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We show that activation of caspase\u20103 and caspase\u20107 is considerably enhanced in gingival tissue from patients with periodontitis. We also demonstrate in in vitro experiments that various periodontopathic bacteria exert a direct growth\u2010suppressing effect and, moreover, can trigger a host\u2010mediated cytotoxic activity involving the CD95 death receptor. Our data suggest that caspase activation is a prominent feature in periodontitis\u2010associated tissue injury.<\/jats:p>","DOI":"10.1016\/j.febslet.2005.09.020","type":"journal-article","created":{"date-parts":[[2005,9,29]],"date-time":"2005-09-29T11:16:43Z","timestamp":1127992603000},"page":"5559-5564","source":"Crossref","is-referenced-by-count":47,"title":["Caspase activation is involved in chronic periodontitis"],"prefix":"10.1002","volume":"579","author":[{"given":"Heike","family":"Bantel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Beikler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas F.","family":"Flemmig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus","family":"Schulze-Osthoff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,9,28]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.1997.tb00199.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001432-200006000-00005"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1128\/iai.63.10.3914-3919.1995"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.66.11.5190-5195.1998"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-9969(99)00002-3"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.68.8.4611-4615.2000"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(00)80062-X"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cdd.4401160"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1432-1327.1998.2540439.x"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.162.12.7140"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.1997.tb00022.x"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.67.3.1450-1454.1999"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2001.28229"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.20411"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200105081"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.11.5860"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2001.72.4.517"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1471-4906(00)01814-7"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-2952(03)00497-0"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.190.12.1879"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.193.2.247"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.micro.53.1.155"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1515\/bchm.2001.382.5.817"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.73.3.1543-1552.2005"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-6968.2001.tb10706.x"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.72.7.3743-3751.2004"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/3276"}],"container-title":["FEBS Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1016%2Fj.febslet.2005.09.020","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.febslet.2005.09.020","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,12]],"date-time":"2023-10-12T04:01:07Z","timestamp":1697083267000},"score":1,"resource":{"primary":{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/10.1016\/j.febslet.2005.09.020"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,9,28]]},"references-count":27,"journal-issue":{"issue":"25","published-print":{"date-parts":[[2005,10,24]]}},"alternative-id":["10.1016\/j.febslet.2005.09.020"],"URL":"https:\/\/doi.org\/10.1016\/j.febslet.2005.09.020","archive":["Portico"],"relation":{},"ISSN":["0014-5793","1873-3468"],"issn-type":[{"value":"0014-5793","type":"print"},{"value":"1873-3468","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,9,28]]}}}