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We have investigated the antigenicity of two distantly related glycosidases, \u03b1\u2010glucosidase (Pompe disease or glycogen storage disease type II, GSD II), and \u03b1\u2010<jats:sc>l<\/jats:sc>\u2010iduronidase (Hurler syndrome, mucopolysaccharidosis type I, MPS I). The linear sequence epitope reactivity of affinity purified polyclonal antibodies to recombinant human \u03b1\u2010glucosidase and \u03b1\u2010<jats:sc>l<\/jats:sc>\u2010iduronidase was defined, to both glycosidases. The polyclonal antibodies exhibited some cross\u2010reactive epitopes on the two proteins. Moreover, a monoclonal antibody to the active site of \u03b1\u2010glucosidase showed cross\u2010reactivity with a catalytic structural element of \u03b1\u2010<jats:sc>l<\/jats:sc>\u2010iduronidase. In a previous study, in MPS I patients who developed an immune response to ERT, this same site on \u03b1\u2010<jats:sc>l<\/jats:sc>\u2010iduronidase was highly antigenic and the last to tolerise following repeated enzyme infusions. We conclude that glycosidases can exhibit cross\u2010reactive epitopes, and infer that this may relate to common structural elements associated with their active sites.<\/jats:p>","DOI":"10.1016\/j.febslet.2005.11.053","type":"journal-article","created":{"date-parts":[[2005,12,7]],"date-time":"2005-12-07T13:36:55Z","timestamp":1133962615000},"page":"87-92","source":"Crossref","is-referenced-by-count":2,"title":["Common antigenicity for two glycosidases"],"prefix":"10.1002","volume":"580","author":[{"given":"Revecca","family":"Kakavanos","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre","family":"Lehn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabelle","family":"Callebaut","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter J.","family":"Meikle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emma J.","family":"Parkinson-Lawrence","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John J.","family":"Hopwood","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Doug A.","family":"Brooks","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,12,6]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr00105a006"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0959-440X(94)90271-2"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj3160695"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/glycob\/7.2.277"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/9.6.967"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(95)00252-5"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(02)02879-X"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)92727-4"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1432-1327.2001.02104.x"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M410468200"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/glycob\/11.9.741"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi034293v"},{"key":"e_1_2_6_14_1","unstructured":"2001 McGraw-Hill New York E.F. 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