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Nuclear tyrosine\u2010 and serine\u2010phosphorylated STAT5 accumulated in VAD liver, whereas nuclear JAK2 tyrosine kinase and SHP\u20101 phosphatase were decreased. Tyrosine\u2010phosphorylated SHP\u20101 was decreased to 36 \u00b1 14% of control (<jats:italic>P<\/jats:italic>\n&lt; 0.01), indicating its impaired activation in VAD liver. Episodic GH pulses increased nuclear phospho\u2010STAT5, especially in control liver, but nuclear phospho\u2010JAK2 and phospho\u2010SHP\u20101 were not restored. CYP2C11 protein and testosterone 16\u03b1\u2010hydroxylation were decreased in VAD liver to 67 \u00b1 16% and 76 \u00b1 19% of control, and were further decreased by GH to 32 \u00b1 8% and 30 \u00b1 14% of control. Thus, hypo\u2010responsiveness of JAK\u2010STAT in VAD liver is associated with impaired nuclear phospho\u2010STAT dephosphorylation.<\/jats:p>","DOI":"10.1016\/j.febslet.2005.05.052","type":"journal-article","created":{"date-parts":[[2005,6,10]],"date-time":"2005-06-10T15:47:16Z","timestamp":1118418436000},"page":"3669-3673","source":"Crossref","is-referenced-by-count":9,"title":["Phospho\u2010STAT5 accumulation in nuclear fractions from vitamin A\u2010deficient rat liver"],"prefix":"10.1002","volume":"579","author":[{"given":"Michael","family":"Murray","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alison M.","family":"Butler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva","family":"Fiala-Beer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gloria M.","family":"Su","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,6,8]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.22.13262"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.83.7.2411"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1006\/smim.1995.0029"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.271.10.5929"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.bi.64.070195.003201"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1210\/mend.14.2.0423"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M107597200"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-199631010-00004"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0704380"},{"key":"e_1_2_6_11_1","first-page":"997","article-title":"Growth hormone and vitamin A induce P4502C7 mRNA expression in primary rat hepatocytes","volume":"44","author":"Westin S.","year":"1993","journal-title":"Mol. 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