{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T21:24:07Z","timestamp":1791321847934,"version":"4.3.1"},"reference-count":29,"publisher":"Wiley","issue":"19","license":[{"start":{"date-parts":[[2005,7,14]],"date-time":"2005-07-14T00:00:00Z","timestamp":1121299200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["FEBS Letters"],"published-print":{"date-parts":[[2005,8]]},"abstract":"<jats:p>In this study, we isolated and pharmacologically characterized the first \u03b1\u2010like toxin from the venom of the scarcely studied Iranian scorpion <jats:italic>Odonthobuthus doriae<\/jats:italic>. The toxin was termed OD1 and its primary sequence was determined: GVRDAYIADDKNCVYTCASNGYCNTECTKNGAESGYCQWIGRYGNACWCIKLPDEVPIRIPGKCR. Using the two\u2010electrode voltage clamp technique, the pharmacological effects of OD1 were studied on three cloned voltage\u2010gated Na<jats:sup>+<\/jats:sup> channels expressed in <jats:italic>Xenopus laevis<\/jats:italic> oocytes (Na<jats:sub>v<\/jats:sub>1.2\/\u03b2<jats:sub>1<\/jats:sub>, Na<jats:sub>v<\/jats:sub>1.5\/\u03b2<jats:sub>1<\/jats:sub>, para\/tipE). The inactivation process of the insect channel, para\/tipE, was severely hampered by 200 nM of OD1 (EC<jats:sub>50<\/jats:sub>\n= 80 \u00b1 14 nM) while Na<jats:sub>v<\/jats:sub>1.2\/\u03b2<jats:sub>1<\/jats:sub> still was not affected at concentrations up to 5 \u03bcM. Na<jats:sub>v<\/jats:sub>1.5\/\u03b2<jats:sub>1<\/jats:sub> was influenced at micromolar concentrations.<\/jats:p>","DOI":"10.1016\/j.febslet.2005.06.052","type":"journal-article","created":{"date-parts":[[2005,7,18]],"date-time":"2005-07-18T13:49:46Z","timestamp":1121694586000},"page":"4181-4186","source":"Crossref","is-referenced-by-count":53,"title":["OD1, the first toxin isolated from the venom of the scorpion <i>Odonthobuthus doriae<\/i> active on voltage\u2010gated Na<sup>+<\/sup> 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