancer treatments","volume":"11","author":"Chi","year":"2021","journal-title":"Front. Oncol."},{"key":"10.1016\/j.fct.2026.116353_bib6","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1007\/s00204-017-2094-7","article-title":"The PPAR\u03b1-dependent rodent liver tumor response is not relevant to humans: addressing misconceptions","volume":"92","author":"Corton","year":"2018","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.fct.2026.116353_bib7","first-page":"2090","article-title":"Euscaphic acid inhibits proliferation and promotes apoptosis of nasopharyngeal carcinoma cells by silencing the PI3K\/AKT\/mTOR signaling pathway","volume":"11","author":"Dai","year":"2019","journal-title":"Am. J. Transl. Res."},{"key":"10.1016\/j.fct.2026.116353_bib8","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1038\/s41419-025-07799-3","article-title":"PPAR\u03b3, a key modulator of metabolic reprogramming, stemness and chemoresistance associated with retro differentiation in human hepatocellular carcinomas","volume":"16","author":"Daniel","year":"2025","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.fct.2026.116353_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2025.118095","article-title":"Lipid metabolism in cancer: exploring phospholipids as potential biomarkers","volume":"187","author":"Delmas","year":"2025","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.fct.2026.116353_bib10","doi-asserted-by":"crossref","first-page":"9967","DOI":"10.1007\/s00253-014-6183-8","article-title":"Leaching of the plasticizer di(2-ethylhexyl)phthalate (DEHP) from plastic containers and the question of human exposure","volume":"98","author":"Erythropel","year":"2014","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"10.1016\/j.fct.2026.116353_bib11","doi-asserted-by":"crossref","first-page":"27997","DOI":"10.1074\/jbc.M302140200","article-title":"Peroxisome proliferator-activated receptor alpha (PPARalpha) agonist treatment reverses PPARalpha dysfunction and abnormalities in hepatic lipid metabolism in ethanol-fed mice","volume":"278","author":"Fischer","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.fct.2026.116353_bib12","doi-asserted-by":"crossref","first-page":"3410","DOI":"10.3390\/cancers16193410","article-title":"Tumor-associated macrophages as major immunosuppressive cells in the tumor microenvironment","volume":"16","author":"Ghebremedhin","year":"2024","journal-title":"Cancers"},{"key":"10.1016\/j.fct.2026.116353_bib13","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1016\/j.envint.2011.03.005","article-title":"Phthalate metabolites in urine from China, and implications for human exposures","volume":"37","author":"Guo","year":"2011","journal-title":"Environ. Int."},{"key":"10.1016\/j.fct.2026.116353_bib14","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1038\/s42004-024-01310-3","article-title":"Photoaging enhances the leaching of di(2-ethylhexyl) phthalate and transformation products from polyvinyl chloride microplastics into aquatic environments","volume":"7","author":"Henkel","year":"2024","journal-title":"Commun. Chem."},{"key":"10.1016\/j.fct.2026.116353_bib15","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1038\/s41575-020-00381-6","article-title":"Global epidemiology of NAFLD-related HCC: trends, predictions, risk factors and prevention","volume":"18","author":"Huang","year":"2021","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.fct.2026.116353_bib16","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1093\/toxsci\/kfg145","article-title":"Activation of PPAR\u03b1 and PPAR\u03b3 by environmental phthalate monoesters","volume":"74","author":"Hurst","year":"2003","journal-title":"Toxicol. Sci."},{"issue":"Suppl. 1","key":"10.1016\/j.fct.2026.116353_bib17","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1002\/rcm.8258","article-title":"Mono(2-ethylhexyl) phthalate (MEHP) and mono(2-ethyl-5-oxohexyl) phthalate (MEOHP) but not di(2-ethylhexyl) phthalate (DEHP) bind productively to the peroxisome proliferator-activated receptor \u03b3","volume":"33","author":"Kratochvil","year":"2019","journal-title":"Rapid Commun. Mass Spectrom."},{"key":"10.1016\/j.fct.2026.116353_bib18","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.mam.2017.06.001","article-title":"Mechanisms of bile acid mediated inflammation in the liver","volume":"56","author":"Li","year":"2017","journal-title":"Mol. Aspect. Med."},{"key":"10.1016\/j.fct.2026.116353_bib19","doi-asserted-by":"crossref","first-page":"2550","DOI":"10.3390\/ijms18122550","article-title":"Aberrant lipid metabolism in hepatocellular carcinoma revealed by liver lipidomics","volume":"18","author":"Li","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.fct.2026.116353_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2026.119814","article-title":"A novel metabolic gene signature induced by Di-(2-ethylhexyl) phthalate and Mono-(2-ethylhexyl) phthalate exposure predicts prognosis in breast cancer: an integrative bioinformatics and experimental study","volume":"310","author":"Liao","year":"2026","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.fct.2026.116353_bib21","article-title":"Positive association between urinary concentration of phthalate metabolites and oxidation of DNA and lipid in adolescents and young adults","volume":"7","author":"Lin","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.fct.2026.116353_bib22","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.fct.2026.116353_bib23","doi-asserted-by":"crossref","first-page":"28235","DOI":"10.1074\/jbc.M111.256008","article-title":"Murine diacylglycerol Acyltransferase-2 (DGAT2) can catalyze triacylglycerol synthesis and promote lipid droplet formation independent of its localization to the endoplasmic reticulum","volume":"286","author":"McFie","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.fct.2026.116353_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2025.117662","article-title":"Eicosanoids and Inflammation: a delicate balance of Pro-Inflammatory and Pro-Resolving mediators","volume":"245","author":"Park","year":"2026","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.fct.2026.116353_bib25","article-title":"Report on the use of Di-(2-ethylhexyl) phthalate (DEHP) in PVC medical devices","author":"Program","year":"2021","journal-title":"Nat. Institut. Environ. Health Sci."},{"key":"10.1016\/j.fct.2026.116353_bib26","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/1750368","article-title":"Toxic effects of Di-2-ethylhexyl phthalate: an overview","volume":"2018","author":"Rowdhwal","year":"2018","journal-title":"Biomed Res. Int."},{"key":"10.1016\/j.fct.2026.116353_bib28","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1080\/10408440600779065","article-title":"Modes of action and species-specific effects of di-(2-ethylhexyl)phthalate in the liver","volume":"36","author":"Rusyn","year":"2006","journal-title":"Crit. Rev. Toxicol."},{"key":"10.1016\/j.fct.2026.116353_bib27","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.mrrev.2011.12.004","article-title":"Mechanistic considerations for human relevance of cancer hazard of di(2-ethylhexyl) phthalate","volume":"750","author":"Rusyn","year":"2012","journal-title":"Mutat. Res."},{"key":"10.1016\/j.fct.2026.116353_bib29","doi-asserted-by":"crossref","DOI":"10.3390\/ijerph19138040","article-title":"Association of serum levels of plasticizers compounds, phthalates and bisphenols, in patients and survivors of breast cancer: a real connection?","volume":"19","author":"Segovia-Mendoza","year":"2022","journal-title":"Int. J. Environ. Res. Publ. Health"},{"key":"10.1016\/j.fct.2026.116353_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2023.121476","article-title":"Long-term DEHP\/MEHP exposure promotes colorectal cancer stemness associated with glycosylation alterations","volume":"327","author":"Shih","year":"2023","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.fct.2026.116353_bib31","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/S2213-8587(24)00318-8","article-title":"Metabolic dysfunction-associated steatotic liver disease: heterogeneous pathomechanisms and effectiveness of metabolism-based treatment","volume":"13","author":"Stefan","year":"2025","journal-title":"Lancet Diabetes Endocrinol."},{"key":"10.1016\/j.fct.2026.116353_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2021.100906","article-title":"Sialic acid <em>O<\/em>-acetylation: from biosynthesis to roles in health and disease","volume":"297","author":"Visser","year":"2021","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.fct.2026.116353_bib33","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1038\/labinvest.2010.46","article-title":"Functional significance of the two ACOX1 isoforms and their crosstalks with PPAR\u03b1 and RXR\u03b1","volume":"90","author":"Vluggens","year":"2010","journal-title":"Lab. Invest."},{"key":"10.1016\/j.fct.2026.116353_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2024.111135","article-title":"Toxic effects of DEHP and MEHP on gut-liver axis in rats via intestinal flora and metabolomics","volume":"27","author":"Wang","year":"2024","journal-title":"iScience"},{"key":"10.1016\/j.fct.2026.116353_bib35","article-title":"Purinosomes involved in the regulation of tumor metabolism: current progress and potential application targets","volume":"14","author":"Xie","year":"2024","journal-title":"Front. Oncol."},{"key":"10.1016\/j.fct.2026.116353_bib36","doi-asserted-by":"crossref","DOI":"10.1289\/EHP9373","article-title":"Role of Hepatocyte- and macrophage-specific PPAR\u03b3 in hepatotoxicity induced by diethylhexyl phthalate in mice","volume":"130","author":"Xu","year":"2022","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.fct.2026.116353_bib37","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1007\/s41048-019-0091-5","article-title":"Perilipin 2 and lipid droplets provide reciprocal stabilization","volume":"5","author":"Xu","year":"2019","journal-title":"Biophys. Rep."},{"key":"10.1016\/j.fct.2026.116353_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2025.121535","article-title":"Associations between urinary phthalate metabolites and reproductive, adrenal, and gonadotropic hormones in peripubertal children: the Hokkaido study","volume":"276","author":"Yasuda","year":"2025","journal-title":"Environ. Res."},{"key":"10.1016\/j.fct.2026.116353_bib39","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2022.1014243","article-title":"Di-(2-ethylhexyl) phthalate exposure induces liver injury by promoting ferroptosis via downregulation of GPX4 in pregnant mice","volume":"10","author":"Zhang","year":"2022","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.fct.2026.116353_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2025.127628","article-title":"Integrative analysis of DEHP exposure and prostate cancer: mechanistic insights and predictive modeling","volume":"392","author":"Zheng","year":"2026","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.fct.2026.116353_bib41","doi-asserted-by":"crossref","first-page":"7269","DOI":"10.1038\/s41467-024-51736-5","article-title":"Lipid synthesis, triggered by PPAR\u03b3 T166 dephosphorylation, sustains reparative function of macrophages during tissue repair","volume":"15","author":"Zuo","year":"2024","journal-title":"Nat. Commun."}],"container-title":["Food and Chemical Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S027869152600428X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S027869152600428X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T06:19:02Z","timestamp":1792563542000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S027869152600428X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":41,"alternative-id":["S027869152600428X"],"URL":"https:\/\/doi.org\/10.1016\/j.fct.2026.116353","relation":{},"ISSN":["0278-6915"],"issn-type":[{"value":"0278-6915","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Di(2-ethylhexyl) phthalate and mono(2-ethylhexyl) phthalate upregulate PPARG and induce metabolic reprogramming in hepatocellular carcinoma cells: a pan-cancer and metabolomics study","name":"articletitle","label":"Article Title"},{"value":"Food and Chemical Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fct.2026.116353","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"116353"}}