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ZAG mRNA was detected by RT\u2010PCR in mature human adipocytes and in SGBS cells post\u2010, but not pre\u2010, differentiation to adipocytes. Relative ZAG mRNA levels increased rapidly after differentiation of SGBS cells, peaking at day 8 post\u2010induction. ZAG protein was evident in differentiated adipocytes (by day 3) and also detected in the culture medium (by day 6) post\u2010induction. The PPAR\u03b3 agonist rosiglitazone induced a 3\u2010fold increase in ZAG mRNA level, while TNF\u2010\u03b1 led to a 4\u2010fold decrease. Human adipocytes express and secrete ZAG, with ZAG expression being regulated particularly through TNF\u2010\u03b1 and the PPAR\u03b3 nuclear receptor. ZAG is a novel adipokine, which may be involved in the local regulation of adipose tissue function.<\/jats:p>","DOI":"10.1016\/j.febslet.2004.11.042","type":"journal-article","created":{"date-parts":[[2004,12,15]],"date-time":"2004-12-15T06:51:40Z","timestamp":1103093500000},"page":"41-47","source":"Crossref","is-referenced-by-count":154,"title":["Zinc\u2010\u03b1<sub>2<\/sub>\u2010glycoprotein, a lipid mobilizing factor, is expressed and secreted by human (SGBS) adipocytes"],"prefix":"10.1002","volume":"579","author":[{"given":"Yi","family":"Bao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Bing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leif","family":"Hunter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John R.","family":"Jenkins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Wabitsch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Trayhurn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,11,26]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)64243-7"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/39.9.1918940"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0959-8049(93)90068-Q"},{"key":"e_1_2_6_5_1","first-page":"846","article-title":"Zinc alpha-2-glycoprotein is expressed by malignant prostatic epithelium and may serve as a potential serum marker for prostate cancer","volume":"7","author":"Hale L.P.","year":"2001","journal-title":"Clin. 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