{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T06:46:15Z","timestamp":1792565175155,"version":"4.5.0"},"reference-count":15,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T00:00:00Z","timestamp":1791763200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Food and Chemical Toxicology"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.fct.2026.116423","type":"journal-article","created":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T16:05:19Z","timestamp":1791216319000},"page":"116423","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["An overview of In vitro genotoxicity testing strategies for fragrance materials: Addressing false positives and advancing non-animal approaches"],"prefix":"10.1016","volume":"218","author":[{"given":"Yax","family":"Thakkar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danielle","family":"Botelho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne Marie","family":"Api","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.fct.2026.116423_bib1","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1093\/mutage\/get068","article-title":"Retrospective analysis of the mutagenicity\/genotoxicity data of the cosmetic ingredients present on the annexes of the cosmetic EU legislation (2000\u201312)","volume":"29","author":"Ates","year":"2014","journal-title":"Mutagenesis"},{"issue":"1\u20132","key":"10.1016\/j.fct.2026.116423_bib2","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.mrgentox.2010.12.001","article-title":"The reconstructed skin micronucleus assay (RSMN) in EpiDerm\u2122: detailed protocol and harmonized scoring atlas","volume":"720","author":"Dahl","year":"2011","journal-title":"Mutat. Res. Genet. Toxicol. Environ. Mutagen"},{"key":"10.1016\/j.fct.2026.116423_bib4","unstructured":"EU Directive 2003\/15\/EC. Off. J. Eur. Union, 66, 26\u201335."},{"issue":"5","key":"10.1016\/j.fct.2026.116423_bib5","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1111\/j.1600-0625.2012.01478.x","article-title":"Xenobiotic metabolism capacities of human skin in comparison with a 3D-epidermis model and keratinocyte-based cell culture as in vitro alternatives for chemical testing: phase II enzymes","volume":"21","author":"Gotz","year":"2012","journal-title":"Exp. Dermatol."},{"issue":"1","key":"10.1016\/j.fct.2026.116423_bib6","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1093\/toxsci\/kfr281","article-title":"The ToxTracker assay: novel GFP reporter systems that provide mechanistic insight into the genotoxic properties of chemicals","volume":"125","author":"Hendriks","year":"2012","journal-title":"Toxicol. Sci."},{"issue":"1","key":"10.1016\/j.fct.2026.116423_bib7","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1093\/toxsci\/kfv323","article-title":"The extended ToxTracker assay discriminates between induction of DNA damage, oxidative stress, and protein misfolding","volume":"150","author":"Hendriks","year":"2016","journal-title":"Toxicol. Sci."},{"issue":"2","key":"10.1016\/j.fct.2026.116423_bib8","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1093\/toxsci\/kft080","article-title":"Use of human in vitro skin models for accurate and ethical risk assessment: metabolic considerations","volume":"133","author":"Hewitt","year":"2013","journal-title":"Toxicol. Sci."},{"issue":"5","key":"10.1016\/j.fct.2026.116423_bib9","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1093\/mutage\/geg018","article-title":"\u03b1,\u03b2-Unsaturated carbonyl compounds: induction of oxidative DNA damage in mammalian cells","volume":"18","author":"Janzowski","year":"2003","journal-title":"Mutagenesis"},{"issue":"1\u20132","key":"10.1016\/j.fct.2026.116423_bib11","first-page":"1","article-title":"Evaluation of the ability of a battery of three in vitro genotoxicity tests to discriminate rodent carcinogens and non-carcinogens: I. Sensitivity, specificity and relative predictivity","volume":"584","author":"Kirkland","year":"2005","journal-title":"Mutat. Res."},{"issue":"1","key":"10.1016\/j.fct.2026.116423_bib10","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/S1383-5718(99)00175-8","article-title":"Interpretation of the biological relevance of genotoxicity test results: the importance of thresholds","volume":"464","author":"Kirkland","year":"2000","journal-title":"Mutat. Res. Genet. Toxicol. Environ. Mutagen"},{"issue":"2","key":"10.1016\/j.fct.2026.116423_bib13","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1093\/mutage\/geab016","article-title":"The Hen's Egg Test for micronucleus induction (HET-MN): validation data set","volume":"37","author":"Reisinger","year":"2022","journal-title":"Mutagenesis"},{"key":"10.1016\/j.fct.2026.116423_bib15","article-title":"ROS and the DNA damage response in cancer","volume":"25","author":"Srinivas","year":"2019","journal-title":"Redox Biol. Jul"},{"key":"10.1016\/j.fct.2026.116423_bib16","series-title":"Environmental and Molecular Mutagenesis","article-title":"Assessment of genotoxic potential of fragrance materials in the chicken egg assays","author":"Thakkar","year":"2024"},{"issue":"2","key":"10.1016\/j.fct.2026.116423_bib17","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1093\/mutage\/geab040","article-title":"Use of the EpiDerm\u2122 3D reconstructed skin micronucleus assay for fragrance materials","volume":"37","author":"Thakkar","year":"2022","journal-title":"Mutagenesis"},{"issue":"4","key":"10.1016\/j.fct.2026.116423_bib18","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1002\/em.22532","article-title":"Utility of ToxTracker in animal alternative testing strategy for fragrance materials","volume":"64","author":"Thakkar","year":"2023","journal-title":"Environ. Mol. Mutagen."}],"container-title":["Food and Chemical Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278691526004989?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278691526004989?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T06:21:06Z","timestamp":1792563666000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0278691526004989"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":15,"alternative-id":["S0278691526004989"],"URL":"https:\/\/doi.org\/10.1016\/j.fct.2026.116423","relation":{},"ISSN":["0278-6915"],"issn-type":[{"value":"0278-6915","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"An overview of In vitro genotoxicity testing strategies for fragrance materials: Addressing false positives and advancing non-animal approaches","name":"articletitle","label":"Article Title"},{"value":"Food and Chemical Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fct.2026.116423","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"116423"}}