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Serum phospholipid, which correlates positively with the scavenger receptor class B type I (SR\u2010BI)\u2010mediated cholesterol efflux, and apolipoprotein A\u2010IV and E, acceptors for ATP\u2010binding cassette transporter A1 (ABCA1)\u2010mediated cholesterol transport, are increased in GSD\u2010Ia mice. Importantly, sera from GSD\u2010Ia mice are more efficient than sera from control littermates in promoting SR\u2010BI\u2010 and ABCA1\u2010mediated cholesterol effluxes. As the first step in reverse cholesterol transport, essential for cholesterol homeostasis, these observations provide one explanation why GSD\u2010Ia patients are apparently protected against premature atherosclerosis.<\/jats:p>","DOI":"10.1016\/j.febslet.2005.07.042","type":"journal-article","created":{"date-parts":[[2005,8,4]],"date-time":"2005-08-04T19:54:58Z","timestamp":1123185298000},"page":"4713-4718","source":"Crossref","is-referenced-by-count":5,"title":["Increased cellular cholesterol efflux in glycogen storage disease type Ia mice: A potential mechanism that protects against premature atherosclerosis"],"prefix":"10.1002","volume":"579","author":[{"given":"Andrew 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