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Here, we show that \u03b4\u2010conotoxin SVIE from <jats:italic>Conus striatus<\/jats:italic> interacts with a conserved hydrophobic triad (YFV) in the domain\u20104 voltage sensor of Na<jats:sub>V<\/jats:sub> channels. This site overlaps with that of the scorpion \u03b1\u2010toxin Lqh\u20102, but not with the \u03b1\u2010like toxin Lqh\u20103 site. \u03b4\u2010SVIE functionally competes with Lqh\u20102, but exhibits strong cooperativity with Lqh\u20103, presumably by synergistically trapping the voltage sensor in its \u201con\u201d position.<\/jats:p>","DOI":"10.1016\/j.febslet.2005.05.077","type":"journal-article","created":{"date-parts":[[2005,6,20]],"date-time":"2005-06-20T20:04:21Z","timestamp":1119297861000},"page":"3881-3884","source":"Crossref","is-referenced-by-count":100,"title":["Molecular interaction of \u03b4\u2010conotoxins with voltage\u2010gated sodium channels"],"prefix":"10.1002","volume":"579","author":[{"given":"Enrico","family":"Leipold","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfred","family":"Hansel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baldomero M.","family":"Olivera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heinrich","family":"Terlau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan H.","family":"Heinemann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,6,16]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ento.44.1.429"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0300-9084(00)01174-3"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00020.2003"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(17)41983-1"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.3.1123"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.1996.67062451.x"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi00427a049"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.1993.tb00205.x"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi00204a003"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M206833200"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M309576200"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(89)90113-X"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004240050959"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi010683a"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0041-0101(98)00080-4"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.271.27.15950"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi010973r"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9568.2002.02142.x"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1124\/mol.65.3.685"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M309594200"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.42.27076"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.1.80"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1124\/mol.59.6.1457"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-1910(01)00143-3"}],"container-title":["FEBS Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1016%2Fj.febslet.2005.05.077","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1016%2Fj.febslet.2005.05.077","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.febslet.2005.05.077","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,18]],"date-time":"2023-09-18T00:46:00Z","timestamp":1694997960000},"score":1,"resource":{"primary":{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/10.1016\/j.febslet.2005.05.077"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,6,16]]},"references-count":24,"journal-issue":{"issue":"18","published-print":{"date-parts":[[2005,7,18]]}},"alternative-id":["10.1016\/j.febslet.2005.05.077"],"URL":"https:\/\/doi.org\/10.1016\/j.febslet.2005.05.077","archive":["Portico"],"relation":{},"ISSN":["0014-5793","1873-3468"],"issn-type":[{"value":"0014-5793","type":"print"},{"value":"1873-3468","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,6,16]]}}}