{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T22:27:03Z","timestamp":1759530423454},"reference-count":26,"publisher":"Wiley","issue":"24","license":[{"start":{"date-parts":[[2005,9,20]],"date-time":"2005-09-20T00:00:00Z","timestamp":1127174400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["FEBS Letters"],"published-print":{"date-parts":[[2005,10,10]]},"abstract":"<jats:p>Botulinum neurotoxin (BoNT) is the most toxic species known to humans and has been identified as a potential bioterrorist threat. Unfortunately, the only existing countermeasures for BoNT intoxication involve vaccinations that are only effective prior to entry of the toxin into neuronal cells. Herein, we disclose the ability of the micronutrient riboflavin (vitamin B<jats:sub>2<\/jats:sub>) to photooxidatively inactivate BoNT in cell\u2010based assays without the need for toxin and riboflavin pre\u2010exposure. In total, this study suggests that botulism neurotoxicity may be blunted with photodynamic therapy technology.<\/jats:p>","DOI":"10.1016\/j.febslet.2005.08.072","type":"journal-article","created":{"date-parts":[[2005,9,21]],"date-time":"2005-09-21T11:11:24Z","timestamp":1127301084000},"page":"5361-5364","source":"Crossref","is-referenced-by-count":12,"title":["Vitamin B<sub>2<\/sub>\u2010mediated cellular photoinhibition of botulinum neurotoxin A"],"prefix":"10.1002","volume":"579","author":[{"given":"Lisa M.","family":"Eubanks","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tobin J.","family":"Dickerson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kim D.","family":"Janda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,9,20]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-2712(18)30023-4"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.3109\/15569549909036013"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.285.8.1059"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1128\/MMBR.44.3.419-448.1980"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0300-9084(00)01173-1"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0041-0101(98)00146-9"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(80)90469-6"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(84)90988-4"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.60.1.21"},{"key":"e_1_2_5_11_1","first-page":"120","article-title":"Comparison of the effects of botulinum neurotoxin types A and E at the rat neuromuscular junction","volume":"61","author":"Sellin L.C.","year":"1983","journal-title":"Med. Biol."},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0076-6879(71)18110-4"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja00904a013"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)64495-3"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)91192-0"},{"key":"e_1_2_5_16_1","first-page":"22","article-title":"Chemistry and biologic activity of the toxin of Clostridium botulinum","volume":"15","author":"Boroff D.A.","year":"1967","journal-title":"J. Albert Einstein Medical Center"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1179\/joc.2002.14.5.431"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3156.2005.01417.x"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(17)42071-0"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(99)00948-5"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/0041-0101(94)00188-E"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.73.7.2424"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M205258200"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi0356698"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-1097.1996.tb01828.x"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4020(01)00952-8"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1177\/153303460500400308"}],"container-title":["FEBS Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1016%2Fj.febslet.2005.08.072","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.febslet.2005.08.072","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,12]],"date-time":"2023-10-12T04:18:04Z","timestamp":1697084284000},"score":1,"resource":{"primary":{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/10.1016\/j.febslet.2005.08.072"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,9,20]]},"references-count":26,"journal-issue":{"issue":"24","published-print":{"date-parts":[[2005,10,10]]}},"alternative-id":["10.1016\/j.febslet.2005.08.072"],"URL":"https:\/\/doi.org\/10.1016\/j.febslet.2005.08.072","archive":["Portico"],"relation":{},"ISSN":["0014-5793","1873-3468"],"issn-type":[{"value":"0014-5793","type":"print"},{"value":"1873-3468","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,9,20]]}}}