{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T19:15:21Z","timestamp":1789758921250,"version":"4.0.1"},"reference-count":35,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,1,18]],"date-time":"2006-01-18T00:00:00Z","timestamp":1137542400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["FEBS Letters"],"published-print":{"date-parts":[[2006,2,6]]},"abstract":"<jats:p>Tight junction (TJ) constitutes the barrier by controlling the passage of ions and molecules via paracellular pathway and the movement of proteins and lipids between apical and basolateral domains of the plasma membrane. Claudins, occludin, and junctional adhesion molecules are the major three transmembrane proteins at TJ. This study focuses a newly identified mammalian TJ gene, claudin\u201019, in kidneys. Mouse claudin\u201019 composes of 224 amino acids and shares 98.2% and 95% amino acid homology with rat and human, respectively; the most evolutionary\u2010related claudins are claudin\u20101 and \u20107, which share \u223c75% DNA sequence homology with claudin\u201019. Claudin\u201019 is abundantly expressed in the mouse and rat kidneys among the organs examined by Northern blots, and to a much less extent, also found in brain by RT\u2010PCR. Claudin\u201019 and zonula occludens\u20101 (ZO\u20101) are localized at junctional regions of Madin\u2013Darby canine kidney (MDCK) cells by immunofluorescent microscopy. In addition, ZO\u20101 is found in the claudin\u201019\u2010associated protein complexes in MDCK cells by co\u2010immunoprecipitation. Using aquaporin\u20101 and aquaporin\u20102 antibodies as markers for different renal segment, strong expression of claudin\u201019 was observed in distal tubules of the cortex as well as in the collecting ducts of the medulla. To less extent, claudin\u201019 is also present in the proximal tubules (cortex) and in the loop of Henle (medulla). Furthermore, intense claudin\u201019 immunoreactivity is found co\u2010localized with the ZO\u20101 in kidneys from postnatal day 15, day 45, and adult rats and mice. Similar localizations of claudin\u201019 and ZO\u20101 are also observed in human kidneys. Since these renal segments are mainly for controlling the paracellular cation transport, it is suggested that claudin\u201019 may participate in these processes. In human polycystic kidneys, decreased expression and dyslocalization of claudin\u201019 are noticed, suggesting a possible correlation between claudin\u201019 and renal disorders. Taken together, claudin\u201019 is a claudin isoform that is highly and specifically expressed in renal tubules with a putative role in TJ homeostasis in renal physiology.<\/jats:p>","DOI":"10.1016\/j.febslet.2006.01.019","type":"journal-article","created":{"date-parts":[[2006,1,19]],"date-time":"2006-01-19T19:00:46Z","timestamp":1137697246000},"page":"923-931","source":"Crossref","is-referenced-by-count":44,"title":["Kidney claudin\u201019: Localization in distal tubules and collecting ducts and dysregulation in polycystic renal disease"],"prefix":"10.1002","volume":"580","author":[{"given":"Nikki P.Y.","family":"Lee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Man K.","family":"Tong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pauline P.","family":"Leung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivian W.","family":"Chan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Leung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Po-Chor","family":"Tam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwok-Wah","family":"Chan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai-Fai","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William S.B.","family":"Yeung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John M.","family":"Luk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,1,18]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00558.2003"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.V1061337"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0955-0674(03)00104-2"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0079-6107(02)00037-8"},{"key":"e_1_2_6_6_1","first-page":"126","article-title":"Molecular structure of tight junctions and their role in epithelial transport","volume":"16","author":"Anderson J.","year":"2001","journal-title":"News Physiol. Sci."},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.58.2.390"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.V134875"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00384.2003"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.0021.2001"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-4165(81)90307-X"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.153.2.263"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81553-6"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200501154"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.1174"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.285.5424.103"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1205741"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/22.22.4673"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.2002.6676"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-291X(03)01250-6"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1939-4640.2004.tb02780.x"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2003.10.032"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2004.05.213"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1043-2760(02)00665-3"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2002.00479.x"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1982.199"},{"key":"e_1_2_6_27_1","volume-title":"Brenner &amp; Rector's the Kidney","author":"Brenner B.M.","year":"2004"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm1469"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.147.6.1351"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M406331200"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1086\/380418"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M213286200"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.2000.279.2.G250"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.149.1.111"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00424-002-0827-8"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2004.11.010"}],"container-title":["FEBS Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1016%2Fj.febslet.2006.01.019","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.febslet.2006.01.019","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,12]],"date-time":"2023-10-12T23:54:27Z","timestamp":1697154867000},"score":1,"resource":{"primary":{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/10.1016\/j.febslet.2006.01.019"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,1,18]]},"references-count":35,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2006,2,6]]}},"alternative-id":["10.1016\/j.febslet.2006.01.019"],"URL":"https:\/\/doi.org\/10.1016\/j.febslet.2006.01.019","archive":["Portico"],"relation":{},"ISSN":["0014-5793","1873-3468"],"issn-type":[{"value":"0014-5793","type":"print"},{"value":"1873-3468","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,1,18]]}}}