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In the first structural study of membrane\u2010associated hIAPP, lamellar neutron diffraction shows that oligomeric hIAPP inserts into phospholipid bilayers, and extends across the membrane. Rifampicin, which inhibits hIAPP\u2010induced membrane permeabilisation in functional studies, prevents membrane insertion. In contrast, rat IAPP (84% identical to hIAPP, but non\u2010amyloidogenic) does not insert into bilayers. Our findings are consistent with the hypothesis that membrane\u2010active pre\u2010fibrillar hIAPP oligomers insert into beta cell membranes in NIDDM.<\/jats:p>","DOI":"10.1016\/j.febslet.2004.12.085","type":"journal-article","created":{"date-parts":[[2005,1,25]],"date-time":"2005-01-25T19:35:59Z","timestamp":1106681759000},"page":"1143-1148","source":"Crossref","is-referenced-by-count":22,"title":["Neutron diffraction reveals sequence\u2010specific membrane insertion of pre\u2010fibrillar islet amyloid polypeptide and inhibition by rifampicin"],"prefix":"10.1002","volume":"579","author":[{"given":"Kia","family":"Balali-Mood","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard H.","family":"Ashley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Hau\u00df","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeremy P.","family":"Bradshaw","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,1,19]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/416507a"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/416483a"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/416535a"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.48.3.491"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(01)02972-6"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.271.4.1988"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-440X(98)80016-X"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.87.13.5036"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1006\/jmbi.1999.3422"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.14.7283"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1107\/S090744499901375X"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1006\/viro.1994.1345"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3495(91)82086-0"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3495(98)77580-0"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi991892m"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi00427a004"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-4622(01)00227-7"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-4165(02)00528-7"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3495(97)78861-1"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/0925-4439(93)90160-3"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3495(01)75966-8"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/nsb0694-368"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1006\/jmbi.1998.2405"},{"key":"e_1_2_6_25_1","first-page":"381","article-title":"A protein sequence that can encode native structure by disfavoring alternate conformations","volume":"9","author":"Wigley W.C.","year":"2002","journal-title":"Nat. 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