{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T12:27:26Z","timestamp":1790166446940,"version":"4.1.0"},"reference-count":33,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,12,1]],"date-time":"2005-12-01T00:00:00Z","timestamp":1133395200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["FEBS Letters"],"published-print":{"date-parts":[[2006,1,9]]},"abstract":"<jats:p>Despite the importance of circadian rhythms in vector\u2010borne disease transmission, very little is known about its molecular control in hematophagous insect vectors. In <jats:italic>Drosophila melanogaster<\/jats:italic>, a negative feedback loop of gene expression has been shown to contribute to the clock mechanism. Here, we describe some features of the circadian clock of the sandfly <jats:italic>Lutzomyia longipalpis<\/jats:italic>, a vector of visceral leishmaniasis. Compared to <jats:italic>D. melanogaster<\/jats:italic>, sandfly <jats:italic>period<\/jats:italic> and <jats:italic>timeless<\/jats:italic>, two negative elements of the feedback loop, show similar peaks of mRNA abundance. On the other hand, the expression of <jats:italic>Clock<\/jats:italic> (a positive transcription factor) differs between the two species, raising the possibility that the different phases of <jats:italic>Clock<\/jats:italic> expression could be associated with the observed differences in circadian activity rhythms. In addition, we show a reduction in locomotor activity after a blood meal, which is correlated with downregulation of <jats:italic>period<\/jats:italic> and <jats:italic>timeless<\/jats:italic> expression levels. Our results suggest that the circadian pacemaker and its control over the activity rhythms in this hematophagous insect are modulated by blood intake.<\/jats:p>","DOI":"10.1016\/j.febslet.2005.11.031","type":"journal-article","created":{"date-parts":[[2005,12,2]],"date-time":"2005-12-02T12:24:27Z","timestamp":1133526267000},"page":"2-8","source":"Crossref","is-referenced-by-count":61,"title":["The biological clock of an hematophagous insect: Locomotor activity rhythms, circadian expression and downregulation after a blood meal"],"prefix":"10.1002","volume":"580","author":[{"given":"Antonio C.A.","family":"Meireles-Filho","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo B.","family":"da S. 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