{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T06:46:13Z","timestamp":1792565173044,"version":"4.5.0"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003569","name":"Ministry of Food and Drug Safety","doi-asserted-by":"publisher","award":["24202MFDS267"],"award-info":[{"award-number":["24202MFDS267"]}],"id":[{"id":"10.13039\/501100003569","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003569","name":"Ministry of Food and Drug Safety","doi-asserted-by":"publisher","award":["24202MFDS269"],"award-info":[{"award-number":["24202MFDS269"]}],"id":[{"id":"10.13039\/501100003569","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Food and Chemical Toxicology"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.fct.2026.116406","type":"journal-article","created":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T23:14:52Z","timestamp":1790378092000},"page":"116406","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["In vitro dermal absorption of Lauryl Isoquinolinium Bromide (LIB) from a cosmetic cream formulation"],"prefix":"10.1016","volume":"218","author":[{"given":"Ji Woo","family":"Kim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyang Yeon","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-8822-4819","authenticated-orcid":false,"given":"Han Nah","family":"Chung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung Dae","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1357-1633","authenticated-orcid":false,"given":"Gi-Wook","family":"Hwang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2139-2296","authenticated-orcid":false,"given":"Kyu-Bong","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.fct.2026.116406_bib1","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.tca.2003.01.001","article-title":"Thermodynamic clarification of interaction between antiseptic compounds and lipids consisting of stratum corneum","volume":"416","author":"Aki","year":"2004","journal-title":"Thermochim. Acta"},{"key":"10.1016\/j.fct.2026.116406_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2026.116292","article-title":"In vitro dermal absorption of acetylhexamethyl indan from a cosmetic cream formulation","volume":"216","author":"Chung","year":"2026","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.fct.2026.116406_bib3","doi-asserted-by":"crossref","first-page":"202","DOI":"10.3390\/sci8080202","article-title":"In vitro dermal absorption of m-phenylenediamine sulfate in mini-pig skin using LC\u2013MS\/MS quantification","volume":"8","author":"Chung","year":"2026","journal-title":"Sci"},{"key":"10.1016\/j.fct.2026.116406_bib4","doi-asserted-by":"crossref","first-page":"2997","DOI":"10.1002\/jat.70081","article-title":"In vitro percutaneous absorption of dehydroacetic acid and benzoic acid from pig skin using the Franz diffusion cell system","volume":"46","author":"Chung","year":"2026","journal-title":"J. Appl. Toxicol."},{"key":"10.1016\/j.fct.2026.116406_bib5","unstructured":"European Commission, n.d. CosIng: Lauryl Isoquinolinium Bromide. European Commission, Brussels. Accessed 25 May 2026."},{"key":"10.1016\/j.fct.2026.116406_bib6","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1111\/1523-1747.ep12533356","article-title":"Percutaneous absorption. On the relevance of in vitro data","volume":"64","author":"Franz","year":"1975","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.fct.2026.116406_bib7","series-title":"ICH Guideline M10 on Bioanalytical Method Validation and Study Sample Analysis","year":"2022"},{"key":"10.1016\/j.fct.2026.116406_bib8","doi-asserted-by":"crossref","first-page":"641","DOI":"10.3390\/pharmaceutics13050641","article-title":"Effect of application amounts on in vitro dermal absorption test using caffeine and testosterone","volume":"13","author":"Im","year":"2021","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.fct.2026.116406_bib11","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1007\/s43188-024-00243-2","article-title":"Safety assessment of cocamidopropyl betaine, a cosmetic ingredient","volume":"40","author":"Kim","year":"2024","journal-title":"Toxicol. Res."},{"key":"10.1016\/j.fct.2026.116406_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.tiv.2026.106255","article-title":"Dermal absorption of steartrimonium chloride (STC) for risk assessment as non-preservative cosmetics ingredient","volume":"116","author":"Kim","year":"2026","journal-title":"Toxicol. In Vitro"},{"key":"10.1016\/j.fct.2026.116406_bib12","doi-asserted-by":"crossref","first-page":"340","DOI":"10.3390\/toxics12050340","article-title":"Analytical method development and dermal absorption of 4-amino-3-nitrophenol (4A3NP), a hair dye ingredient under the oxidative or non-oxidative condition","volume":"12","author":"Kim","year":"2024","journal-title":"Toxics"},{"key":"10.1016\/j.fct.2026.116406_bib14","doi-asserted-by":"crossref","DOI":"10.1007\/s43188-026-00380-w","article-title":"Risk assessment of ethyl hexyl salicylate as a UV filter","author":"Kim","year":"2026","journal-title":"Toxicol. Res."},{"key":"10.1016\/j.fct.2026.116406_bib15","doi-asserted-by":"crossref","first-page":"103","DOI":"10.5487\/TR.2019.35.2.103","article-title":"Risk assessment of 5-chloro-2-methylisothiazol-3(2H)-one\/2-methylisothiazol-3(2H)-one (CMIT\/MIT) used as a preservative in cosmetics","volume":"35","author":"Kim","year":"2019","journal-title":"Toxicol. Res."},{"key":"10.1016\/j.fct.2026.116406_bib16","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1007\/s43188-022-00159-9","article-title":"Analytical method development and dermal absorption of 2-amino-5-nitrophenol, a hair dye ingredient under oxidative condition","volume":"39","author":"Kim","year":"2023","journal-title":"Toxicol. Res."},{"key":"10.1016\/j.fct.2026.116406_bib17","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1007\/s43188-024-00230-7","article-title":"Analytical method development and dermal absorption of gallic acid, a hair dye ingredient","volume":"40","author":"Kim","year":"2024","journal-title":"Toxicol. Res."},{"key":"10.1016\/j.fct.2026.116406_bib10","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1007\/s43188-024-00235-2","article-title":"Risk assessment of cyclohexasiloxane D6 in cosmetic products","volume":"40","author":"Ko","year":"2024","journal-title":"Toxicol. Res."},{"key":"10.1016\/j.fct.2026.116406_bib9","unstructured":"Korean Cosmetic Association, n.d. Lauryl Isoquinolinium Bromide. Korean Cosmetic Ingredient Dictionary. Accessed 25 May 2026."},{"key":"10.1016\/j.fct.2026.116406_bib19","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1007\/s43188-026-00352-0","article-title":"Risk assessment of diethylamino hydroxybenzoyl hexyl benzoate (DHHB) as a UV filter in cosmetics","volume":"42","author":"Lee","year":"2026","journal-title":"Toxicol. Res."},{"key":"10.1016\/j.fct.2026.116406_bib18","doi-asserted-by":"crossref","first-page":"137","DOI":"10.5487\/TR.2019.35.2.137","article-title":"Risk assessment of triclosan, a cosmetic preservative","volume":"35","author":"Lee","year":"2019","journal-title":"Toxicol. Res."},{"key":"10.1016\/j.fct.2026.116406_bib20","series-title":"Guidelines for Alternative Test Methods for Skin Absorption of Cosmetics, Skin Absorption: in Vitro Method","year":"2023"},{"key":"10.1016\/j.fct.2026.116406_bib21","unstructured":"National Center for Biotechnology Information. PubChem compound summary for CID 7132, Lauryl Isoquinolinium Bromide. https:\/\/pubchem.ncbi.nlm.nih.gov\/compound\/Lauryl-Isoquinolinium-Bromide. Accessed 25 May 2026."},{"key":"10.1016\/j.fct.2026.116406_bib22","article-title":"Test No. 428: skin absorption: in Vitro method","volume":"4","year":"2004"},{"key":"10.1016\/j.fct.2026.116406_bib23","series-title":"OECD Series on Testing and Assessment No. 28","article-title":"Guidance document for the conduct of skin absorption studies","year":"2004"},{"key":"10.1016\/j.fct.2026.116406_bib24","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1080\/10937404.2025.2503784","article-title":"Perspectives on safety of quaternary ammonium compounds (QACs)","volume":"28","author":"Osimitz","year":"2025","journal-title":"J. Toxicol. Environ. Health B Crit. Rev."},{"key":"10.1016\/j.fct.2026.116406_bib25","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1023\/A:1015810312465","article-title":"Predicting skin permeability","volume":"9","author":"Potts","year":"1992","journal-title":"Pharm. Res."},{"key":"10.1016\/j.fct.2026.116406_bib26","series-title":"The SCCS Notes of Guidance for the Testing of Cosmetic Ingredients and their Safety Evaluation, 12th Revision. SCCS\/1647\/22","year":"2023"},{"key":"10.1016\/j.fct.2026.116406_bib27","series-title":"SpecialChem Cosmetics Ingredients Database","article-title":"Lauryl isoquinolinium bromide","year":"2021"},{"key":"10.1016\/j.fct.2026.116406_bib28","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1007\/s43188-023-00185-1","article-title":"Comparison of structural characteristics and molecular markers of rabbit skin, pig skin, and reconstructed human epidermis for an ex vivo human skin model","volume":"39","author":"Uhm","year":"2023","journal-title":"Toxicol. Res."},{"key":"10.1016\/j.fct.2026.116406_bib29","series-title":"Bioanalytical Method Validation: Guidance for Industry","year":"2018"},{"key":"10.1016\/j.fct.2026.116406_bib30","doi-asserted-by":"crossref","first-page":"2034","DOI":"10.1002\/jps.23086","article-title":"Human skin permeation of neutral species and ionic species: extended linear free-energy relationship analyses","volume":"101","author":"Zhang","year":"2012","journal-title":"J. Pharmaceut. Sci."}],"container-title":["Food and Chemical Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278691526004813?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278691526004813?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T06:20:01Z","timestamp":1792563601000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0278691526004813"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":30,"alternative-id":["S0278691526004813"],"URL":"https:\/\/doi.org\/10.1016\/j.fct.2026.116406","relation":{},"ISSN":["0278-6915"],"issn-type":[{"value":"0278-6915","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"In vitro dermal absorption of Lauryl Isoquinolinium Bromide (LIB) from a cosmetic cream formulation","name":"articletitle","label":"Article Title"},{"value":"Food and Chemical Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fct.2026.116406","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"116406"}}