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Activation of n\u2010sphingomyelinase (n\u2010SMase) in mice liver and brain is coincided in time with increased level of peroxide products (conjugated dienes) after injection of tumor necrosis factor \u03b1 (TNF\u2010\u03b1). We found that ceramide can induce peroxide oxidation and lead to accumulation of TNF\u2010\u03b1 in animal organs. Nitric oxide (NO) donors (<jats:italic>S<\/jats:italic>\u2010nitrosoglutathione and dinitrosyl iron complex) reversibly inhibited activity of n\u2010SMase and decreased level of lipid peroxidation products. This data proposed that both SMase and messengers of oxidative systems could be targets for NO\u2010derived oxidants.<\/jats:p>","DOI":"10.1016\/j.febslet.2005.08.085","type":"journal-article","created":{"date-parts":[[2005,9,29]],"date-time":"2005-09-29T11:16:43Z","timestamp":1127992603000},"page":"5571-5576","source":"Crossref","is-referenced-by-count":19,"title":["The relation between sphingomyelinase activity, lipid peroxide oxidation and NO\u2010releasing in mice liver and brain"],"prefix":"10.1002","volume":"579","author":[{"given":"A.V.","family":"Alessenko","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.A.","family":"Shupik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"U.A.","family":"Gutner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.E.","family":"Bugrova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.B.","family":"Dudnik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.N.","family":"Shingarova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Mikoyan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.F.","family":"Vanin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,9,28]]},"reference":[{"key":"e_1_2_5_2_1","first-page":"1237","article-title":"Multiple redox regulation in NF-kappaB transcription factor activation","volume":"378","author":"Piette J.","year":"1997","journal-title":"Biol. 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