{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T06:49:43Z","timestamp":1787726983151,"version":"build-2784847793"},"reference-count":20,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2004,12,24]],"date-time":"2004-12-24T00:00:00Z","timestamp":1103846400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["FEBS Letters"],"published-print":{"date-parts":[[2005,1,31]]},"abstract":"<jats:p>The <jats:italic>Caenorhabditis elegans<\/jats:italic> PMR1, a P\u2010type Ca<jats:sup>2+<\/jats:sup>\/Mn<jats:sup>2+<\/jats:sup> ATPase, is expressed in hypodermal seam cells, intestinal cells and spermatheca; localized in Golgi complex. Knock down of <jats:italic>pmr\u20101<\/jats:italic> as well as overexpression of truncated <jats:italic>Caenorhabditis elegans<\/jats:italic> PMR1, which mimics dominant mutations observed in human Hailey\u2013Hailey disease, renders the worm highly sensitive to EGTA and Mn<jats:sup>2+<\/jats:sup>. Interestingly, <jats:italic>pmr\u20101<\/jats:italic> knock down not only causes animals to become resistant to oxidative stress but also suppresses high reactive oxygen species sensitivity of <jats:italic>smf\u20103<\/jats:italic> RNA\u2010mediated interference and <jats:italic>daf\u201016<\/jats:italic> worms. These findings suggest that <jats:italic>C. elegans<\/jats:italic> PMR1 has important roles in Ca<jats:sup>2+<\/jats:sup> and Mn<jats:sup>2+<\/jats:sup> homeostasis and oxidative stress response.<\/jats:p>","DOI":"10.1016\/j.febslet.2004.12.032","type":"journal-article","created":{"date-parts":[[2004,12,28]],"date-time":"2004-12-28T23:44:54Z","timestamp":1104277494000},"page":"778-782","source":"Crossref","is-referenced-by-count":27,"title":["<i>Caenorhabditis elegans<\/i> PMR1, a P\u2010type calcium ATPase, is important for calcium\/manganese homeostasis and oxidative stress response"],"prefix":"10.1002","volume":"579","author":[{"given":"Jeong Hoon","family":"Cho","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyung Min","family":"Ko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gunasekaran","family":"Singaravelu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joohong","family":"Ahnn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,12,24]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(89)90410-8"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.15.9895"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.9.5.1149"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1992.tb00658.x"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.15.3.1382"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M010553200"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.01-10-0514"},{"key":"e_1_2_5_9_1","first-page":"451","volume-title":"Methods in Cell Biology","author":"Mello C.","year":"1995"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/20694"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110612200"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/71701"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1356-9597.2004.00699.x"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)36959-5"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00424-003-1011-5"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M108923200"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1081447"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature01298"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1078223"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/366461a0"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature01789"}],"container-title":["FEBS Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1016%2Fj.febslet.2004.12.032","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.febslet.2004.12.032","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,13]],"date-time":"2025-04-13T10:38:02Z","timestamp":1744540682000},"score":1,"resource":{"primary":{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/10.1016\/j.febslet.2004.12.032"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,12,24]]},"references-count":20,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2005,1,31]]}},"alternative-id":["10.1016\/j.febslet.2004.12.032"],"URL":"https:\/\/doi.org\/10.1016\/j.febslet.2004.12.032","archive":["Portico"],"relation":{},"ISSN":["0014-5793","1873-3468"],"issn-type":[{"value":"0014-5793","type":"print"},{"value":"1873-3468","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,12,24]]}}}