{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T06:46:09Z","timestamp":1792565169308,"version":"4.5.0"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82504377"],"award-info":[{"award-number":["82504377"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82500013"],"award-info":[{"award-number":["82500013"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2025QC896"],"award-info":[{"award-number":["ZR2025QC896"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2024QH518"],"award-info":[{"award-number":["ZR2024QH518"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2024M751894"],"award-info":[{"award-number":["2024M751894"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Food and Chemical Toxicology"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.fct.2026.116401","type":"journal-article","created":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T04:23:49Z","timestamp":1790137429000},"page":"116401","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Association between mixed per- and polyfluoroalkyl substance exposure and thyroid hormone levels in the general population of Shandong, China"],"prefix":"10.1016","volume":"218","author":[{"given":"Shuting","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuezhen","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongxu","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiliang","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohan","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingjia","family":"Shan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zixin","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanxiang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhixiong","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.fct.2026.116401_bib1","doi-asserted-by":"crossref","first-page":"8081","DOI":"10.1021\/es2001985","article-title":"Long-term environmental fate of perfluorinated compounds after accidental release at Toronto airport","volume":"45","author":"Awad","year":"2011","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.fct.2026.116401_bib2","first-page":"39554","article-title":"Per- and Polyfluoroalkyl (PFAS) disruption of thyroid hormone synthesis","volume":"9","author":"Bali","year":"2024","journal-title":"ACS Omega"},{"key":"10.1016\/j.fct.2026.116401_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2021.132674","article-title":"Brazilian overview of per- and polyfluoroalkyl substances listed as persistent organic pollutants in the stockholm convention","volume":"291","author":"Barbosa Machado Torres","year":"2022","journal-title":"Chemosphere"},{"key":"10.1016\/j.fct.2026.116401_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijheh.2021.113905","article-title":"Cross-sectional associations between serum PFASs and inflammatory biomarkers in a population exposed to AFFF-contaminated drinking water","volume":"240","author":"Barton","year":"2022","journal-title":"Int. J. Hyg Environ. Health"},{"key":"10.1016\/j.fct.2026.116401_bib5","doi-asserted-by":"crossref","first-page":"1596","DOI":"10.1289\/ehp.10598","article-title":"Polyfluoroalkyl chemicals in the U.S. population: data from the National health and nutrition examination survey (NHANES) 2003-2004 and comparisons with NHANES 1999-2000","volume":"115","author":"Calafat","year":"2007","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.fct.2026.116401_bib6","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.ntt.2018.03.004","article-title":"Perfluorooctane sulfonate mediates secretion of IL-1\u03b2 through PI3K\/AKT NF-\u043aB pathway in astrocytes","volume":"67","author":"Chen","year":"2018","journal-title":"Neurotoxicol. Teratol."},{"key":"10.1016\/j.fct.2026.116401_bib7","article-title":"Thyroid disrupting effects of old and new generation PFAS","volume":"11","author":"Coperchini","year":"2020","journal-title":"Front Endocrinol (Lausanne)"},{"key":"10.1016\/j.fct.2026.116401_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2022.119340","article-title":"PFOS-induced thyroid hormone system disrupted rats display organ-specific changes in their transcriptomes","volume":"305","author":"Davidsen","year":"2022","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.fct.2026.116401_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2024.175958","article-title":"Association between PFAS exposure and thyroid health: a systematic review and meta-analysis for adolescents, pregnant women, adults and toxicological evidence","volume":"953","author":"Du","year":"2024","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.fct.2026.116401_bib10","doi-asserted-by":"crossref","first-page":"2031","DOI":"10.1021\/acs.est.4c09088","article-title":"An overview of potential alternatives for the multiple uses of Per- and Polyfluoroalkyl substances","volume":"59","author":"Figui\u00e8re","year":"2025","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.fct.2026.116401_bib11","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1038\/nprot.2016.051","article-title":"Computational protein-ligand docking and virtual drug screening with the AutoDock suite","volume":"11","author":"Forli","year":"2016","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.fct.2026.116401_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2022.107108","article-title":"Human exposure to F-53B in China and the evaluation of its potential toxicity: an overview","volume":"161","author":"He","year":"2022","journal-title":"Environ. Int."},{"key":"10.1016\/j.fct.2026.116401_bib13","doi-asserted-by":"crossref","first-page":"8368","DOI":"10.1021\/acs.est.4c11265","article-title":"Hold my beer: the linkage between municipal water and brewing location on PFAS in popular beverages","volume":"59","author":"Hoponick Redmon","year":"2025","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.fct.2026.116401_bib14","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1007\/s10654-025-01271-4","article-title":"The relationship between PFAS exposure and dyslipidemia: an updated review, meta-analysis, and evaluation of bias","volume":"40","author":"Hussey","year":"2025","journal-title":"Eur. J. Epidemiol."},{"key":"10.1016\/j.fct.2026.116401_bib15","doi-asserted-by":"crossref","first-page":"6098","DOI":"10.3390\/ijerph120606098","article-title":"Serum biomarkers of exposure to Perfluoroalkyl substances in relation to serum testosterone and measures of thyroid function among adults and adolescents from NHANES 2011-2012","volume":"12","author":"Lewis","year":"2015","journal-title":"Int. J. Environ. Res. Publ. Health"},{"key":"10.1016\/j.fct.2026.116401_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.tifs.2026.105667","article-title":"Per- and polyfluoroalkyl substances in food contact materials: Migration, health risks and sustainable alternatives","volume":"172","author":"Li","year":"2026","journal-title":"Trends Food Sci. Technol."},{"key":"10.1016\/j.fct.2026.116401_bib17","first-page":"252","article-title":"[Determination of 17 perfluorinated\/polyfluoroalkyl compounds in serum by high-throughput solid-phase extraction-ultra-high performance liquid chromatography-tandem mass spectrometry]","volume":"43","author":"Lin","year":"2025","journal-title":"Se Pu"},{"key":"10.1016\/j.fct.2026.116401_bib18","doi-asserted-by":"crossref","first-page":"1630","DOI":"10.1038\/s41564-025-02032-5","article-title":"Human gut bacteria bioaccumulate per- and polyfluoroalkyl substances","volume":"10","author":"Lindell","year":"2025","journal-title":"Nat. Microbiol."},{"key":"10.1016\/j.fct.2026.116401_bib19","doi-asserted-by":"crossref","first-page":"6144","DOI":"10.1021\/acs.est.1c02850","article-title":"Associations between novel and legacy Per- and Polyfluoroalkyl substances in human serum and thyroid cancer: a case and healthy population in Shandong Province, East China","volume":"56","author":"Liu","year":"2022","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.fct.2026.116401_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2021.116460","article-title":"The occurrence of PFAS in human placenta and their binding abilities to human serum albumin and organic anion transporter 4","volume":"273","author":"Lu","year":"2021","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.fct.2026.116401_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2024.117567","article-title":"Mitigation PFHxA-induced neurotoxicity in Carassius auratus brain cells by selenium-enriched Bacillus subtilis via the BDNF\/PI3K\/AKT\/GSK-3\u03b2 pathway","volume":"290","author":"Lu","year":"2025","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.fct.2026.116401_bib22","doi-asserted-by":"crossref","first-page":"6517","DOI":"10.1038\/s41598-022-10501-8","article-title":"Emerging and legacy PFAS and cytokine homeostasis in women of childbearing age","volume":"12","author":"Nian","year":"2022","journal-title":"Sci. Rep."},{"key":"10.1016\/j.fct.2026.116401_bib23","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.tox.2016.08.011","article-title":"Binding interactions of perfluoroalkyl substances with thyroid hormone transport proteins and potential toxicological implications","volume":"366\u2013367","author":"Ren","year":"2016","journal-title":"Toxicology"},{"key":"10.1016\/j.fct.2026.116401_bib24","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1007\/s00204-014-1258-y","article-title":"Structure-activity relations in binding of perfluoroalkyl compounds to human thyroid hormone T3 receptor","volume":"89","author":"Ren","year":"2015","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.fct.2026.116401_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2021.106843","article-title":"Exposure to a mixture of legacy, alternative, and replacement per- and polyfluoroalkyl substances (PFAS) results in sex-dependent modulation of cholesterol metabolism and liver injury","volume":"157","author":"Roth","year":"2021","journal-title":"Environ. Int."},{"key":"10.1016\/j.fct.2026.116401_bib26","first-page":"411","article-title":"[Thyroxine (T4) and tri-iodothyronine (T3) determinations: techniques and value in the assessment of thyroid function]","volume":"61","author":"Sapin","year":"2003","journal-title":"Ann Biol Clin (Paris)"},{"key":"10.1016\/j.fct.2026.116401_bib27","doi-asserted-by":"crossref","first-page":"6719","DOI":"10.1021\/acs.est.4c11394","article-title":"Emission of Perfluoroalkyl acids and Perfluoroalkyl Ether carboxylic acids to the atmosphere from a fluorochemical industrial Park in China","volume":"59","author":"Sha","year":"2025","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.fct.2026.116401_bib28","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1038\/s41370-018-0094-1","article-title":"A review of the pathways of human exposure to poly- and perfluoroalkyl substances (PFASs) and present understanding of health effects","volume":"29","author":"Sunderland","year":"2019","journal-title":"J. Expo. Sci. Environ. Epidemiol."},{"key":"10.1016\/j.fct.2026.116401_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2023.104831","article-title":"Per- and polyfluoroalkyl substances (PFAS) exposure and thyroid cancer risk","volume":"97","author":"van Gerwen","year":"2023","journal-title":"EBioMedicine"},{"key":"10.1016\/j.fct.2026.116401_bib30","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/s12940-025-01188-1","article-title":"Per- and polyfluoroalkyl substances (PFAS), thyroid hormones, sexual hormones and pubertal development in adolescents residing in the neighborhood of a 3M factory","volume":"24","author":"van Larebeke","year":"2025","journal-title":"Environ. Health"},{"key":"10.1016\/j.fct.2026.116401_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2024.109203","article-title":"Serum metabolome associated with novel and legacy per- and polyfluoroalkyl substances exposure and thyroid cancer risk: a multi-module integrated analysis based on machine learning","volume":"195","author":"Wang","year":"2025","journal-title":"Environ. Int."},{"key":"10.1016\/j.fct.2026.116401_bib32","doi-asserted-by":"crossref","first-page":"12850","DOI":"10.1021\/acs.est.0c01877","article-title":"Temporal trends in prenatal exposure (1998-2018) to emerging and legacy Per- and Polyfluoroalkyl substances (PFASs) in cord Plasma from the Beijing cord blood bank, China","volume":"54","author":"Wang","year":"2020","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.fct.2026.116401_bib33","doi-asserted-by":"crossref","first-page":"756","DOI":"10.3724\/SP.J.1123.2024.11028","article-title":"[Fast determination of per- and polyfluoroalkyl substances in human serum by cold-induced phase separation coupled with liquid chromatography-tandem mass spectrometry]","volume":"43","author":"Wang","year":"2025","journal-title":"Chin. J. Chromatogr."},{"key":"10.1016\/j.fct.2026.116401_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbd.2024.106658","article-title":"The role of thyroid-stimulating hormone in regulating lipid metabolism: implications for body-brain communication","volume":"201","author":"Wang","year":"2024","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.fct.2026.116401_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2025.117901","article-title":"Association between exposure to per- and polyfluoroalkyl substances (PFAS) and chronic cough in American adults: results from NHANES 2003-2012","volume":"291","author":"Wu","year":"2025","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.fct.2026.116401_bib36","doi-asserted-by":"crossref","DOI":"10.3390\/toxics12010046","article-title":"In vitro and in Silico analysis of the bindings between legacy and novel Per- and Polyfluoroalkyl substances and human serum albumin","volume":"12","author":"Wu","year":"2024","journal-title":"Toxics"},{"key":"10.1016\/j.fct.2026.116401_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2024.108459","article-title":"Associations between serum per- and polyfluoroalkyl substances and thyroid hormones in Chinese adults: a nationally representative cross-sectional study","volume":"184","author":"Xing","year":"2024","journal-title":"Environ. Int."},{"key":"10.1016\/j.fct.2026.116401_bib38","first-page":"481","article-title":"[Effects of PFOS on inflammatory factors in human placental trophoblast cells]","volume":"38","author":"Zhu","year":"2020","journal-title":"Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi"}],"container-title":["Food and Chemical Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S027869152600476X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S027869152600476X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T06:19:52Z","timestamp":1792563592000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S027869152600476X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":38,"alternative-id":["S027869152600476X"],"URL":"https:\/\/doi.org\/10.1016\/j.fct.2026.116401","relation":{},"ISSN":["0278-6915"],"issn-type":[{"value":"0278-6915","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Association between mixed per- and polyfluoroalkyl substance exposure and thyroid hormone levels in the general population of Shandong, China","name":"articletitle","label":"Article Title"},{"value":"Food and Chemical Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fct.2026.116401","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"116401"}}