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As there is no evidence of maternal acute\u2010phase protein transplacental transfer and trophoblast plays an important role in regulating immune responses at the feto\u2010maternal interface, the expression of acute\u2010phase serum amyloid A (A\u2010SAA) was investigated in human first trimester trophoblast and trophoblast\u2010like JAR and Jeg\u20103 choriocarcinoma cells. We here show expression of cytokine receptors and cytokine\u2010dependent induction of A\u2010SAA in JAR and Jeg\u20103 cells. While interleukin\u20101\u03b1\/\u03b2 is a major agonist for A\u2010SAA expression in JAR, tumor necrosis factor\u2010\u03b1 is the predominant agonist in Jeg\u20103. First trimester trophoblast and JAR\/Jeg\u20103 cells further express the human homolog of SAA\u2010activating factor\u20101, a transcription factor involved in cytokine\u2010mediated induction of A\u2010<jats:italic>SAA<\/jats:italic> genes. A\u2010<jats:italic>SAA1<\/jats:italic> and A\u2010<jats:italic>SAA2<\/jats:italic> transcripts were increased in first trimester trophoblast during pregnancy weeks 10 and 12 suggesting that A\u2010SAA plays a role during early fetal development.<\/jats:p>","DOI":"10.1016\/j.febslet.2005.11.067","type":"journal-article","created":{"date-parts":[[2005,12,7]],"date-time":"2005-12-07T13:36:55Z","timestamp":1133962615000},"page":"161-167","source":"Crossref","is-referenced-by-count":33,"title":["Expression of serum amyloid A transcripts in human trophoblast and fetal\u2010derived trophoblast\u2010like choriocarcinoma cells"],"prefix":"10.1002","volume":"580","author":[{"given":"Alenka","family":"Kovacevic","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Astrid","family":"Hammer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monika","family":"Sundl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bettina","family":"Pfister","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andelko","family":"Hrzenjak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alpana","family":"Ray","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bimal K.","family":"Ray","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wolfgang","family":"Sattler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ernst","family":"Malle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,12,6]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9150(93)90155-N"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1432-1327.1999.00657.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-291X(03)00045-7"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3083.1985.tb01431.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2362.1996.159291.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.20.3.763"},{"key":"e_1_2_6_8_1","unstructured":"K. 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