{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T01:58:51Z","timestamp":1767146331606,"version":"build-2238731810"},"reference-count":36,"publisher":"Wiley","issue":"1-2","license":[{"start":{"date-parts":[[2004,10,18]],"date-time":"2004-10-18T00:00:00Z","timestamp":1098057600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["FEBS Letters"],"published-print":{"date-parts":[[2004,11,5]]},"abstract":"<jats:p>\n                    The norepinephrine\u2010driven increase in mitogen\u2010activated protein kinase (MAPK) activity is part of the mechanism that regulates arylalkylamine\n                    <jats:italic>N<\/jats:italic>\n                    \u2010acetyltransferase (AA\u2010NAT) activity in the rat pineal gland. We now report a marked nocturnal increase in the expression of a MAPK phosphatase, MAP kinase phosphatase\u20101 (MKP\u20101), that was blocked by maintaining animals in constant light or treatment with propranolol. MKP\u20101 expression was regulated by norepinephrine acting through both \u03b1\u2010 and \u03b2\u2010adrenergic receptors. These results establish a nocturnal increase in pineal MKP\u20101 expression that is under the control of a photoneural system. Because substrates of MKP\u20101 can influence AA\u2010NAT activity, our findings suggest the involvement of MKP\u20101 in the regulation of the nocturnal AA\u2010NAT signal.\n                  <\/jats:p>","DOI":"10.1016\/j.febslet.2004.09.083","type":"journal-article","created":{"date-parts":[[2004,10,21]],"date-time":"2004-10-21T14:48:22Z","timestamp":1098370102000},"page":"220-226","source":"Crossref","is-referenced-by-count":24,"title":["Expression of Concern: Mitogen\u2010activated protein kinase phosphatase\u20101 (MKP\u20101): &gt;100\u2010fold nocturnal and norepinephrine\u2010induced changes in the rat pineal gland"],"prefix":"10.1002","volume":"577","author":[{"given":"Donald M.","family":"Price","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Constance L.","family":"Chik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Terriff","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joan","family":"Weller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ann","family":"Humphries","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David A.","family":"Carter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David C.","family":"Klein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony K.","family":"Ho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,10,18]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"38","volume-title":"Ciba Foundation Symposium","author":"Klein D.C.","year":"1985"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0079-6107(89)90002-3"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/314359a0"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)61075-0"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)67286-2"},{"key":"e_1_2_6_7_1","first-page":"307","volume":"52","author":"Klein D.C.","year":"1997","journal-title":"Recent Prog. 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