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We have demonstrated that reduced dietary thiamin in F344 rats decreased transketolase activity and increased \u03b1\u2010oxoaldehyde adduct levels. The methylglyoxal protein adduct level was not affected by oral glyoxal or methylglyoxal in the animals receiving thiamin at the control levels but was markedly increased in the animals on a thiamin\u2010reduced diet. These observations are consistent with our suggestion that the induction of aberrant crypt foci with marginally thiamin\u2010deficient diets may be a consequence of the formation of methylglyoxal adducts.<\/jats:p>","DOI":"10.1016\/j.febslet.2005.09.027","type":"journal-article","created":{"date-parts":[[2005,9,29]],"date-time":"2005-09-29T11:16:43Z","timestamp":1127992603000},"page":"5596-5602","source":"Crossref","is-referenced-by-count":24,"title":["The effects of partial thiamin deficiency and oxidative stress (i.e., glyoxal and methylglyoxal) on the levels of \u03b1\u2010oxoaldehyde plasma protein adducts in Fischer 344 rats"],"prefix":"10.1002","volume":"579","author":[{"given":"Nandita","family":"Shangari","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Flore","family":"Depeint","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rudolf","family":"Furrer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W. 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