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Interestingly, equipotent doses of the CB1 antagonist SR141716A and the CB1\/CB2 agonist anandamide inflicted additive negative effects on viability. Moreover, treatment with the CB1\/CB2 agonist Win\u201055,212\u20102 caused a decrease in long\u2010term growth of MCL cells in culture. Induction of apoptosis, as measured by FACS\/Annexin V\u2013FITC, contributed to the growth suppressive effect of Win\u201055,212\u20102. Our data suggest that cannabinoid receptors may be considered as potential therapeutic targets in MCL.<\/jats:p>","DOI":"10.1016\/j.febslet.2005.11.020","type":"journal-article","created":{"date-parts":[[2005,11,30]],"date-time":"2005-11-30T12:14:39Z","timestamp":1133352879000},"page":"6885-6889","source":"Crossref","is-referenced-by-count":67,"title":["Cannabinoid receptor ligands mediate growth inhibition and cell death in mantle cell lymphoma"],"prefix":"10.1002","volume":"579","author":[{"given":"Jenny","family":"Flygare","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristin","family":"Gustafsson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva","family":"Kimby","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Birger","family":"Christensson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Birgitta","family":"Sander","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,29]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/10428190290016881"},{"key":"e_1_2_5_3_1","first-page":"4398","article-title":"Mantle cell lymphomas express a distinct genetic signature affecting lymphocyte trafficking and growth regulation as compared with subpopulations of normal human B cells","volume":"62","author":"Ek S.","year":"2002","journal-title":"Cancer Res."},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2403057"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1124\/pr.54.2.161"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1188"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-04-3410"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-03-3720"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(95)00746-V"},{"key":"e_1_2_5_10_1","first-page":"736","article-title":"Identification of a functionally relevant cannabinoid receptor on mouse spleen cells that is involved in cannabinoid-mediated immune modulation","volume":"42","author":"Kaminski N.E.","year":"1992","journal-title":"Mol. 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