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We demonstrate that gliadin alters barrier function almost immediately by decreasing transepithelial resistance and increasing permeability to small molecules (4 kDa). Gliadin caused a reorganisation of actin filaments and altered expression of the tight junction proteins occludin, claudin\u20103 and claudin\u20104, the TJ\u2010associated protein ZO\u20101 and the adherens junction protein E\u2010cadherin.<\/jats:p>","DOI":"10.1016\/j.febslet.2005.07.066","type":"journal-article","created":{"date-parts":[[2005,8,9]],"date-time":"2005-08-09T11:30:18Z","timestamp":1123587018000},"page":"4851-4855","source":"Crossref","is-referenced-by-count":150,"title":["Rapid disruption of intestinal barrier function by gliadin involves altered expression of apical junctional proteins"],"prefix":"10.1002","volume":"579","author":[{"given":"Guy R.","family":"Sander","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adrian G.","family":"Cummins","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barry C.","family":"Powell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,8,8]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(96)70237-4"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.163.3.286"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2003.09.004"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(83)92742-3"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-199804000-00001"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.113.10.1771"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1461-5347(99)00170-4"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0955-0674(99)00016-2"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2001.21736"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0854.2001.020203.x"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.35.1_Suppl.S18"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.33.11.1487"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1159\/000063817"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2004.01.013"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.54.9.684"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(03)00236-9"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-198212000-00006"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-197911000-00010"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.52.2.218"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)02169-3"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.1987.253.6.C749"},{"key":"e_1_2_6_23_1","first-page":"32","article-title":"Effects of wheat germ agglutinin on the cellular content of filamentous actin in Intestine 407 cells","volume":"47","author":"Sjolander A.","year":"1988","journal-title":"Eur. 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